C-Raf

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Structure

Chromosome 3 MRNA Alternative exon Exons Protein kinase

18 related topics

Evolutionary relationships

Drosophila C. elegans Paralogous KSR1 KSR2

9 related topics

Regulation of activity

TGF-beta activated kinase 1 Protein phosphatase 1 Activation loop BAD Adenylate cyclases

9 related topics

Discovery

Retrovirus Cell lines Mitogen-activated protein kinase Vertebrate A-Raf

6 related topics

Key facts & relationships

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2.7.11.1: ↗
Aliases: RAF1, Raf-1 proto-oncogene, serine/threonine kinase, CMD1NN, CRAF, NS5, Raf-1, c-Raf
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C1Y, 1FAQ, 1FAR, 1GUA, 1RFA, 3CU8, 3IQJ, 3IQU, 3IQV, 3KUC, 3KUD, 3NKX, 3O8I, 3OMV, 4FJ3, 4G0N, 4G3X, 4IEA,…
Band: 6 E3|6 53.62 cM
Bgee: granulocyte · epithelium of stomach · zygote · medullary collecting duct · ventricular zone
BioGPS: More reference expression data

Topics to explore

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Overview

Enzyme
Encoded Genetic code
Gene
ERK1/2 pathway MAPK/ERK pathway
Ras subfamily
Raf kinase
Serine/threonine-specific protein kinases Serine/threonine-specific protein kinase

Discovery

Structure

Chromosome 3 Chromosome 3 (human)
MRNA Messenger RNA
Alternative exon Alternative splicing
Exons Exon
Protein kinase
MAPKKKs MAP kinase kinase kinase
Domains Protein domain
Ras-binding domain Raf-like Ras-binding domain
C1 domain
Zinc finger
Protein kinase C
Serine
Sequence Sequence (biology)
Island Short linear motif
14-3-3 protein
Kinase domain Protein kinase domain
MKK1 MAP2K1
MKK2 MAP2K2

Evolutionary relationships

Drosophila
C. elegans Caenorhabditis elegans
Paralogous Homology (biology)
KSR1
KSR2
SAM Sterile alpha motif
Coiled-coils Coiled coil
Opisthokonts Opisthokont
Capsaspora owczarzaki Capsaspora

Regulation of activity

TGF-beta activated kinase 1 MAP3K7
Protein phosphatase 1
Activation loop
BAD Bcl-2-associated death promoter
Adenylate cyclases Adenylate cyclase
Myosin phosphatase (myosin-light-chain) phosphatase
Cardiac muscle troponin T Troponin
Retinoblastoma protein
Cdc25 phosphatase Cdc25

Associated human diseases

As a therapeutic target

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes64

Edges63

Triples317

Avg. degree1.97

Density0.03125

Components1

How this topic connects Entity context

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C-Raf

Top relations

Gene ontology · 67

C-Raf → activation of adenylate cyclase activity, adenylate cyclase activator activity, adenylate cyclase binding, apoptotic process, ATP binding, cell differentiation, cell population proliferation, cellular glucose homeostasis, cytoplasm, cytosol, death-inducing signaling complex assembly, development of the heart, enzyme binding, face development, Golgi apparatus, identical protein binding, insulin secretion involved in cellular response to glucose stimulus, intermediate filament cytoskeleton organization, intracellular anatomical structure, intracellular signal transduction

related to Evolutionary relationships · 56

C-Raf → A-Raf, According, All, Although, Apart, ASK1/ASK2, ASK2, B-Raf, But, C-terminal, C1, CA1, CA2, CA3, CA4, CA5, Caenorhabditis, CC-SAM, CR3, Draf

related to List of interacting proteins · 33

C-Raf → AKT1, ASK1, BAG1, Bcl-2, BRAF, CDC25A, CFLAR, FYN, GRB10, HRAS, HSP90AA1, KRAS, MAP2K1, MAP3K1, MAPK7, MAPK8IP3, PAK1, PEBP1, PHB, PRKCZ

related to Discovery · 20

C-Raf → A-Raf, B-Raf, ERK1/2, In, It, MAP3, MAPK, MEK1/2, MH2, Mil, Normal, Raf, Researchers, Several, Subsequent, The, These, Thus, V-RAF, Virus-induced Rapidly Accelerated Fibrosarcoma

related to External links · 20

C-Raf → A-Raf, B-Raf, Drosophila, GeneReviews/NCBI/NIH/UW, Human RAF1, Medicine Medical Subject Headings, MeSH, National Library, Noonan, Overview, P04049, PDB, PDBe-KB, Proteins, RAF, Raf-1, RAF1, The Interactive Flyc-raf, UCSC Genome Browser, UniProt

related to Regulation of activity · 20

C-Raf → Activated, As, ERK1/2, G-proteins, GTP-bound Ras, It, KSRs, N-terminal, PP1, PP2A, Raf, Rafs, Ser, TAK1, TGF-beta, The, This, Thus, Unphosphorylated, When

related to As a therapeutic target · 18

C-Raf → ATP-competitive B-Raf, B-Raf, B-Raf-inhibitor, Dabrafenib, Due, K-Ras, K-Ras-dependent, Raf, Ras, Regorafenib, Several, Sorafenib, They, This, Unfortunately, V600E, Vemurafenib, While

related to Associated human diseases · 14

C-Raf → Abnormal, Deafness, Electrocardiographic, Hereditary, Lentigo, LEOPARD, Most, Mutation, Noonan, Ocular, Pulmonary, Raf, Retarded, Similar

related to Structure · 12

C-Raf → At, C-kinase, C1, MAPKKKs, N-terminal, On, Raf, Ras-binding, RBD, Similarly, Structures, The

Bgee · 10

C-Raf → epithelium of stomach, ganglionic eminence, granulocyte, medullary collecting duct, muscle of thigh, secondary oocyte, temporal muscle, triceps brachii muscle, ventricular zone, zygote

Important terminology Word statistics

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Important terminology

raf kinase kinases domain protein activity b-raf also gene domains activation catalytic serine binding two structure proteins erk1 human enzymes

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
C-Raf	2.7.11.1	↗	1.00	infobox
C-Raf	Aliases	RAF1, Raf-1 proto-oncogene, serine/threonine kinase, CMD1NN, CRAF, NS5, Raf-1, c-Raf	1.00	infobox
C-Raf	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C1Y, 1FAQ, 1FAR, 1GUA, 1RFA, 3CU8, 3IQJ, 3IQU, 3IQV, 3KUC, 3KUD, 3NKX, 3O8I, 3OMV, 4FJ3, 4G0N, 4G3X, 4IEA,…	1.00	infobox
C-Raf	Band	6 E3\|6 53.62 cM	1.00	infobox
C-Raf	Bgee	granulocyte	1.00	infobox
C-Raf	Bgee	epithelium of stomach	1.00	infobox
C-Raf	Bgee	zygote	1.00	infobox
C-Raf	Bgee	medullary collecting duct	1.00	infobox
C-Raf	Bgee	ventricular zone	1.00	infobox
C-Raf	Bgee	secondary oocyte	1.00	infobox
C-Raf	Bgee	ganglionic eminence	1.00	infobox
C-Raf	Bgee	temporal muscle	1.00	infobox
C-Raf	Bgee	triceps brachii muscle	1.00	infobox
C-Raf	Bgee	muscle of thigh	1.00	infobox
C-Raf	BioGPS	More reference expression data	1.00	infobox
C-Raf	Chr.	Chromosome 6 (mouse)	1.00	infobox
C-Raf	Databases	NCBI: entry; OMA: entry	1.00	infobox
C-Raf	End	115,653,596 bp	1.00	infobox
C-Raf	Ensembl	ENSG00000132155	1.00	infobox
C-Raf	Entrez	5894	1.00	infobox
C-Raf	Enzyme activity	Enzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.11.1↗↗↗↗	1.00	infobox
C-Raf	External IDs	OMIM: 164760; MGI: 97847; GeneCards: RAF1	1.00	infobox
C-Raf	Gene location (Mouse)	Gene location (Mouse)Chr.Chromosome 6 (mouse)Band6 E3\|6 53.62 cMStart115,595,028 bpEnd115,653,596 bp	1.00	infobox
C-Raf	Gene ontology	transferase activity	1.00	infobox
C-Raf	Gene ontology	protein kinase activity	1.00	infobox
C-Raf	Gene ontology	nucleotide binding	1.00	infobox
C-Raf	Gene ontology	metal ion binding	1.00	infobox
C-Raf	Gene ontology	protein serine/threonine kinase activity	1.00	infobox
C-Raf	Gene ontology	small GTPase binding	1.00	infobox
C-Raf	Gene ontology	protein binding	1.00	infobox

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