Colchicine

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Colchicine topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Colchicine.

Related topics: 179
Source areas: 10
Connected nodes: 189
Extracted relationships: 110
Related term clusters: 33
Bridge connections: 189

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Toxicity · 40 topics

Sources and uses · 30 topics

Overview · 27 topics

Drug interactions · 20 topics

History · 19 topics

Pharmacology · 18 topics

Medical uses · 12 topics

Contraindications · 8 topics

Adverse effects · 4 topics

Society and culture · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
AHFS/Drugs.com: Monograph
ATC code: M04AC01 (WHO)
Bioavailability: 45%
CAS Number: 64-86-8
ChEBI: CHEBI:27882

Start with your topic. Discover where to go next.

Explore different angles and find fresh ideas to shape your next piece of content.

Colchicine

9Medication · Gout · Familial Mediterranean fever

6P-glycoprotein · Membrane transport protein · CYP3A4

26By mouth · Toxicity · Food and Drug Administration

6Cornea · Fever · Vomiting

11Bone marrow · Kidney · Nerve

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Medical uses

Contraindications

Adverse effects

Pharmacology

History

Society and culture

Committee for Medicinal Products for Human Use

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Colchicine connects Entity context

The extracted context around Colchicine shows recurring relationship patterns in the source. For example, Colchicine → Alexander, Ambroise Paré, Avicenna, Benjamin Franklin, Caventou, Colchicum, De Materia Medica, Ebers Papyrus, Egyptian, France, French, Geiger, London Pharmacopoeia, Michael Dewar, North America, Pedanius Dioscorides, Pelletier, Persian, Tralles, United States Ambassador Another extracted example is Colchicine → Agepha Pharma, Colchicine Agepha Pharma, Colchicine Tiofarma, Committee, EMA, European Union, Human Use, In May, Medicinal Products. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to history · 21

Colchicine → Alexander, Ambroise Paré, Avicenna, Benjamin Franklin, Caventou, Colchicum, De Materia Medica, Ebers Papyrus, Egyptian, France, French, Geiger, London Pharmacopoeia, Michael Dewar, North America, Pedanius Dioscorides, Pelletier, Persian, Tralles, United States Ambassador

related to Legal status · 9

Colchicine → Agepha Pharma, Colchicine Agepha Pharma, Colchicine Tiofarma, Committee, EMA, European Union, Human Use, In May, Medicinal Products

related to Biosynthesis · 8

Colchicine → According, Colchicaceae, Giving, N-formyldemecolcine, O-methylation, Radioactive, S-adenosylmethionine, Two

related to Drug interactions · 7

Colchicine → CYP3A4, Fatal, Grapefruit, HIV/AIDS, P-glycoprotein, People, Symptoms

related to Botanical use and seedless fruit · 5

Colchicine → Citrullus, Growers, Many, Seeds, Since

Legal status · 4

Colchicine → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only

has effect · 3

Colchicine → Deaths, High, Typical

related to Epidemiology · 3

Colchicine → Many, Mary Yoder, United States

related to Formulations and dosing · 3

Colchicine → Brand, Colcrys, Mitigare

related to Gout · 3

Colchicine → Low, NSAIDs, Subsequent

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

may gout used toxicity use include effects gastrointestinal medication anti-inflammatory also colchicum drug risk symptoms plants side diploid treatment doses

Colchicine relationships Subject–Predicate–Object triples

TTTA extracted 110 structured relationships around Colchicine. Examples in this analysis include Colchicine → 3D model (JSmol) → Interactive image and Colchicine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Colchicine	3D model (JSmol)	Interactive image	1.00	infobox
Colchicine	AHFS/Drugs.com	Monograph	1.00	infobox
Colchicine	ATC code	M04AC01 (WHO)	1.00	infobox
Colchicine	Bioavailability	45%	1.00	infobox
Colchicine	CAS Number	64-86-8	1.00	infobox
Colchicine	ChEBI	CHEBI:27882	1.00	infobox
Colchicine	ChEMBL	ChEMBL107	1.00	infobox
Colchicine	ChemSpider	5933	1.00	infobox
Colchicine	CompTox Dashboard (EPA)	DTXSID5024845	1.00	infobox
Colchicine	DrugBank	DB01394	1.00	infobox
Colchicine	ECHA InfoCard	100.000.544	1.00	infobox
Colchicine	Elimination half-life	26.6-31.2 hours	1.00	infobox
Colchicine	Excretion	Feces (65%)	1.00	infobox
Colchicine	Formula	C22H25NO6	1.00	infobox
Colchicine	IUPHAR/BPS	2367	1.00	infobox
Colchicine	KEGG	D00570	1.00	infobox
Colchicine	Legal status	AU: S4 (Prescription only)	1.00	infobox
Colchicine	Legal status	CA: ℞-only	1.00	infobox
Colchicine	Legal status	UK: POM (Prescription only)	1.00	infobox
Colchicine	Legal status	US: ℞-only	1.00	infobox
Colchicine	License data	US DailyMed: Colchicine	1.00	infobox
Colchicine	MedlinePlus	a682711	1.00	infobox
Colchicine	Metabolism	Metabolism, partly by CYP3A4	1.00	infobox
Colchicine	Molar mass	399.443 g·mol−1	1.00	infobox
Colchicine	Pregnancy category	AU: D	1.00	infobox
Colchicine	Pronunciation	/ˈkɒltʃɪsiːn/ KOL-chiss-een	1.00	infobox
Colchicine	Protein binding	35-44%	1.00	infobox
Colchicine	PubChem CID	6167	1.00	infobox
Colchicine	Routes of administration	By mouth	1.00	infobox
Colchicine	Trade names	Colbenemid, others	1.00	infobox

Related concept clusters Related term clusters

The concept neighborhoods around Colchicine bring nearby vocabulary together. In this analysis, examples include Used, Toxicity and Gout. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Colchicine
- Used
- Toxicity
- Gout
- Anti-inflammatory
- Drug
- May
- Drugs
- Long-term
- Cells
- Plant
- Risk
- Include
colchicine
- Used
- Toxicity
- Gout
- Anti-inflammatory
- Drug
- May
- Drugs
- Long-term
- Cells
- Plant
- Risk
- Include
gout
- Anti-inflammatory
- Reduce
- Risk
- Colchicum
- Symptoms
- Disease
- Drugs
- Used
- Low
- Treatment
- May
- Effects
low white blood cell counts
- Blood
- Cell
- Low
- Damage
- Kidney
- Include
- Reduce
- Failure
- Long-term
- Toxicity
- Cells
- Side
adverse gastrointestinal effects
- Side
- Include
- Gastrointestinal
- Failure
- Low
- Doses
- Use
- May
- Damage
- Toxicity
- Blood
- Cell
adverse effects
- Side
- Include
- Gastrointestinal
- Low
- Doses
- Use
- May
- Damage
- Toxicity
- Blood
- Cell
- Long-term
behçet's disease
- Fever
- Gout
- Drugs
- Medication
- Reduce
- States
- United
- Used
- Blood
- Kidney
- Long-term
- May
familial mediterranean fever
- Risk
- Symptoms
- Include
- Disease
- Medication
- Reduce
- Toxic
- Used
- Blood
- Cell
- Failure
- Long-term

Connections between topic areas Semantic bridges

For Colchicine, one of the stronger structural bridges in this analysis connects Colchicine with Toxicity. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Colchicine — Toxicity · splits 149 ⟂ 41

Colchicine — Sources and uses · splits 159 ⟂ 31

Colchicine — Overview · splits 162 ⟂ 28

Colchicine — Drug interactions · splits 169 ⟂ 21

Colchicine — History · splits 170 ⟂ 20

Colchicine — Pharmacology · splits 171 ⟂ 19

Colchicine — Medical uses · splits 177 ⟂ 13

Colchicine — Contraindications · splits 181 ⟂ 9

Colchicine — Adverse effects · splits 185 ⟂ 5

Map overview Semantic statistics

Colchicine

Nodes190

Edges189

Triples110

Avg. degree1.99

Density0.010526

Components1

Source & methodology

TTTA analyzes the structure around Colchicine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Colchicine · EN edition · Analysis: TopicsToTalkAbout

Colchicine: History, Community, Culture & Applications

Colchicine topic overview

What this topic covers Research coverage

Key facts & relationships

Start with your topic. Discover where to go next.

Questions to explore

Explore all related topics Closing gaps

Overview

Medical uses

Contraindications

Adverse effects

Toxicity

Drug interactions

Pharmacology

History

Sources and uses

Society and culture

For the semantics nerds

Advanced semantic analysis

How Colchicine connects Entity context

Colchicine

Top relations

Important terminology

Important terminology

Colchicine relationships Subject–Predicate–Object triples

Related concept clusters Related term clusters

Connections between topic areas Semantic bridges

Map overview Semantic statistics

Colchicine

Source & methodology