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Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency.
The analysis highlights Research, Related proteins and Interactions as prominent areas in the source structure around Gelsolin.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Gelsolin shows recurring relationship patterns in the source. For example, Gelsolin → actin binding, actin cap, actin cytoskeleton, actin filament binding, actin filament capping, actin filament polymerization, actin filament reorganization, actin filament severing, actin nucleation, actin polymerization or depolymerization, ageing, amyloid fibril formation, apoptotic process, barbed-end actin filament capping, blood microparticle, calcium ion binding, cell projection organization, cellular response to cadmium ion, cellular response to interferon-gamma, cilium assembly Another extracted example is Gelsolin → Although, Among, Ca2, Gelsolin's, PPI, PPI-binding, S1, S2, S2's, S3, S6, The, The C-terminal, The N-terminal, When. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
actin protein plasma cellular villin proteins calcium blood bp binds actin-binding gelsolin's important mitochondria n-terminal filaments related external binding severing
TTTA extracted 152 structured relationships around Gelsolin. Examples in this analysis include Gelsolin → Aliases → GSN, Gsn, ADF, AGEL, gelsolin and Gelsolin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C0F, 1C0G, 1D4X, 1DEJ, 1EQY, 1ESV, 1H1V, 1KCQ, 1MDU, 1NLV, 1NM1, 1NMD, 1P8X, 1P8Z, 1SOL, 1T44, 1YAG, 1YVN,…. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Gelsolin | Aliases | GSN, Gsn, ADF, AGEL, gelsolin | 1.00 | infobox |
| Gelsolin | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C0F, 1C0G, 1D4X, 1DEJ, 1EQY, 1ESV, 1H1V, 1KCQ, 1MDU, 1NLV, 1NM1, 1NMD, 1P8X, 1P8Z, 1SOL, 1T44, 1YAG, 1YVN,… | 1.00 | infobox |
| Gelsolin | Band | 2 B|2 23.5 cM | 1.00 | infobox |
| Gelsolin | Bgee | skin of external ear | 1.00 | infobox |
| Gelsolin | Bgee | subcutaneous adipose tissue | 1.00 | infobox |
| Gelsolin | Bgee | right lung | 1.00 | infobox |
| Gelsolin | Bgee | white adipose tissue | 1.00 | infobox |
| Gelsolin | Bgee | right lung lobe | 1.00 | infobox |
| Gelsolin | Bgee | tunica adventitia of aorta | 1.00 | infobox |
| Gelsolin | Bgee | stroma of bone marrow | 1.00 | infobox |
| Gelsolin | Bgee | left lung | 1.00 | infobox |
| Gelsolin | Bgee | superior surface of tongue | 1.00 | infobox |
| Gelsolin | Bgee | conjunctival fornix | 1.00 | infobox |
| Gelsolin | BioGPS | More reference expression data | 1.00 | infobox |
| Gelsolin | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| Gelsolin | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Gelsolin | End | 35,197,904 bp | 1.00 | infobox |
| Gelsolin | Ensembl | ENSG00000148180 | 1.00 | infobox |
| Gelsolin | Entrez | 2934 | 1.00 | infobox |
| Gelsolin | External IDs | OMIM: 137350; MGI: 95851; GeneCards: GSN | 1.00 | infobox |
| Gelsolin | Gene location (Mouse) | Gene location (Mouse)Chr.Chromosome 2 (mouse)Band2 B|2 23.5 cMStart35,146,392 bpEnd35,197,904 bp | 1.00 | infobox |
| Gelsolin | Gene ontology | metal ion binding | 1.00 | infobox |
| Gelsolin | Gene ontology | protein binding | 1.00 | infobox |
| Gelsolin | Gene ontology | actin binding | 1.00 | infobox |
| Gelsolin | Gene ontology | myosin II binding | 1.00 | infobox |
| Gelsolin | Gene ontology | calcium ion binding | 1.00 | infobox |
| Gelsolin | Gene ontology | actin filament binding | 1.00 | infobox |
| Gelsolin | Gene ontology | cytoplasm | 1.00 | infobox |
| Gelsolin | Gene ontology | cytosol | 1.00 | infobox |
| Gelsolin | Gene ontology | blood microparticle | 1.00 | infobox |
The concept neighborhoods around Gelsolin bring nearby vocabulary together. In this analysis, examples include Actin, Villin and Binds. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Gelsolin, one of the stronger structural bridges in this analysis connects Gelsolin with Related proteins. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Gelsolin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Related proteins & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Gelsolin · EN edition · Analysis: TopicsToTalkAbout