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Colchicine: History, Community, Culture & Applications

Colchicine, sold under the brand name Colbenemid among others, is a medication used to prevent and treat gout, to treat familial Mediterranean fever and Behçet's disease, and to reduce the risk of myocardial infarction. The American College of Rheumatology recommends colchicine, nonsteroidal anti-inflammatory drugs (NSAIDs) or steroids in the treatment…

Language: English [EN]
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Colchicine topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Colchicine.

Related topics
179
Source areas
10
Connected nodes
189
Extracted relationships
147
Concept neighborhoods
33
Bridge connections
189

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Toxicity · 40 topics
Sources and uses · 30 topics
Overview · 27 topics
Drug interactions · 20 topics
History · 19 topics
Pharmacology · 18 topics
Medical uses · 12 topics
Contraindications · 8 topics
Adverse effects · 4 topics
Society and culture · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
M04AC01 (WHO)
Bioavailability
45%
CAS Number
64-86-8
ChEBI
CHEBI:27882

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Adverse effects

Toxicity

Drug interactions

Pharmacology

History

Sources and uses

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Colchicine connects Entity context

The extracted context around Colchicine shows recurring relationship patterns in the source. For example, Colchicine → AD, Alexander, Ambroise Paré, Avicenna, BC, Benjamin Franklin, Caventou, Colchicum, De Materia Medica, Ebers Papyrus, Egyptian, France, French, Geiger, In, It, London Pharmacopoeia, Michael Dewar, North America, Pedanius Dioscorides Another extracted example is Colchicine → According, Colchicaceae, Giving, However, N-formyldemecolcine, O-methylation, Radioactive, S-adenosylmethionine, That, The, Two. Use these groups to spot repeated connection types before inspecting the individual relationships.

Colchicine

Top relations

related to history · 26
Colchicine → AD, Alexander, Ambroise Paré, Avicenna, BC, Benjamin Franklin, Caventou, Colchicum, De Materia Medica, Ebers Papyrus, Egyptian, France, French, Geiger, In, It, London Pharmacopoeia, Michael Dewar, North America, Pedanius Dioscorides
related to Biosynthesis · 11
Colchicine → According, Colchicaceae, Giving, However, N-formyldemecolcine, O-methylation, Radioactive, S-adenosylmethionine, That, The, Two
related to Legal status · 10
Colchicine → Agepha Pharma, Colchicine Agepha Pharma, Colchicine Tiofarma, Committee, EMA, European Union, Human Use, In May, Medicinal Products, The
related to Botanical use and seedless fruit · 9
Colchicine → Citrullus, For, Growers, In, Many, Seeds, Since, When, While
related to Drug interactions · 7
Colchicine → CYP3A4, Fatal, Grapefruit, HIV/AIDS, P-glycoprotein, People, Symptoms
related to Epidemiology · 6
Colchicine → In, It, Many, Mary Yoder, Most, United States
related to Gout · 5
Colchicine → At, For, Low, NSAIDs, Subsequent
related to Risk of cardiovascular disorders · 5
Colchicine → As, In June, Lodoco, The, US FDA
Legal status · 4
Colchicine → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only
has effect · 4
Colchicine → All, Deaths, High, Typical

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

may gout used toxicity use include effects gastrointestinal medication anti-inflammatory also colchicum drug risk symptoms plants side diploid treatment doses

Colchicine relationships Subject–Predicate–Object triples

TTTA extracted 147 structured relationships around Colchicine. Examples in this analysis include Colchicine → 3D model (JSmol) → Interactive image and Colchicine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Colchicine3D model (JSmol)Interactive image1.00infobox
ColchicineAHFS/Drugs.comMonograph1.00infobox
ColchicineATC codeM04AC01 (WHO)1.00infobox
ColchicineBioavailability45%1.00infobox
ColchicineCAS Number64-86-81.00infobox
ColchicineChEBICHEBI:278821.00infobox
ColchicineChEMBLChEMBL1071.00infobox
ColchicineChemSpider59331.00infobox
ColchicineCompTox Dashboard (EPA)DTXSID50248451.00infobox
ColchicineDrugBankDB013941.00infobox
ColchicineECHA InfoCard100.000.5441.00infobox
ColchicineElimination half-life26.6-31.2 hours1.00infobox
ColchicineExcretionFeces (65%)1.00infobox
ColchicineFormulaC22H25NO61.00infobox
ColchicineIUPHAR/BPS23671.00infobox
ColchicineKEGGD005701.00infobox
ColchicineLegal statusAU: S4 (Prescription only)1.00infobox
ColchicineLegal statusCA: ℞-only1.00infobox
ColchicineLegal statusUK: POM (Prescription only)1.00infobox
ColchicineLegal statusUS: ℞-only1.00infobox
ColchicineLicense dataUS DailyMed: Colchicine1.00infobox
ColchicineMedlinePlusa6827111.00infobox
ColchicineMetabolismMetabolism, partly by CYP3A41.00infobox
ColchicineMolar mass399.443 g·mol−11.00infobox
ColchicinePregnancy categoryAU: D1.00infobox
ColchicinePronunciation/ˈkɒltʃɪsiːn/ KOL-chiss-een1.00infobox
ColchicineProtein binding35-44%1.00infobox
ColchicinePubChem CID61671.00infobox
ColchicineRoutes of administrationBy mouth1.00infobox
ColchicineTrade namesColbenemid, others1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Colchicine bring nearby vocabulary together. In this analysis, examples include Used, Toxicity and Gout. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Colchicine
    • Used
    • Toxicity
    • Gout
    • Anti-inflammatory
    • Drug
    • May
    • Drugs
    • Long-term
    • Cells
    • Plant
    • Risk
    • Include
  • colchicine
    • Used
    • Toxicity
    • Gout
    • Anti-inflammatory
    • Drug
    • May
    • Drugs
    • Long-term
    • Cells
    • Plant
    • Risk
    • Include
  • gout
    • Anti-inflammatory
    • Reduce
    • Risk
    • Colchicum
    • Symptoms
    • Disease
    • Drugs
    • Used
    • Low
    • Treatment
    • May
    • Effects
  • low white blood cell counts
    • Blood
    • Cell
    • Low
    • Damage
    • Kidney
    • Include
    • Reduce
    • Failure
    • Long-term
    • Toxicity
    • Cells
    • Side
  • adverse gastrointestinal effects
    • Side
    • Include
    • Gastrointestinal
    • Failure
    • Low
    • Doses
    • Use
    • May
    • Damage
    • Toxicity
    • Blood
    • Cell
  • adverse effects
    • Side
    • Include
    • Gastrointestinal
    • Low
    • Doses
    • Use
    • May
    • Damage
    • Toxicity
    • Blood
    • Cell
    • Long-term
  • behçet's disease
    • Fever
    • Gout
    • Drugs
    • Medication
    • Reduce
    • States
    • United
    • Used
    • Blood
    • Kidney
    • Long-term
    • May
  • familial mediterranean fever
    • Risk
    • Symptoms
    • Include
    • Disease
    • Medication
    • Reduce
    • Toxic
    • Used
    • Blood
    • Cell
    • Failure
    • Long-term

Connections between topic areas Semantic bridges

For Colchicine, one of the stronger structural bridges in this analysis connects Colchicine with Toxicity. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Colchicine — Toxicity · splits 149 ⟂ 41
Colchicine — Sources and uses · splits 159 ⟂ 31
Colchicine — Overview · splits 162 ⟂ 28
Colchicine — Drug interactions · splits 169 ⟂ 21
Colchicine — History · splits 170 ⟂ 20
Colchicine — Pharmacology · splits 171 ⟂ 19
Colchicine — Medical uses · splits 177 ⟂ 13
Colchicine — Contraindications · splits 181 ⟂ 9
Colchicine — Adverse effects · splits 185 ⟂ 5

Map overview Semantic statistics

Colchicine

Nodes190
Edges189
Triples147
Avg. degree1.99
Density0.010526
Components1

Source & methodology

TTTA analyzes the structure around Colchicine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Colchicine · EN edition · Analysis: TopicsToTalkAbout

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