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PP2 (kinase inhibitor)

PP2 is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of epidermal growth factor receptor (480 nM) and practically no inhibition of ZAP-70 (100 μM) and JAK2 (50 μM). Despite its extensive…

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InhibitorSrc-family kinasesLckIC50NM
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PP2 (kinase inhibitor)

Nodes12
Edges11
Triples0
Avg. degree1.83
Density0.166667
Components1

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pp2 kinases inhibitor pp2a subunit research inhibits 100 references dephosphorylation phosphorylation proteins cancer inhibition standard state function lck ic50 nm

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SubjectPredicateObjectConfidenceSrc

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