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GroEL

GroEL is a protein which belongs to the chaperonin family of molecular chaperones, and is found in many bacteria. It is required for the proper folding of many proteins. To function properly, GroEL requires the lid-like cochaperonin protein complex GroES. In eukaryotes the organellar proteins Hsp60 and Hsp10 are structurally and functionally nearly…

Structure, Function & Immunological role

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5.6.1.7
Aliases
HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13, heat shock protein family D (Hsp60) member 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJ1
Band
2q33.1 · 1|1 C1.2
Bgee
right adrenal gland · right adrenal cortex · left adrenal gland · left adrenal cortex · ventricular zone
BioGPS
More reference expression data

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Overview

Discovery

Structure

Function

Synthesis and assembly

Immunological role

Stress response

Relationship to cancer

Mechanism

Interactions

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Map overview Semantic statistics

GroEL

Nodes121
Edges120
Triples218
Avg. degree1.98
Density0.016529
Components1

How this topic connects Entity context

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GroEL

Top relations

Gene ontology · 69
GroEL → 'de novo' protein folding, activation of cysteine-type endopeptidase activity involved in apoptotic process, apolipoprotein A-I binding, apolipoprotein binding, apoptotic mitochondrial changes, ATP binding, ATPase activity, B cell activation, B cell cytokine production, B cell proliferation, cell surface, chaperone binding, chaperone-mediated protein complex assembly, chaperone-mediated protein folding, clathrin-coated pit, coated vesicle, cyclin-dependent protein kinase activating kinase holoenzyme complex, cytoplasm, cytosol, DNA replication origin binding
Bgee · 20
GroEL → adrenal gland, blastocyst, body of pancreas, embryo, epiblast, epithelium of colon, ganglionic eminence, genital tubercle, left adrenal cortex, left adrenal gland, mucosa of transverse colon, ovary, proximal tubule, rectum, right adrenal cortex, right adrenal gland, right kidney, tail of embryo, ventricular zone, yolk sac
RNA expression pattern · 20
GroEL → adrenal gland, blastocyst, body of pancreas, embryo, epiblast, epithelium of colon, ganglionic eminence, genital tubercle, left adrenal cortex, left adrenal gland, mucosa of transverse colon, ovary, proximal tubule, rectum, right adrenal cortex, right adrenal gland, right kidney, tail of embryo, ventricular zone, yolk sac
related to Immunological role · 12
GroEL → According, As, However, HSP60, In, Infection, LPS, PBMCs, The, There, This, When
related to Relationship to cancer · 12
GroEL → Although, Despite, Group, Hsp60, Hsp70, HSPD1, Human Hsp60, Neither, Positive, Recently, There, This
related to External links · 9
GroEL → Archived, EMDB, Medicine Medical Subject Headings, MeSH, National Library, No, Palaeos Bacteria, Pieces, Protein
related to Mechanism · 9
GroEL → Alternatively, ATP, Binding, GroEL/ES, GroES, Hydrolysis, The, Unfolded, Within
related to Common · 8
GroEL → DNA, Heat, HSP60, HSP60’s, In, Moreover, Stresses, The
related to Discovery · 8
GroEL → HSP60, It, Mammalian HSP60, P1, Radhey Gupta, Recent, The, This
related to Phage T4 morphogenesis · 7
GroEL → GroES, However, Most, Snustad, T4, The, These

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Important terminology

hsp60 protein proteins mitochondrial mitochondria folding chaperonin structure heat shock cytoplasm groes binding atp sequence hydrophobic also cell response assembly

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
GroEL5.6.1.71.00infobox
GroELAliasesHSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13, heat shock protein family D (Hsp60) member 11.00infobox
GroELAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJ11.00infobox
GroELBand2q33.11.00infobox
GroELBand1|1 C1.21.00infobox
GroELBgeeright adrenal gland1.00infobox
GroELBgeeright adrenal cortex1.00infobox
GroELBgeeleft adrenal gland1.00infobox
GroELBgeeleft adrenal cortex1.00infobox
GroELBgeeventricular zone1.00infobox
GroELBgeebody of pancreas1.00infobox
GroELBgeeepithelium of colon1.00infobox
GroELBgeemucosa of transverse colon1.00infobox
GroELBgeeganglionic eminence1.00infobox
GroELBgeerectum1.00infobox
GroELBgeetail of embryo1.00infobox
GroELBgeeepiblast1.00infobox
GroELBgeeovary1.00infobox
GroELBgeegenital tubercle1.00infobox
GroELBgeeadrenal gland1.00infobox
GroELBgeeright kidney1.00infobox
GroELBgeeproximal tubule1.00infobox
GroELBgeeembryo1.00infobox
GroELBgeeblastocyst1.00infobox
GroELBgeeyolk sac1.00infobox
GroELBioGPSMore reference expression data1.00infobox
GroELChr.Chromosome 2 (human)1.00infobox
GroELChr.Chromosome 1 (mouse)1.00infobox
GroELDatabasesNCBI: entry; OMA: entry1.00infobox
GroELEnd197,516,737 bp1.00infobox

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