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ASK1

Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of…

Art, Interactions & Mechanism of activation

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2.7.11.25
Aliases
MAP3K5, ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CLQ, 3VW6, 4BF2, 4BHN, 4BIB, 4BIC, 4BID, 4BIE
Band
6q23.3 · 10|10 A3
Bgee
endothelial cell · Brodmann area 23 · decidua · pancreatic ductal cell · adrenal cortex
BioGPS
More reference expression data

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Mechanism of activation

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ASK1

Nodes35
Edges34
Triples157
Avg. degree1.94
Density0.057143
Components1

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ASK1

Top relations

Gene ontology · 56
ASK1 → apoptotic process, apoptotic signaling pathway, ATP binding, cellular response to amino acid starvation, cellular response to hydrogen peroxide, cellular response to reactive nitrogen species, cellular response to tumor necrosis factor, cytoplasm, cytosol, endoplasmic reticulum, endothelial cell apoptotic process, external side of plasma membrane, identical protein binding, immune system process, innate immune response, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, intrinsic apoptotic signaling pathway in response to oxidative stress, IRE1-TRAF2-ASK1 complex, JNK cascade, kinase activity
Bgee · 20
ASK1 → adrenal cortex, ascending aorta, Brodmann area 23, ciliary body, cumulus cell, decidua, dorsal motor nucleus of vagus nerve, endothelial cell, granulocyte, hair follicle, iris, left adrenal cortex, left adrenal gland, pancreatic ductal cell, pineal gland, retinal pigment epithelium, right adrenal cortex, right adrenal gland, transitional epithelium of urinary bladder, vestibular membrane of cochlear duct
RNA expression pattern · 20
ASK1 → adrenal cortex, ascending aorta, Brodmann area 23, ciliary body, cumulus cell, decidua, dorsal motor nucleus of vagus nerve, endothelial cell, granulocyte, hair follicle, iris, left adrenal cortex, left adrenal gland, pancreatic ductal cell, pineal gland, retinal pigment epithelium, right adrenal cortex, right adrenal gland, transitional epithelium of urinary bladder, vestibular membrane of cochlear duct
related to Mechanism of activation · 17
ASK1 → Both, C-terminal, CCC, CIB1, IL-1, Interestingly, N-terminal, NCC, NF-kb, RelA, Subsequently, Thus, TNF-α, TRAF2, TRAF6, Trx, Under
related to Interactions · 14
ASK1 → C-Raf, CDC25A, DAXX, DUSP19, EIF2AK2, GADD45B, HSPA1A, MAP2K6, MAP3K7, PDCD6, PPP5C, RB1CC1, TRAF2, TRAF5
Band · 2
ASK1 → 10|10 A3, 6q23.3
Chr. · 2
ASK1 → Chromosome 10 (mouse), Chromosome 6 (human)
End · 2
ASK1 → 136,792,477 bp, 20,018,499 bp
2.7.11.25 · 1
ASK1 → ↗
Aliases · 1
ASK1 → MAP3K5, ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5

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Important terminology

protein kinase map3k5 human bp gene chromosome mitogen-activated chr band activation location external also activity trx tnf-α traf2 mouse binding

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ASK12.7.11.251.00infobox
ASK1AliasesMAP3K5, ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 51.00infobox
ASK1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CLQ, 3VW6, 4BF2, 4BHN, 4BIB, 4BIC, 4BID, 4BIE1.00infobox
ASK1Band6q23.31.00infobox
ASK1Band10|10 A31.00infobox
ASK1Bgeeendothelial cell1.00infobox
ASK1BgeeBrodmann area 231.00infobox
ASK1Bgeedecidua1.00infobox
ASK1Bgeepancreatic ductal cell1.00infobox
ASK1Bgeeadrenal cortex1.00infobox
ASK1Bgeeleft adrenal gland1.00infobox
ASK1Bgeeright adrenal gland1.00infobox
ASK1Bgeeleft adrenal cortex1.00infobox
ASK1Bgeeright adrenal cortex1.00infobox
ASK1Bgeedorsal motor nucleus of vagus nerve1.00infobox
ASK1Bgeeciliary body1.00infobox
ASK1Bgeecumulus cell1.00infobox
ASK1Bgeepineal gland1.00infobox
ASK1Bgeeretinal pigment epithelium1.00infobox
ASK1Bgeehair follicle1.00infobox
ASK1Bgeegranulocyte1.00infobox
ASK1Bgeeiris1.00infobox
ASK1Bgeetransitional epithelium of urinary bladder1.00infobox
ASK1Bgeeascending aorta1.00infobox
ASK1Bgeevestibular membrane of cochlear duct1.00infobox
ASK1BioGPSMore reference expression data1.00infobox
ASK1Chr.Chromosome 6 (human)1.00infobox
ASK1Chr.Chromosome 10 (mouse)1.00infobox
ASK1DatabasesNCBI: entry; OMA: entry1.00infobox
ASK1End136,792,477 bp1.00infobox

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