Methotrexate

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Methotrexate topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Methotrexate.

Related topics: 136
Source areas: 5
Connected nodes: 141
Extracted relationships: 99
Related term clusters: 30
Bridge connections: 141

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Medical uses · 43 topics

Adverse effects · 36 topics

Overview · 25 topics

Mechanism of action · 19 topics

History · 13 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
AHFS/Drugs.com: Monograph
ATC code: L01BA01 (WHO) L04AX03 (WHO)
Bioavailability: 60% at lower doses, less at higher doses.
CAS Number: 59-05-2 Y
ChEBI: CHEBI:44185 Y

Start with your topic. Discover where to go next.

Explore different angles and find fresh ideas to shape your next piece of content.

Methotrexate

15Chemotherapy agent · Immunosuppressive drug · Cancer

7Intramuscular · Intravenous · Subcutaneous injection

5Chemotherapy · Acute lymphoblastic leukemia · Choriocarcinoma

8Leukopenia · Mucositis · Liver disease

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Mechanism of action

History

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Methotrexate connects Entity context

The extracted context around Methotrexate shows recurring relationship patterns in the source. For example, Methotrexate → Animal, Jane, Lederle, Min Chiu Li, Sidney Farber, Wright, Wright's, Yellapragada Subbarao Another extracted example is Methotrexate → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to history · 8

Methotrexate → Animal, Jane, Lederle, Min Chiu Li, Sidney Farber, Wright, Wright's, Yellapragada Subbarao

Legal status · 6

Methotrexate → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only

related to Drug interactions · 6

Methotrexate → GI, Likewise, Nitrous, NSAIDs, Penicillins, Probenecid

related to Mechanism of action · 5

Methotrexate → CD95, DHFR, DNA, RNA, Tetrahydrofolate

related to Administration · 4

Methotrexate → Doses, Folic, Measurements, Routine

related to Vaccine interactions · 3

Methotrexate → COVID-19, Pausing, Taking

is a · 2

Methotrexate → competitive inhibitor of many enzymes that use folates.Methotrexate, generally safe and well-tolerated drug in the treatment of certain autoimmune diseases.Methotrexate is used as a disease-modifying treatment for several autoimmune diseases in a…

related to Autoimmune disorders · 2

Methotrexate → Although, Crohn's

3D model (JSmol) · 1

Methotrexate → Interactive image

AHFS/Drugs.com · 1

Methotrexate → Monograph

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

used effects cancer treatment arthritis acid rheumatoid doses may drug use side folic disease lower autoimmune also toxicity risk treat

Methotrexate relationships Subject–Predicate–Object triples

TTTA extracted 99 structured relationships around Methotrexate. Examples in this analysis include Methotrexate → 3D model (JSmol) → Interactive image and Methotrexate → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Methotrexate	3D model (JSmol)	Interactive image	1.00	infobox
Methotrexate	AHFS/Drugs.com	Monograph	1.00	infobox
Methotrexate	ATC code	L01BA01 (WHO) L04AX03 (WHO)	1.00	infobox
Methotrexate	Bioavailability	60% at lower doses, less at higher doses.	1.00	infobox
Methotrexate	CAS Number	59-05-2 Y	1.00	infobox
Methotrexate	ChEBI	CHEBI:44185 Y	1.00	infobox
Methotrexate	ChEMBL	ChEMBL34259 Y	1.00	infobox
Methotrexate	ChemSpider	112728 Y	1.00	infobox
Methotrexate	CompTox Dashboard (EPA)	DTXSID4020822	1.00	infobox
Methotrexate	DrugBank	DB00563 Y	1.00	infobox
Methotrexate	ECHA InfoCard	100.000.376	1.00	infobox
Methotrexate	Elimination half-life	3–10 hours (lower doses), 8–15 hours (higher doses)	1.00	infobox
Methotrexate	Excretion	Urine (80–100%), feces (small amounts)	1.00	infobox
Methotrexate	Formula	C20H22N8O5	1.00	infobox
Methotrexate	IUPHAR/BPS	4815	1.00	infobox
Methotrexate	KEGG	D00142 Y	1.00	infobox
Methotrexate	Legal status	AU: S4 (Prescription only)	1.00	infobox
Methotrexate	Legal status	CA: ℞-only	1.00	infobox
Methotrexate	Legal status	UK: POM (Prescription only)	1.00	infobox
Methotrexate	Legal status	US: ℞-only	1.00	infobox
Methotrexate	Legal status	EU: Rx-only	1.00	infobox
Methotrexate	Legal status	In general: ℞ (Prescription only)	1.00	infobox
Methotrexate	License data	US DailyMed: Methotrexate	1.00	infobox
Methotrexate	MedlinePlus	a682019	1.00	infobox
Methotrexate	Metabolism	Hepatic and intracellular	1.00	infobox
Methotrexate	Molar mass	454.447 g·mol−1	1.00	infobox
Methotrexate	Other names	MTX, amethopterin	1.00	infobox
Methotrexate	PDB ligand	MTX (PDBe, RCSB PDB)	1.00	infobox
Methotrexate	Pregnancy category	AU: D	1.00	infobox
Methotrexate	Pronunciation	/ˌmɛθəˈtrɛkˌseɪt, ˌmiː-, -θoʊ-/ ⓘ	1.00	infobox

Related concept clusters Related term clusters

The concept neighborhoods around Methotrexate bring nearby vocabulary together. In this analysis, examples include Used, Treatment and Rheumatoid. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

rheumatoid arthritis
- Arthritis
- Rheumatoid
- Treatment
- Disease
- Therapy
- Lung
- Autoimmune
- Diseases
- Lower
- Methotrexate
- Used
- Cancer
psoriatic arthritis
- Rheumatoid
- Treatment
- Disease
- Lung
- Therapy
- Autoimmune
- Diseases
- Lower
- Methotrexate
- Used
- Cancer
- Lymphoma
reactive arthritis
- Rheumatoid
- Treatment
- Disease
- Lung
- Therapy
- Autoimmune
- Diseases
- Lower
- Methotrexate
- Used
- Cancer
- Lymphoma
enteropathic arthritis
- Rheumatoid
- Treatment
- Disease
- Lung
- Therapy
- Autoimmune
- Diseases
- Lower
- Methotrexate
- Used
- Cancer
- Lymphoma
juvenile idiopathic arthritis
- Rheumatoid
- Treatment
- Disease
- Lung
- Therapy
- Autoimmune
- Diseases
- Lower
- Methotrexate
- Used
- Cancer
- Lymphoma
adverse effects
- Side
- Adverse
- Effects
- Include
- Risk
- Acid
- Blood
- Mouth
- Pregnancy
- People
- Chemotherapy
- Folic
lung cancer
- Lymphoma
- Disease
- May
- Autoimmune
- Diseases
- Pregnancy
- Rheumatoid
- Treat
- Arthritis
- Include
- Needed
- Treatment
Methotrexate
- Used
- Treatment
- Rheumatoid
- Also
- Drug
- Use
- Found
- Toxicity
- Combination
- Treat
- Risk
- Pregnancy

Connections between topic areas Semantic bridges

For Methotrexate, one of the stronger structural bridges in this analysis connects Methotrexate with Medical uses. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Methotrexate — Medical uses · splits 98 ⟂ 44

Methotrexate — Adverse effects · splits 105 ⟂ 37

Methotrexate — Overview · splits 116 ⟂ 26

Methotrexate — Mechanism of action · splits 122 ⟂ 20

Methotrexate — History · splits 128 ⟂ 14

Map overview Semantic statistics

Methotrexate

Nodes142

Edges141

Triples99

Avg. degree1.99

Density0.014085

Components1

Source & methodology

TTTA analyzes the structure around Methotrexate to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Methotrexate · EN edition · Analysis: TopicsToTalkAbout

Methotrexate: History & Applications

Methotrexate topic overview

What this topic covers Research coverage

Key facts & relationships

Start with your topic. Discover where to go next.

Questions to explore

Explore all related topics Closing gaps

Overview

Medical uses

Adverse effects

Mechanism of action

History

For the semantics nerds

Advanced semantic analysis

How Methotrexate connects Entity context

Methotrexate

Top relations

Important terminology

Important terminology

Methotrexate relationships Subject–Predicate–Object triples

Related concept clusters Related term clusters

Connections between topic areas Semantic bridges

Map overview Semantic statistics

Methotrexate

Source & methodology