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Phenobarbital

Phenobarbital, also known as phenobarbitone, sold under the brand name Luminal among others, is a medication of the barbiturate type. It is recommended by the World Health Organization (WHO) for the treatment of certain types of epilepsy in developing countries. In the developed world, it is commonly used to treat seizures in young children, while other…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N03AA02 (WHO)
Bioavailability
>95%
CAS Number
50-06-6 Y
ChEBI
CHEBI:8069 Y

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Overview

Medical uses

Side effects

Contraindications

Overdose

Mechanism of action

Pharmacokinetics

History

Society and culture

Veterinary uses

Advanced semantic analysis

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Map overview Semantic statistics

Phenobarbital

Nodes180
Edges179
Triples140
Avg. degree1.99
Density0.011111
Components1

How this topic connects Entity context

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Phenobarbital

Top relations

related to history · 21
Phenobarbital → Alfred Hauptmann, As, Bayer, By, Emil Fischer, Fischer, Friedr, German, Hauptmann, In, It, Joseph, Luminal, Mering, Most, On, Patients, Phenobarbital's, The, Veronal
related to Selected overdoses · 13
Phenobarbital → Activist Abbie Hoffman, All Creatures Great, April, Bergen, British, Donald Sinclair, Her, Isdal Woman, James Herriot, Norway, November, Siegfried Farnon, Small
related to Regulation · 12
Phenobarbital → ACSCN, Controlled Substances Act, ID, III, IV, Non-Narcotic, OTC, Schedule, Schedule II, Schedule IV, The, United States
related to Medical uses · 9
Phenobarbital → Carbamazepine, Failing, If, It, The, The World Health Organization, UK, US, WHO
related to Synthesis · 9
Phenobarbital → Barbiturate, Claisen, Finally, Malonic, Pinner, Subsequently, The, To, Upon
Legal status · 7
Phenobarbital → AU: S4 (Prescription only), BR: Class B1 (Psychoactive drugs), CA: Schedule IV, DE: Prescription only (Anlage III for higher doses), EU: Rx-only, UK: Class B, US: Schedule IV
has effect · 7
Phenobarbital → Among, Caution, Central, In, It, P450, Sedation
related to Other uses · 7
Phenobarbital → Crigler, Gilbert's, HIDA, IDA, II, In, Najjar
related to Pharmacokinetics · 7
Phenobarbital → CAR/RXR, Cmax, CYP2B6, Cytochrome P450, It, P450, Peak
related to Mechanism of action · 6
Phenobarbital → AMPA, By, Direct, GABAA, Hyperpolarizing, Through

Important terminology Word statistics

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Important terminology

used seizures may also treatment drug treat drugs barbiturate epilepsy effects patients world overdose luminal iv effective well withdrawal suicide

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Phenobarbital3D model (JSmol)Interactive image1.00infobox
PhenobarbitalAHFS/Drugs.comMonograph1.00infobox
PhenobarbitalATC codeN03AA02 (WHO)1.00infobox
PhenobarbitalBioavailability>95%1.00infobox
PhenobarbitalCAS Number50-06-6 Y1.00infobox
PhenobarbitalChEBICHEBI:8069 Y1.00infobox
PhenobarbitalChEMBLChEMBL40 Y1.00infobox
PhenobarbitalChemSpider4599 Y1.00infobox
PhenobarbitalCompTox Dashboard (EPA)DTXSID50211221.00infobox
PhenobarbitalDependence liabilityHigh1.00infobox
PhenobarbitalDrug classBarbiturate, Anticonvulsant1.00infobox
PhenobarbitalDrugBankDB01174 Y1.00infobox
PhenobarbitalDuration of action4 hours–2 days1.00infobox
PhenobarbitalECHA InfoCard100.000.0071.00infobox
PhenobarbitalElimination half-life53–118 hours1.00infobox
PhenobarbitalExcretionKidney and fecal1.00infobox
PhenobarbitalFormulaC12H12N2O31.00infobox
PhenobarbitalIUPHAR/BPS28041.00infobox
PhenobarbitalKEGGD00506 Y1.00infobox
PhenobarbitalLegal statusAU: S4 (Prescription only)1.00infobox
PhenobarbitalLegal statusBR: Class B1 (Psychoactive drugs)1.00infobox
PhenobarbitalLegal statusCA: Schedule IV1.00infobox
PhenobarbitalLegal statusDE: Prescription only (Anlage III for higher doses)1.00infobox
PhenobarbitalLegal statusUK: Class B1.00infobox
PhenobarbitalLegal statusUS: Schedule IV1.00infobox
PhenobarbitalLegal statusEU: Rx-only1.00infobox
PhenobarbitalLicense dataUS DailyMed: Phenobarbital1.00infobox
PhenobarbitalMedlinePlusa6820071.00infobox
PhenobarbitalMetabolismLiver (mostly CYP2C19)1.00infobox
PhenobarbitalMolar mass232.239 g·mol−11.00infobox

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