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MAP3K7

Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene.

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2.7.11.25
Aliases
MAP3K7, MEKK7, TAK1, TGF1a, mitogen-activated protein kinase kinase kinase 7, FMD2, CSCF
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EVA, 2YIY, 4GS6, 4L3P, 4L52, 4L53, 4O91, 5JGD, 5JGA
Band
6q15 · 4|4 A5
Bgee
tendon of biceps brachii · corpus epididymis · internal globus pallidus · stromal cell of endometrium · tail of epididymis
BioGPS
More reference expression data

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MAP3K7

Nodes15
Edges14
Triples155
Avg. degree1.87
Density0.133333
Components1

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MAP3K7

Top relations

Gene ontology · 51
MAP3K7 → activation of NF-kappaB-inducing kinase activity, anoikis, apoptotic process, ATP binding, cytoplasm, cytosol, endosome membrane, Fc-epsilon receptor signaling pathway, histone H3 acetylation, I-kappaB kinase/NF-kappaB signaling, I-kappaB phosphorylation, identical protein binding, IkappaB kinase complex, interleukin-1-mediated signaling pathway, JNK cascade, kinase activity, magnesium ion binding, MAP kinase kinase kinase activity, membrane, metal ion binding
related to Signaling · 24
MAP3K7 → BMP, Following, Following TNF, Four, IL-1, In, LPS, MAP2K4/MKK4, MAP3K7P1/TAB1, MAP3K7P2/TAB2, MAPK8/JNK, NF-κB, NF-κB-independent, RIPK1, TAB1, TAB2/3, TAK1, TAK1has, TGF, TGFB
Bgee · 20
MAP3K7 → Achilles tendon, aortic valve, Brodmann area 23, caput epididymis, corpus callosum, corpus epididymis, ganglionic eminence, genital tubercle, internal globus pallidus, mandibular prominence, maxillary prominence, molar, Paneth cell, somite, stromal cell of endometrium, tail of embryo, tail of epididymis, tendon of biceps brachii, vastus lateralis muscle, ventricular zone
RNA expression pattern · 20
MAP3K7 → Achilles tendon, aortic valve, Brodmann area 23, caput epididymis, corpus callosum, corpus epididymis, ganglionic eminence, genital tubercle, internal globus pallidus, mandibular prominence, maxillary prominence, molar, Paneth cell, somite, stromal cell of endometrium, tail of embryo, tail of epididymis, tendon of biceps brachii, vastus lateralis muscle, ventricular zone
related to Interactions · 8
MAP3K7 → ASK1, CHUK, MAP2K6, MAP3K7IP2, MAP3K7IP3, Mothers, PPM1B, TAB1
Band · 2
MAP3K7 → 4|4 A5, 6q15
Chr. · 2
MAP3K7 → Chromosome 4 (mouse), Chromosome 6 (human)
End · 2
MAP3K7 → 32,023,467 bp, 90,587,072 bp
2.7.11.25 · 1
MAP3K7 → ↗
Aliases · 1
MAP3K7 → MAP3K7, MEKK7, TAK1, TGF1a, mitogen-activated protein kinase kinase kinase 7, FMD2, CSCF

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Important terminology

tak1 kinase protein bp human gene chr band shown also chromosome cell activation tnf structure humans mouse mitogen-activated location signaling

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MAP3K72.7.11.251.00infobox
MAP3K7AliasesMAP3K7, MEKK7, TAK1, TGF1a, mitogen-activated protein kinase kinase kinase 7, FMD2, CSCF1.00infobox
MAP3K7Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EVA, 2YIY, 4GS6, 4L3P, 4L52, 4L53, 4O91, 5JGD, 5JGA1.00infobox
MAP3K7Band6q151.00infobox
MAP3K7Band4|4 A51.00infobox
MAP3K7Bgeetendon of biceps brachii1.00infobox
MAP3K7Bgeecorpus epididymis1.00infobox
MAP3K7Bgeeinternal globus pallidus1.00infobox
MAP3K7Bgeestromal cell of endometrium1.00infobox
MAP3K7Bgeetail of epididymis1.00infobox
MAP3K7Bgeecaput epididymis1.00infobox
MAP3K7Bgeeganglionic eminence1.00infobox
MAP3K7Bgeecorpus callosum1.00infobox
MAP3K7BgeeBrodmann area 231.00infobox
MAP3K7BgeeAchilles tendon1.00infobox
MAP3K7Bgeegenital tubercle1.00infobox
MAP3K7Bgeetail of embryo1.00infobox
MAP3K7BgeePaneth cell1.00infobox
MAP3K7Bgeemolar1.00infobox
MAP3K7Bgeeaortic valve1.00infobox
MAP3K7Bgeeventricular zone1.00infobox
MAP3K7Bgeemaxillary prominence1.00infobox
MAP3K7Bgeesomite1.00infobox
MAP3K7Bgeevastus lateralis muscle1.00infobox
MAP3K7Bgeemandibular prominence1.00infobox
MAP3K7BioGPSMore reference expression data1.00infobox
MAP3K7Chr.Chromosome 6 (human)1.00infobox
MAP3K7Chr.Chromosome 4 (mouse)1.00infobox
MAP3K7DatabasesNCBI: entry; OMA: entry1.00infobox
MAP3K7End90,587,072 bp1.00infobox

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