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Colchicine

Colchicine, sold under the brand name Colbenemid among others, is a medication used to prevent and treat gout, to treat familial Mediterranean fever and Behçet's disease, and to reduce the risk of myocardial infarction. The American College of Rheumatology recommends colchicine, nonsteroidal anti-inflammatory drugs (NSAIDs) or steroids in the treatment…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
M04AC01 (WHO)
Bioavailability
45%
CAS Number
64-86-8
ChEBI
CHEBI:27882

Topics to explore

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Overview

Medical uses

Contraindications

Adverse effects

Toxicity

Drug interactions

Pharmacology

History

Sources and uses

Society and culture

Advanced semantic analysis

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Map overview Semantic statistics

Colchicine

Nodes190
Edges189
Triples147
Avg. degree1.99
Density0.010526
Components1

How this topic connects Entity context

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Colchicine

Top relations

related to history · 26
Colchicine → AD, Alexander, Ambroise Paré, Avicenna, BC, Benjamin Franklin, Caventou, Colchicum, De Materia Medica, Ebers Papyrus, Egyptian, France, French, Geiger, In, It, London Pharmacopoeia, Michael Dewar, North America, Pedanius Dioscorides
related to Biosynthesis · 11
Colchicine → According, Colchicaceae, Giving, However, N-formyldemecolcine, O-methylation, Radioactive, S-adenosylmethionine, That, The, Two
related to Legal status · 10
Colchicine → Agepha Pharma, Colchicine Agepha Pharma, Colchicine Tiofarma, Committee, EMA, European Union, Human Use, In May, Medicinal Products, The
related to Botanical use and seedless fruit · 9
Colchicine → Citrullus, For, Growers, In, Many, Seeds, Since, When, While
related to Drug interactions · 7
Colchicine → CYP3A4, Fatal, Grapefruit, HIV/AIDS, P-glycoprotein, People, Symptoms
related to Epidemiology · 6
Colchicine → In, It, Many, Mary Yoder, Most, United States
related to Gout · 5
Colchicine → At, For, Low, NSAIDs, Subsequent
related to Risk of cardiovascular disorders · 5
Colchicine → As, In June, Lodoco, The, US FDA
Legal status · 4
Colchicine → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only
has effect · 4
Colchicine → All, Deaths, High, Typical

Important terminology Word statistics

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Important terminology

may gout used toxicity use include effects gastrointestinal medication anti-inflammatory also colchicum drug risk symptoms plants side diploid treatment doses

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Colchicine3D model (JSmol)Interactive image1.00infobox
ColchicineAHFS/Drugs.comMonograph1.00infobox
ColchicineATC codeM04AC01 (WHO)1.00infobox
ColchicineBioavailability45%1.00infobox
ColchicineCAS Number64-86-81.00infobox
ColchicineChEBICHEBI:278821.00infobox
ColchicineChEMBLChEMBL1071.00infobox
ColchicineChemSpider59331.00infobox
ColchicineCompTox Dashboard (EPA)DTXSID50248451.00infobox
ColchicineDrugBankDB013941.00infobox
ColchicineECHA InfoCard100.000.5441.00infobox
ColchicineElimination half-life26.6-31.2 hours1.00infobox
ColchicineExcretionFeces (65%)1.00infobox
ColchicineFormulaC22H25NO61.00infobox
ColchicineIUPHAR/BPS23671.00infobox
ColchicineKEGGD005701.00infobox
ColchicineLegal statusAU: S4 (Prescription only)1.00infobox
ColchicineLegal statusCA: ℞-only1.00infobox
ColchicineLegal statusUK: POM (Prescription only)1.00infobox
ColchicineLegal statusUS: ℞-only1.00infobox
ColchicineLicense dataUS DailyMed: Colchicine1.00infobox
ColchicineMedlinePlusa6827111.00infobox
ColchicineMetabolismMetabolism, partly by CYP3A41.00infobox
ColchicineMolar mass399.443 g·mol−11.00infobox
ColchicinePregnancy categoryAU: D1.00infobox
ColchicinePronunciation/ˈkɒltʃɪsiːn/ KOL-chiss-een1.00infobox
ColchicineProtein binding35-44%1.00infobox
ColchicinePubChem CID61671.00infobox
ColchicineRoutes of administrationBy mouth1.00infobox
ColchicineTrade namesColbenemid, others1.00infobox

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