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Cimetidine

Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. It is mainly used in the treatment of heartburn and peptic ulcers.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A02BA01 (WHO)
Bioavailability
60–70%
CAS Number
51481-61-9 Y
ChEBI
CHEBI:3699 Y

Topics to explore

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Overview

Medical uses

Side effects

Overdose

Interactions

Pharmacology

History

Research

Veterinary use

Advanced semantic analysis

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Map overview Semantic statistics

Cimetidine

Nodes203
Edges202
Triples127
Avg. degree1.99
Density0.009852
Components1

How this topic connects Entity context

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Cimetidine

Top relations

related to Lawsuit · 34
Cimetidine → Appeals, August, BPTTT, BPTTT's, Bureau, CA, CA's, Certiorari, Court, Danlex, Danlex Research Laboratories, Filipino Bureau, French, French's Motion, Inc, January, July, Kline, No, October
related to history · 20
Cimetidine → At, Black, FDA, French, GlaxoSmithKline, H2, In, James, Kline, Laboratories, Medicine, Nobel Prize, Physiology, Robin Ganellin, Sir James, SK, SKF, Smith, This, Welwyn Garden City
related to Interactions · 18
Cimetidine → Accumulation, Clinically, Creatinine, CYP1A2, CYP2C9, CYP2D6, CYP2E1, CYP3A4, Due, E-selectin, Examples, Following, Interactions, Like, N-acetyl-p-benzoquinone, NAPQI, P450, This
has effect · 4
Cimetidine → Because, It, Rarely, Reported
related to Pharmacokinetics · 4
Cimetidine → It, Its, L/kg, The
Legal status · 3
Cimetidine → AU: S4 (Prescription only), UK: POM (Prescription only), US: ℞-only / OTC
related to External links · 3
Cimetidine → Media, Wikimedia Commons, Wiktionary-logo-en-v2
is a · 2
Cimetidine → potent inhibitor of tubular creatinine secretion, sulfoxide
related to Research · 2
Cimetidine → Some, Tentative
3D model (JSmol) · 1
Cimetidine → Interactive image

Important terminology Word statistics

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Important terminology

receptor h2 antagonist levels histamine effects gynecomastia also used treatment drug inhibition enzymes cyp2d6 reported may acid metabolism interactions research

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Cimetidine3D model (JSmol)Interactive image1.00infobox
CimetidineAHFS/Drugs.comMonograph1.00infobox
CimetidineATC codeA02BA01 (WHO)1.00infobox
CimetidineBioavailability60–70%1.00infobox
CimetidineCAS Number51481-61-9 Y1.00infobox
CimetidineChEBICHEBI:3699 Y1.00infobox
CimetidineChEMBLChEMBL30 Y1.00infobox
CimetidineChemSpider2654 Y1.00infobox
CimetidineCompTox Dashboard (EPA)DTXSID40203291.00infobox
CimetidineDrugBankDB00501 Y1.00infobox
CimetidineDuration of action4–8 hours1.00infobox
CimetidineECHA InfoCard100.052.0121.00infobox
CimetidineElimination half-life123 minutes (~2 hours)1.00infobox
CimetidineExcretionUrine1.00infobox
CimetidineFormulaC10H16N6S1.00infobox
CimetidineIUPHAR/BPS12311.00infobox
CimetidineKEGGD00295 Y1.00infobox
CimetidineLegal statusAU: S4 (Prescription only)1.00infobox
CimetidineLegal statusUK: POM (Prescription only)1.00infobox
CimetidineLegal statusUS: ℞-only / OTC1.00infobox
CimetidineLicense dataUS DailyMed: Cimetidine1.00infobox
CimetidineMedlinePlusa6822561.00infobox
CimetidineMetabolismLiver1.00infobox
CimetidineMetabolites• Cimetidine sulfoxide • Hydroxycimetidine • Guanyl urea cimetidine1.00infobox
CimetidineMolar mass252.34 g·mol−11.00infobox
CimetidineOnset of action30 minutes1.00infobox
CimetidineOther namesSKF-923341.00infobox
CimetidinePregnancy categoryAU: B11.00infobox
CimetidinePronunciation/sɪˈmɛtɪdiːn/ or /saɪˈmɛtɪdiːn/1.00infobox
CimetidineProtein binding13–25%1.00infobox

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