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GroEL: Structure, Function & Immunological role

GroEL is a protein which belongs to the chaperonin family of molecular chaperones, and is found in many bacteria. It is required for the proper folding of many proteins. To function properly, GroEL requires the lid-like cochaperonin protein complex GroES. In eukaryotes the organellar proteins Hsp60 and Hsp10 are structurally and functionally nearly…

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GroEL topic overview

The analysis highlights Structure, Function and Immunological role as prominent areas in the source structure around GroEL.

Related topics
110
Source areas
10
Connected nodes
120
Extracted relationships
218
Concept neighborhoods
26
Bridge connections
120

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 28 topics
Function · 17 topics
Immunological role · 16 topics
Overview · 15 topics
Interactions · 9 topics
Discovery · 6 topics
Relationship to cancer · 6 topics
Mechanism · 5 topics
Stress response · 4 topics
Synthesis and assembly · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

5.6.1.7
↗
Aliases
HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13, heat shock protein family D (Hsp60) member 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJ1
Band
2q33.1 · 1|1 C1.2
Bgee
right adrenal gland · right adrenal cortex · left adrenal gland · left adrenal cortex · ventricular zone
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Structure

Function

Synthesis and assembly

Immunological role

Stress response

Relationship to cancer

Mechanism

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How GroEL connects Entity context

The extracted context around GroEL shows recurring relationship patterns in the source. For example, GroEL → 'de novo' protein folding, activation of cysteine-type endopeptidase activity involved in apoptotic process, apolipoprotein A-I binding, apolipoprotein binding, apoptotic mitochondrial changes, ATP binding, ATPase activity, B cell activation, B cell cytokine production, B cell proliferation, cell surface, chaperone binding, chaperone-mediated protein complex assembly, chaperone-mediated protein folding, clathrin-coated pit, coated vesicle, cyclin-dependent protein kinase activating kinase holoenzyme complex, cytoplasm, cytosol, DNA replication origin binding Another extracted example is GroEL → adrenal gland, blastocyst, body of pancreas, embryo, epiblast, epithelium of colon, ganglionic eminence, genital tubercle, left adrenal cortex, left adrenal gland, mucosa of transverse colon, ovary, proximal tubule, rectum, right adrenal cortex, right adrenal gland, right kidney, tail of embryo, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

GroEL

Top relations

Gene ontology · 69
GroEL → 'de novo' protein folding, activation of cysteine-type endopeptidase activity involved in apoptotic process, apolipoprotein A-I binding, apolipoprotein binding, apoptotic mitochondrial changes, ATP binding, ATPase activity, B cell activation, B cell cytokine production, B cell proliferation, cell surface, chaperone binding, chaperone-mediated protein complex assembly, chaperone-mediated protein folding, clathrin-coated pit, coated vesicle, cyclin-dependent protein kinase activating kinase holoenzyme complex, cytoplasm, cytosol, DNA replication origin binding
Bgee · 20
GroEL → adrenal gland, blastocyst, body of pancreas, embryo, epiblast, epithelium of colon, ganglionic eminence, genital tubercle, left adrenal cortex, left adrenal gland, mucosa of transverse colon, ovary, proximal tubule, rectum, right adrenal cortex, right adrenal gland, right kidney, tail of embryo, ventricular zone, yolk sac
RNA expression pattern · 20
GroEL → adrenal gland, blastocyst, body of pancreas, embryo, epiblast, epithelium of colon, ganglionic eminence, genital tubercle, left adrenal cortex, left adrenal gland, mucosa of transverse colon, ovary, proximal tubule, rectum, right adrenal cortex, right adrenal gland, right kidney, tail of embryo, ventricular zone, yolk sac
related to Immunological role · 12
GroEL → According, As, However, HSP60, In, Infection, LPS, PBMCs, The, There, This, When
related to Relationship to cancer · 12
GroEL → Although, Despite, Group, Hsp60, Hsp70, HSPD1, Human Hsp60, Neither, Positive, Recently, There, This
related to External links · 9
GroEL → Archived, EMDB, Medicine Medical Subject Headings, MeSH, National Library, No, Palaeos Bacteria, Pieces, Protein
related to Mechanism · 9
GroEL → Alternatively, ATP, Binding, GroEL/ES, GroES, Hydrolysis, The, Unfolded, Within
related to Common · 8
GroEL → DNA, Heat, HSP60, HSP60’s, In, Moreover, Stresses, The
related to Discovery · 8
GroEL → HSP60, It, Mammalian HSP60, P1, Radhey Gupta, Recent, The, This
related to Phage T4 morphogenesis · 7
GroEL → GroES, However, Most, Snustad, T4, The, These

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

hsp60 protein proteins mitochondrial mitochondria folding chaperonin structure heat shock cytoplasm groes binding atp sequence hydrophobic also cell response assembly

GroEL relationships Subject–Predicate–Object triples

TTTA extracted 218 structured relationships around GroEL. Examples in this analysis include GroEL → 5.6.1.7 → ↗ and GroEL → Aliases → HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13, heat shock protein family D (Hsp60) member 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
GroEL5.6.1.7↗1.00infobox
GroELAliasesHSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13, heat shock protein family D (Hsp60) member 11.00infobox
GroELAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJ11.00infobox
GroELBand2q33.11.00infobox
GroELBand1|1 C1.21.00infobox
GroELBgeeright adrenal gland1.00infobox
GroELBgeeright adrenal cortex1.00infobox
GroELBgeeleft adrenal gland1.00infobox
GroELBgeeleft adrenal cortex1.00infobox
GroELBgeeventricular zone1.00infobox
GroELBgeebody of pancreas1.00infobox
GroELBgeeepithelium of colon1.00infobox
GroELBgeemucosa of transverse colon1.00infobox
GroELBgeeganglionic eminence1.00infobox
GroELBgeerectum1.00infobox
GroELBgeetail of embryo1.00infobox
GroELBgeeepiblast1.00infobox
GroELBgeeovary1.00infobox
GroELBgeegenital tubercle1.00infobox
GroELBgeeadrenal gland1.00infobox
GroELBgeeright kidney1.00infobox
GroELBgeeproximal tubule1.00infobox
GroELBgeeembryo1.00infobox
GroELBgeeblastocyst1.00infobox
GroELBgeeyolk sac1.00infobox
GroELBioGPSMore reference expression data1.00infobox
GroELChr.Chromosome 2 (human)1.00infobox
GroELChr.Chromosome 1 (mouse)1.00infobox
GroELDatabasesNCBI: entry; OMA: entry1.00infobox
GroELEnd197,516,737 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around GroEL bring nearby vocabulary together. In this analysis, examples include Groes, Complex and Chaperonin. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • GroEL
    • Groes
    • Complex
    • Chaperonin
    • Protein
    • Shown
    • Binding
    • Folding
    • Hsp60
    • Phage
    • Mitochondrial
    • Human
    • Assembly
  • groel
    • Groes
    • Complex
    • Chaperonin
    • Protein
    • Shown
    • Binding
    • Folding
    • Hsp60
    • Phage
    • Mitochondrial
    • Human
    • Assembly
  • chaperonin
    • Heat
    • Shock
    • Protein
    • Groel
    • Folding
    • Found
    • Human
    • Hydrophobic
    • Substrate
    • Binding
    • Proteins
    • Hsp60
  • folding
    • Protein
    • Unfolded
    • Matrix
    • Assembly
    • Proteins
    • Atp
    • Role
    • Addition
    • Mitochondrial
    • Hsp60
    • Groel
    • Hydrophobic
  • mitochondrial
    • Cytoplasmic
    • Matrix
    • Protein
    • Stress
    • Addition
    • Proteins
    • Human
    • Studies
    • Cytoplasm
    • Response
    • Role
    • Sequence
  • cytoplasm
    • Mitochondria
    • Matrix
    • Hsp60
    • Found
    • Studies
    • Expression
    • Mitochondrial
    • Cell
    • Bp
    • Stress
    • Protein
    • Addition
  • mitochondrial matrix
    • Unfolded
    • Cytoplasmic
    • Cytoplasm
    • Matrix
    • Mitochondrial
    • Proteins
    • Protein
    • Stress
    • Addition
    • Cell
    • Human
    • Studies
  • atp
    • Binding
    • Domain
    • Groes
    • Substrate
    • Folding
    • Two
    • Complex
    • Protein
    • Bp
    • Matrix
    • Immune
    • Unfolded

Connections between topic areas Semantic bridges

For GroEL, one of the stronger structural bridges in this analysis connects GroEL with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
GroEL — Structure · splits 92 ⟂ 29
GroEL — Function · splits 103 ⟂ 18
GroEL — Immunological role · splits 104 ⟂ 17
GroEL — Overview · splits 105 ⟂ 16
GroEL — Interactions · splits 111 ⟂ 10
GroEL — Discovery · splits 114 ⟂ 7
GroEL — Relationship to cancer · splits 114 ⟂ 7
GroEL — Mechanism · splits 115 ⟂ 6
GroEL — Synthesis and assembly · splits 116 ⟂ 5
GroEL — Stress response · splits 116 ⟂ 5

Map overview Semantic statistics

GroEL

Nodes121
Edges120
Triples218
Avg. degree1.98
Density0.016529
Components1

Source & methodology

TTTA analyzes the structure around GroEL to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Immunological role, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — GroEL · EN edition · Analysis: TopicsToTalkAbout

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