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S-Adenosyl methionine: Applications, Biochemistry & Adverse effects

S-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or Adonat, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver. More than 40 methyl transfers from SAM are known, to…

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S-Adenosyl methionine topic overview

The analysis highlights Applications, Biochemistry and Adverse effects as prominent areas in the source structure around S-Adenosyl methionine.

Related topics
89
Source areas
6
Connected nodes
95
Extracted relationships
16
Concept neighborhoods
22
Bridge connections
95

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 30 topics
Biochemistry · 26 topics
Adverse effects · 17 topics
Therapeutic uses · 7 topics
Structure · 6 topics
Availability in different countries · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Biochemistry

Therapeutic uses

Availability in different countries

Adverse effects

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How S-Adenosyl methionine connects Entity context

The extracted context around S-Adenosyl methionine shows recurring relationship patterns in the source. For example, S-Adenosyl methionine → ATP, Depending, It, S-Adenosyl, S-adenosylmethionine, The Another extracted example is S-Adenosyl methionine → center of its peculiar reactivity. Use these groups to spot repeated connection types before inspecting the individual relationships.

S-Adenosyl methionine

Top relations

related to Structure · 6
S-Adenosyl methionine → ATP, Depending, It, S-Adenosyl, S-adenosylmethionine, The
is a · 1
S-Adenosyl methionine → center of its peculiar reactivity

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

sam methionine methyl enzymes radical biosynthesis s-adenosyl also liver methylation depression cycle dna group use people disorder sam-e homocysteine epigenetic

S-Adenosyl methionine relationships Subject–Predicate–Object triples

TTTA extracted 16 structured relationships around S-Adenosyl methionine. Examples in this analysis include S-Adenosyl methionine → is a → center of its peculiar reactivity and nucleic acids → instance of → to various substrates. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
S-Adenosyl methionineis acenter of its peculiar reactivity0.90text
nucleic acidsinstance ofto various substrates0.80text
proteinsinstance ofto various substrates0.80text
lipidsinstance ofto various substrates0.80text
secondary metabolitesinstance ofto various substrates0.80text
spermidineinstance ofS-Adenosylmethioninamine then donates its n-propylamine group in the biosynthesis of polyamines0.80text
spermine from putrescine.SAM is required for cellular growthinstance ofS-Adenosylmethioninamine then donates its n-propylamine group in the biosynthesis of polyamines0.80text
repairinstance ofS-Adenosylmethioninamine then donates its n-propylamine group in the biosynthesis of polyamines0.80text
colorectal cancerinstance ofIn cancers0.80text
aberrant global hypermethylation can inhibit promoter regions of tumor-suppressing genesinstance ofIn cancers0.80text
S-Adenosyl methioninerelated to StructureS-Adenosyl0.60section
S-Adenosyl methioninerelated to StructureIt0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around S-Adenosyl methionine bring nearby vocabulary together. In this analysis, examples include Homocysteine, S-adenosyl and Group. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • sam riboswitch
    • Radical
    • Cycle
    • Enzymes
    • Biosynthesis
    • Liver
    • Occur
    • Various
    • Epigenetic
    • Including
    • Sam-e
    • Methylation
    • Transsulfuration
  • liver diseases
    • Studied
    • Diseases
    • Liver
    • Immune
    • Inconclusive
    • Long-term
    • Osteoarthritis
    • Depression
    • People
    • Disorder
    • Use
    • Cycle
  • methyl group
    • S-adenosyl
    • Methionine
    • Radical
    • Enzymes
    • Sam
    • Homocysteine
    • Sam-e
    • Group
    • Methyl
    • Transsulfuration
    • Cycle
    • Involved
  • S-Adenosyl methionine
    • Homocysteine
    • S-adenosyl
    • Group
    • Methyl
    • Cycle
    • Also
    • Sam-e
    • Radical
    • Transsulfuration
    • First
    • Involved
    • Regulator
  • s-adenosyl methionine
    • Homocysteine
    • S-adenosyl
    • Group
    • Cycle
    • Methyl
    • Also
    • Sam-e
    • Involved
    • Sam
    • Liver
    • Biosynthesis
    • Radical
  • s-adenosyl homocysteine
    • Homocysteine
    • S-adenosyl
    • Group
    • Methyl
    • Cycle
    • Also
    • Sam-e
    • Methionine
    • Regulator
    • Reactions
    • Radical
    • Use
  • depression
    • Treatment
    • Disorder
    • People
    • Use
    • Liver
    • Immune
    • Inconclusive
    • Long-term
    • Osteoarthritis
    • Studied
    • Diseases
    • Sam-e
  • methionine
    • S-adenosyl
    • Group
    • Cycle
    • Methyl
    • Also
    • Involved
    • Homocysteine
    • Sam-e
    • Sam
    • Liver
    • Biosynthesis
    • Radical

Connections between topic areas Semantic bridges

For S-Adenosyl methionine, one of the stronger structural bridges in this analysis connects S-Adenosyl methionine with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
S-Adenosyl methionine — Overview · splits 65 ⟂ 31
S-Adenosyl methionine — Biochemistry · splits 69 ⟂ 27
S-Adenosyl methionine — Adverse effects · splits 78 ⟂ 18
S-Adenosyl methionine — Therapeutic uses · splits 88 ⟂ 8
S-Adenosyl methionine — Structure · splits 89 ⟂ 7
S-Adenosyl methionine — Availability in different countries · splits 92 ⟂ 4

Map overview Semantic statistics

S-Adenosyl methionine

Nodes96
Edges95
Triples16
Avg. degree1.98
Density0.020833
Components1

Source & methodology

TTTA analyzes the structure around S-Adenosyl methionine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Biochemistry & Adverse effects, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — S-Adenosyl methionine · EN edition · Analysis: TopicsToTalkAbout

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