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Tropomyosin receptor kinase B

Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF).

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2.7.10.1
Aliases
NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE58
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4
Band
9q21.33 · 13 B1|13 31.2 cM
Bgee
optic nerve · external globus pallidus · Region I of hippocampus proper · internal globus pallidus · Epithelium of choroid plexus
BioGPS
More reference expression data

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Tropomyosin receptor kinase B

Nodes89
Edges88
Triples166
Avg. degree1.98
Density0.022472
Components1

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Tropomyosin receptor kinase B

Top relations

Gene ontology · 89
Tropomyosin receptor kinase B → activation of phospholipase C activity, ATP binding, axon, axon terminus, brain-derived neurotrophic factor binding, brain-derived neurotrophic factor receptor signaling pathway, brain-derived neurotrophic factor-activated receptor activity, cell differentiation, cell projection, cellular response to amino acid stimulus, cellular response to brain-derived neurotrophic factor stimulus, cellular response to nerve growth factor stimulus, central nervous system neuron development, cerebral cortex development, circadian rhythm, cytoplasm, cytosol, dendrite, dendritic spine, early endosome
Bgee · 19
Tropomyosin receptor kinase B → anterior amygdaloid area, arcuate nucleus, dorsal motor nucleus of vagus nerve, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, Epithelium of choroid plexus, external globus pallidus, internal globus pallidus, lateral septal nucleus, median eminence, optic nerve, pars reticulata, postcentral gyrus, Region I of hippocampus proper, subiculum, substantia nigra, superior frontal gyrus, superior vestibular nucleus, ventral tegmental area
RNA expression pattern · 19
Tropomyosin receptor kinase B → anterior amygdaloid area, arcuate nucleus, dorsal motor nucleus of vagus nerve, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, Epithelium of choroid plexus, external globus pallidus, internal globus pallidus, lateral septal nucleus, median eminence, optic nerve, pars reticulata, postcentral gyrus, Region I of hippocampus proper, subiculum, substantia nigra, superior frontal gyrus, superior vestibular nucleus, ventral tegmental area
related to Function · 14
Tropomyosin receptor kinase B → As, BDNF, Brain Derived Neurotrophic Factor, IGF1, MuSK, NT-3, NT-4, Other, The, The TrkB, TrkB, Tropomyosin, Vascular Endothelial Growth Factor, VEGF
Band · 2
Tropomyosin receptor kinase B → 13 B1|13 31.2 cM, 9q21.33
Chr. · 2
Tropomyosin receptor kinase B → Chromosome 13 (mouse), Chromosome 9 (human)
End · 2
Tropomyosin receptor kinase B → 59,281,784 bp, 85,027,070 bp
2.7.10.1 · 1
Tropomyosin receptor kinase B → ↗
Aliases · 1
Tropomyosin receptor kinase B → NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE58
Available structures · 1
Tropomyosin receptor kinase B → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4

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Important terminology

trkb bdnf receptor kinase neurotrophic nt-3 tyrosine human bp protein gene factor ntrk2 chr band binding growth nt-4 trkc shown

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Tropomyosin receptor kinase B2.7.10.11.00infobox
Tropomyosin receptor kinase BAliasesNTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD, EIEE581.00infobox
Tropomyosin receptor kinase BAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT41.00infobox
Tropomyosin receptor kinase BBand9q21.331.00infobox
Tropomyosin receptor kinase BBand13 B1|13 31.2 cM1.00infobox
Tropomyosin receptor kinase BBgeeoptic nerve1.00infobox
Tropomyosin receptor kinase BBgeeexternal globus pallidus1.00infobox
Tropomyosin receptor kinase BBgeeRegion I of hippocampus proper1.00infobox
Tropomyosin receptor kinase BBgeeinternal globus pallidus1.00infobox
Tropomyosin receptor kinase BBgeeEpithelium of choroid plexus1.00infobox
Tropomyosin receptor kinase BBgeesuperior vestibular nucleus1.00infobox
Tropomyosin receptor kinase BBgeedorsal motor nucleus of vagus nerve1.00infobox
Tropomyosin receptor kinase BBgeeventral tegmental area1.00infobox
Tropomyosin receptor kinase BBgeepostcentral gyrus1.00infobox
Tropomyosin receptor kinase BBgeepars reticulata1.00infobox
Tropomyosin receptor kinase BBgeemedian eminence1.00infobox
Tropomyosin receptor kinase BBgeearcuate nucleus1.00infobox
Tropomyosin receptor kinase BBgeedorsomedial hypothalamic nucleus1.00infobox
Tropomyosin receptor kinase BBgeelateral septal nucleus1.00infobox
Tropomyosin receptor kinase BBgeesuperior frontal gyrus1.00infobox
Tropomyosin receptor kinase BBgeesubstantia nigra1.00infobox
Tropomyosin receptor kinase BBgeesubiculum1.00infobox
Tropomyosin receptor kinase BBgeeanterior amygdaloid area1.00infobox
Tropomyosin receptor kinase BBgeedorsal tegmental nucleus1.00infobox
Tropomyosin receptor kinase BBioGPSMore reference expression data1.00infobox
Tropomyosin receptor kinase BChr.Chromosome 9 (human)1.00infobox
Tropomyosin receptor kinase BChr.Chromosome 13 (mouse)1.00infobox
Tropomyosin receptor kinase BDatabasesNCBI: entry; OMA: entry1.00infobox
Tropomyosin receptor kinase BEnd85,027,070 bp1.00infobox
Tropomyosin receptor kinase BEnd59,281,784 bp1.00infobox

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