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MAP2K7: Regions & Standards

Dual specificity mitogen-activated protein kinase kinase 7, also known as MAP kinase kinase 7 or MKK7, is an enzyme that in humans is encoded by the MAP2K7 gene. This protein is a member of the mitogen-activated protein kinase kinase family. The MKK7 protein exists as six different isoforms with three possible N-termini (α, β, and γ isoforms) and two…

Language: English [EN]
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MAP2K7 topic overview

The analysis highlights Regions and Standards as prominent areas in the source structure around MAP2K7.

Related topics
50
Source areas
6
Connected nodes
56
Extracted relationships
155
Concept neighborhoods
18
Bridge connections
56

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 18 topics
Structure and function · 9 topics
Signaling and regulation · 8 topics
Interactions · 7 topics
Isoforms · 5 topics
Biological relevance · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.12.2
Aliases
MAP2K7, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, mitogen-activated protein kinase kinase 7
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DYL, 3WZU, 4UX9, 5B2K, 5B2L, 5B2M
Band
19p13.2 · 8|8 A1.1
Bgee
buccal mucosa cell · tendon of biceps brachii · gastrocnemius muscle · right hemisphere of cerebellum · Skeletal muscle tissue of rectus abdominis
BioGPS
n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Isoforms

Structure and function

Signaling and regulation

Interactions

Biological relevance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MAP2K7 connects Entity context

The extracted context around MAP2K7 shows recurring relationship patterns in the source. For example, MAP2K7 → activation of protein kinase activity, apoptotic process, ATP binding, cytoplasm, cytosol, enzyme binding, Fc-epsilon receptor signaling pathway, JNK cascade, JUN kinase kinase activity, kinase activity, magnesium ion binding, MAP kinase kinase activity, metal ion binding, nucleotide binding, nucleus, peptidyl-tyrosine phosphorylation, phosphorylation, positive regulation of ERK1 and ERK2 cascade, positive regulation of telomerase activity, positive regulation of telomere capping Another extracted example is MAP2K7 → Although MKK7, As, C-terminus, DVD, In, JNK, JNKs, Jun N-terminal, MKK4, MKK7, MKK7s, MKKKs, MKKs, Once, Overall, Phosphorylated, S-K-A-K-T, SAP/JNK, T-P-Y, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

MAP2K7

Top relations

Gene ontology · 39
MAP2K7 → activation of protein kinase activity, apoptotic process, ATP binding, cytoplasm, cytosol, enzyme binding, Fc-epsilon receptor signaling pathway, JNK cascade, JUN kinase kinase activity, kinase activity, magnesium ion binding, MAP kinase kinase activity, metal ion binding, nucleotide binding, nucleus, peptidyl-tyrosine phosphorylation, phosphorylation, positive regulation of ERK1 and ERK2 cascade, positive regulation of telomerase activity, positive regulation of telomere capping
related to Signaling and regulation · 23
MAP2K7 → Although MKK7, As, C-terminus, DVD, In, JNK, JNKs, Jun N-terminal, MKK4, MKK7, MKK7s, MKKKs, MKKs, Once, Overall, Phosphorylated, S-K-A-K-T, SAP/JNK, T-P-Y, The
Bgee · 20
MAP2K7 → arcuate nucleus, body of tongue, body of uterus, buccal mucosa cell, cardia, dorsomedial hypothalamic nucleus, external carotid artery, gastrocnemius muscle, Gonadal ridge, habenula, internal carotid artery, lateral geniculate nucleus, lateral hypothalamus, median eminence, muscle of thigh, nipple, paraventricular nucleus of hypothalamus, right hemisphere of cerebellum, Skeletal muscle tissue of rectus abdominis, tendon of biceps brachii
RNA expression pattern · 20
MAP2K7 → arcuate nucleus, body of tongue, body of uterus, buccal mucosa cell, cardia, dorsomedial hypothalamic nucleus, external carotid artery, gastrocnemius muscle, Gonadal ridge, habenula, internal carotid artery, lateral geniculate nucleus, lateral hypothalamus, median eminence, muscle of thigh, nipple, paraventricular nucleus of hypothalamus, right hemisphere of cerebellum, Skeletal muscle tissue of rectus abdominis, tendon of biceps brachii
related to Nomenclature · 10
MAP2K7 → ERK, JNK, JNKK2, Jun N-terminal, MEK7, MKK7JNK-activated, SAPK, SAPKK4, SEK2, Stress-activated
related to Biological relevance · 9
MAP2K7 → Conditional, Experiments, Genetic, In, Metastase Suppressor Gene, MKK4, MKK7, MSG, Neuron-specific
Band · 2
MAP2K7 → 19p13.2, 8|8 A1.1
Chr. · 2
MAP2K7 → Chromosome 19 (human), Chromosome 8 (mouse)
End · 2
MAP2K7 → 4,297,897 bp, 7,914,478 bp
2.7.12.2 · 1
MAP2K7 → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mkk7 kinase jnk protein isoforms phosphorylation d-motifs also mkk4 bp threonine gene dvd region kinases chr human band signaling activated

MAP2K7 relationships Subject–Predicate–Object triples

TTTA extracted 155 structured relationships around MAP2K7. Examples in this analysis include MAP2K7 → 2.7.12.2 → ↗ and MAP2K7 → Aliases → MAP2K7, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, mitogen-activated protein kinase kinase 7. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MAP2K72.7.12.21.00infobox
MAP2K7AliasesMAP2K7, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, mitogen-activated protein kinase kinase 71.00infobox
MAP2K7Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DYL, 3WZU, 4UX9, 5B2K, 5B2L, 5B2M1.00infobox
MAP2K7Band19p13.21.00infobox
MAP2K7Band8|8 A1.11.00infobox
MAP2K7Bgeebuccal mucosa cell1.00infobox
MAP2K7Bgeetendon of biceps brachii1.00infobox
MAP2K7Bgeegastrocnemius muscle1.00infobox
MAP2K7Bgeeright hemisphere of cerebellum1.00infobox
MAP2K7BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
MAP2K7Bgeenipple1.00infobox
MAP2K7Bgeemuscle of thigh1.00infobox
MAP2K7Bgeecardia1.00infobox
MAP2K7Bgeebody of tongue1.00infobox
MAP2K7Bgeebody of uterus1.00infobox
MAP2K7Bgeeexternal carotid artery1.00infobox
MAP2K7Bgeeinternal carotid artery1.00infobox
MAP2K7Bgeemedian eminence1.00infobox
MAP2K7BgeeGonadal ridge1.00infobox
MAP2K7Bgeehabenula1.00infobox
MAP2K7Bgeearcuate nucleus1.00infobox
MAP2K7Bgeelateral geniculate nucleus1.00infobox
MAP2K7Bgeeparaventricular nucleus of hypothalamus1.00infobox
MAP2K7Bgeedorsomedial hypothalamic nucleus1.00infobox
MAP2K7Bgeelateral hypothalamus1.00infobox
MAP2K7BioGPSn/a1.00infobox
MAP2K7Chr.Chromosome 19 (human)1.00infobox
MAP2K7Chr.Chromosome 8 (mouse)1.00infobox
MAP2K7DatabasesNCBI: entry; OMA: entry1.00infobox
MAP2K7End7,914,478 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MAP2K7 bring nearby vocabulary together. In this analysis, examples include Gene, Chromosome and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • MAP2K7
    • Gene
    • Chromosome
    • Function
    • Human
    • Mitogen-activated
    • Activity
    • Bp
    • Chr
    • Mkk7
    • Signaling
    • Protein
    • Expression
  • map2k7
    • Gene
    • Chromosome
    • Function
    • Human
    • Mitogen-activated
    • Activity
    • Bp
    • Chr
    • Mkk7
    • Signaling
    • Protein
    • Expression
  • enzyme
    • Gene
    • Map
    • Chromosome
    • Function
    • Human
    • Mitogen-activated
    • Map2k7
    • Activity
    • Bp
    • Chr
    • Signaling
    • Protein
  • gene
    • Chromosome
    • Function
    • Human
    • Bp
    • Chr
    • Map
    • Map2k7
    • Band
    • Mitogen-activated
    • Activity
    • Signaling
    • Protein
  • mitogen-activated protein kinase kinase
    • Enzyme
    • Region
    • Signaling
    • Protein
    • Domain
    • Dvd
    • Gene
    • Jnk
    • Kinase
    • Mitogen-activated
    • Mkk7
    • Phosphorylation
  • kinase
    • Region
    • Protein
    • Domain
    • Dvd
    • Mitogen-activated
    • Signaling
    • Mkk7
    • Phosphorylation
    • Enzyme
    • Map
    • Gene
    • Kinases
  • map kinase kinase kinases
    • Enzyme
    • Region
    • Gene
    • Kinases
    • Map
    • Mapk
    • Protein
    • Domain
    • Dvd
    • Function
    • Mitogen-activated
    • Addition
  • d-motifs
    • Three
    • Activity
    • Region
    • Isoforms
    • Mkk7
    • Enzyme
    • Kinase
    • Chromosome
    • Function
    • Human
    • Mitogen-activated
    • Bp

Connections between topic areas Semantic bridges

For MAP2K7, one of the stronger structural bridges in this analysis connects MAP2K7 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MAP2K7Overview · splits 38 ⟂ 19
MAP2K7Structure and function · splits 47 ⟂ 10
MAP2K7Signaling and regulation · splits 48 ⟂ 9
MAP2K7Interactions · splits 49 ⟂ 8
MAP2K7Isoforms · splits 51 ⟂ 6
MAP2K7Biological relevance · splits 53 ⟂ 4

Map overview Semantic statistics

MAP2K7

Nodes57
Edges56
Triples155
Avg. degree1.96
Density0.035088
Components1

Source & methodology

TTTA analyzes the structure around MAP2K7 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MAP2K7 · EN edition · Analysis: TopicsToTalkAbout

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