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Methotrexate

Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, and ectopic pregnancies. It is used for cancers such as breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma, as well as autoimmune diseases such as psoriasis…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01BA01 (WHO) L04AX03 (WHO)
Bioavailability
60% at lower doses, less at higher doses.
CAS Number
59-05-2 Y
ChEBI
CHEBI:44185 Y

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Overview

Medical uses

Adverse effects

Mechanism of action

History

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Map overview Semantic statistics

Methotrexate

Nodes142
Edges141
Triples117
Avg. degree1.99
Density0.014085
Components1

How this topic connects Entity context

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Methotrexate

Top relations

related to history · 11
Methotrexate → Animal, In, Jane, Lederle, Min Chiu Li, Other, Sidney Farber, The, Wright, Wright's, Yellapragada Subbarao
related to Drug interactions · 9
Methotrexate → GI, Likewise, Nitrous, NSAIDs, Other, Penicillins, Probenecid, The, While
related to Mechanism of action · 9
Methotrexate → An, CD95, DHFR, DNA, For, It, RNA, Tetrahydrofolate, The
Legal status · 6
Methotrexate → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
related to Vaccine interactions · 5
Methotrexate → COVID-19, It, Not, Pausing, Taking
related to Administration · 4
Methotrexate → Doses, Folic, Measurements, Routine
has effect · 3
Methotrexate → ILD, In, The
related to Autoimmune disorders · 3
Methotrexate → Although, Crohn's, In
is a · 2
Methotrexate → competitive inhibitor of many enzymes that use folates.Methotrexate, generally safe and well-tolerated drug in the treatment of certain autoimmune diseases.Methotrexate is used as a disease-modifying treatment for several autoimmune diseases in a…
related to Chemotherapy · 2
Methotrexate → Hodgkin's, It

Important terminology Word statistics

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Important terminology

used effects cancer treatment arthritis acid rheumatoid doses may drug use side folic disease lower autoimmune also toxicity risk treat

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Methotrexate3D model (JSmol)Interactive image1.00infobox
MethotrexateAHFS/Drugs.comMonograph1.00infobox
MethotrexateATC codeL01BA01 (WHO) L04AX03 (WHO)1.00infobox
MethotrexateBioavailability60% at lower doses, less at higher doses.1.00infobox
MethotrexateCAS Number59-05-2 Y1.00infobox
MethotrexateChEBICHEBI:44185 Y1.00infobox
MethotrexateChEMBLChEMBL34259 Y1.00infobox
MethotrexateChemSpider112728 Y1.00infobox
MethotrexateCompTox Dashboard (EPA)DTXSID40208221.00infobox
MethotrexateDrugBankDB00563 Y1.00infobox
MethotrexateECHA InfoCard100.000.3761.00infobox
MethotrexateElimination half-life3–10 hours (lower doses), 8–15 hours (higher doses)1.00infobox
MethotrexateExcretionUrine (80–100%), feces (small amounts)1.00infobox
MethotrexateFormulaC20H22N8O51.00infobox
MethotrexateIUPHAR/BPS48151.00infobox
MethotrexateKEGGD00142 Y1.00infobox
MethotrexateLegal statusAU: S4 (Prescription only)1.00infobox
MethotrexateLegal statusCA: ℞-only1.00infobox
MethotrexateLegal statusUK: POM (Prescription only)1.00infobox
MethotrexateLegal statusUS: ℞-only1.00infobox
MethotrexateLegal statusEU: Rx-only1.00infobox
MethotrexateLegal statusIn general: ℞ (Prescription only)1.00infobox
MethotrexateLicense dataUS DailyMed: Methotrexate1.00infobox
MethotrexateMedlinePlusa6820191.00infobox
MethotrexateMetabolismHepatic and intracellular1.00infobox
MethotrexateMolar mass454.447 g·mol−11.00infobox
MethotrexateOther namesMTX, amethopterin1.00infobox
MethotrexatePDB ligandMTX (PDBe, RCSB PDB)1.00infobox
MethotrexatePregnancy categoryAU: D1.00infobox
MethotrexatePronunciation/ˌmɛθəˈtrɛkˌseɪt, ˌmiː-, -θoʊ-/ ⓘ1.00infobox

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