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EPHA8: Function, Interactions & Overview

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.

Language: English [EN]
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EPHA8 topic overview

The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around EPHA8.

Related topics
8
Source areas
3
Connected nodes
11
Extracted relationships
110
Concept neighborhoods
9
Bridge connections
11

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 4 topics
Interactions · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1
Aliases
EPHA8, EEK, EK3, HEK3, EPH receptor A8
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCV, 1X5L, 3KUL
Band
1p36.12 · 4|4 D3
Bgee
endothelial cell · gonad · spleen · hypothalamus · secondary oocyte
BioGPS
n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How EPHA8 connects Entity context

The extracted context around EPHA8 shows recurring relationship patterns in the source. For example, EPHA8 → ATP binding, axon guidance, cell adhesion, cell differentiation, cell projection, cellular response to follicle-stimulating hormone stimulus, cytoplasm, early endosome membrane, endosome, ephrin receptor activity, ephrin receptor signaling pathway, GPI-linked ephrin receptor activity, integral component of membrane, integral component of plasma membrane, kinase activity, membrane, multicellular organism development, negative regulation of apoptotic process, negative regulation of signal transduction, nervous system development Another extracted example is EPHA8 → anterior cingulate cortex, cerebellar cortex, cingulate gyrus, endothelial cell, entorhinal cortex, gonad, hypothalamus, Ileal epithelium, lacrimal groove, lens, mesencephalon, neural layer of retina, perirhinal cortex, prefrontal cortex, primary visual cortex, secondary oocyte, spleen, substantia nigra, superior frontal gyrus, visual cortex. Use these groups to spot repeated connection types before inspecting the individual relationships.

EPHA8

Top relations

Gene ontology · 44
EPHA8 → ATP binding, axon guidance, cell adhesion, cell differentiation, cell projection, cellular response to follicle-stimulating hormone stimulus, cytoplasm, early endosome membrane, endosome, ephrin receptor activity, ephrin receptor signaling pathway, GPI-linked ephrin receptor activity, integral component of membrane, integral component of plasma membrane, kinase activity, membrane, multicellular organism development, negative regulation of apoptotic process, negative regulation of signal transduction, nervous system development
Bgee · 20
EPHA8 → anterior cingulate cortex, cerebellar cortex, cingulate gyrus, endothelial cell, entorhinal cortex, gonad, hypothalamus, Ileal epithelium, lacrimal groove, lens, mesencephalon, neural layer of retina, perirhinal cortex, prefrontal cortex, primary visual cortex, secondary oocyte, spleen, substantia nigra, superior frontal gyrus, visual cortex
RNA expression pattern · 20
EPHA8 → anterior cingulate cortex, cerebellar cortex, cingulate gyrus, endothelial cell, entorhinal cortex, gonad, hypothalamus, Ileal epithelium, lacrimal groove, lens, mesencephalon, neural layer of retina, perirhinal cortex, prefrontal cortex, primary visual cortex, secondary oocyte, spleen, substantia nigra, superior frontal gyrus, visual cortex
Band · 2
EPHA8 → 1p36.12, 4|4 D3
Chr. · 2
EPHA8 → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
EPHA8 → 136,956,816 bp, 22,603,595 bp
2.7.10.1 · 1
EPHA8 → ↗
Aliases · 1
EPHA8 → EPHA8, EEK, EK3, HEK3, EPH receptor A8
Available structures · 1
EPHA8 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCV, 1X5L, 3KUL
BioGPS · 1
EPHA8 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene chr human band receptor ephrin chromosome protein location mouse eph kinase nervous system function receptors encoded search activity

EPHA8 relationships Subject–Predicate–Object triples

TTTA extracted 110 structured relationships around EPHA8. Examples in this analysis include EPHA8 → 2.7.10.1 → ↗ and EPHA8 → Aliases → EPHA8, EEK, EK3, HEK3, EPH receptor A8. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
EPHA82.7.10.11.00infobox
EPHA8AliasesEPHA8, EEK, EK3, HEK3, EPH receptor A81.00infobox
EPHA8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UCV, 1X5L, 3KUL1.00infobox
EPHA8Band1p36.121.00infobox
EPHA8Band4|4 D31.00infobox
EPHA8Bgeeendothelial cell1.00infobox
EPHA8Bgeegonad1.00infobox
EPHA8Bgeespleen1.00infobox
EPHA8Bgeehypothalamus1.00infobox
EPHA8Bgeesecondary oocyte1.00infobox
EPHA8Bgeemesencephalon1.00infobox
EPHA8Bgeesubstantia nigra1.00infobox
EPHA8Bgeeprefrontal cortex1.00infobox
EPHA8Bgeecingulate gyrus1.00infobox
EPHA8Bgeeanterior cingulate cortex1.00infobox
EPHA8Bgeeneural layer of retina1.00infobox
EPHA8Bgeecerebellar cortex1.00infobox
EPHA8BgeeIleal epithelium1.00infobox
EPHA8Bgeeperirhinal cortex1.00infobox
EPHA8Bgeevisual cortex1.00infobox
EPHA8Bgeesuperior frontal gyrus1.00infobox
EPHA8Bgeelacrimal groove1.00infobox
EPHA8Bgeeprimary visual cortex1.00infobox
EPHA8Bgeeentorhinal cortex1.00infobox
EPHA8Bgeelens1.00infobox
EPHA8BioGPSn/a1.00infobox
EPHA8Chr.Chromosome 1 (human)1.00infobox
EPHA8Chr.Chromosome 4 (mouse)1.00infobox
EPHA8DatabasesNCBI: entry; OMA: entry1.00infobox
EPHA8End22,603,595 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around EPHA8 bring nearby vocabulary together. In this analysis, examples include Receptor, Activity and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • EPHA8
    • Receptor
    • Activity
    • Function
    • Gene
    • Search
    • Location
    • Protein
    • Chromosome
    • Ephrin
    • Human
    • Bp
    • Chr
  • epha8
    • Receptor
    • Activity
    • Function
    • Gene
    • Search
    • Location
    • Protein
    • Chromosome
    • Ephrin
    • Human
    • Bp
    • Chr
  • gene
    • Receptor
    • Location
    • Protein
    • Chromosome
    • Human
    • Bp
    • Chr
    • Activity
    • Development
    • End
    • Function
    • Guidance
  • ephrin receptor
    • Gene
    • Protein
    • Receptor
    • Activity
    • Binding
    • Development
    • Encoded
    • Function
    • Guidance
    • Search
    • Location
    • Nervous
  • function
    • Activity
    • Search
    • Location
    • Chromosome
    • Human
    • Interactions
    • Reading
    • Receptor
    • References
    • Bp
    • Chr
    • Gene
  • protein
    • Receptor
    • Development
    • Guidance
    • Gene
    • Nervous
    • System
    • Humans
    • Type-a
    • Activity
    • Binding
    • End
    • Function
  • protein-tyrosine kinase
    • Subfamily
    • Development
    • Domain
    • Extracellular
    • Guidance
    • Mouse
    • Search
    • Location
    • Nervous
    • Protein
    • Receptors
    • System
  • axonal guidance
    • Nervous
    • Protein
    • System
    • Receptor
    • Kinase
    • Mouse
    • Search
    • Subfamily
    • Location
    • Human

Connections between topic areas Semantic bridges

For EPHA8, one of the stronger structural bridges in this analysis connects EPHA8 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
EPHA8Function · splits 7 ⟂ 5
EPHA8Overview · splits 9 ⟂ 3
EPHA8Interactions · splits 9 ⟂ 3

Map overview Semantic statistics

EPHA8

Nodes12
Edges11
Triples110
Avg. degree1.83
Density0.166667
Components1

Source & methodology

TTTA analyzes the structure around EPHA8 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — EPHA8 · EN edition · Analysis: TopicsToTalkAbout

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