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Valproate: History, Community, Culture & Applications

Valproate (valproic acid, VPA, sodium valproate, or valproate semisodium) is a medication primarily used to treat epilepsy and as a mood stabilizer in the treatment of bipolar disorder. It is useful for the prevention of seizures in those with absence seizures, partial seizures, and generalized seizures. It can be given intravenously or by mouth, and the…

Language: English [EN]
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Valproate topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Valproate.

Related topics
202
Source areas
10
Connected nodes
212
Extracted relationships
165
Concept neighborhoods
36
Bridge connections
212

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 59 topics
Pharmacology · 42 topics
Interactions · 22 topics
Adverse effects · 18 topics
Medical uses · 18 topics
Overdose · 13 topics
Chemistry · 11 topics
History · 7 topics
Society and culture · 7 topics
Contraindications · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N03AG01 (WHO)
Bioavailability
~90%
CAS Number
99-66-1 Y
ChEBI
CHEBI:39867 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Adverse effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Valproate connects Entity context

The extracted context around Valproate shows recurring relationship patterns in the source. For example, Valproate → AKAP5, Although, BDNF, By, DNA, Earlier, For, GABA, GDNF, HDAC1, HDAC2, HDAC3, HDAC8, HDACs, IC50Tooltip, In, Intermediate, Kv7, PIP3, Prevention Another extracted example is Valproate → Concentrations, CYP2A6, CYP2B6, CYP2C9, CYP3A5, It, P450, Protein, Some, Taken, The, UDP-glucuronosyltransferase, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B7. Use these groups to spot repeated connection types before inspecting the individual relationships.

Valproate

Top relations

related to Pharmacodynamics · 24
Valproate → AKAP5, Although, BDNF, By, DNA, Earlier, For, GABA, GDNF, HDAC1, HDAC2, HDAC3, HDAC8, HDACs, IC50Tooltip, In, Intermediate, Kv7, PIP3, Prevention
related to Pharmacokinetics · 21
Valproate → Concentrations, CYP2A6, CYP2B6, CYP2C9, CYP3A5, It, P450, Protein, Some, Taken, The, UDP-glucuronosyltransferase, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B7
related to Interactions · 17
Valproate → Aspirin, Benzodiazepines, Carbapenem, Cimetidine, CNS, CYP2C9, Erythromycin, Ethosuximide, Felbamate, It, May, Mefloquine, Oral, Primidone, Rifampicin, Warfarin, Zidovudine
related to Pregnancy · 12
Valproate → ADHD, ASD, European Union, Fetal, FVS, FVSD, It, Teratogens, This, United Kingdom, United States, VPA
related to Restrictions · 9
Valproate → European Union, French, In, In February, Jean-Marc Laurent, Patients, Similar, The, United Kingdom
related to Overdose · 8
Valproate → Acetyl-L-carnitine, Excessive, In, L-carnitine, Monitoring, Salivary, Supplemental L-carnitine, Supportive
related to Formulations · 6
Valproate → China, Divalproex, In Europe, It, Magnesium, US
Legal status · 5
Valproate → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, UK: POM (Prescription only), US: ℞-only
related to Chemistry · 5
Valproate → GABA, It, Other, SCFA, Valproic
related to Off-label uses · 5
Valproate → Abbott, Depakote, In, Some, US

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

acid valproic also sodium may include drug effects concentrations epilepsy women tablets bipolar united metabolism liver abbott disorder known men

Valproate relationships Subject–Predicate–Object triples

TTTA extracted 165 structured relationships around Valproate. Examples in this analysis include Valproate → 3D model (JSmol) → Interactive image and Valproate → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Valproate3D model (JSmol)Interactive image1.00infobox
ValproateAHFS/Drugs.comMonograph1.00infobox
ValproateATC codeN03AG01 (WHO)1.00infobox
ValproateBioavailability~90%1.00infobox
ValproateCAS Number99-66-1 Y1.00infobox
ValproateChEBICHEBI:39867 Y1.00infobox
ValproateChEMBLChEMBL109 Y1.00infobox
ValproateChemSpider3009 Y1.00infobox
ValproateCompTox Dashboard (EPA)DTXSID60237331.00infobox
ValproateDrug classAnticonvulsant; Mood stabilizer; Sodium channel blocker; GABA-T inhibitor; Histone deacetylase inhibitor1.00infobox
ValproateDrugBankDB00313 Y1.00infobox
ValproateECHA InfoCard100.002.5251.00infobox
ValproateElimination half-life9–16 hours1.00infobox
ValproateExcretionMostly via hepatic metabolism, <3% in urine1.00infobox
ValproateFormulaC8H16O21.00infobox
ValproateIUPHAR/BPS70091.00infobox
ValproateKEGGD00399 Y1.00infobox
ValproateLegal statusAU: S4 (Prescription only)1.00infobox
ValproateLegal statusBR: Class C1 (Other controlled substances)1.00infobox
ValproateLegal statusCA: ℞-only1.00infobox
ValproateLegal statusUK: POM (Prescription only)1.00infobox
ValproateLegal statusUS: ℞-only1.00infobox
ValproateLicense dataUS DailyMed: Valproic acid1.00infobox
ValproateMedlinePlusa6824121.00infobox
ValproateMetabolismLiver—glucuronide conjugation 30–50%; mitochondrial β-oxidation over 40%; oxidation, hydroxylation, and dehydrogenation 15–20%1.00infobox
ValproateMolar mass144.214 g·mol−11.00infobox
ValproateNIAID ChemDB0571771.00infobox
ValproateOther namesVPA; valproic acid; sodium valproate (sodium); valproate semisodium (semisodium); 2-propylvaleric acid1.00infobox
ValproatePregnancy categoryAU: D1.00infobox
ValproateProtein binding80–90%1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Valproate bring nearby vocabulary together. In this analysis, examples include Sodium, Acid and Valproic. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Valproate
    • Sodium
    • Acid
    • Valproic
    • May
    • Concentrations
    • Known
    • Metabolism
    • Used
    • Age
    • Increase
    • Tablets
    • Semisodium
  • valproate
    • Sodium
    • Acid
    • Valproic
    • May
    • Concentrations
    • Known
    • Metabolism
    • Used
    • Age
    • Increase
    • Tablets
    • Semisodium
  • epilepsy
    • Bipolar
    • Disorder
    • Semisodium
    • Treat
    • Used
    • Medication
    • Known
    • Treatment
    • Sodium
    • Epilim
    • Women
    • Pregnancy
  • bipolar disorder
    • Disorder
    • Epilepsy
    • Used
    • Treat
    • Semisodium
    • Medication
    • Valproic
    • Sodium
    • Known
    • Treatment
    • Women
    • Drug
  • united states food and drug administration
    • Pregnancy
    • Men
    • Women
    • Effects
    • Also
    • Due
    • Seizures
    • Restrictions
    • Sanofi
    • Abbott
    • Semisodium
    • Valproic
  • voltage-gated sodium channels
    • Semisodium
    • Valproic
    • Tablets
    • Valproate
    • Epilim
    • Epilepsy
    • Sanofi
    • Levels
    • Bipolar
    • Treat
    • Known
    • Used
  • short-chain fatty acid
    • Valproic
    • Sodium
    • Valproate
    • Bipolar
    • Disorder
    • Used
    • Also
    • Epilepsy
    • Found
    • Known
    • Levels
    • Treatment
  • valeric acid
    • Valproic
    • Sodium
    • Valproate
    • Bipolar
    • Disorder
    • Used
    • Also
    • Epilepsy
    • Found
    • Known
    • Levels
    • Treatment

Connections between topic areas Semantic bridges

For Valproate, one of the stronger structural bridges in this analysis connects Valproate with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Valproate — Overview · splits 153 ⟂ 60
Valproate — Pharmacology · splits 170 ⟂ 43
Valproate — Interactions · splits 190 ⟂ 23
Valproate — Medical uses · splits 194 ⟂ 19
Valproate — Adverse effects · splits 194 ⟂ 19
Valproate — Overdose · splits 199 ⟂ 14
Valproate — Chemistry · splits 201 ⟂ 12
Valproate — History · splits 205 ⟂ 8
Valproate — Society and culture · splits 205 ⟂ 8
Valproate — Contraindications · splits 207 ⟂ 6

Map overview Semantic statistics

Valproate

Nodes213
Edges212
Triples165
Avg. degree1.99
Density0.00939
Components1

Source & methodology

TTTA analyzes the structure around Valproate to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Valproate · EN edition · Analysis: TopicsToTalkAbout

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