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FYN: Interactions, Role in signaling pathways & Function

Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded by the FYN gene.

Language: English [EN]
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FYN topic overview

The analysis highlights Interactions, Role in signaling pathways and Function as prominent areas in the source structure around FYN.

Related topics
71
Source areas
4
Connected nodes
75
Extracted relationships
277
Concept neighborhoods
16
Bridge connections
75

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 43 topics
Role in signaling pathways · 17 topics
Overview · 7 topics
Function · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.2
Aliases
FYN, SLK, SYN, p59-FYN proto-oncogene, Src family tyrosine kinase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A0N, 1AOT, 1AOU, 1AVZ, 1AZG, 1EFN, 1FYN, 1G83, 1M27, 1NYF, 1NYG, 1SHF, 1ZBJ, 2DQ7, 3H0F, 3H0H, 3H0I, 3UA6,…
Band
6q21 · 10 B1|10 20.51 cM
Bgee
ganglionic eminence · corpus callosum · granulocyte · olfactory bulb · lymph node
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Role in signaling pathways

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How FYN connects Entity context

The extracted context around FYN shows recurring relationship patterns in the source. For example, FYN → actin filament, activated T cell proliferation, adaptive immune response, alpha-tubulin binding, ATP binding, axon guidance, blood coagulation, calcium ion transport, CD4 receptor binding, CD8 receptor binding, cell body, cell differentiation, cell migration, cell periphery, cell surface receptor signaling pathway, cellular response to amyloid-beta, cellular response to glycine, cellular response to growth factor stimulus, cellular response to L-glutamate, cellular response to peptide hormone stimulus Another extracted example is FYN → ADD2, BCAR1, C-Raf, CBL, CBLC, CD36, CD44, CDH1, CHRNA7, CSF1R, CTNND1, DLG4, Dystroglycan, EPHA8, FASLG, FYB, GNB2L1, GRIN2A, ITK, Janus. Use these groups to spot repeated connection types before inspecting the individual relationships.

FYN

Top relations

Gene ontology · 132
FYN → actin filament, activated T cell proliferation, adaptive immune response, alpha-tubulin binding, ATP binding, axon guidance, blood coagulation, calcium ion transport, CD4 receptor binding, CD8 receptor binding, cell body, cell differentiation, cell migration, cell periphery, cell surface receptor signaling pathway, cellular response to amyloid-beta, cellular response to glycine, cellular response to growth factor stimulus, cellular response to L-glutamate, cellular response to peptide hormone stimulus
related to Interactions · 41
FYN → ADD2, BCAR1, C-Raf, CBL, CBLC, CD36, CD44, CDH1, CHRNA7, CSF1R, CTNND1, DLG4, Dystroglycan, EPHA8, FASLG, FYB, GNB2L1, GRIN2A, ITK, Janus
Bgee · 16
FYN → amygdala, barrel cortex, corpus callosum, dentate gyrus of hippocampal formation granule cell, dorsal motor nucleus of vagus nerve, ganglionic eminence, gastrula, granulocyte, lymph node, olfactory bulb, optic nerve, right lung, Rostral migratory stream, secondary oocyte, ventricular zone, zygote
RNA expression pattern · 16
FYN → amygdala, barrel cortex, corpus callosum, dentate gyrus of hippocampal formation granule cell, dorsal motor nucleus of vagus nerve, ganglionic eminence, gastrula, granulocyte, lymph node, olfactory bulb, optic nerve, right lung, Rostral migratory stream, secondary oocyte, ventricular zone, zygote
related to history · 11
FYN → Bishop, FAK, Nobel, PXN, SFK, SFKs, Slk, Src-family, Syn, The, Varmus
related to Function · 10
FYN → Abl, Inositol, Janus, Several, Src, T-cell, T-cells, This, Tyrosine, When
related to External links · 8
FYN → Human Tyrosine-protein, Mouse Tyrosine-protein, Overview, P06241, P39688, PDB, PDBe-KB, UniProt
related to Role in cancer biology · 8
FYN → Additionally, Akt, EGFR, Fyn's, Overexpression, Src, The Src, This
is a · 3
FYN → 59-kDa member of the Src family of kinases typically associated with T-cell and neuronal signaling in development and normal cell physiology, member of the protein-tyrosine kinase oncogene family, tyrosine-specific phospho-transferase that is a member of the Src family of non-receptor tyrosine protein kinases
related to Role in signaling pathways · 3
FYN → An, At, Knowing

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cell signaling kinase normal cancer family growth role pathways protein src tyrosine cells bp human chr band also gene development

FYN relationships Subject–Predicate–Object triples

TTTA extracted 277 structured relationships around FYN. Examples in this analysis include FYN → 2.7.10.2 → ↗ and FYN → Aliases → FYN, SLK, SYN, p59-FYN proto-oncogene, Src family tyrosine kinase. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
FYN2.7.10.21.00infobox
FYNAliasesFYN, SLK, SYN, p59-FYN proto-oncogene, Src family tyrosine kinase1.00infobox
FYNAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A0N, 1AOT, 1AOU, 1AVZ, 1AZG, 1EFN, 1FYN, 1G83, 1M27, 1NYF, 1NYG, 1SHF, 1ZBJ, 2DQ7, 3H0F, 3H0H, 3H0I, 3UA6,…1.00infobox
FYNBand6q211.00infobox
FYNBand10 B1|10 20.51 cM1.00infobox
FYNBgeeganglionic eminence1.00infobox
FYNBgeecorpus callosum1.00infobox
FYNBgeegranulocyte1.00infobox
FYNBgeeolfactory bulb1.00infobox
FYNBgeelymph node1.00infobox
FYNBgeeoptic nerve1.00infobox
FYNBgeeright lung1.00infobox
FYNBgeeventricular zone1.00infobox
FYNBgeeamygdala1.00infobox
FYNBgeedorsal motor nucleus of vagus nerve1.00infobox
FYNBgeeRostral migratory stream1.00infobox
FYNBgeedentate gyrus of hippocampal formation granule cell1.00infobox
FYNBgeegastrula1.00infobox
FYNBgeezygote1.00infobox
FYNBgeebarrel cortex1.00infobox
FYNBgeesecondary oocyte1.00infobox
FYNBioGPSMore reference expression data1.00infobox
FYNChr.Chromosome 6 (human)1.00infobox
FYNChr.Chromosome 10 (mouse)1.00infobox
FYNDatabasesNCBI: entry; OMA: entry1.00infobox
FYNEnd111,873,452 bp1.00infobox
FYNEnd39,565,381 bp1.00infobox
FYNEnsemblENSG000000108101.00infobox
FYNEntrez25341.00infobox
FYNEnzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.10.2↗↗↗↗1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around FYN bring nearby vocabulary together. In this analysis, examples include Signaling, Cell and Kinase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • FYN
    • Signaling
    • Cell
    • Kinase
    • Also
    • Family
    • Cells
    • Role
    • Cancer
    • Src
    • Protein
    • Tyrosine
    • Growth
  • fyn
    • Signaling
    • Cell
    • Kinase
    • Also
    • Family
    • Cells
    • Role
    • Cancer
    • Src
    • Protein
    • Tyrosine
    • Growth
  • enzyme
    • Gene
    • Proto-oncogene
    • Location
    • Slk
    • Syn
    • Activity
    • Chromosome
    • Bp
    • Chr
    • Function
    • Human
    • Kinase
  • gene
    • Enzyme
    • Location
    • Chromosome
    • Proto-oncogene
    • Bp
    • Chr
    • Human
    • Mouse
    • Slk
    • Syn
    • Activity
    • Band
  • src family of kinases
    • Src
    • Member
    • Kinases
    • Protein
    • Development
    • Tyrosine
    • Kinase
    • Signaling
    • Function
    • Also
    • Role
    • Fyn
  • protein-tyrosine kinase
    • Tyrosine
    • Enzyme
    • Pdb
    • Uniprot
    • Family
    • Gene
    • Member
    • Proto-oncogene
    • Development
    • Human
    • Kinases
    • Src
  • b cell
    • Growth
    • Normal
    • Fyn
    • Signaling
    • Tyrosine
    • Regulation
    • Kinase
    • Member
    • Cancer
    • Development
    • Kinases
    • Src
  • growth factor
    • Cells
    • Function
    • Proto-oncogene
    • Cancer
    • Normal
    • Tyrosine
    • Kinase
    • Signaling
    • Location
    • Mouse
    • Regulation
    • Uniprot

Connections between topic areas Semantic bridges

For FYN, one of the stronger structural bridges in this analysis connects FYN with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FYNInteractions · splits 32 ⟂ 44
FYNRole in signaling pathways · splits 58 ⟂ 18
FYNOverview · splits 68 ⟂ 8
FYNFunction · splits 71 ⟂ 5

Map overview Semantic statistics

FYN

Nodes76
Edges75
Triples277
Avg. degree1.97
Density0.026316
Components1

Source & methodology

TTTA analyzes the structure around FYN to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Role in signaling pathways & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — FYN · EN edition · Analysis: TopicsToTalkAbout

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