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MAP3K8

Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene.

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2.7.11.25
Aliases
MAP3K8, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT, AURA2, mitogen-activated protein kinase kinase kinase 8, Tpl2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4Y83, 4Y85
Band
10p11.23 · 18 A1|18 2.73 cM
Bgee
gastric mucosa · mucosa of paranasal sinus · upper lobe of left lung · left uterine tube · germinal epithelium
BioGPS
More reference expression data

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MAP3K8

Nodes19
Edges18
Triples95
Avg. degree1.89
Density0.105263
Components1

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MAP3K8

Top relations

Gene ontology · 24
MAP3K8 → activation of protein kinase activity, ATP binding, cell cycle, cytoplasm, cytosol, immune system process, interleukin-1-mediated signaling pathway, kinase activity, magnesium ion binding, MAP kinase kinase kinase activity, metal ion binding, nucleotide binding, phosphorylation, protein binding, protein kinase activity, protein phosphorylation, protein serine/threonine kinase activity, regulation of apoptotic process, regulation of mitotic cell cycle, signal transduction
Bgee · 20
MAP3K8 → Achilles tendon, gastric mucosa, germinal epithelium, granulocyte, hair follicle, left uterine tube, lip, monocyte, mucosa of paranasal sinus, olfactory zone of nasal mucosa, otic placode, otic vesicle, right lung, saccule, skin of external ear, spleen, stroma of bone marrow, subcutaneous adipose tissue, tibial nerve, upper lobe of left lung
RNA expression pattern · 20
MAP3K8 → Achilles tendon, gastric mucosa, germinal epithelium, granulocyte, hair follicle, left uterine tube, lip, monocyte, mucosa of paranasal sinus, olfactory zone of nasal mucosa, otic placode, otic vesicle, right lung, saccule, skin of external ear, spleen, stroma of bone marrow, subcutaneous adipose tissue, tibial nerve, upper lobe of left lung
related to Interactions · 6
MAP3K8 → AKT1, C22orf25, CHUK, NFKB1, NFKB2, TNIP2
Band · 2
MAP3K8 → 10p11.23, 18 A1|18 2.73 cM
Chr. · 2
MAP3K8 → Chromosome 10 (human), Chromosome 18 (mouse)
End · 2
MAP3K8 → 30,461,833 bp, 4,353,015 bp
2.7.11.25 · 1
MAP3K8 → ↗
Aliases · 1
MAP3K8 → MAP3K8, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT, AURA2, mitogen-activated protein kinase kinase kinase 8, Tpl2
Available structures · 1
MAP3K8 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4Y83, 4Y85

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Important terminology

gene kinase bp chr human band protein chromosome 10 activity location enzyme mouse mitogen-activated function shown encoded external search 461

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MAP3K82.7.11.251.00infobox
MAP3K8AliasesMAP3K8, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT, AURA2, mitogen-activated protein kinase kinase kinase 8, Tpl21.00infobox
MAP3K8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4Y83, 4Y851.00infobox
MAP3K8Band10p11.231.00infobox
MAP3K8Band18 A1|18 2.73 cM1.00infobox
MAP3K8Bgeegastric mucosa1.00infobox
MAP3K8Bgeemucosa of paranasal sinus1.00infobox
MAP3K8Bgeeupper lobe of left lung1.00infobox
MAP3K8Bgeeleft uterine tube1.00infobox
MAP3K8Bgeegerminal epithelium1.00infobox
MAP3K8Bgeemonocyte1.00infobox
MAP3K8Bgeeolfactory zone of nasal mucosa1.00infobox
MAP3K8BgeeAchilles tendon1.00infobox
MAP3K8Bgeetibial nerve1.00infobox
MAP3K8Bgeeright lung1.00infobox
MAP3K8Bgeegranulocyte1.00infobox
MAP3K8Bgeesaccule1.00infobox
MAP3K8Bgeelip1.00infobox
MAP3K8Bgeeotic placode1.00infobox
MAP3K8Bgeeskin of external ear1.00infobox
MAP3K8Bgeestroma of bone marrow1.00infobox
MAP3K8Bgeespleen1.00infobox
MAP3K8Bgeeotic vesicle1.00infobox
MAP3K8Bgeehair follicle1.00infobox
MAP3K8Bgeesubcutaneous adipose tissue1.00infobox
MAP3K8BioGPSMore reference expression data1.00infobox
MAP3K8Chr.Chromosome 10 (human)1.00infobox
MAP3K8Chr.Chromosome 18 (mouse)1.00infobox
MAP3K8DatabasesNCBI: entry; OMA: entry1.00infobox
MAP3K8End30,461,833 bp1.00infobox

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