Valproate

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Valproate topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Valproate.

Related topics: 199
Source areas: 10
Connected nodes: 209
Extracted relationships: 141
Related term clusters: 36
Bridge connections: 209

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 57 topics

Pharmacology · 42 topics

Interactions · 22 topics

Adverse effects · 18 topics

Medical uses · 18 topics

Overdose · 13 topics

Chemistry · 11 topics

Society and culture · 7 topics

History · 6 topics

Contraindications · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
AHFS/Drugs.com: Monograph
ATC code: N03AG01 (WHO)
Bioavailability: ~90%
CAS Number: 99-66-1 Y
ChEBI: CHEBI:39867 Y

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Explore different angles and find fresh ideas to shape your next piece of content.

Valproate

7Epilepsy · Mood stabilizer · Bipolar disorder

7GABA · Voltage-gated sodium channel · Histone deacetylase

8Anticonvulsant · Tonic–clonic seizures · Absence seizures

4Urine · Mitochondria · Elimination half-life

10Fetal valproate spectrum disorder · Rare disease · Valproic acid

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Adverse effects

Overdose

Chemistry

History

Society and culture

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Valproate connects Entity context

The extracted context around Valproate shows recurring relationship patterns in the source. For example, Valproate → AKAP5, Although, BDNF, DNA, Earlier, GABA, GDNF, HDAC1, HDAC2, HDAC3, HDAC8, HDACs, IC50Tooltip, Intermediate, Kv7, PIP3, Prevention, The GABAergic, Valproic, VEGF Another extracted example is Valproate → Concentrations, CYP2A6, CYP2B6, CYP2C9, CYP3A5, P450, Protein, Taken, UDP-glucuronosyltransferase, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B7. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Pharmacodynamics · 20

Valproate → AKAP5, Although, BDNF, DNA, Earlier, GABA, GDNF, HDAC1, HDAC2, HDAC3, HDAC8, HDACs, IC50Tooltip, Intermediate, Kv7, PIP3, Prevention, The GABAergic, Valproic, VEGF

related to Pharmacokinetics · 17

Valproate → Concentrations, CYP2A6, CYP2B6, CYP2C9, CYP3A5, P450, Protein, Taken, UDP-glucuronosyltransferase, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B7

related to Interactions · 16

Valproate → Aspirin, Benzodiazepines, Carbapenem, Cimetidine, CNS, CYP2C9, Erythromycin, Ethosuximide, Felbamate, May, Mefloquine, Oral, Primidone, Rifampicin, Warfarin, Zidovudine

related to Pregnancy · 10

Valproate → ADHD, ASD, European Union, Fetal, FVS, FVSD, Teratogens, United Kingdom, United States, VPA

related to Overdose · 7

Valproate → Acetyl-L-carnitine, Excessive, L-carnitine, Monitoring, Salivary, Supplemental L-carnitine, Supportive

related to Restrictions · 7

Valproate → European Union, French, In February, Jean-Marc Laurent, Patients, Similar, United Kingdom

Legal status · 5

Valproate → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, UK: POM (Prescription only), US: ℞-only

related to Formulations · 5

Valproate → China, Divalproex, In Europe, Magnesium, US

is a · 4

Valproate → active form of the drug, sodium salt of valproic acid, teratogen, weak or low-potency histone deacetylase inhibitor

related to Terminology · 4

Valproate → Divalproex, Sodium, Valproic, VPA

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

acid valproic also sodium may include drug effects concentrations epilepsy women tablets bipolar united metabolism liver abbott disorder known men

Valproate relationships Subject–Predicate–Object triples

TTTA extracted 141 structured relationships around Valproate. Examples in this analysis include Valproate → 3D model (JSmol) → Interactive image and Valproate → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Valproate	3D model (JSmol)	Interactive image	1.00	infobox
Valproate	AHFS/Drugs.com	Monograph	1.00	infobox
Valproate	ATC code	N03AG01 (WHO)	1.00	infobox
Valproate	Bioavailability	~90%	1.00	infobox
Valproate	CAS Number	99-66-1 Y	1.00	infobox
Valproate	ChEBI	CHEBI:39867 Y	1.00	infobox
Valproate	ChEMBL	ChEMBL109 Y	1.00	infobox
Valproate	ChemSpider	3009 Y	1.00	infobox
Valproate	CompTox Dashboard (EPA)	DTXSID6023733	1.00	infobox
Valproate	Drug class	Anticonvulsant; Mood stabilizer; Sodium channel blocker; GABA-T inhibitor; Histone deacetylase inhibitor	1.00	infobox
Valproate	DrugBank	DB00313 Y	1.00	infobox
Valproate	ECHA InfoCard	100.002.525	1.00	infobox
Valproate	Elimination half-life	9–16 hours	1.00	infobox
Valproate	Excretion	Mostly via hepatic metabolism, <3% in urine	1.00	infobox
Valproate	Formula	C8H16O2	1.00	infobox
Valproate	IUPHAR/BPS	7009	1.00	infobox
Valproate	KEGG	D00399 Y	1.00	infobox
Valproate	Legal status	AU: S4 (Prescription only)	1.00	infobox
Valproate	Legal status	BR: Class C1 (Other controlled substances)	1.00	infobox
Valproate	Legal status	CA: ℞-only	1.00	infobox
Valproate	Legal status	UK: POM (Prescription only)	1.00	infobox
Valproate	Legal status	US: ℞-only	1.00	infobox
Valproate	License data	US DailyMed: Valproic acid	1.00	infobox
Valproate	MedlinePlus	a682412	1.00	infobox
Valproate	Metabolism	Liver—glucuronide conjugation 30–50%; mitochondrial β-oxidation over 40%; oxidation, hydroxylation, and dehydrogenation 15–20%	1.00	infobox
Valproate	Molar mass	144.214 g·mol−1	1.00	infobox
Valproate	NIAID ChemDB	057177	1.00	infobox
Valproate	Other names	VPA; valproic acid; sodium valproate (sodium); valproate semisodium (semisodium); 2-propylvaleric acid	1.00	infobox
Valproate	Pregnancy category	AU: D	1.00	infobox
Valproate	Protein binding	80–90%	1.00	infobox

Related concept clusters Related term clusters

The concept neighborhoods around Valproate bring nearby vocabulary together. In this analysis, examples include Sodium, Acid and Valproic. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Valproate
- Sodium
- Acid
- Valproic
- May
- Concentrations
- Known
- Metabolism
- Used
- Age
- Increase
- Tablets
- Semisodium
valproate
- Sodium
- Acid
- Valproic
- May
- Concentrations
- Known
- Metabolism
- Used
- Age
- Increase
- Tablets
- Semisodium
epilepsy
- Bipolar
- Disorder
- Semisodium
- Treat
- Used
- Medication
- Known
- Treatment
- Sodium
- Epilim
- Women
- Pregnancy
bipolar disorder
- Disorder
- Epilepsy
- Used
- Treat
- Semisodium
- Medication
- Valproic
- Sodium
- Known
- Treatment
- Women
- Drug
united states food and drug administration
- Pregnancy
- Men
- Women
- Effects
- Also
- Due
- Seizures
- Restrictions
- Sanofi
- Abbott
- Semisodium
- Valproic
voltage-gated sodium channels
- Semisodium
- Valproic
- Tablets
- Valproate
- Epilim
- Epilepsy
- Sanofi
- Levels
- Bipolar
- Treat
- Known
- Used
short-chain fatty acid
- Valproic
- Sodium
- Valproate
- Bipolar
- Disorder
- Used
- Also
- Epilepsy
- Found
- Known
- Levels
- Treatment
valeric acid
- Valproic
- Sodium
- Valproate
- Bipolar
- Disorder
- Used
- Also
- Epilepsy
- Found
- Known
- Levels
- Treatment

Connections between topic areas Semantic bridges

For Valproate, one of the stronger structural bridges in this analysis connects Valproate with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Valproate — Overview · splits 152 ⟂ 58

Valproate — Pharmacology · splits 167 ⟂ 43

Valproate — Interactions · splits 187 ⟂ 23

Valproate — Medical uses · splits 191 ⟂ 19

Valproate — Adverse effects · splits 191 ⟂ 19

Valproate — Overdose · splits 196 ⟂ 14

Valproate — Chemistry · splits 198 ⟂ 12

Valproate — Society and culture · splits 202 ⟂ 8

Valproate — History · splits 203 ⟂ 7

Valproate — Contraindications · splits 204 ⟂ 6

Map overview Semantic statistics

Valproate

Nodes210

Edges209

Triples141

Avg. degree1.99

Density0.009524

Components1

Source & methodology

TTTA analyzes the structure around Valproate to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Valproate · EN edition · Analysis: TopicsToTalkAbout

Valproate: History, Community, Culture & Applications

Valproate topic overview

What this topic covers Research coverage

Key facts & relationships

Start with your topic. Discover where to go next.

Questions to explore

Explore all related topics Closing gaps

Overview

Medical uses

Contraindications

Adverse effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

For the semantics nerds

Advanced semantic analysis

How Valproate connects Entity context

Valproate

Top relations

Important terminology

Important terminology

Valproate relationships Subject–Predicate–Object triples

Related concept clusters Related term clusters

Connections between topic areas Semantic bridges

Map overview Semantic statistics

Valproate

Source & methodology