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Phalloidin

Phalloidin belongs to a class of toxins called phallotoxins, which are found in mushrooms of the genus Amanita. It is a rigid bicyclic heptapeptide that is lethal after a few days when injected into the bloodstream. The major symptom of phalloidin poisoning is acute hunger[citation needed] due to the destruction of liver cells. It functions by binding…

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Discovery and background

Cyclic peptidesFeodor LynenUlrich WielandCysteineTryptophan
7 related topics

Symptoms

LD50IP injectionNephrosis
3 related topics

Synthesis

Proline
1 related topics

Mechanism of action

Depolymerization
1 related topics

Topics to explore

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Overview

Discovery and background

Synthesis

Mechanism of action

Symptoms

Use as an imaging tool

Advanced semantic analysis

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Map overview Semantic statistics

Phalloidin

Nodes29
Edges28
Triples69
Avg. degree1.93
Density0.068966
Components1

How this topic connects Entity context

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Phalloidin

Top relations

related to background · 18
Phalloidin → Because, Derivatives, Due, Edman, F-actin, Feodor Lynen, G-actin, It, Its, Once, Raney, Schön, The, They, This, Ulrich Wieland, UV, Wieland
related to Biosynthesis · 12
Phalloidin → After, Ala, Ala-Trp-Leu-Ala-Thr-Cys-Pro, D-Thr, Death Cap, It, MSDIN, POP, Pro, The, The POP, Trp-Cys
related to Symptoms · 10
Phalloidin → F-actin, Here, IP, It, LD50, Once, Soon, The, This, When
related to Chemical synthesis · 9
Phalloidin → Ala7-phalloidin, Anderson, Below, Essentially, F-actin, Note, Since, The, THPP
related to Mechanism of action · 9
Phalloidin → ADP, ATP, F-actin, G-actin, Moreover, Overall, Thus, Wehland, When
related to Use as an imaging tool · 7
Phalloidin → Consequently, DAB, F-actin, Fluorescent, In, The, Therefore
related to Uses and limitations · 2
Phalloidin → Derivatives, Unmodified
causes · 1
Phalloidin → nephrosis
part of · 1
Phalloidin → the MSDIN family in the Death Cap mushroom and codes for a 34 amino acid propeptide

Important terminology Word statistics

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Important terminology

actin f-actin fluorescent cells synthesis microscopy found used bicyclic heptapeptide depolymerization liver derivatives structure cell filamentous due chemical using acid

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Phalloidincausesnephrosis0.90text
Phalloidinpart ofthe MSDIN family in the Death Cap mushroom and codes for a 34 amino acid propeptide0.85text
Phalloidinrelated to backgroundIt0.60section
Phalloidinrelated to backgroundFeodor Lynen0.60section
Phalloidinrelated to backgroundUlrich Wieland0.60section
Phalloidinrelated to backgroundIts0.60section
Phalloidinrelated to backgroundThis0.60section
Phalloidinrelated to backgroundThey0.60section
Phalloidinrelated to backgroundUV0.60section
Phalloidinrelated to backgroundRaney0.60section
Phalloidinrelated to backgroundThe0.60section
Phalloidinrelated to backgroundOnce0.60section

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    Min side: 3
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