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TRPC6: Function, Clinical significance & Ligands
Transient receptor potential cation channel, subfamily C, member 6 or Transient receptor potential canonical 6, also known as TRPC6, is a protein encoded in the human by the TRPC6 gene. TRPC6 is a transient receptor potential channel of the classical TRPC subfamily.
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TRPC6 topic overview
The analysis highlights Function, Clinical significance and Ligands as prominent areas in the source structure around TRPC6.
Related topics
74
Source areas
5
Connected nodes
79
Extracted relationships
127
Concept neighborhoods
11
Bridge connections
79
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Function · 26 topics
Clinical significance · 17 topics
Ligands · 16 topics
Overview · 11 topics
Interactions · 4 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Aliases
TRPC6, FSGS2, TRP6, transient receptor potential cation channel subfamily C member 6
Band
11q22.1 · 9 A1|9 2.46 cM
Bgee
right lung · upper lobe of left lung · right uterine tube · testicle · left lobe of thyroid gland
BioGPS
n/a
Chr.
Chromosome 11 (human) · Chromosome 9 (mouse)
Databases
NCBI: entry; OMA: entry
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How TRPC6 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around TRPC6 shows recurring relationship patterns in the source. For example, TRPC6 → actin binding, actinin binding, ageing, ATPase binding, calcium channel activity, calcium ion transmembrane transport, calcium ion transport, cation channel activity, cation channel complex, cation transport, cellular response to hydrogen peroxide, cellular response to hypoxia, clathrin binding, cytoplasm, inositol 1,4,5 trisphosphate binding, integral component of membrane, integral component of plasma membrane, ion channel activity, ion transport, manganese ion transport Another extracted example is TRPC6 → Achilles tendon, body of femur, cumulus cell, dentate gyrus of hippocampal formation granule cell, embryo, hippocampus proper, left lobe of thyroid gland, left lung lobe, lens, lumbar spinal ganglion, right lobe of liver, right lobe of thyroid gland, right lung, right uterine tube, stromal cell of endometrium, subcutaneous adipose tissue, substantia nigra, testicle, upper lobe of left lung, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.
TRPC6
Top relations
Gene ontology· 37
TRPC6 → actin binding, actinin binding, ageing, ATPase binding, calcium channel activity, calcium ion transmembrane transport, calcium ion transport, cation channel activity, cation channel complex, cation transport, cellular response to hydrogen peroxide, cellular response to hypoxia, clathrin binding, cytoplasm, inositol 1,4,5 trisphosphate binding, integral component of membrane, integral component of plasma membrane, ion channel activity, ion transport, manganese ion transport
Bgee· 20
TRPC6 → Achilles tendon, body of femur, cumulus cell, dentate gyrus of hippocampal formation granule cell, embryo, hippocampus proper, left lobe of thyroid gland, left lung lobe, lens, lumbar spinal ganglion, right lobe of liver, right lobe of thyroid gland, right lung, right uterine tube, stromal cell of endometrium, subcutaneous adipose tissue, substantia nigra, testicle, upper lobe of left lung, visceral pleura
RNA expression pattern· 20
TRPC6 → Achilles tendon, body of femur, cumulus cell, dentate gyrus of hippocampal formation granule cell, embryo, hippocampus proper, left lobe of thyroid gland, left lung lobe, lens, lumbar spinal ganglion, right lobe of liver, right lobe of thyroid gland, right lung, right uterine tube, stromal cell of endometrium, subcutaneous adipose tissue, substantia nigra, testicle, upper lobe of left lung, visceral pleura
related to Ligands· 7
TRPC6 → Hyperforin, Hypericum, John's Wort, Recent, St, These, Two
related to In blood vessels· 6
TRPC6 → Conversely, However, Small, This, TPRC6-mediated, When
related to In the central nervous system· 4
TRPC6 → NMDA, NMDAR, PSD-95, Research
related to In the kidneys· 4
TRPC6 → Despite, Nevertheless, Podocytes, Within
related to External links· 3
TRPC6 → Medicine Medical Subject Headings, MeSH, National Library
related to Interactions· 3
TRPC6 → APP, FYN, TRPC2
Band· 2
TRPC6 → 11q22.1, 9 A1|9 2.46 cM
Important terminology
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 127 structured relationships around TRPC6. Examples in this analysis include TRPC6 → Aliases → TRPC6, FSGS2, TRP6, transient receptor potential cation channel subfamily C member 6 and TRPC6 → Band → 11q22.1. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
TRPC6
Aliases
TRPC6, FSGS2, TRP6, transient receptor potential cation channel subfamily C member 6
1.00
infobox
TRPC6
Band
11q22.1
1.00
infobox
TRPC6
Band
9 A1|9 2.46 cM
1.00
infobox
TRPC6
Bgee
right lung
1.00
infobox
TRPC6
Bgee
upper lobe of left lung
1.00
infobox
TRPC6
Bgee
right uterine tube
1.00
infobox
TRPC6
Bgee
testicle
1.00
infobox
TRPC6
Bgee
left lobe of thyroid gland
1.00
infobox
TRPC6
Bgee
right lobe of thyroid gland
1.00
infobox
TRPC6
Bgee
Achilles tendon
1.00
infobox
TRPC6
Bgee
stromal cell of endometrium
1.00
infobox
TRPC6
Bgee
visceral pleura
1.00
infobox
TRPC6
Bgee
subcutaneous adipose tissue
1.00
infobox
TRPC6
Bgee
lumbar spinal ganglion
1.00
infobox
TRPC6
Bgee
right lobe of liver
1.00
infobox
TRPC6
Bgee
dentate gyrus of hippocampal formation granule cell
1.00
infobox
TRPC6
Bgee
lens
1.00
infobox
TRPC6
Bgee
cumulus cell
1.00
infobox
TRPC6
Bgee
substantia nigra
1.00
infobox
TRPC6
Bgee
embryo
1.00
infobox
TRPC6
Bgee
hippocampus proper
1.00
infobox
TRPC6
Bgee
left lung lobe
1.00
infobox
TRPC6
Bgee
body of femur
1.00
infobox
TRPC6
BioGPS
n/a
1.00
infobox
TRPC6
Chr.
Chromosome 11 (human)
1.00
infobox
TRPC6
Chr.
Chromosome 9 (mouse)
1.00
infobox
TRPC6
Databases
NCBI: entry; OMA: entry
1.00
infobox
TRPC6
End
101,872,562 bp
1.00
infobox
TRPC6
End
8,680,742 bp
1.00
infobox
TRPC6
Ensembl
ENSG00000137672
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around TRPC6 bring nearby vocabulary together. In this analysis, examples include Podocytes, Ca2 and Influx. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
transient receptor potential channel
Subfamily
Transient
Potential
Receptor
Channel
Also
Cation
Gene
Function
Human
Trpc6
Activation
cation channels
Gene
Human
Trpc6
Location
Potential
Subfamily
Transient
Channel
Chromosome
Protein
Receptor
Activity
calcium
Pca
Preference
Ratio
Nmdar
Despite
Influx
Ions
Location
Transport
Trpc3
Band
Cation
big potassium (bk) channels
Trpc6
Activity
Transport
Podocytes
Function
Blood
Cells
Influx
Ions
Trpc3
Ca2
Vessels
gene
Location
Human
Chromosome
Bp
Chr
Potential
Subfamily
Transient
Band
Protein
Receptor
Function
nmda receptor
Potential
Subfamily
Transient
Also
Channel
Cation
Gene
Human
Known
Location
Trpc6
Chromosome
function
Location
Chromosome
Gene
Vessels
Bp
Chr
Human
Trpc6
Potential
Subfamily
Transient
Transport
TRPC6
Podocytes
Ca2
Influx
Location
Nmdar
Vessels
Band
Increase
Pressure
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For TRPC6, one of the stronger structural bridges in this analysis connects TRPC6 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
TRPC6
Nodes80
Edges79
Triples127
Avg. degree1.98
Density0.025
Components1
Source & methodology
TTTA analyzes the structure around TRPC6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Ligands, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TRPC6 · EN edition · Analysis: TopicsToTalkAbout
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