ASK1

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ASK1 topic overview

The analysis highlights Art, Interactions and Mechanism of activation as prominent areas in the source structure around ASK1.

Related topics: 31
Source areas: 3
Connected nodes: 34
Extracted relationships: 157
Concept neighborhoods: 11
Bridge connections: 34

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 15 topics

Mechanism of activation · 9 topics

Overview · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.25: ↗
Aliases: MAP3K5, ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CLQ, 3VW6, 4BF2, 4BHN, 4BIB, 4BIC, 4BID, 4BIE
Band: 6q23.3 · 10|10 A3
Bgee: endothelial cell · Brodmann area 23 · decidua · pancreatic ductal cell · adrenal cortex
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Mitogen-activated protein kinase
C-Jun N-terminal kinase (JNK) C-Jun N-terminal kinases
P38 mitogen-activated protein kinases
Oxidative stress
Endoplasmic reticulum stress Unfolded protein response
Rheumatoid arthritis
Locus Locus (genetics)

Mechanism of activation

Coiled-coil Coiled coil
Trx Thioredoxin
CIB1
TRAF2
TRAF6
NF-kb NF-κB
TNF-α
Deubiquitination Deubiquitinating enzyme
Post-transcriptional Post-transcriptional regulation

Interactions

Interact Protein-protein interaction
C-Raf
CDC25A
DAXX Death associated protein 6
DUSP19
EIF2AK2 Protein kinase R
GADD45B
HSPA1A
MAP2K6
MAP3K7
MAPK8IP3
PDCD6
PPP5C
RB1CC1
TRAF5

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ASK1 connects Entity context

The extracted context around ASK1 shows recurring relationship patterns in the source. For example, ASK1 → apoptotic process, apoptotic signaling pathway, ATP binding, cellular response to amino acid starvation, cellular response to hydrogen peroxide, cellular response to reactive nitrogen species, cellular response to tumor necrosis factor, cytoplasm, cytosol, endoplasmic reticulum, endothelial cell apoptotic process, external side of plasma membrane, identical protein binding, immune system process, innate immune response, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, intrinsic apoptotic signaling pathway in response to oxidative stress, IRE1-TRAF2-ASK1 complex, JNK cascade, kinase activity Another extracted example is ASK1 → adrenal cortex, ascending aorta, Brodmann area 23, ciliary body, cumulus cell, decidua, dorsal motor nucleus of vagus nerve, endothelial cell, granulocyte, hair follicle, iris, left adrenal cortex, left adrenal gland, pancreatic ductal cell, pineal gland, retinal pigment epithelium, right adrenal cortex, right adrenal gland, transitional epithelium of urinary bladder, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 56

ASK1 → apoptotic process, apoptotic signaling pathway, ATP binding, cellular response to amino acid starvation, cellular response to hydrogen peroxide, cellular response to reactive nitrogen species, cellular response to tumor necrosis factor, cytoplasm, cytosol, endoplasmic reticulum, endothelial cell apoptotic process, external side of plasma membrane, identical protein binding, immune system process, innate immune response, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, intrinsic apoptotic signaling pathway in response to oxidative stress, IRE1-TRAF2-ASK1 complex, JNK cascade, kinase activity

Bgee · 20

ASK1 → adrenal cortex, ascending aorta, Brodmann area 23, ciliary body, cumulus cell, decidua, dorsal motor nucleus of vagus nerve, endothelial cell, granulocyte, hair follicle, iris, left adrenal cortex, left adrenal gland, pancreatic ductal cell, pineal gland, retinal pigment epithelium, right adrenal cortex, right adrenal gland, transitional epithelium of urinary bladder, vestibular membrane of cochlear duct

RNA expression pattern · 20

related to Mechanism of activation · 17

ASK1 → Both, C-terminal, CCC, CIB1, IL-1, Interestingly, N-terminal, NCC, NF-kb, RelA, Subsequently, Thus, TNF-α, TRAF2, TRAF6, Trx, Under

related to Interactions · 14

ASK1 → C-Raf, CDC25A, DAXX, DUSP19, EIF2AK2, GADD45B, HSPA1A, MAP2K6, MAP3K7, PDCD6, PPP5C, RB1CC1, TRAF2, TRAF5

Band · 2

ASK1 → 10|10 A3, 6q23.3

Chr. · 2

ASK1 → Chromosome 10 (mouse), Chromosome 6 (human)

End · 2

ASK1 → 136,792,477 bp, 20,018,499 bp

2.7.11.25 · 1

ASK1 → ↗

Aliases · 1

ASK1 → MAP3K5, ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein kinase map3k5 human bp gene chromosome mitogen-activated chr band activation location external also activity trx tnf-α traf2 mouse binding

ASK1 relationships Subject–Predicate–Object triples

TTTA extracted 157 structured relationships around ASK1. Examples in this analysis include ASK1 → 2.7.11.25 → ↗ and ASK1 → Aliases → MAP3K5, ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
ASK1	2.7.11.25	↗	1.00	infobox
ASK1	Aliases	MAP3K5, ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5	1.00	infobox
ASK1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CLQ, 3VW6, 4BF2, 4BHN, 4BIB, 4BIC, 4BID, 4BIE	1.00	infobox
ASK1	Band	6q23.3	1.00	infobox
ASK1	Band	10\|10 A3	1.00	infobox
ASK1	Bgee	endothelial cell	1.00	infobox
ASK1	Bgee	Brodmann area 23	1.00	infobox
ASK1	Bgee	decidua	1.00	infobox
ASK1	Bgee	pancreatic ductal cell	1.00	infobox
ASK1	Bgee	adrenal cortex	1.00	infobox
ASK1	Bgee	left adrenal gland	1.00	infobox
ASK1	Bgee	right adrenal gland	1.00	infobox
ASK1	Bgee	left adrenal cortex	1.00	infobox
ASK1	Bgee	right adrenal cortex	1.00	infobox
ASK1	Bgee	dorsal motor nucleus of vagus nerve	1.00	infobox
ASK1	Bgee	ciliary body	1.00	infobox
ASK1	Bgee	cumulus cell	1.00	infobox
ASK1	Bgee	pineal gland	1.00	infobox
ASK1	Bgee	retinal pigment epithelium	1.00	infobox
ASK1	Bgee	hair follicle	1.00	infobox
ASK1	Bgee	granulocyte	1.00	infobox
ASK1	Bgee	iris	1.00	infobox
ASK1	Bgee	transitional epithelium of urinary bladder	1.00	infobox
ASK1	Bgee	ascending aorta	1.00	infobox
ASK1	Bgee	vestibular membrane of cochlear duct	1.00	infobox
ASK1	BioGPS	More reference expression data	1.00	infobox
ASK1	Chr.	Chromosome 6 (human)	1.00	infobox
ASK1	Chr.	Chromosome 10 (mouse)	1.00	infobox
ASK1	Databases	NCBI: entry; OMA: entry	1.00	infobox
ASK1	End	136,792,477 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ASK1 bring nearby vocabulary together. In this analysis, examples include Activation, Protein and Kinase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

ASK1
- Activation
- Protein
- Kinase
- Activity
- Also
- Tnf-α
- Traf2
- Trx
- Map3k5
- Mitogen-activated
- Gene
- Binding
ask1
- Activation
- Protein
- Kinase
- Activity
- Also
- Tnf-α
- Traf2
- Trx
- Map3k5
- Mitogen-activated
- Gene
- Binding
mitogen-activated protein kinase
- Protein
- Mitogen-activated
- Map3k5
- Pdb
- Activity
- Gene
- Chromosome
- Activation
- Human
- Amino
- Calcium
- Endoplasmic
c-jun n-terminal kinase (jnk)
- Calcium
- Endoplasmic
- Oxidative
- Response
- Reticulum
- Stress
- Protein
- Mitogen-activated
- Map3k5
- Activity
- Amino
- Binding
p38 mitogen-activated protein kinases
- Protein
- Pdb
- Gene
- Activation
- Chromosome
- Human
- Map3k5
- Amino
- External
- Oxidative
- Q99683
- Response
oxidative stress
- Response
- Reticulum
- Stress
- Amino
- Binding
- Domain
- External
- Involved
- Mouse
- Pathway
- Q99683
- Search
endoplasmic reticulum stress
- Calcium
- Jnk
- Oxidative
- Response
- Reticulum
- Stress
- Amino
- Binding
- Domain
- External
- Involved
- Map
mechanism of activation
- External
- Search
- Ask1
- Gene
- Activity
- Trx
- Location
- Protein
- Bp
- Chr
- Chromosome
- Map3k5

Connections between topic areas Semantic bridges

For ASK1, one of the stronger structural bridges in this analysis connects ASK1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

ASK1 — Interactions · splits 19 ⟂ 16

ASK1 — Mechanism of activation · splits 25 ⟂ 10

ASK1 — Overview · splits 27 ⟂ 8

Map overview Semantic statistics

ASK1

Nodes35

Edges34

Triples157

Avg. degree1.94

Density0.057143

Components1

Source & methodology

TTTA analyzes the structure around ASK1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Interactions & Mechanism of activation, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ASK1 · EN edition · Analysis: TopicsToTalkAbout