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Folate: History, Health effects & Absorption, metabolism and excretion

Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Folate is required for the body to make DNA and RNA and metabolize amino acids necessary for cell division and maturation of blood cells. As the human body cannot make folate, it is required in the diet, making it an essential nutrient. It occurs naturally in many foods. The…

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Folate topic overview

The analysis highlights History, Health effects and Absorption, metabolism and excretion as prominent areas in the source structure around Folate.

Related topics
158
Source areas
10
Connected nodes
171
Extracted relationships
311
Concept neighborhoods
40
Bridge connections
171

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Absorption, metabolism and excretion · 41 topics
Health effects · 25 topics
Overview · 25 topics
Definition · 14 topics
Food fortification · 13 topics
Function · 11 topics
History · 11 topics
Deficiency · 8 topics
Drug interference · 6 topics
Dietary recommendations · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
B03BB01 (WHO) V04CX02 (WHO) B03AE02 (WHO) B03AE01 (WHO) B03BB51 (WHO)
Bioavailability
50–100%
CAS Number
59-30-3 · as salt: 6484-89-5
ChEBI
CHEBI:27470

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Definition

Function

Health effects

Absorption, metabolism and excretion

Drug interference

Dietary recommendations

Deficiency

Sources

Food fortification

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Folate connects Entity context

The extracted context around Folate shows recurring relationship patterns in the source. For example, Folate → Adequate Intakes, AI, AIs, Authority, Average Requirement, Because, Committee, DFE, Dietary Reference Intakes, Dietary Reference Values, DRIs, EAR, EARs, EFSA, Estimated Average Requirements, Food, For, Institute, Medical Aspects, Medicine Another extracted example is Folate → American Cyanamid Company, Bc, Bob Stokstad, Director, Esmond, Herschel, Historic, In, It, Latin, Lederle Lab, Lederle Laboratories, Lucy Wills, Mitchell, New York, Pearl River, Research Dr, Roger, Sidney Farber, Snell. Use these groups to spot repeated connection types before inspecting the individual relationships.

Folate

Top relations

related to Dietary recommendations · 37
Folate → Adequate Intakes, AI, AIs, Authority, Average Requirement, Because, Committee, DFE, Dietary Reference Intakes, Dietary Reference Values, DRIs, EAR, EARs, EFSA, Estimated Average Requirements, Food, For, Institute, Medical Aspects, Medicine
related to history · 25
Folate → American Cyanamid Company, Bc, Bob Stokstad, Director, Esmond, Herschel, Historic, In, It, Latin, Lederle Lab, Lederle Laboratories, Lucy Wills, Mitchell, New York, Pearl River, Research Dr, Roger, Sidney Farber, Snell
related to Safety · 17
Folate → B12, B12-deficient, Evidence, Excessive, Health, In, Long-term, Nutrition, One, Reviews, The, The EFSA, The Japan National Institute, This, UL, ULs, United States
related to Bioactivation · 16
Folate → All, B3, B6, C6, CH2-THF, Each, Folic, Hence, Mechanistically, MTHFD2, NADP, NADPH, PLP, SHMT, THF, This
related to Food labeling · 16
Folate → As, Compliance, Daily Value, Daily Values, DV, European Union, For, Instead, January, May, Reference Daily Intake, Reference Intakes, RI, RIs, US, Voluntary
related to Absorption, metabolism and excretion · 13
Folate → In, It, PCFT, Production, RFC, SLC19A1, SLC46A1, Subsequently, The, THF, This, Tolerable Upper Intake Level, When
related to Birth defects · 13
Folate → CDC, Deficiency, Disease Control, Many, NTDs, One, Prenatal, Prevention, Services Task Force, Some, The Center, The United States Preventive, There
related to External links · 13
Folate → Biochemical, Biochemistry, Current, Enzyme Nomenclature, International Union, Miscellaneous Reaction Schemes, Molecular Biology's Recommendations, Organic Nomenclature, Pterins, Queen Mary College, Riboflavins, Symbols, Terminology
related to Neurological disorders · 13
Folate → Alzheimer's, American, ASD, Asian, B12, Cerebral, Conversion, Elevated, European, However, Maternal, Supplementing, Treatment
related to Australia and New Zealand · 12
Folate → Australia, Bakers, Food Safety Minister Kate, Food Standards Australia New, Green Party, In, July, New Zealand, The, The Association, Wilkinson, Zealand

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

acid folic fortification deficiency food dietary μg risk vitamin supplementation may blood intake foods also used b12 cancer countries defects

Folate relationships Subject–Predicate–Object triples

TTTA extracted 311 structured relationships around Folate. Examples in this analysis include Folate → 3D model (JSmol) → Interactive image and Folate → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Folate3D model (JSmol)Interactive image1.00infobox
FolateAHFS/Drugs.comMonograph1.00infobox
FolateATC codeB03BB01 (WHO) V04CX02 (WHO) B03AE02 (WHO) B03AE01 (WHO) B03BB51 (WHO)1.00infobox
FolateBioavailability50–100%1.00infobox
FolateCAS Number59-30-31.00infobox
FolateCAS Numberas salt: 6484-89-51.00infobox
FolateChEBICHEBI:274701.00infobox
FolateChEMBLChEMBL16221.00infobox
FolateChemSpider58151.00infobox
FolateChemSpideras salt: 215121.00infobox
FolateCompTox Dashboard (EPA)DTXSID00225191.00infobox
FolateDensity1.6±0.1 g/cm31.00infobox
FolateDrugBankDB001581.00infobox
FolateDrugBankas salt: DBSALT0019181.00infobox
FolateECHA InfoCard100.000.3811.00infobox
FolateExcretionUrine1.00infobox
FolateFormulaC19H19N7O61.00infobox
FolateIUPHAR/BPS45631.00infobox
FolateKEGGD000701.00infobox
FolateKEGGas salt: D079851.00infobox
FolateLegal statusAU: S4 (Prescription only) / S21.00infobox
FolateLegal statusUS: ℞-only / OTC1.00infobox
FolateLicense dataUS DailyMed: Folic acid1.00infobox
FolateMedlinePlusa6825911.00infobox
FolateMelting point250 °C (482 °F) (decomposition)1.00infobox
FolateMetabolismLiver1.00infobox
FolateMolar mass441.404 g·mol−11.00infobox
FolateOther namesWills factor, FA, N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid, pteroyl-L-glutamic acid (PteGlu), folacin, vitamin B9; formerly, vitamin…1.00infobox
FolatePDB ligandFOL (PDBe, RCSB PDB)1.00infobox
FolatePregnancy categoryAU: A1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Folate bring nearby vocabulary together. In this analysis, examples include Deficiency, Dietary and Acid. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Folate
    • Deficiency
    • Dietary
    • Acid
    • Folic
    • Food
    • Intake
    • Risk
    • Μg
    • Vitamin
    • Cells
    • Supplement
    • Foods
  • folate
    • Deficiency
    • Dietary
    • Acid
    • Folic
    • Food
    • Intake
    • Risk
    • Μg
    • Vitamin
    • Cells
    • Supplement
    • Foods
  • blood cells
    • Cells
    • Anemia
    • Health
    • Levels
    • Body
    • Fortification
    • Folic
    • Folate
    • Acid
    • Cancer
    • Deficiency
    • B12
  • dietary supplement
    • Used
    • Supplement
    • Intake
    • Food
    • Cancer
    • Supplements
    • Folate
    • Folic
    • Acid
    • Risk
    • Ntds
    • Pregnancy
  • food fortification
    • Mandatory
    • Countries
    • Fortification
    • Foods
    • Neural
    • Tube
    • United
    • Supplement
    • Defects
    • Required
    • Intake
    • Health
  • folate deficiency
    • B12
    • Deficiency
    • Folate
    • Vitamin
    • Levels
    • Dietary
    • May
    • Acid
    • Defects
    • Folic
    • Food
    • Intake
  • neural tube defects
    • Tube
    • Neural
    • Ntds
    • Women
    • Risk
    • Pregnancy
    • Mandatory
    • Deficiency
    • United
    • Fortification
    • Health
    • Reported
  • folinic acid
    • Folic
    • Fortification
    • Supplementation
    • Folate
    • Dietary
    • Risk
    • Μg
    • Food
    • Supplement
    • Associated
    • Used
    • Cancer

Connections between topic areas Semantic bridges

For Folate, one of the stronger structural bridges in this analysis connects Folate with Absorption, metabolism and excretion. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FolateAbsorption, metabolism and excretion · splits 130 ⟂ 42
FolateOverview · splits 146 ⟂ 26
FolateHealth effects · splits 146 ⟂ 26
FolateDefinition · splits 157 ⟂ 15
FolateFood fortification · splits 158 ⟂ 14
FolateFunction · splits 160 ⟂ 12
FolateHistory · splits 160 ⟂ 12
FolateDeficiency · splits 163 ⟂ 9
FolateDrug interference · splits 165 ⟂ 7
FolateDietary recommendations · splits 167 ⟂ 5
FolateSources · splits 169 ⟂ 3

Map overview Semantic statistics

Folate

Nodes172
Edges171
Triples311
Avg. degree1.99
Density0.011628
Components1

Source & methodology

TTTA analyzes the structure around Folate to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Health effects & Absorption, metabolism and excretion, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Folate · EN edition · Analysis: TopicsToTalkAbout

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