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Vitamin B12: History, Community, Culture & Applications

Vitamin B12, also known as cobalamin or extrinsic factor, is a water-soluble vitamin involved in metabolism. One of eight B vitamins, it serves as a vital cofactor in DNA synthesis and both fatty acid and amino acid metabolism. It plays an essential role in the nervous system by supporting myelin synthesis and is critical for the maturation of red blood…

Language: English [EN]
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Vitamin B12 topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Vitamin B12. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
264
Source areas
12
Connected nodes
320
Extracted relationships
357
Concept neighborhoods
44
Bridge connections
320

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 65 topics
Synthesis · 52 topics
Deficiency · 37 topics
Drug interactions · 26 topics
Definition · 22 topics
History · 21 topics
Physiology · 16 topics
Dietary recommendations · 10 topics
Chemistry · 8 topics
Medical uses · 4 topics
Biochemistry · 3 topics
Society and culture · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
B03BA01 (WHO)
Bioavailability
Readily absorbed in the distal half of the ileum.
CAS Number
68-19-9
ChEMBL
ChEMBL2110563

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Definition

Deficiency

Medical uses

Dietary recommendations

Sources

Drug interactions

Chemistry

Biochemistry

Physiology

Synthesis

History

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Vitamin B12 connects Entity context

The extracted context around Vitamin B12 shows recurring relationship patterns in the source. For example, Vitamin B12 → Agriculture, Alexander, B12, Bureau, Cambridge, Chemistry, Dairy Industry, Department, Dorner, Dorothy Hodgkin, Folker, George Minot, George Whipple, Hodgkin, In, Karl Folkers, Lactobacillus, LLD, Mary Shaw Shorb, Maryland Another extracted example is Vitamin B12 → Acetobacterium, Aerobacter, Agrobacterium, Alcaligenes, Azotobacter, B12, Bacillus, Clostridium, Corynebacterium, Flavobacterium, III, It, Lactobacillus, Later, Micromonospora, Mycobacterium, Nocardia, Propionibacterium, Proteus, Pseudomonas. Use these groups to spot repeated connection types before inspecting the individual relationships.

Vitamin B12

Top relations

related to Identification of the active compound · 32
Vitamin B12 → Agriculture, Alexander, B12, Bureau, Cambridge, Chemistry, Dairy Industry, Department, Dorner, Dorothy Hodgkin, Folker, George Minot, George Whipple, Hodgkin, In, Karl Folkers, Lactobacillus, LLD, Mary Shaw Shorb, Maryland
related to Biosynthesis · 29
Vitamin B12 → Acetobacterium, Aerobacter, Agrobacterium, Alcaligenes, Azotobacter, B12, Bacillus, Clostridium, Corynebacterium, Flavobacterium, III, It, Lactobacillus, Later, Micromonospora, Mycobacterium, Nocardia, Propionibacterium, Proteus, Pseudomonas
related to Dietary recommendations · 27
Vitamin B12 → AI, AIs, As, B12, Because, Children, Collectively, DRIs, EAR, EARs, For, Grain-based, However, In, Medicine, Pharmaceutical, RDA, RDAs, Since, Some
related to Diagnosis · 16
Vitamin B12 → According, At, B12, Diagnosis, For, However, If, II, In, MCV, MMA, Serum, Several, The, Therefore, This
related to Pregnancy, lactation, and early childhood · 15
Vitamin B12 → AI, As, B12, Determination, During, EFSA, European Food Safety Authority, However, Low, RDA, Recommended Dietary Allowance, The, This, Women, World Health Organization
has method · 12
Vitamin B12 → ATCC7830, B12, B12-requiring, Currently, Furthermore, However, IF, Lactobacillus, Previous, RIDA, Several, The
related to Chemistry · 12
Vitamin B12 → Animals, As, B12, B12r, B12s, Biochemically, CH3, CN, Four, Historically, OH, The
related to Identification of liver as an anti-anemia food · 12
Vitamin B12 → B12, During, Edwin Cohn, George Minot, George Whipple, In, Medicine, Murphy, Nobel Prize, Physiology, William, William Castle
related to Industrial · 12
Vitamin B12 → B12, Drug Administration, Food, GRAS, Industrial, Propionibacterium, Pseudomonas, Rhone-Poulenc, Streptomyces, The, These, United States
related to Society and culture · 12
Vitamin B12 → After, B12, Baltimore, Healthcare, However, In, John, Mayo Clinic, Myers, The, There, This

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

b12 vitamin deficiency may anemia also food cyanocobalamin dietary liver μg foods absorption acid bacteria levels risk synthesis used fermentation

Vitamin B12 relationships Subject–Predicate–Object triples

TTTA extracted 357 structured relationships around Vitamin B12. Examples in this analysis include Vitamin B12 → 3D model (JSmol) → Interactive image and Vitamin B12 → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Vitamin B123D model (JSmol)Interactive image1.00infobox
Vitamin B12AHFS/Drugs.comMonograph1.00infobox
Vitamin B12ATC codeB03BA01 (WHO)1.00infobox
Vitamin B12BioavailabilityReadily absorbed in the distal half of the ileum.1.00infobox
Vitamin B12CAS Number68-19-91.00infobox
Vitamin B12ChEMBLChEMBL21105631.00infobox
Vitamin B12ChemSpider104695041.00infobox
Vitamin B12DrugBankDB001151.00infobox
Vitamin B12Elimination half-lifeApproximately 6 days (400 days in the liver).1.00infobox
Vitamin B12ExcretionKidney1.00infobox
Vitamin B12FormulaC63H88CoN14O14P1.00infobox
Vitamin B12KEGGD001661.00infobox
Vitamin B12Legal statusUK: OTC1.00infobox
Vitamin B12Legal statusUS: OTC1.00infobox
Vitamin B12License dataUS DailyMed: Vitamin_b121.00infobox
Vitamin B12MedlinePlusa6050071.00infobox
Vitamin B12MetabolismLiver1.00infobox
Vitamin B12Molar mass1355.388 g·mol−11.00infobox
Vitamin B12Other namesVitamin B12, vitamin B-12, cobalamin1.00infobox
Vitamin B12Protein bindingVery high to specific transcobalamins plasma proteins. Binding of hydroxocobalamin is slightly higher than cyanocobalamin.1.00infobox
Vitamin B12PubChem CID1849331.00infobox
Vitamin B12Routes of administrationBy mouth, sublingual, intravenous (IV), intramuscular (IM), intranasal1.00infobox
Vitamin B12UNIIP6YC3EG2041.00infobox
Vitamin B12is amost chemically complex of all vitamins0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Vitamin B12 bring nearby vocabulary together. In this analysis, examples include Vitamin, Deficiency and Foods. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Vitamin B12
    • Vitamin
    • Deficiency
    • Foods
    • Food
    • Also
    • Absorption
    • May
    • Acid
    • Bacteria
    • Used
    • Liver
    • Anemia
  • vitamin b12
    • Vitamin
    • Deficiency
    • Foods
    • Dietary
    • May
    • Food
    • Absorption
    • Also
    • Serum
    • Bacteria
    • Levels
    • Acid
  • vitamin
    • Deficiency
    • Foods
    • Food
    • Absorption
    • May
    • Bacteria
    • Used
    • Liver
    • Anemia
    • Dietary
    • Gastric
    • Low
  • dietary supplement
    • Food
    • Intake
    • Fortified
    • Deficiency
    • Absorption
    • Anemia
    • Μg
    • Cyanide
    • Gastric
    • Day
    • Pregnancy
    • Low
  • vitamin b12 deficiency
    • Vitamin
    • Deficiency
    • Risk
    • Foods
    • Anemia
    • Dietary
    • Serum
    • May
    • Food
    • Absorption
    • Also
    • Gastric
  • pseudovitamin b12
    • Vitamin
    • Deficiency
    • Dietary
    • May
    • Absorption
    • Foods
    • Also
    • Serum
    • Bacteria
    • Levels
    • Acid
    • Anemia
  • recommended dietary allowance (rda)
    • Food
    • Intake
    • Fortified
    • Deficiency
    • Absorption
    • Anemia
    • Μg
    • Cyanide
    • Gastric
    • Day
    • Pregnancy
    • Low
  • dietary reference intakes
    • Food
    • Intake
    • Fortified
    • Deficiency
    • Absorption
    • Anemia
    • Μg
    • Cyanide
    • Gastric
    • Day
    • Pregnancy
    • Low

Connections between topic areas Semantic bridges

For Vitamin B12, one of the stronger structural bridges in this analysis connects Vitamin B12 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Vitamin B12 — Overview · splits 255 ⟂ 66
Vitamin B12 — Synthesis · splits 268 ⟂ 53
Vitamin B12 — Sources · splits 278 ⟂ 43
Vitamin B12 — Deficiency · splits 283 ⟂ 38
Vitamin B12 — Drug interactions · splits 294 ⟂ 27
Vitamin B12 — Definition · splits 298 ⟂ 23
Vitamin B12 — History · splits 299 ⟂ 22
Vitamin B12 — Physiology · splits 304 ⟂ 17
Vitamin B12 — Dietary recommendations · splits 310 ⟂ 11
Vitamin B12 — Chemistry · splits 312 ⟂ 9
Vitamin B12 — Medical uses · splits 316 ⟂ 5
Vitamin B12 — Biochemistry · splits 317 ⟂ 4

Map overview Semantic statistics

Vitamin B12

Nodes321
Edges320
Triples357
Avg. degree1.99
Density0.006231
Components1

Source & methodology

TTTA analyzes the structure around Vitamin B12 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Vitamin B12 · EN edition · Analysis: TopicsToTalkAbout

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