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Calpain

A calpain (/ˈkælpeɪn/; EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain…

Clinical significance, Function & Discovery

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Key facts & relationships

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AlphaFold
IPR001300 · PF00648
Available protein structures:
IPR001300 · PF00648
InterPro
IPR001300
MEROPS
C2
PDB
1tl9​ A:55-354; 1kxr​ B:55-354; 1tlo​ A:55-354; 2ary​ B:55-354; 1zcm​ A:55-353; 1mdw​ B:45-344; 1u5i​ A:45-344; 1kfx​ L:45-344; 1kfu​ L:45-344; 1ziv​ A:42-337 IPR001300 PF00648…
Pfam
PF00648

Topics to explore

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Overview

Discovery

Cleavage specificity

Extended family

Function

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

Calpain

Nodes86
Edges85
Triples104
Avg. degree1.98
Density0.023256
Components1

How this topic connects Entity context

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Calpain

Top relations

related to Discovery · 15
Calpain → Ca2, CANP, CAPN1, CAPN2, CAPN4, CAPNS1, II, In, Shortly, Structurally, The, Their, These, To, When
related to Pathology · 14
Calpain → Alzheimer's, At, Ca2, Excessive, Excessively, II, Increase, It, Moreover, Recently, The, This, Upon, When
related to External links · 12
Calpain → Arizona, Calpain Info, CaMPDB, Cell Migration GatewayAlzheimers, Family, Medicine Medical Subject Headings, MeSH, Modulatory Proteolysis DatabaseThe Calpain, National Library, PMAP The Proteolysis Map-animation, Proteases, University
related to Cleavage specificity · 11
Calpain → Ala, Ala-Glu-Arg-Lys, Amongst, Arguably, DABCYL, EDANS, Glu-Pro-Leu-Phe, No, P1, P2, Phe
related to Function · 11
Calpain → Additionally, Although, Ca2, Calpains, CAPNS1, Detergent, Enhanced, However, Other, Phosphorylation, Under
related to Therapeutic inhibitors · 10
Calpain → ABT-705253, AK275, Also, As, However, MDL28170, PD150606, SJA6017, SNJ-1945, The
related to Extended family · 4
Calpain → As, C2, MEROPS, The Human Genome Project
AlphaFold · 2
Calpain → IPR001300, PF00648
Available protein structures: · 2
Calpain → IPR001300, PF00648
InterPro · 1
Calpain → IPR001300

Important terminology Word statistics

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Important terminology

cell calpains also family brain activity proteolysis protein calcium protease known small proteases proteolytic isoforms merops two injury capns1 c2

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CalpainAlphaFoldIPR0013001.00infobox
CalpainAlphaFoldPF006481.00infobox
CalpainAvailable protein structures:IPR0013001.00infobox
CalpainAvailable protein structures:PF006481.00infobox
CalpainInterProIPR0013001.00infobox
CalpainMEROPSC21.00infobox
CalpainPDB1tl9​ A:55-354; 1kxr​ B:55-354; 1tlo​ A:55-354; 2ary​ B:55-354; 1zcm​ A:55-353; 1mdw​ B:45-344; 1u5i​ A:45-344; 1kfx​ L:45-344; 1kfu​ L:45-344; 1ziv​ A:42-337 IPR001300 PF00648…1.00infobox
CalpainPfamPF006481.00infobox
CalpainPfam clanCL01251.00infobox
CalpainPROSITEPDOC502031.00infobox
CalpainSCOP21mdw / SCOPe / SUPFAM1.00infobox
CalpainSMARTCysPc1.00infobox
CalpainSymbolCalpain1.00infobox
Calpainis atype-protease for the C20.90text

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