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Formins

Formins (formin homology proteins) are a group of proteins that are involved in the polymerization of actin and associate with the fast-growing end (barbed end) of actin filaments. Most formins are Rho-GTPase effector proteins. Formins regulate the actin and microtubule cytoskeleton and are involved in various cellular functions such as cell polarity…

Structure and interactions, Overview & Diversity

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Structure and interactions

DomainsPDZWH2ProlineActin-binding protein
29 related topics

Overview

ProteinsPolymerizationActinRho-GTPaseMicrotubule
16 related topics

Diversity

EukaryotesYeasts
2 related topics

Key facts & relationships

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Alt. symbols
LD, FMN
Domains
InterPro
HGNC
3768
Locus
Chr. 15 q13-q14
NCBI gene
342184
OMIM
136535

Topics to explore

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Overview

Diversity

Structure and interactions

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Map overview Semantic statistics

Formins

Nodes51
Edges50
Triples49
Avg. degree1.96
Density0.039216
Components1

How this topic connects Entity context

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Formins

Top relations

related to Structure and interactions · 32
Formins → Another, ARR, C-terminal, Cdc42, CRIB-like, DAD, Dia-autoregulatory, Drf3, FH, FH1, FH2, FH3, FHA, GBD, GTP-bound Rho, GTPase-binding, GTPases, In, Mammalian Drf3, N-terminal GBD
related to Diversity · 2
Formins → By, In
Alt. symbols · 1
Formins → LD, FMN
Domains · 1
Formins → InterPro
HGNC · 1
Formins → 3768
Locus · 1
Formins → Chr. 15 q13-q14
NCBI gene · 1
Formins → 342184
OMIM · 1
Formins → 136535
RefSeq · 1
Formins → NM_001103184
Search for · 1
Formins → Search forStructuresSwiss-modelDomainsInterPro

Important terminology Word statistics

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Important terminology

actin proteins domain formin domains microtubules fh2 also dad required gbd homology 15 involved functions q13-q14 polymerization srf contain fh3

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ForminsAlt. symbolsLD, FMN1.00infobox
ForminsDomainsInterPro1.00infobox
ForminsHGNC37681.00infobox
ForminsLocusChr. 15 q13-q141.00infobox
ForminsNCBI gene3421841.00infobox
ForminsOMIM1365351.00infobox
ForminsRefSeqNM_0011031841.00infobox
ForminsSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
ForminsStructuresSwiss-model1.00infobox
ForminsSymbolFMN11.00infobox
ForminsUniProtQ68DA71.00infobox
cell polarityinstance ofFormins regulate the actin and microtubule cytoskeleton and are involved in various cellular functions0.80text

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    Min side: 3
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