C-Raf

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C-Raf topic overview

The analysis highlights Art, Structure and Evolutionary relationships as prominent areas in the source structure around C-Raf.

Related topics: 56
Source areas: 7
Connected nodes: 63
Extracted relationships: 317
Concept neighborhoods: 27
Bridge connections: 63

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 18 topics

Evolutionary relationships · 9 topics

Regulation of activity · 9 topics

Overview · 7 topics

Discovery · 6 topics

As a therapeutic target · 5 topics

Associated human diseases · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.1: ↗
Aliases: RAF1, Raf-1 proto-oncogene, serine/threonine kinase, CMD1NN, CRAF, NS5, Raf-1, c-Raf
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C1Y, 1FAQ, 1FAR, 1GUA, 1RFA, 3CU8, 3IQJ, 3IQU, 3IQV, 3KUC, 3KUD, 3NKX, 3O8I, 3OMV, 4FJ3, 4G0N, 4G3X, 4IEA,…
Band: 6 E3|6 53.62 cM
Bgee: granulocyte · epithelium of stomach · zygote · medullary collecting duct · ventricular zone
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Enzyme
Encoded Genetic code
Gene
ERK1/2 pathway MAPK/ERK pathway
Ras subfamily
Raf kinase
Serine/threonine-specific protein kinases Serine/threonine-specific protein kinase

Discovery

Structure

Chromosome 3 Chromosome 3 (human)
MRNA Messenger RNA
Alternative exon Alternative splicing
Exons Exon
Protein kinase
MAPKKKs MAP kinase kinase kinase
Domains Protein domain
Ras-binding domain Raf-like Ras-binding domain
C1 domain
Zinc finger
Protein kinase C
Serine
Sequence Sequence (biology)
Island Short linear motif
14-3-3 protein
Kinase domain Protein kinase domain
MKK1 MAP2K1
MKK2 MAP2K2

Evolutionary relationships

Drosophila
C. elegans Caenorhabditis elegans
Paralogous Homology (biology)
KSR1
KSR2
SAM Sterile alpha motif
Coiled-coils Coiled coil
Opisthokonts Opisthokont
Capsaspora owczarzaki Capsaspora

Regulation of activity

TGF-beta activated kinase 1 MAP3K7
Protein phosphatase 1
Activation loop
BAD Bcl-2-associated death promoter
Adenylate cyclases Adenylate cyclase
Myosin phosphatase (myosin-light-chain) phosphatase
Cardiac muscle troponin T Troponin
Retinoblastoma protein
Cdc25 phosphatase Cdc25

Associated human diseases

As a therapeutic target

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How C-Raf connects Entity context

The extracted context around C-Raf shows recurring relationship patterns in the source. For example, C-Raf → activation of adenylate cyclase activity, adenylate cyclase activator activity, adenylate cyclase binding, apoptotic process, ATP binding, cell differentiation, cell population proliferation, cellular glucose homeostasis, cytoplasm, cytosol, death-inducing signaling complex assembly, development of the heart, enzyme binding, face development, Golgi apparatus, identical protein binding, insulin secretion involved in cellular response to glucose stimulus, intermediate filament cytoskeleton organization, intracellular anatomical structure, intracellular signal transduction Another extracted example is C-Raf → A-Raf, According, All, Although, Apart, ASK1/ASK2, ASK2, B-Raf, But, C-terminal, C1, CA1, CA2, CA3, CA4, CA5, Caenorhabditis, CC-SAM, CR3, Draf. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 67

C-Raf → activation of adenylate cyclase activity, adenylate cyclase activator activity, adenylate cyclase binding, apoptotic process, ATP binding, cell differentiation, cell population proliferation, cellular glucose homeostasis, cytoplasm, cytosol, death-inducing signaling complex assembly, development of the heart, enzyme binding, face development, Golgi apparatus, identical protein binding, insulin secretion involved in cellular response to glucose stimulus, intermediate filament cytoskeleton organization, intracellular anatomical structure, intracellular signal transduction

related to Evolutionary relationships · 56

C-Raf → A-Raf, According, All, Although, Apart, ASK1/ASK2, ASK2, B-Raf, But, C-terminal, C1, CA1, CA2, CA3, CA4, CA5, Caenorhabditis, CC-SAM, CR3, Draf

related to List of interacting proteins · 33

C-Raf → AKT1, ASK1, BAG1, Bcl-2, BRAF, CDC25A, CFLAR, FYN, GRB10, HRAS, HSP90AA1, KRAS, MAP2K1, MAP3K1, MAPK7, MAPK8IP3, PAK1, PEBP1, PHB, PRKCZ

related to Discovery · 20

C-Raf → A-Raf, B-Raf, ERK1/2, In, It, MAP3, MAPK, MEK1/2, MH2, Mil, Normal, Raf, Researchers, Several, Subsequent, The, These, Thus, V-RAF, Virus-induced Rapidly Accelerated Fibrosarcoma

related to External links · 20

C-Raf → A-Raf, B-Raf, Drosophila, GeneReviews/NCBI/NIH/UW, Human RAF1, Medicine Medical Subject Headings, MeSH, National Library, Noonan, Overview, P04049, PDB, PDBe-KB, Proteins, RAF, Raf-1, RAF1, The Interactive Flyc-raf, UCSC Genome Browser, UniProt

related to Regulation of activity · 20

C-Raf → Activated, As, ERK1/2, G-proteins, GTP-bound Ras, It, KSRs, N-terminal, PP1, PP2A, Raf, Rafs, Ser, TAK1, TGF-beta, The, This, Thus, Unphosphorylated, When

related to As a therapeutic target · 18

C-Raf → ATP-competitive B-Raf, B-Raf, B-Raf-inhibitor, Dabrafenib, Due, K-Ras, K-Ras-dependent, Raf, Ras, Regorafenib, Several, Sorafenib, They, This, Unfortunately, V600E, Vemurafenib, While

related to Associated human diseases · 14

C-Raf → Abnormal, Deafness, Electrocardiographic, Hereditary, Lentigo, LEOPARD, Most, Mutation, Noonan, Ocular, Pulmonary, Raf, Retarded, Similar

related to Structure · 12

C-Raf → At, C-kinase, C1, MAPKKKs, N-terminal, On, Raf, Ras-binding, RBD, Similarly, Structures, The

Bgee · 10

C-Raf → epithelium of stomach, ganglionic eminence, granulocyte, medullary collecting duct, muscle of thigh, secondary oocyte, temporal muscle, triceps brachii muscle, ventricular zone, zygote

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

raf kinase kinases domain protein activity b-raf also gene domains activation catalytic serine binding two structure proteins erk1 human enzymes

C-Raf relationships Subject–Predicate–Object triples

TTTA extracted 317 structured relationships around C-Raf. Examples in this analysis include C-Raf → 2.7.11.1 → ↗ and C-Raf → Aliases → RAF1, Raf-1 proto-oncogene, serine/threonine kinase, CMD1NN, CRAF, NS5, Raf-1, c-Raf. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
C-Raf	2.7.11.1	↗	1.00	infobox
C-Raf	Aliases	RAF1, Raf-1 proto-oncogene, serine/threonine kinase, CMD1NN, CRAF, NS5, Raf-1, c-Raf	1.00	infobox
C-Raf	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C1Y, 1FAQ, 1FAR, 1GUA, 1RFA, 3CU8, 3IQJ, 3IQU, 3IQV, 3KUC, 3KUD, 3NKX, 3O8I, 3OMV, 4FJ3, 4G0N, 4G3X, 4IEA,…	1.00	infobox
C-Raf	Band	6 E3\|6 53.62 cM	1.00	infobox
C-Raf	Bgee	granulocyte	1.00	infobox
C-Raf	Bgee	epithelium of stomach	1.00	infobox
C-Raf	Bgee	zygote	1.00	infobox
C-Raf	Bgee	medullary collecting duct	1.00	infobox
C-Raf	Bgee	ventricular zone	1.00	infobox
C-Raf	Bgee	secondary oocyte	1.00	infobox
C-Raf	Bgee	ganglionic eminence	1.00	infobox
C-Raf	Bgee	temporal muscle	1.00	infobox
C-Raf	Bgee	triceps brachii muscle	1.00	infobox
C-Raf	Bgee	muscle of thigh	1.00	infobox
C-Raf	BioGPS	More reference expression data	1.00	infobox
C-Raf	Chr.	Chromosome 6 (mouse)	1.00	infobox
C-Raf	Databases	NCBI: entry; OMA: entry	1.00	infobox
C-Raf	End	115,653,596 bp	1.00	infobox
C-Raf	Ensembl	ENSG00000132155	1.00	infobox
C-Raf	Entrez	5894	1.00	infobox
C-Raf	Enzyme activity	Enzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.11.1↗↗↗↗	1.00	infobox
C-Raf	External IDs	OMIM: 164760; MGI: 97847; GeneCards: RAF1	1.00	infobox
C-Raf	Gene location (Mouse)	Gene location (Mouse)Chr.Chromosome 6 (mouse)Band6 E3\|6 53.62 cMStart115,595,028 bpEnd115,653,596 bp	1.00	infobox
C-Raf	Gene ontology	transferase activity	1.00	infobox
C-Raf	Gene ontology	protein kinase activity	1.00	infobox
C-Raf	Gene ontology	nucleotide binding	1.00	infobox
C-Raf	Gene ontology	metal ion binding	1.00	infobox
C-Raf	Gene ontology	protein serine/threonine kinase activity	1.00	infobox
C-Raf	Gene ontology	small GTPase binding	1.00	infobox
C-Raf	Gene ontology	protein binding	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around C-Raf bring nearby vocabulary together. In this analysis, examples include B-raf, Protein and Kinase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

C-Raf
- B-raf
- Protein
- Kinase
- Activity
- Human
- Activation
- Complex
- Known
- Regulation
- Serine
- Mutations
- Role
c-raf
- B-raf
- Protein
- Kinase
- Activity
- Human
- Activation
- Complex
- Known
- Regulation
- Serine
- Mutations
- Role
gene
- Human
- Cell
- Found
- Serine
- Single
- Mutations
- Role
- B-raf
- Kinase
- Pathway
- Raf
- Regulation
erk1/2 pathway
- Pathway
- Cell
- Activated
- Found
- Regulation
- Role
- Kinase
- Protein
- Gene
- Raf
- Activity
- Complex
raf kinase
- Domain
- Kinases
- Protein
- Kinase
- Raf
- Genes
- Enzymes
- C-raf
- Structure
- Activity
- Activation
- Autoinhibitory
serine/threonine-specific protein kinases
- Raf
- Kinases
- Protein
- Catalytic
- Domains
- Activity
- Serine
- Phosphorylation
- Domain
- Structure
- Single
- Human
mitogen-activated protein kinase
- Domain
- Protein
- Kinases
- Raf
- Catalytic
- Domains
- Activity
- Serine
- C-raf
- Structure
- Activation
- Autoinhibitory
b-raf
- C-raf
- Human
- Mutations
- Structure
- Known
- Two
- Gene
- Kinase
- Family
- Domain
- Kinases
- Activation

Connections between topic areas Semantic bridges

For C-Raf, one of the stronger structural bridges in this analysis connects C-Raf with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

C-Raf — Structure · splits 45 ⟂ 19

C-Raf — Evolutionary relationships · splits 54 ⟂ 10

C-Raf — Regulation of activity · splits 54 ⟂ 10

C-Raf — Overview · splits 56 ⟂ 8

C-Raf — Discovery · splits 57 ⟂ 7

C-Raf — As a therapeutic target · splits 58 ⟂ 6

C-Raf — Associated human diseases · splits 61 ⟂ 3

Map overview Semantic statistics

C-Raf

Nodes64

Edges63

Triples317

Avg. degree1.97

Density0.03125

Components1

Source & methodology

TTTA analyzes the structure around C-Raf to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Structure & Evolutionary relationships, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — C-Raf · EN edition · Analysis: TopicsToTalkAbout