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Rabeprazole: History, Community, Culture & Applications

Rabeprazole, sold under the brand name Aciphex, among others, is a medication that decreases stomach acid. It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and excess stomach acid production such as in Zollinger–Ellison syndrome. It may also be used in combination with other medications to treat Helicobacter pylori.…

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Rabeprazole topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Rabeprazole.

Related topics
166
Source areas
10
Connected nodes
176
Extracted relationships
231
Concept neighborhoods
41
Bridge connections
176

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Adverse effects · 41 topics
Overview · 38 topics
Pharmacology · 27 topics
Chemistry · 19 topics
Interactions · 16 topics
Medical uses · 13 topics
Contraindications · 4 topics
History · 3 topics
Society and culture · 3 topics
Research · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A02BC04 (WHO) A02BC54 (WHO) A02BD12 (WHO) A02BD13 (WHO)
Bioavailability
52%
CAS Number
117976-89-3 Y
ChEBI
CHEBI:8768 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Adverse effects

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Rabeprazole connects Entity context

The extracted context around Rabeprazole shows recurring relationship patterns in the source. For example, Rabeprazole → Acid, GERD, H2, Helicobacter, IGAH, In, MEN-1, Notably, Only, PPI, PPIs, South Korean, The, There, This, ZES, Zollinger-Ellison Another extracted example is Rabeprazole → CC-BY-SA-3, ISSN, Joseph Cusimano, Lock-gray-alt-2, Lock-green, Lock-red-alt-2, Medicine, November, PDF, The, This, Wikidata Q113996572, WikiJournal, Wikipedia, Wikisource-logo. Use these groups to spot repeated connection types before inspecting the individual relationships.

Rabeprazole

Top relations

related to Medical uses · 17
Rabeprazole → Acid, GERD, H2, Helicobacter, IGAH, In, MEN-1, Notably, Only, PPI, PPIs, South Korean, The, There, This, ZES, Zollinger-Ellison
related to References · 15
Rabeprazole → CC-BY-SA-3, ISSN, Joseph Cusimano, Lock-gray-alt-2, Lock-green, Lock-red-alt-2, Medicine, November, PDF, The, This, Wikidata Q113996572, WikiJournal, Wikipedia, Wikisource-logo
related to Infection risk · 14
Rabeprazole → Both, Campylobacter, Clostridioides, However, In, It, Japanese, One, Other, PPI, PPI-associated, PPI-induced, PPIs, Salmonella
related to Mechanism of action · 14
Rabeprazole → After, At, ATPase, Due, HCl, Here, However, Like, Once, PPIs, Rabeprazole's, These, This, Thus
related to Comparative chemistry · 13
Rabeprazole → CF3-CH2-O, CH2, CH3-O, CH3O, CHF2O, Comparative, Esomeprazole, Lansoprazole, Omeprazole, PPI, PPIs, Table, The
related to Pharmacogenetics · 13
Rabeprazole → Asian, Caucasian, Conversely, CYP2C19, For, However, In, Japanese, People, The, Therefore, This, United States
has effect · 11
Rabeprazole → Characteristic, Clostridioides, CYP2C19, ECL, Enterochromafin-like, Gastrin, Hypergastrinemia, In, PPIs, Rare, The
related to Development · 10
Rabeprazole → August, Developed, E3810, Eisai Medical Research, February, LY307640, October, On August, The, US
related to Nephrotoxicity · 10
Rabeprazole → AIN, AKI, Australia, CKD, Forms, GERD, It, PPI-induced, PPIs, The
related to Pharmacokinetics · 9
Rabeprazole → CYP2C19, CYP3A4, However, It, Once, Oral, Rabeprazole's, Some, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

acid ppis stomach omeprazole cyp2c19 drug rabeprazole's like may ppi used include effect side use esomeprazole effects treatment medication gastric

Rabeprazole relationships Subject–Predicate–Object triples

TTTA extracted 231 structured relationships around Rabeprazole. Examples in this analysis include Rabeprazole → 3D model (JSmol) → Interactive image and Rabeprazole → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Rabeprazole3D model (JSmol)Interactive image1.00infobox
RabeprazoleAHFS/Drugs.comMonograph1.00infobox
RabeprazoleATC codeA02BC04 (WHO) A02BC54 (WHO) A02BD12 (WHO) A02BD13 (WHO)1.00infobox
RabeprazoleBioavailability52%1.00infobox
RabeprazoleCAS Number117976-89-3 Y1.00infobox
RabeprazoleChEBICHEBI:8768 Y1.00infobox
RabeprazoleChEMBLChEMBL1219 Y1.00infobox
RabeprazoleChemSpider4853 Y1.00infobox
RabeprazoleChiralityRacemic mixture1.00infobox
RabeprazoleCompTox Dashboard (EPA)DTXSID30441221.00infobox
RabeprazoleDrug classProton pump inhibitor1.00infobox
RabeprazoleDrugBankDB01129 Y1.00infobox
RabeprazoleECHA InfoCard100.123.4081.00infobox
RabeprazoleElimination half-life~1 hour1.00infobox
RabeprazoleExcretion90% via kidney as metabolites1.00infobox
RabeprazoleFormulaC18H21N3O3S1.00infobox
RabeprazoleIUPHAR/BPS72901.00infobox
RabeprazoleKEGGD08463 Y1.00infobox
RabeprazoleKEGGC07864 Y1.00infobox
RabeprazoleLegal statusUK: POM (Prescription only)1.00infobox
RabeprazoleLegal statusUS: ℞-only1.00infobox
RabeprazoleLicense dataUS DailyMed: Rabeprazole1.00infobox
RabeprazoleLicense dataUS FDA: Rabeprazole1.00infobox
RabeprazoleMedlinePlusa6990601.00infobox
RabeprazoleMetabolismCYP2C19 and CYP3A4 in the liver1.00infobox
RabeprazoleMetabolitesthioether carboyxlic acid metabolite, thioether glucuronide metabolite, sulfone metabolite1.00infobox
RabeprazoleMolar mass359.44 g·mol−11.00infobox
RabeprazolePDB ligandRZX (PDBe, RCSB PDB)1.00infobox
RabeprazolePregnancy categoryAU: B11.00infobox
RabeprazolePronunciation/rəˈbɛprəˌzɔːl/1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Rabeprazole bring nearby vocabulary together. In this analysis, examples include Acid, Omeprazole and Like. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Rabeprazole
    • Acid
    • Omeprazole
    • Like
    • May
    • Use
    • Drug
    • Lansoprazole
    • Class
    • Ppis
    • Esomeprazole
    • Treatment
    • Used
  • rabeprazole
    • Acid
    • Omeprazole
    • Like
    • May
    • Use
    • Drug
    • Lansoprazole
    • Class
    • Ppis
    • Esomeprazole
    • Treatment
    • Used
  • stomach acid
    • Stomach
    • Gastric
    • Cells
    • Secretion
    • Suppression
    • Rabeprazole
    • Like
    • Used
    • Pump
    • Ppis
    • Also
    • Syndrome
  • zollinger–ellison syndrome
    • Risk
    • Used
    • Like
    • Suppression
    • Class
    • Gastric
    • Hypersensitivity
    • Pump
    • Kidney
    • Liver
    • Rilpivirine
    • Mechanism
  • end-stage kidney disease
    • Kidney
    • Liver
    • Metabolism
    • Syndrome
    • Class
    • Include
    • Stomach
    • Hypersensitivity
    • Rabeprazole's
    • Pump
    • Rilpivirine
    • Due
  • zollinger-ellison syndrome
    • Risk
    • Used
    • Like
    • Suppression
    • Class
    • Gastric
    • Hypersensitivity
    • Pump
    • Kidney
    • Liver
    • Rilpivirine
    • Mechanism
  • food and drug administration
    • However
    • Metabolism
    • Cyp2c19
    • Liver
    • Risk
    • Rabeprazole
    • Class
    • Used
    • Omeprazole
    • Rabeprazole's
    • Hypersensitivity
    • Pump
  • stevens-johnson syndrome
    • Risk
    • Used
    • Like
    • Suppression
    • Class
    • Gastric
    • Hypersensitivity
    • Pump
    • Kidney
    • Liver
    • Rilpivirine
    • Mechanism

Connections between topic areas Semantic bridges

For Rabeprazole, one of the stronger structural bridges in this analysis connects Rabeprazole with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
RabeprazoleAdverse effects · splits 135 ⟂ 42
RabeprazoleOverview · splits 138 ⟂ 39
RabeprazolePharmacology · splits 149 ⟂ 28
RabeprazoleChemistry · splits 157 ⟂ 20
RabeprazoleInteractions · splits 160 ⟂ 17
RabeprazoleMedical uses · splits 163 ⟂ 14
RabeprazoleContraindications · splits 172 ⟂ 5
RabeprazoleHistory · splits 173 ⟂ 4
RabeprazoleSociety and culture · splits 173 ⟂ 4
RabeprazoleResearch · splits 174 ⟂ 3

Map overview Semantic statistics

Rabeprazole

Nodes177
Edges176
Triples231
Avg. degree1.99
Density0.011299
Components1

Source & methodology

TTTA analyzes the structure around Rabeprazole to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Rabeprazole · EN edition · Analysis: TopicsToTalkAbout

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