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Neomycin

Neomycin, also known as framycetin, is an aminoglycoside antibiotic that displays bactericidal activity against Gram-negative aerobic bacilli and some anaerobic bacilli where resistance has not yet arisen. It is generally not effective against Gram-positive bacilli and anaerobic Gram-negative bacilli. Neomycin comes in oral and topical formulations…

Applications, Medical uses & Mechanism of action

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A01AB08 (WHO) A07AA01 (WHO), B05CA09 (WHO), D06AX04 (WHO), J01GB05 (WHO), R02AB01 (WHO), S01AA03 (WHO), S02AA07 (WHO), S03AA01 (WHO)
Bioavailability
< 3% (oral)
CAS Number
1404-04-2 Y
ChEBI
CHEBI:7508 Y

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Overview

Discovery

Medical uses

Side effects

Mechanism of action

Chemistry

Biosynthetic pathway

Additional activities

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Map overview Semantic statistics

Neomycin

Nodes89
Edges88
Triples120
Avg. degree1.98
Density0.022472
Components1

How this topic connects Entity context

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Neomycin

Top relations

related to Immunostimulation · 14
Neomycin → Although, An, In, IRF3, IRF7, ISG, ISGs, It, Neosporin, The, TICAM1, TLR3, Yale University, Zika
related to Structure · 12
Neomycin → C-5, D-neosamine, D-ribose, DOS, II, II-I-III-IV, III, IV, L-neosamine, Ring, The, Three
related to Resistance · 11
Neomycin → Although, APH, APH/neo, As, Currently, DNA, G418, Many, Other, Specific, This
has effect · 9
Neomycin → Allergen, Although, Hearing, In, It, Like, Patients, Routes, Year
related to DNA binding · 9
Neomycin → A-form, A-site RNA, Aminoglycosides, B-DNA, DNA, DNA-binding, However, RNA, The
related to Medical uses · 9
Neomycin → B/bacitracin, B/hydrocortisone, By, In, It, Neosporin, Orally, The, United States
related to Spectrum · 9
Neomycin → Enterobacter, Gram-negative, Gram-positive, It, MIC, Physicians, Polysporin, Similar, The
related to Biosynthetic pathway · 7
Neomycin → Addition, In, N-acetylparomamine, Production, Streptomyces, The, UDP-N-acetylglucosamine
related to Discovery · 7
Neomycin → Hubert Lechevalier, It, Rutgers University, Selman Waksman, Streptomyces, Synthesis, The
related to Composition · 5
Neomycin → NBRC, Pharmaceutical, Streptomyces, The, This

Important terminology Word statistics

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Important terminology

also topical aminoglycosides gram-negative used activity antibiotic bacteria known university oral dna aminoglycoside ribostamycin binding cell gene one effective use

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Neomycin3D model (JSmol)Interactive image1.00infobox
NeomycinAHFS/Drugs.comMonograph1.00infobox
NeomycinATC codeA01AB08 (WHO) A07AA01 (WHO), B05CA09 (WHO), D06AX04 (WHO), J01GB05 (WHO), R02AB01 (WHO), S01AA03 (WHO), S02AA07 (WHO), S03AA01 (WHO)1.00infobox
NeomycinBioavailability< 3% (oral)1.00infobox
NeomycinCAS Number1404-04-2 Y1.00infobox
NeomycinChEBICHEBI:7508 Y1.00infobox
NeomycinChEMBLChEMBL449118 N1.00infobox
NeomycinChemSpider8075 Y1.00infobox
NeomycinDrugBankDB00994 Y1.00infobox
NeomycinECHA InfoCard100.014.3331.00infobox
NeomycinElimination half-life2 to 3 hours1.00infobox
NeomycinFormulaC23H46N6O131.00infobox
NeomycinIUPHAR/BPS7091.00infobox
NeomycinKEGGD08260 Y1.00infobox
NeomycinLegal statusUS: ℞-only but OTC in Neosporin and similar ointments1.00infobox
NeomycinMedlinePlusa6822741.00infobox
NeomycinMetabolism(Not used systemically)1.00infobox
NeomycinMolar mass614.650 g·mol−11.00infobox
NeomycinProtein binding(Not used systemically)1.00infobox
NeomycinPubChem CID83781.00infobox
NeomycinRoutes of administrationTopical, oral1.00infobox
NeomycinTrade namesNeo-rx1.00infobox
NeomycinUNIII16QD7X2971.00infobox

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