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SH2D1A: Art, Interactions & Overview

SH2 domain–containing protein 1A is a protein that in humans is encoded by the SH2D1A gene. It is often called SLAM-associated protein (symbol SAP), where "SLAM" refers to signaling lymphocytic activation molecules. It is a SH2 domain–containing molecule (part of a family of such molecules) that plays a role in SLAM signaling. A putative function is as…

Language: English [EN]
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SH2D1A topic overview

The analysis highlights Art, Interactions and Overview as prominent areas in the source structure around SH2D1A.

Related topics
15
Source areas
2
Connected nodes
17
Extracted relationships
69
Concept neighborhoods
11
Bridge connections
17

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 10 topics
Interactions · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SH2D1A, DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/XLP, XLPD, XLPD1, SH2 domain containing 1A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D1Z, 1D4T, 1D4W, 1KA6, 1KA7, 1M27
Band
Xq25 · X|X A4
Bgee
thymus · lymph node · granulocyte · blood · appendix
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SH2D1A connects Entity context

The extracted context around SH2D1A shows recurring relationship patterns in the source. For example, SH2D1A → appendix, blood, bone marrow, bone marrow cell, embryo, gallbladder, granulocyte, lymph node, mesenteric lymph nodes, neural layer of retina, retinal pigment epithelium, spermatid, spleen, testicle, thymus Another extracted example is SH2D1A → adaptive immune response, cell-cell signaling, cellular defense response, cytoplasm, cytosol, humoral immune response, immune system process, innate immune response, positive regulation of natural killer cell mediated cytotoxicity, positive regulation of signal transduction, protein binding, regulation of immune response. Use these groups to spot repeated connection types before inspecting the individual relationships.

SH2D1A

Top relations

Bgee · 15
SH2D1A → appendix, blood, bone marrow, bone marrow cell, embryo, gallbladder, granulocyte, lymph node, mesenteric lymph nodes, neural layer of retina, retinal pigment epithelium, spermatid, spleen, testicle, thymus
RNA expression pattern · 15
SH2D1A → appendix, blood, bone marrow, bone marrow cell, embryo, gallbladder, granulocyte, lymph node, mesenteric lymph nodes, neural layer of retina, retinal pigment epithelium, spermatid, spleen, testicle, thymus
Gene ontology · 12
SH2D1A → adaptive immune response, cell-cell signaling, cellular defense response, cytoplasm, cytosol, humoral immune response, immune system process, innate immune response, positive regulation of natural killer cell mediated cytotoxicity, positive regulation of signal transduction, protein binding, regulation of immune response
related to Interactions · 4
SH2D1A → CD84, DOK1, FYN, LY9
Band · 2
SH2D1A → Xq25, X|X A4
Chr. · 2
SH2D1A → X chromosome (human), X chromosome (mouse)
End · 2
SH2D1A → 124,373,197 bp, 41,618,207 bp
Aliases · 1
SH2D1A → SH2D1A, DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/XLP, XLPD, XLPD1, SH2 domain containing 1A
Available structures · 1
SH2D1A → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D1Z, 1D4T, 1D4W, 1KA6, 1KA7, 1M27
BioGPS · 1
SH2D1A → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp chr human band protein signaling chromosome slam sh2 domain containing sap location molecules family mouse fyn 1a function

SH2D1A relationships Subject–Predicate–Object triples

TTTA extracted 69 structured relationships around SH2D1A. Examples in this analysis include SH2D1A → Aliases → SH2D1A, DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/XLP, XLPD, XLPD1, SH2 domain containing 1A and SH2D1A → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D1Z, 1D4T, 1D4W, 1KA6, 1KA7, 1M27. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SH2D1AAliasesSH2D1A, DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/XLP, XLPD, XLPD1, SH2 domain containing 1A1.00infobox
SH2D1AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D1Z, 1D4T, 1D4W, 1KA6, 1KA7, 1M271.00infobox
SH2D1ABandXq251.00infobox
SH2D1ABandX|X A41.00infobox
SH2D1ABgeethymus1.00infobox
SH2D1ABgeelymph node1.00infobox
SH2D1ABgeegranulocyte1.00infobox
SH2D1ABgeeblood1.00infobox
SH2D1ABgeeappendix1.00infobox
SH2D1ABgeespleen1.00infobox
SH2D1ABgeebone marrow1.00infobox
SH2D1ABgeetesticle1.00infobox
SH2D1ABgeegallbladder1.00infobox
SH2D1ABgeebone marrow cell1.00infobox
SH2D1ABgeeneural layer of retina1.00infobox
SH2D1ABgeespermatid1.00infobox
SH2D1ABgeeembryo1.00infobox
SH2D1ABgeemesenteric lymph nodes1.00infobox
SH2D1ABgeeretinal pigment epithelium1.00infobox
SH2D1ABioGPSMore reference expression data1.00infobox
SH2D1AChr.X chromosome (human)1.00infobox
SH2D1AChr.X chromosome (mouse)1.00infobox
SH2D1ADatabasesNCBI: entry; OMA: entry1.00infobox
SH2D1AEnd124,373,197 bp1.00infobox
SH2D1AEnd41,618,207 bp1.00infobox
SH2D1AEnsemblENSG000001839181.00infobox
SH2D1AEntrez40681.00infobox
SH2D1AExternal IDsOMIM: 300490; MGI: 1328352; GeneCards: SH2D1A1.00infobox
SH2D1AGene location (Human)Gene location (Human)Chr.X chromosome (human)BandXq25Start124,227,868 bpEnd124,373,197 bp1.00infobox
SH2D1AGene location (Mouse)Gene location (Mouse)Chr.X chromosome (mouse)BandX|X A4Start41,591,330 bpEnd41,618,207 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SH2D1A bring nearby vocabulary together. In this analysis, examples include Signaling, Sh2d1a and Activation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • protein
    • Sh2d1a
    • Signaling
    • Activation
    • Called
    • Encoded
    • Gene
    • Humans
    • Lymphocytic
    • Often
    • Refers
    • Slam-associated
    • Symbol
  • signaling lymphocytic activation molecules
    • Activation
    • Called
    • Lymphocytic
    • Often
    • Refers
    • Slam-associated
    • Symbol
    • Signaling
    • Slam
    • Molecules
    • Family
    • Protein
  • sh2 domain
    • Containing
    • Sh2
    • 1a
    • Sh2d1a
    • Encoded
    • Gene
    • Humans
    • Family
    • Molecules
    • Search
    • Location
    • Protein
  • gene
    • Location
    • Sh2d1a
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • Mouse
    • Search
    • Protein
    • Sh2
    • Band
  • signaling
    • Slam
    • Slam-associated
    • Symbol
    • End
    • Family
    • Function
    • Fyn
    • Mouse
    • Search
    • Location
    • Sh2d1a
    • Band
  • fyn
    • Phosphatases
    • End
    • Mouse
    • Search
    • Location
    • Protein
    • Sh2d1a
    • Signaling
    • Slam
    • Band
    • Chromosome
    • Human
  • autoimmunity
    • Mutation
    • Sap
  • SH2D1A
    • Signaling

Connections between topic areas Semantic bridges

For SH2D1A, one of the stronger structural bridges in this analysis connects SH2D1A with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SH2D1AOverview · splits 7 ⟂ 11
SH2D1AInteractions · splits 12 ⟂ 6

Map overview Semantic statistics

SH2D1A

Nodes18
Edges17
Triples69
Avg. degree1.89
Density0.111111
Components1

Source & methodology

TTTA analyzes the structure around SH2D1A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SH2D1A · EN edition · Analysis: TopicsToTalkAbout

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