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Primidone

Primidone, sold under various brand names (including Mysoline), is a barbiturate medication that is used to treat partial and generalized seizures and essential tremors. It is taken by mouth.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N03AA03 (WHO)
Bioavailability
~100%
CAS Number
125-33-7 Y
ChEBI
CHEBI:8412 N

Topics to explore

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Overview

Medical uses

Adverse effects

Interactions

Mechanism of action

Pharmacokinetics

History

Available forms

Veterinary uses

Advanced semantic analysis

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Map overview Semantic statistics

Primidone

Nodes192
Edges191
Triples215
Avg. degree1.99
Density0.010417
Components1

How this topic connects Entity context

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Primidone

Top relations

related to Available forms · 26
Primidone → Apo-Primidone, AWD, Canada, Co, Desitin, Germany, GmbH, Hungary, ICN Pharmaceuticals Inc, Ireland, Israel, It, Japan, KG, Liskantin, Ltd, Mylepsinum, Mysoline, Prysoline, Rekah Pharmaceutical Products
has effect · 22
Primidone → Anticonvulsants, Australia, Caucasians, Critcheley, Dr, Drs, Dupuytren's, Hart, HIV, Hooper, Iceland, It, Lund, Norway, Only, People, Scotland, These, They, This
related to Interactions · 19
Primidone → Clobazam, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP3A4, Eldepryl, In, Isoniazid, It, Like, MAOI, MAOIs, Marplan, Matulane, Mesuximide, Nardil, Parnate, Taking
related to Pharmacokinetics · 18
Primidone → CAR, CYP1A2, CYP1E1, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2E, CYP3A4, CYP3A5, In, Its, P450, PEMA, Phenobarbital, PXR, The
related to Further reading · 15
Primidone → Abstract, B6C3F1 Mice, Carcinogenesis Studies, Department, F344/N Rats, Feed Studies, Health, Human Services National Toxicology, Lay, National Toxicology Program, PDF, Program, September, Toxicology, TR-476
related to Association with megaloblastic anemia · 13
Primidone → B12, Between, Boheimer, Chalmers, CNS, Five, Folic, In, PNS, Some, The, This, What
related to Psychiatric disorders · 12
Primidone → EEG, EEGs, Hayes, In, In March, Medicine, Monroe, Southern California School, University, What, When, Wise
related to history · 10
Primidone → AstraZeneca, Germany, He, Imperial Chemical Industry, In, It, Netherlands, The, United Kingdom, Yule Bogue
related to Mechanism of action · 8
Primidone → According, Brenner's Pharmacology, GABA-mediated, It, PEMA, Phenylethylmalonamide, The, TRPM3
related to Overdose · 7
Primidone → Center, Complete, Dutch National Poison Control, In, Netherlands, Of, The

Important terminology Word statistics

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Important terminology

phenobarbital also reported anticonvulsant one people phenytoin associated epilepsy effects anticonvulsants cause mg taking use united anemia drugs levels due

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Primidone3D model (JSmol)Interactive image1.00infobox
PrimidoneAHFS/Drugs.comMonograph1.00infobox
PrimidoneATC codeN03AA03 (WHO)1.00infobox
PrimidoneBioavailability~100%1.00infobox
PrimidoneCAS Number125-33-7 Y1.00infobox
PrimidoneChEBICHEBI:8412 N1.00infobox
PrimidoneChEMBLChEMBL856 Y1.00infobox
PrimidoneChemSpider4740 Y1.00infobox
PrimidoneCompTox Dashboard (EPA)DTXSID70235101.00infobox
PrimidoneDrug classAnticonvulsant, barbiturate1.00infobox
PrimidoneDrugBankDB00794 Y1.00infobox
PrimidoneECHA InfoCard100.004.3071.00infobox
PrimidoneElimination half-lifePrimidone: 5-18 h, Phenobarbital: 75-120 h, PEMA: 16 h Time to reach steady state: Primidone: 2-3 days, Phenobarbital&PEMA 1-4weeks1.00infobox
PrimidoneExcretionKidney1.00infobox
PrimidoneFormulaC12H14N2O21.00infobox
PrimidoneKEGGD00474 Y1.00infobox
PrimidoneKEGGC07371 Y1.00infobox
PrimidoneLegal statusAU: S4 (Prescription only)1.00infobox
PrimidoneLegal statusBR: Class C1 (Other controlled substances)1.00infobox
PrimidoneLegal statusCA: ℞-only1.00infobox
PrimidoneLegal statusUK: POM (Prescription only)1.00infobox
PrimidoneLegal statusUS: ℞-only1.00infobox
PrimidoneLicense dataUS DailyMed: Primidone1.00infobox
PrimidoneMedlinePlusa6820231.00infobox
PrimidoneMetabolismLiver1.00infobox
PrimidoneMolar mass218.256 g·mol−11.00infobox
PrimidoneOther namesdesoxyphenobarbital, desoxyphenobarbitone1.00infobox
PrimidonePregnancy categoryAU: D1.00infobox
PrimidoneProtein binding25%1.00infobox
PrimidonePubChem CID49091.00infobox

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