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MAP2K6

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.

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2.7.12.2
Aliases
MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, mitogen-activated protein kinase kinase 6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2Y8O, 3ENM, 3FME, 3VN9
Band
17q24.3 · 11|11 E1-E2
Bgee
rectum · mucosa of transverse colon · biceps brachii · vastus lateralis muscle · Skeletal muscle tissue of biceps brachii
BioGPS
More reference expression data

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MAP2K6

Nodes22
Edges21
Triples103
Avg. degree1.91
Density0.090909
Components1

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MAP2K6

Top relations

Gene ontology · 39
MAP2K6 → activation of protein kinase activity, apoptotic process, ATP binding, cardiac muscle contraction, cellular response to sorbitol, cytoplasm, cytoskeleton, cytosol, DNA damage induced protein phosphorylation, identical protein binding, kinase activity, MAP kinase kinase activity, MAPK cascade, negative regulation of cold-induced thermogenesis, nucleoplasm, nucleotide binding, nucleotide-binding oligomerization domain containing signaling pathway, nucleus, ovulation cycle process, peptidyl-tyrosine phosphorylation
Bgee · 16
MAP2K6 → biceps brachii, deltoid muscle, gastrocnemius muscle, mandibular prominence, maxillary prominence, mucosa of transverse colon, muscle of thigh, rectum, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, somite, sternocleidomastoid muscle, tail of embryo, temporal muscle, triceps brachii muscle, vastus lateralis muscle
RNA expression pattern · 16
MAP2K6 → biceps brachii, deltoid muscle, gastrocnemius muscle, mandibular prominence, maxillary prominence, mucosa of transverse colon, muscle of thigh, rectum, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, somite, sternocleidomastoid muscle, tail of embryo, temporal muscle, triceps brachii muscle, vastus lateralis muscle
related to Interactions · 4
MAP2K6 → ASK1, MAP3K7, MAPK14, TAOK2
Band · 2
MAP2K6 → 11|11 E1-E2, 17q24.3
Chr. · 2
MAP2K6 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
MAP2K6 → 110,525,522 bp, 69,553,865 bp
2.7.12.2 · 1
MAP2K6 → ↗
Aliases · 1
MAP2K6 → MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, mitogen-activated protein kinase kinase 6
Available structures · 1
MAP2K6 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2Y8O, 3ENM, 3FME, 3VN9

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Important terminology

bp kinase chromosome 17 gene map chr human band protein mitogen-activated location enzyme mouse mapk function dual specificity also known

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MAP2K62.7.12.21.00infobox
MAP2K6AliasesMAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, mitogen-activated protein kinase kinase 61.00infobox
MAP2K6Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2Y8O, 3ENM, 3FME, 3VN91.00infobox
MAP2K6Band17q24.31.00infobox
MAP2K6Band11|11 E1-E21.00infobox
MAP2K6Bgeerectum1.00infobox
MAP2K6Bgeemucosa of transverse colon1.00infobox
MAP2K6Bgeebiceps brachii1.00infobox
MAP2K6Bgeevastus lateralis muscle1.00infobox
MAP2K6BgeeSkeletal muscle tissue of biceps brachii1.00infobox
MAP2K6Bgeegastrocnemius muscle1.00infobox
MAP2K6Bgeetriceps brachii muscle1.00infobox
MAP2K6Bgeedeltoid muscle1.00infobox
MAP2K6BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
MAP2K6Bgeemuscle of thigh1.00infobox
MAP2K6Bgeetemporal muscle1.00infobox
MAP2K6Bgeesternocleidomastoid muscle1.00infobox
MAP2K6Bgeemaxillary prominence1.00infobox
MAP2K6Bgeesomite1.00infobox
MAP2K6Bgeemandibular prominence1.00infobox
MAP2K6Bgeetail of embryo1.00infobox
MAP2K6BioGPSMore reference expression data1.00infobox
MAP2K6Chr.Chromosome 17 (human)1.00infobox
MAP2K6Chr.Chromosome 11 (mouse)1.00infobox
MAP2K6DatabasesNCBI: entry; OMA: entry1.00infobox
MAP2K6End69,553,865 bp1.00infobox
MAP2K6End110,525,522 bp1.00infobox
MAP2K6EnsemblENSG000001089841.00infobox
MAP2K6Entrez56081.00infobox
MAP2K6Enzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.12.2↗↗↗↗1.00infobox

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