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Valproate

Valproate (valproic acid, VPA, sodium valproate, or valproate semisodium) is a medication primarily used to treat epilepsy and as a mood stabilizer in the treatment of bipolar disorder. It is useful for the prevention of seizures in those with absence seizures, partial seizures, and generalized seizures. It can be given intravenously or by mouth, and the…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N03AG01 (WHO)
Bioavailability
~90%
CAS Number
99-66-1 Y
ChEBI
CHEBI:39867 Y

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Overview

Medical uses

Contraindications

Adverse effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Advanced semantic analysis

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Map overview Semantic statistics

Valproate

Nodes213
Edges212
Triples165
Avg. degree1.99
Density0.00939
Components1

How this topic connects Entity context

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Valproate

Top relations

related to Pharmacodynamics · 24
Valproate → AKAP5, Although, BDNF, By, DNA, Earlier, For, GABA, GDNF, HDAC1, HDAC2, HDAC3, HDAC8, HDACs, IC50Tooltip, In, Intermediate, Kv7, PIP3, Prevention
related to Pharmacokinetics · 21
Valproate → Concentrations, CYP2A6, CYP2B6, CYP2C9, CYP3A5, It, P450, Protein, Some, Taken, The, UDP-glucuronosyltransferase, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B7
related to Interactions · 17
Valproate → Aspirin, Benzodiazepines, Carbapenem, Cimetidine, CNS, CYP2C9, Erythromycin, Ethosuximide, Felbamate, It, May, Mefloquine, Oral, Primidone, Rifampicin, Warfarin, Zidovudine
related to Pregnancy · 12
Valproate → ADHD, ASD, European Union, Fetal, FVS, FVSD, It, Teratogens, This, United Kingdom, United States, VPA
related to Restrictions · 9
Valproate → European Union, French, In, In February, Jean-Marc Laurent, Patients, Similar, The, United Kingdom
related to Overdose · 8
Valproate → Acetyl-L-carnitine, Excessive, In, L-carnitine, Monitoring, Salivary, Supplemental L-carnitine, Supportive
related to Formulations · 6
Valproate → China, Divalproex, In Europe, It, Magnesium, US
Legal status · 5
Valproate → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, UK: POM (Prescription only), US: ℞-only
related to Chemistry · 5
Valproate → GABA, It, Other, SCFA, Valproic
related to Off-label uses · 5
Valproate → Abbott, Depakote, In, Some, US

Important terminology Word statistics

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Important terminology

acid valproic also sodium may include drug effects concentrations epilepsy women tablets bipolar united metabolism liver abbott disorder known men

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Valproate3D model (JSmol)Interactive image1.00infobox
ValproateAHFS/Drugs.comMonograph1.00infobox
ValproateATC codeN03AG01 (WHO)1.00infobox
ValproateBioavailability~90%1.00infobox
ValproateCAS Number99-66-1 Y1.00infobox
ValproateChEBICHEBI:39867 Y1.00infobox
ValproateChEMBLChEMBL109 Y1.00infobox
ValproateChemSpider3009 Y1.00infobox
ValproateCompTox Dashboard (EPA)DTXSID60237331.00infobox
ValproateDrug classAnticonvulsant; Mood stabilizer; Sodium channel blocker; GABA-T inhibitor; Histone deacetylase inhibitor1.00infobox
ValproateDrugBankDB00313 Y1.00infobox
ValproateECHA InfoCard100.002.5251.00infobox
ValproateElimination half-life9–16 hours1.00infobox
ValproateExcretionMostly via hepatic metabolism, <3% in urine1.00infobox
ValproateFormulaC8H16O21.00infobox
ValproateIUPHAR/BPS70091.00infobox
ValproateKEGGD00399 Y1.00infobox
ValproateLegal statusAU: S4 (Prescription only)1.00infobox
ValproateLegal statusBR: Class C1 (Other controlled substances)1.00infobox
ValproateLegal statusCA: ℞-only1.00infobox
ValproateLegal statusUK: POM (Prescription only)1.00infobox
ValproateLegal statusUS: ℞-only1.00infobox
ValproateLicense dataUS DailyMed: Valproic acid1.00infobox
ValproateMedlinePlusa6824121.00infobox
ValproateMetabolismLiver—glucuronide conjugation 30–50%; mitochondrial β-oxidation over 40%; oxidation, hydroxylation, and dehydrogenation 15–20%1.00infobox
ValproateMolar mass144.214 g·mol−11.00infobox
ValproateNIAID ChemDB0571771.00infobox
ValproateOther namesVPA; valproic acid; sodium valproate (sodium); valproate semisodium (semisodium); 2-propylvaleric acid1.00infobox
ValproatePregnancy categoryAU: D1.00infobox
ValproateProtein binding80–90%1.00infobox

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