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STK11

Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.

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2.7.11.1
Aliases
STK11, LKB1, PJS, hLKB1, serine/threonine kinase 11
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2WTK, 4ZDR
Band
19p13.3 · 10|10 C1
Bgee
left testis · right testis · muscle of thigh · gastrocnemius muscle · granulocyte
BioGPS
More reference expression data

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Overview

Expression

Function

Clinical significance

Activation

Structure

Splice variants

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Map overview Semantic statistics

STK11

Nodes53
Edges52
Triples148
Avg. degree1.96
Density0.037736
Components1

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STK11

Top relations

Gene ontology · 67
STK11 → activation of protein kinase activity, anoikis, apoptotic process, ATP binding, autophagy, axonogenesis, canonical Wnt signaling pathway, cell cycle, cell differentiation, cellular response to DNA damage stimulus, cellular response to UV-B, cytoplasm, cytosol, dendrite extension, establishment of cell polarity, extracellular exosome, glucose homeostasis, Golgi localization, intrinsic apoptotic signaling pathway by p53 class mediator, kinase activity
Bgee · 18
STK11 → apex of heart, gastrocnemius muscle, granulocyte, Ileal epithelium, left testis, lip, mucosa of transverse colon, muscle of thigh, neural layer of retina, otic placode, right hemisphere of cerebellum, right testis, saccule, stromal cell of endometrium, tendon of biceps brachii, ventricular zone, yolk sac, zygote
RNA expression pattern · 18
STK11 → apex of heart, gastrocnemius muscle, granulocyte, Ileal epithelium, left testis, lip, mucosa of transverse colon, muscle of thigh, neural layer of retina, otic placode, right hemisphere of cerebellum, right testis, saccule, stromal cell of endometrium, tendon of biceps brachii, ventricular zone, yolk sac, zygote
related to Expression · 12
STK11 → AMPK, DHT, ER-positive, ERα, However, In, L1, LKB1, MCF-7, Moreover, SGBS, Testosterone
related to Function · 6
STK11 → Activation, AMPK, AMPK-related, It, LKB1, The STK11/LKB1
Band · 2
STK11 → 10|10 C1, 19p13.3
Chr. · 2
STK11 → Chromosome 10 (mouse), Chromosome 19 (human)
End · 2
STK11 → 1,228,431 bp, 79,966,516 bp
related to Interactions · 2
STK11 → CDC37, FYNHSP90AA1LYK5SMARCA4ESR1
2.7.11.1 · 1
STK11 → ↗

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Important terminology

lkb1 gene kinase ampk bp protein human expression activation chr band activity cell serine threonine chromosome 19 growth splice kinases

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
STK112.7.11.11.00infobox
STK11AliasesSTK11, LKB1, PJS, hLKB1, serine/threonine kinase 111.00infobox
STK11Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2WTK, 4ZDR1.00infobox
STK11Band19p13.31.00infobox
STK11Band10|10 C11.00infobox
STK11Bgeeleft testis1.00infobox
STK11Bgeeright testis1.00infobox
STK11Bgeemuscle of thigh1.00infobox
STK11Bgeegastrocnemius muscle1.00infobox
STK11Bgeegranulocyte1.00infobox
STK11Bgeestromal cell of endometrium1.00infobox
STK11Bgeeright hemisphere of cerebellum1.00infobox
STK11Bgeetendon of biceps brachii1.00infobox
STK11Bgeemucosa of transverse colon1.00infobox
STK11Bgeeapex of heart1.00infobox
STK11BgeeIleal epithelium1.00infobox
STK11Bgeesaccule1.00infobox
STK11Bgeeventricular zone1.00infobox
STK11Bgeeotic placode1.00infobox
STK11Bgeeneural layer of retina1.00infobox
STK11Bgeelip1.00infobox
STK11Bgeezygote1.00infobox
STK11Bgeeyolk sac1.00infobox
STK11BioGPSMore reference expression data1.00infobox
STK11Chr.Chromosome 19 (human)1.00infobox
STK11Chr.Chromosome 10 (mouse)1.00infobox
STK11DatabasesNCBI: entry; OMA: entry1.00infobox
STK11End1,228,431 bp1.00infobox
STK11End79,966,516 bp1.00infobox
STK11EnsemblENSG000001180461.00infobox

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