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Methotrexate: History & Applications

Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, and ectopic pregnancies. It is used for cancers such as breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma, as well as autoimmune diseases such as psoriasis…

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Methotrexate topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Methotrexate.

Related topics
136
Source areas
5
Connected nodes
141
Extracted relationships
117
Concept neighborhoods
30
Bridge connections
141

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Medical uses · 43 topics
Adverse effects · 36 topics
Overview · 25 topics
Mechanism of action · 19 topics
History · 13 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01BA01 (WHO) L04AX03 (WHO)
Bioavailability
60% at lower doses, less at higher doses.
CAS Number
59-05-2 Y
ChEBI
CHEBI:44185 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Mechanism of action

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Methotrexate connects Entity context

The extracted context around Methotrexate shows recurring relationship patterns in the source. For example, Methotrexate → Animal, In, Jane, Lederle, Min Chiu Li, Other, Sidney Farber, The, Wright, Wright's, Yellapragada Subbarao Another extracted example is Methotrexate → GI, Likewise, Nitrous, NSAIDs, Other, Penicillins, Probenecid, The, While. Use these groups to spot repeated connection types before inspecting the individual relationships.

Methotrexate

Top relations

related to history · 11
Methotrexate → Animal, In, Jane, Lederle, Min Chiu Li, Other, Sidney Farber, The, Wright, Wright's, Yellapragada Subbarao
related to Drug interactions · 9
Methotrexate → GI, Likewise, Nitrous, NSAIDs, Other, Penicillins, Probenecid, The, While
related to Mechanism of action · 9
Methotrexate → An, CD95, DHFR, DNA, For, It, RNA, Tetrahydrofolate, The
Legal status · 6
Methotrexate → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
related to Vaccine interactions · 5
Methotrexate → COVID-19, It, Not, Pausing, Taking
related to Administration · 4
Methotrexate → Doses, Folic, Measurements, Routine
has effect · 3
Methotrexate → ILD, In, The
related to Autoimmune disorders · 3
Methotrexate → Although, Crohn's, In
is a · 2
Methotrexate → competitive inhibitor of many enzymes that use folates.Methotrexate, generally safe and well-tolerated drug in the treatment of certain autoimmune diseases.Methotrexate is used as a disease-modifying treatment for several autoimmune diseases in a…
related to Chemotherapy · 2
Methotrexate → Hodgkin's, It

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

used effects cancer treatment arthritis acid rheumatoid doses may drug use side folic disease lower autoimmune also toxicity risk treat

Methotrexate relationships Subject–Predicate–Object triples

TTTA extracted 117 structured relationships around Methotrexate. Examples in this analysis include Methotrexate → 3D model (JSmol) → Interactive image and Methotrexate → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Methotrexate3D model (JSmol)Interactive image1.00infobox
MethotrexateAHFS/Drugs.comMonograph1.00infobox
MethotrexateATC codeL01BA01 (WHO) L04AX03 (WHO)1.00infobox
MethotrexateBioavailability60% at lower doses, less at higher doses.1.00infobox
MethotrexateCAS Number59-05-2 Y1.00infobox
MethotrexateChEBICHEBI:44185 Y1.00infobox
MethotrexateChEMBLChEMBL34259 Y1.00infobox
MethotrexateChemSpider112728 Y1.00infobox
MethotrexateCompTox Dashboard (EPA)DTXSID40208221.00infobox
MethotrexateDrugBankDB00563 Y1.00infobox
MethotrexateECHA InfoCard100.000.3761.00infobox
MethotrexateElimination half-life3–10 hours (lower doses), 8–15 hours (higher doses)1.00infobox
MethotrexateExcretionUrine (80–100%), feces (small amounts)1.00infobox
MethotrexateFormulaC20H22N8O51.00infobox
MethotrexateIUPHAR/BPS48151.00infobox
MethotrexateKEGGD00142 Y1.00infobox
MethotrexateLegal statusAU: S4 (Prescription only)1.00infobox
MethotrexateLegal statusCA: ℞-only1.00infobox
MethotrexateLegal statusUK: POM (Prescription only)1.00infobox
MethotrexateLegal statusUS: ℞-only1.00infobox
MethotrexateLegal statusEU: Rx-only1.00infobox
MethotrexateLegal statusIn general: ℞ (Prescription only)1.00infobox
MethotrexateLicense dataUS DailyMed: Methotrexate1.00infobox
MethotrexateMedlinePlusa6820191.00infobox
MethotrexateMetabolismHepatic and intracellular1.00infobox
MethotrexateMolar mass454.447 g·mol−11.00infobox
MethotrexateOther namesMTX, amethopterin1.00infobox
MethotrexatePDB ligandMTX (PDBe, RCSB PDB)1.00infobox
MethotrexatePregnancy categoryAU: D1.00infobox
MethotrexatePronunciation/ˌmɛθəˈtrɛkˌseɪt, ˌmiː-, -θoʊ-/ ⓘ1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Methotrexate bring nearby vocabulary together. In this analysis, examples include Used, Treatment and Rheumatoid. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • lung cancer
    • Lymphoma
    • Disease
    • First
    • May
    • Autoimmune
    • Diseases
    • Pregnancy
    • Rheumatoid
    • Treat
    • Arthritis
    • Include
    • Needed
  • rheumatoid arthritis
    • Arthritis
    • Rheumatoid
    • Treatment
    • Disease
    • Therapy
    • Lung
    • Autoimmune
    • Diseases
    • Lower
    • Methotrexate
    • Used
    • Cancer
  • psoriatic arthritis
    • Rheumatoid
    • Treatment
    • Disease
    • Lung
    • Therapy
    • Autoimmune
    • Diseases
    • Lower
    • Methotrexate
    • Used
    • Cancer
    • Lymphoma
  • reactive arthritis
    • Rheumatoid
    • Treatment
    • Disease
    • Lung
    • Therapy
    • Autoimmune
    • Diseases
    • Lower
    • Methotrexate
    • Used
    • Cancer
    • Lymphoma
  • enteropathic arthritis
    • Rheumatoid
    • Treatment
    • Disease
    • Lung
    • Therapy
    • Autoimmune
    • Diseases
    • Lower
    • Methotrexate
    • Used
    • Cancer
    • Lymphoma
  • juvenile idiopathic arthritis
    • Rheumatoid
    • Treatment
    • Disease
    • Lung
    • Therapy
    • Autoimmune
    • Diseases
    • Lower
    • Methotrexate
    • Used
    • Cancer
    • Lymphoma
  • adverse effects
    • Side
    • Adverse
    • Effects
    • Include
    • Risk
    • Acid
    • Blood
    • Mouth
    • Pregnancy
    • People
    • Chemotherapy
    • Folic
  • Methotrexate
    • Used
    • Treatment
    • Rheumatoid
    • Also
    • Drug
    • Use
    • Found
    • Toxicity
    • Combination
    • Treat
    • Risk
    • Pregnancy

Connections between topic areas Semantic bridges

For Methotrexate, one of the stronger structural bridges in this analysis connects Methotrexate with Medical uses. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Methotrexate — Medical uses · splits 98 ⟂ 44
Methotrexate — Adverse effects · splits 105 ⟂ 37
Methotrexate — Overview · splits 116 ⟂ 26
Methotrexate — Mechanism of action · splits 122 ⟂ 20
Methotrexate — History · splits 128 ⟂ 14

Map overview Semantic statistics

Methotrexate

Nodes142
Edges141
Triples117
Avg. degree1.99
Density0.014085
Components1

Source & methodology

TTTA analyzes the structure around Methotrexate to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Methotrexate · EN edition · Analysis: TopicsToTalkAbout

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