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FYN

Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded by the FYN gene.

Interactions, Role in signaling pathways & Function

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Interactions

43 related topics

Role in signaling pathways

17 related topics

Function

4 related topics

Overview

7 related topics

Key facts & relationships

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2.7.10.2
Aliases
FYN, SLK, SYN, p59-FYN proto-oncogene, Src family tyrosine kinase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A0N, 1AOT, 1AOU, 1AVZ, 1AZG, 1EFN, 1FYN, 1G83, 1M27, 1NYF, 1NYG, 1SHF, 1ZBJ, 2DQ7, 3H0F, 3H0H, 3H0I, 3UA6,…
Band
6q21 · 10 B1|10 20.51 cM
Bgee
ganglionic eminence · corpus callosum · granulocyte · olfactory bulb · lymph node
BioGPS
More reference expression data

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Overview

Function

Role in signaling pathways

Interactions

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Map overview Semantic statistics

FYN

Nodes76
Edges75
Triples277
Avg. degree1.97
Density0.026316
Components1

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FYN

Top relations

Gene ontology · 132
FYN → actin filament, activated T cell proliferation, adaptive immune response, alpha-tubulin binding, ATP binding, axon guidance, blood coagulation, calcium ion transport, CD4 receptor binding, CD8 receptor binding, cell body, cell differentiation, cell migration, cell periphery, cell surface receptor signaling pathway, cellular response to amyloid-beta, cellular response to glycine, cellular response to growth factor stimulus, cellular response to L-glutamate, cellular response to peptide hormone stimulus
related to Interactions · 41
FYN → ADD2, BCAR1, C-Raf, CBL, CBLC, CD36, CD44, CDH1, CHRNA7, CSF1R, CTNND1, DLG4, Dystroglycan, EPHA8, FASLG, FYB, GNB2L1, GRIN2A, ITK, Janus
Bgee · 16
FYN → amygdala, barrel cortex, corpus callosum, dentate gyrus of hippocampal formation granule cell, dorsal motor nucleus of vagus nerve, ganglionic eminence, gastrula, granulocyte, lymph node, olfactory bulb, optic nerve, right lung, Rostral migratory stream, secondary oocyte, ventricular zone, zygote
RNA expression pattern · 16
FYN → amygdala, barrel cortex, corpus callosum, dentate gyrus of hippocampal formation granule cell, dorsal motor nucleus of vagus nerve, ganglionic eminence, gastrula, granulocyte, lymph node, olfactory bulb, optic nerve, right lung, Rostral migratory stream, secondary oocyte, ventricular zone, zygote
related to history · 11
FYN → Bishop, FAK, Nobel, PXN, SFK, SFKs, Slk, Src-family, Syn, The, Varmus
related to Function · 10
FYN → Abl, Inositol, Janus, Several, Src, T-cell, T-cells, This, Tyrosine, When
related to External links · 8
FYN → Human Tyrosine-protein, Mouse Tyrosine-protein, Overview, P06241, P39688, PDB, PDBe-KB, UniProt
related to Role in cancer biology · 8
FYN → Additionally, Akt, EGFR, Fyn's, Overexpression, Src, The Src, This
is a · 3
FYN → 59-kDa member of the Src family of kinases typically associated with T-cell and neuronal signaling in development and normal cell physiology, member of the protein-tyrosine kinase oncogene family, tyrosine-specific phospho-transferase that is a member of the Src family of non-receptor tyrosine protein kinases
related to Role in signaling pathways · 3
FYN → An, At, Knowing

Important terminology Word statistics

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Important terminology

cell signaling kinase normal cancer family growth role pathways protein src tyrosine cells bp human chr band also gene development

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FYN2.7.10.21.00infobox
FYNAliasesFYN, SLK, SYN, p59-FYN proto-oncogene, Src family tyrosine kinase1.00infobox
FYNAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A0N, 1AOT, 1AOU, 1AVZ, 1AZG, 1EFN, 1FYN, 1G83, 1M27, 1NYF, 1NYG, 1SHF, 1ZBJ, 2DQ7, 3H0F, 3H0H, 3H0I, 3UA6,…1.00infobox
FYNBand6q211.00infobox
FYNBand10 B1|10 20.51 cM1.00infobox
FYNBgeeganglionic eminence1.00infobox
FYNBgeecorpus callosum1.00infobox
FYNBgeegranulocyte1.00infobox
FYNBgeeolfactory bulb1.00infobox
FYNBgeelymph node1.00infobox
FYNBgeeoptic nerve1.00infobox
FYNBgeeright lung1.00infobox
FYNBgeeventricular zone1.00infobox
FYNBgeeamygdala1.00infobox
FYNBgeedorsal motor nucleus of vagus nerve1.00infobox
FYNBgeeRostral migratory stream1.00infobox
FYNBgeedentate gyrus of hippocampal formation granule cell1.00infobox
FYNBgeegastrula1.00infobox
FYNBgeezygote1.00infobox
FYNBgeebarrel cortex1.00infobox
FYNBgeesecondary oocyte1.00infobox
FYNBioGPSMore reference expression data1.00infobox
FYNChr.Chromosome 6 (human)1.00infobox
FYNChr.Chromosome 10 (mouse)1.00infobox
FYNDatabasesNCBI: entry; OMA: entry1.00infobox
FYNEnd111,873,452 bp1.00infobox
FYNEnd39,565,381 bp1.00infobox
FYNEnsemblENSG000000108101.00infobox
FYNEntrez25341.00infobox
FYNEnzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.10.2↗↗↗↗1.00infobox

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