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Gelsolin

Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency.

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Aliases
GSN, Gsn, ADF, AGEL, gelsolin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C0F, 1C0G, 1D4X, 1DEJ, 1EQY, 1ESV, 1H1V, 1KCQ, 1MDU, 1NLV, 1NM1, 1NMD, 1P8X, 1P8Z, 1SOL, 1T44, 1YAG, 1YVN,…
Band
2 B|2 23.5 cM
Bgee
skin of external ear · subcutaneous adipose tissue · right lung · white adipose tissue · right lung lobe
BioGPS
More reference expression data
Chr.
Chromosome 2 (mouse)

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Structure

Regulation

Cellular function

Animal studies

Related proteins

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Map overview Semantic statistics

Gelsolin

Nodes61
Edges60
Triples152
Avg. degree1.97
Density0.032787
Components1

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Gelsolin

Top relations

Gene ontology · 68
Gelsolin → actin binding, actin cap, actin cytoskeleton, actin filament binding, actin filament capping, actin filament polymerization, actin filament reorganization, actin filament severing, actin nucleation, actin polymerization or depolymerization, ageing, amyloid fibril formation, apoptotic process, barbed-end actin filament capping, blood microparticle, calcium ion binding, cell projection organization, cellular response to cadmium ion, cellular response to interferon-gamma, cilium assembly
related to Regulation · 15
Gelsolin → Although, Among, Ca2, Gelsolin's, PPI, PPI-binding, S1, S2, S2's, S3, S6, The, The C-terminal, The N-terminal, When
Bgee · 10
Gelsolin → conjunctival fornix, left lung, right lung, right lung lobe, skin of external ear, stroma of bone marrow, subcutaneous adipose tissue, superior surface of tongue, tunica adventitia of aorta, white adipose tissue
RNA expression pattern · 10
Gelsolin → conjunctival fornix, left lung, right lung, right lung lobe, skin of external ear, stroma of bone marrow, subcutaneous adipose tissue, superior surface of tongue, tunica adventitia of aorta, white adipose tissue
related to Related proteins · 7
Gelsolin → ADF-H, Asgard, InterPro, IPR029006, Sequence, Six, The
related to Structure · 7
Gelsolin → C-terminal, Each, N-terminal, S1-S3, S1-S6, S4-S6, The
related to Animal studies · 4
Gelsolin → An, In, Mice, Research
related to Cellular function · 4
Gelsolin → Arp3, As, Prior, Rho GTPases
related to External links · 3
Gelsolin → Medicine Medical Subject Headings, MeSH, National Library
related to Interactions · 3
Gelsolin → In, It, Plasma

Important terminology Word statistics

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Important terminology

actin protein plasma cellular villin proteins calcium blood bp binds actin-binding gelsolin's important mitochondria n-terminal filaments related external binding severing

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
GelsolinAliasesGSN, Gsn, ADF, AGEL, gelsolin1.00infobox
GelsolinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C0F, 1C0G, 1D4X, 1DEJ, 1EQY, 1ESV, 1H1V, 1KCQ, 1MDU, 1NLV, 1NM1, 1NMD, 1P8X, 1P8Z, 1SOL, 1T44, 1YAG, 1YVN,…1.00infobox
GelsolinBand2 B|2 23.5 cM1.00infobox
GelsolinBgeeskin of external ear1.00infobox
GelsolinBgeesubcutaneous adipose tissue1.00infobox
GelsolinBgeeright lung1.00infobox
GelsolinBgeewhite adipose tissue1.00infobox
GelsolinBgeeright lung lobe1.00infobox
GelsolinBgeetunica adventitia of aorta1.00infobox
GelsolinBgeestroma of bone marrow1.00infobox
GelsolinBgeeleft lung1.00infobox
GelsolinBgeesuperior surface of tongue1.00infobox
GelsolinBgeeconjunctival fornix1.00infobox
GelsolinBioGPSMore reference expression data1.00infobox
GelsolinChr.Chromosome 2 (mouse)1.00infobox
GelsolinDatabasesNCBI: entry; OMA: entry1.00infobox
GelsolinEnd35,197,904 bp1.00infobox
GelsolinEnsemblENSG000001481801.00infobox
GelsolinEntrez29341.00infobox
GelsolinExternal IDsOMIM: 137350; MGI: 95851; GeneCards: GSN1.00infobox
GelsolinGene location (Mouse)Gene location (Mouse)Chr.Chromosome 2 (mouse)Band2 B|2 23.5 cMStart35,146,392 bpEnd35,197,904 bp1.00infobox
GelsolinGene ontologymetal ion binding1.00infobox
GelsolinGene ontologyprotein binding1.00infobox
GelsolinGene ontologyactin binding1.00infobox
GelsolinGene ontologymyosin II binding1.00infobox
GelsolinGene ontologycalcium ion binding1.00infobox
GelsolinGene ontologyactin filament binding1.00infobox
GelsolinGene ontologycytoplasm1.00infobox
GelsolinGene ontologycytosol1.00infobox
GelsolinGene ontologyblood microparticle1.00infobox

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