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Primidone: History, Applications & Art

Primidone, sold under various brand names (including Mysoline), is a barbiturate medication that is used to treat partial and generalized seizures and essential tremors. It is taken by mouth.

Language: English [EN]
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Primidone topic overview

The analysis highlights History, Applications and Art as prominent areas in the source structure around Primidone.

Related topics
182
Source areas
9
Connected nodes
191
Extracted relationships
215
Concept neighborhoods
15
Bridge connections
191

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Adverse effects · 75 topics
Interactions · 45 topics
Medical uses · 24 topics
Overview · 11 topics
Pharmacokinetics · 11 topics
History · 6 topics
Available forms · 5 topics
Mechanism of action · 3 topics
Veterinary uses · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N03AA03 (WHO)
Bioavailability
~100%
CAS Number
125-33-7 Y
ChEBI
CHEBI:8412 N

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Interactions

Mechanism of action

Pharmacokinetics

History

Available forms

Veterinary uses

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Primidone connects Entity context

The extracted context around Primidone shows recurring relationship patterns in the source. For example, Primidone → Apo-Primidone, AWD, Canada, Co, Desitin, Germany, GmbH, Hungary, ICN Pharmaceuticals Inc, Ireland, Israel, It, Japan, KG, Liskantin, Ltd, Mylepsinum, Mysoline, Prysoline, Rekah Pharmaceutical Products Another extracted example is Primidone → Anticonvulsants, Australia, Caucasians, Critcheley, Dr, Drs, Dupuytren's, Hart, HIV, Hooper, Iceland, It, Lund, Norway, Only, People, Scotland, These, They, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Primidone

Top relations

related to Available forms · 26
Primidone → Apo-Primidone, AWD, Canada, Co, Desitin, Germany, GmbH, Hungary, ICN Pharmaceuticals Inc, Ireland, Israel, It, Japan, KG, Liskantin, Ltd, Mylepsinum, Mysoline, Prysoline, Rekah Pharmaceutical Products
has effect · 22
Primidone → Anticonvulsants, Australia, Caucasians, Critcheley, Dr, Drs, Dupuytren's, Hart, HIV, Hooper, Iceland, It, Lund, Norway, Only, People, Scotland, These, They, This
related to Interactions · 19
Primidone → Clobazam, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP3A4, Eldepryl, In, Isoniazid, It, Like, MAOI, MAOIs, Marplan, Matulane, Mesuximide, Nardil, Parnate, Taking
related to Pharmacokinetics · 18
Primidone → CAR, CYP1A2, CYP1E1, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2E, CYP3A4, CYP3A5, In, Its, P450, PEMA, Phenobarbital, PXR, The
related to Further reading · 15
Primidone → Abstract, B6C3F1 Mice, Carcinogenesis Studies, Department, F344/N Rats, Feed Studies, Health, Human Services National Toxicology, Lay, National Toxicology Program, PDF, Program, September, Toxicology, TR-476
related to Association with megaloblastic anemia · 13
Primidone → B12, Between, Boheimer, Chalmers, CNS, Five, Folic, In, PNS, Some, The, This, What
related to Psychiatric disorders · 12
Primidone → EEG, EEGs, Hayes, In, In March, Medicine, Monroe, Southern California School, University, What, When, Wise
related to history · 10
Primidone → AstraZeneca, Germany, He, Imperial Chemical Industry, In, It, Netherlands, The, United Kingdom, Yule Bogue
related to Mechanism of action · 8
Primidone → According, Brenner's Pharmacology, GABA-mediated, It, PEMA, Phenylethylmalonamide, The, TRPM3
related to Overdose · 7
Primidone → Center, Complete, Dutch National Poison Control, In, Netherlands, Of, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

phenobarbital also reported anticonvulsant one people phenytoin associated epilepsy effects anticonvulsants cause mg taking use united anemia drugs levels due

Primidone relationships Subject–Predicate–Object triples

TTTA extracted 215 structured relationships around Primidone. Examples in this analysis include Primidone → 3D model (JSmol) → Interactive image and Primidone → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Primidone3D model (JSmol)Interactive image1.00infobox
PrimidoneAHFS/Drugs.comMonograph1.00infobox
PrimidoneATC codeN03AA03 (WHO)1.00infobox
PrimidoneBioavailability~100%1.00infobox
PrimidoneCAS Number125-33-7 Y1.00infobox
PrimidoneChEBICHEBI:8412 N1.00infobox
PrimidoneChEMBLChEMBL856 Y1.00infobox
PrimidoneChemSpider4740 Y1.00infobox
PrimidoneCompTox Dashboard (EPA)DTXSID70235101.00infobox
PrimidoneDrug classAnticonvulsant, barbiturate1.00infobox
PrimidoneDrugBankDB00794 Y1.00infobox
PrimidoneECHA InfoCard100.004.3071.00infobox
PrimidoneElimination half-lifePrimidone: 5-18 h, Phenobarbital: 75-120 h, PEMA: 16 h Time to reach steady state: Primidone: 2-3 days, Phenobarbital&PEMA 1-4weeks1.00infobox
PrimidoneExcretionKidney1.00infobox
PrimidoneFormulaC12H14N2O21.00infobox
PrimidoneKEGGD00474 Y1.00infobox
PrimidoneKEGGC07371 Y1.00infobox
PrimidoneLegal statusAU: S4 (Prescription only)1.00infobox
PrimidoneLegal statusBR: Class C1 (Other controlled substances)1.00infobox
PrimidoneLegal statusCA: ℞-only1.00infobox
PrimidoneLegal statusUK: POM (Prescription only)1.00infobox
PrimidoneLegal statusUS: ℞-only1.00infobox
PrimidoneLicense dataUS DailyMed: Primidone1.00infobox
PrimidoneMedlinePlusa6820231.00infobox
PrimidoneMetabolismLiver1.00infobox
PrimidoneMolar mass218.256 g·mol−11.00infobox
PrimidoneOther namesdesoxyphenobarbital, desoxyphenobarbitone1.00infobox
PrimidonePregnancy categoryAU: D1.00infobox
PrimidoneProtein binding25%1.00infobox
PrimidonePubChem CID49091.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Primidone bring nearby vocabulary together. In this analysis, examples include Phenobarbital, Reported and Phenytoin. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Primidone
    • Phenobarbital
    • Reported
    • Phenytoin
    • Mg
    • Associated
    • One
    • Pema
    • Metabolism
    • United
    • Use
    • Drugs
    • Also
  • primidone
    • Phenobarbital
    • Reported
    • Phenytoin
    • Mg
    • Associated
    • One
    • Pema
    • Metabolism
    • United
    • Use
    • Drugs
    • Also
  • anticonvulsant
    • Epilepsy
    • Effect
    • Associated
    • One
    • Effects
    • Barbiturate
    • Metabolite
    • People
    • Found
    • Rate
    • Years
    • Drugs
  • phenobarbital
    • Primidone
    • Phenytoin
    • Pema
    • Metabolism
    • One
    • Serum
    • Levels
    • Associated
    • Found
    • Acid
    • Rate
    • Drugs
  • anticonvulsant hypersensitivity syndrome
    • Epilepsy
    • Effect
    • Associated
    • One
    • Effects
    • Barbiturate
    • Metabolite
    • People
    • Found
    • Rate
    • Years
    • Drugs
  • megaloblastic anemia
    • Megaloblastic
    • Acid
    • Associated
    • Barbiturate
    • Pema
    • Reported
    • Found
    • Metabolism
    • Patient
    • Risk
    • United
    • Use
  • barbiturate
    • Effect
    • Anticonvulsant
    • Medication
    • Metabolite
    • Side
    • Pema
    • Seizure
    • Metabolism
    • Patient
    • Serum
    • Phenobarbital
    • Due
  • juvenile myoclonic epilepsy
    • Patients
    • Associated
    • Use
    • Also
    • People
    • Reported
    • Primidone
    • Metabolite
    • Pema
    • Seizure
    • Metabolism
    • Patient

Connections between topic areas Semantic bridges

For Primidone, one of the stronger structural bridges in this analysis connects Primidone with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PrimidoneAdverse effects · splits 116 ⟂ 76
PrimidoneInteractions · splits 146 ⟂ 46
PrimidoneMedical uses · splits 167 ⟂ 25
PrimidoneOverview · splits 180 ⟂ 12
PrimidonePharmacokinetics · splits 180 ⟂ 12
PrimidoneHistory · splits 185 ⟂ 7
PrimidoneAvailable forms · splits 186 ⟂ 6
PrimidoneMechanism of action · splits 188 ⟂ 4
PrimidoneVeterinary uses · splits 189 ⟂ 3

Map overview Semantic statistics

Primidone

Nodes192
Edges191
Triples215
Avg. degree1.99
Density0.010417
Components1

Source & methodology

TTTA analyzes the structure around Primidone to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Art, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Primidone · EN edition · Analysis: TopicsToTalkAbout

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