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Vinculin: Regions, Binding site & Splice variants

In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell–cell and cell–matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring…

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Vinculin topic overview

The analysis highlights Regions, Binding site and Splice variants as prominent areas in the source structure around Vinculin.

Related topics
52
Source areas
7
Connected nodes
59
Extracted relationships
167
Concept neighborhoods
20
Bridge connections
59

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Binding site · 11 topics
Splice variants · 10 topics
Overview · 8 topics
Structure · 8 topics
Mechanism and function · 7 topics
Interactions · 5 topics
Activation · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
VCL, CMD1W, CMH15, HEL114, MV, Mvinculin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RKC, 1RKE, 1SYQ, 1TR2, 2GWW, 2IBF, 3H2U, 3H2V, 3MYI, 3TJ5, 3TJ6, 3VF0, 4DJ9, 4EHP, 1YDI, 2HSQ, 3RF3, 3S90,…
Band
10q22.2 · 14 A3|14 11.53 cM
Bgee
saphenous vein · urethra · vena cava · smooth muscle tissue · right coronary artery
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 14 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Mechanism and function

Activation

Binding site

Splice variants

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Vinculin connects Entity context

The extracted context around Vinculin shows recurring relationship patterns in the source. For example, Vinculin → actin binding, actin cytoskeleton, adherens junction, adherens junction assembly, alpha-catenin binding, apical junction assembly, axon extension, beta-catenin binding, brush border, cadherin binding, cell adhesion, cell junction, cell-cell junction, cell-matrix adhesion, cell-substrate junction, costamere, cytoplasm, cytoskeleton, cytosol, dystroglycan binding Another extracted example is Vinculin → ascending aorta, calvaria, carotid body, Descending thoracic aorta, endothelial cell of lymphatic vessel, left lung, left lung lobe, nipple, popliteal artery, right coronary artery, right lung, saphenous vein, seminal vesicula, smooth muscle tissue, tibial arteries, tibiofemoral joint, tunica media of zone of aorta, umbilical cord, urethra, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.

Vinculin

Top relations

Gene ontology · 50
Vinculin → actin binding, actin cytoskeleton, adherens junction, adherens junction assembly, alpha-catenin binding, apical junction assembly, axon extension, beta-catenin binding, brush border, cadherin binding, cell adhesion, cell junction, cell-cell junction, cell-matrix adhesion, cell-substrate junction, costamere, cytoplasm, cytoskeleton, cytosol, dystroglycan binding
Bgee · 20
Vinculin → ascending aorta, calvaria, carotid body, Descending thoracic aorta, endothelial cell of lymphatic vessel, left lung, left lung lobe, nipple, popliteal artery, right coronary artery, right lung, saphenous vein, seminal vesicula, smooth muscle tissue, tibial arteries, tibiofemoral joint, tunica media of zone of aorta, umbilical cord, urethra, vena cava
RNA expression pattern · 20
Vinculin → ascending aorta, calvaria, carotid body, Descending thoracic aorta, endothelial cell of lymphatic vessel, left lung, left lung lobe, nipple, popliteal artery, right coronary artery, right lung, saphenous vein, seminal vesicula, smooth muscle tissue, tibial arteries, tibiofemoral joint, tunica media of zone of aorta, umbilical cord, urethra, vena cava
related to Splice variants · 11
Vinculin → Both, C-terminal, Compared, II, In, Metavinculin, Mutations, Smooth, The, Translation, VCL
related to External links · 8
Vinculin → Human Vinculin, Mouse Vinculin, Overview, P18206, PDB, PDBe-KB, Q64727, UniProt
related to Structure · 6
Vinculin → C-terminal, Essentially, F-actin, N-terminal, The, This
related to Activation · 5
Vinculin → PIP2, The, These, This, When
related to Binding site · 4
Vinculin → LxxAAxxVAxxVxxLIxxA, Talin, The, VBS
related to Mechanism and function · 4
Vinculin → Cell, In, The, These
Band · 2
Vinculin → 10q22.2, 14 A3|14 11.53 cM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

binding talin focal actin adhesion protein function bp human cytoskeleton cell chr band tail membrane gene α-actinin domain head metavinculin

Vinculin relationships Subject–Predicate–Object triples

TTTA extracted 167 structured relationships around Vinculin. Examples in this analysis include Vinculin → Aliases → VCL, CMD1W, CMH15, HEL114, MV, Mvinculin and Vinculin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RKC, 1RKE, 1SYQ, 1TR2, 2GWW, 2IBF, 3H2U, 3H2V, 3MYI, 3TJ5, 3TJ6, 3VF0, 4DJ9, 4EHP, 1YDI, 2HSQ, 3RF3, 3S90,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
VinculinAliasesVCL, CMD1W, CMH15, HEL114, MV, Mvinculin1.00infobox
VinculinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RKC, 1RKE, 1SYQ, 1TR2, 2GWW, 2IBF, 3H2U, 3H2V, 3MYI, 3TJ5, 3TJ6, 3VF0, 4DJ9, 4EHP, 1YDI, 2HSQ, 3RF3, 3S90,…1.00infobox
VinculinBand10q22.21.00infobox
VinculinBand14 A3|14 11.53 cM1.00infobox
VinculinBgeesaphenous vein1.00infobox
VinculinBgeeurethra1.00infobox
VinculinBgeevena cava1.00infobox
VinculinBgeesmooth muscle tissue1.00infobox
VinculinBgeeright coronary artery1.00infobox
VinculinBgeepopliteal artery1.00infobox
VinculinBgeetibial arteries1.00infobox
VinculinBgeenipple1.00infobox
VinculinBgeeseminal vesicula1.00infobox
VinculinBgeeDescending thoracic aorta1.00infobox
VinculinBgeetunica media of zone of aorta1.00infobox
VinculinBgeecalvaria1.00infobox
VinculinBgeeendothelial cell of lymphatic vessel1.00infobox
VinculinBgeetibiofemoral joint1.00infobox
VinculinBgeeumbilical cord1.00infobox
VinculinBgeeascending aorta1.00infobox
VinculinBgeeright lung1.00infobox
VinculinBgeeleft lung1.00infobox
VinculinBgeecarotid body1.00infobox
VinculinBgeeleft lung lobe1.00infobox
VinculinBioGPSMore reference expression data1.00infobox
VinculinChr.Chromosome 10 (human)1.00infobox
VinculinChr.Chromosome 14 (mouse)1.00infobox
VinculinDatabasesNCBI: entry; OMA: entry1.00infobox
VinculinEnd74,121,363 bp1.00infobox
VinculinEnd21,083,744 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Vinculin bring nearby vocabulary together. In this analysis, examples include Α-actinin, State and Tail. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • focal adhesion
    • Focal
    • Cell
    • Spreading
    • Protein
    • Vinculin
    • Integrin
    • Cytoskeletal
    • Cytoskeleton
    • Binding
    • Membrane
    • Actin
    • Talin
  • actin
    • Cytoskeleton
    • Talin
    • Membrane
    • Focal
    • Adhesion
    • Vinculin
    • Cell
    • Protein
    • Binding
    • Integrin
    • Location
    • Mouse
  • protein dynamics
    • Focal
    • Vcl
    • Cytoskeletal
    • Vinculin
    • Cytoskeleton
    • Membrane
    • Region
    • State
    • Cell
    • Function
    • Integrin
    • Location
  • binding sites
    • Talin
    • Structure
    • Head
    • Vinculin
    • Integrin
    • Location
    • Vcl
    • Chromosome
    • Cytoskeletal
    • Gene
    • Vinculin's
    • Α-actinin
  • binding
    • Talin
    • Structure
    • Head
    • Vinculin
    • Integrin
    • Location
    • Vcl
    • Chromosome
    • Cytoskeletal
    • Gene
    • Vinculin's
    • Α-actinin
  • binding site
    • Talin
    • Structure
    • Head
    • Vinculin
    • Integrin
    • Location
    • Vcl
    • Chromosome
    • Cytoskeletal
    • Gene
    • Vinculin's
    • Α-actinin
  • cytoskeleton
    • Cytoskeletal
    • Membrane
    • Cell
    • Focal
    • Protein
    • Integrin
    • Location
    • Mouse
    • Uniprot
    • Vcl
    • Band
    • Chromosome
  • cytoskeletal
    • Cell
    • Cytoskeleton
    • Membrane
    • Spreading
    • Function
    • Focal
    • Protein
    • Integrin
    • Location
    • Mouse
    • Uniprot
    • Vcl

Connections between topic areas Semantic bridges

For Vinculin, one of the stronger structural bridges in this analysis connects Vinculin with Binding site. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
VinculinBinding site · splits 48 ⟂ 12
VinculinSplice variants · splits 49 ⟂ 11
VinculinOverview · splits 51 ⟂ 9
VinculinStructure · splits 51 ⟂ 9
VinculinMechanism and function · splits 52 ⟂ 8
VinculinInteractions · splits 54 ⟂ 6
VinculinActivation · splits 56 ⟂ 4

Map overview Semantic statistics

Vinculin

Nodes60
Edges59
Triples167
Avg. degree1.97
Density0.033333
Components1

Source & methodology

TTTA analyzes the structure around Vinculin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Binding site & Splice variants, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Vinculin · EN edition · Analysis: TopicsToTalkAbout

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