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P-glycoprotein: History & Research

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent…

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P-glycoprotein topic overview

The analysis highlights History and Research as prominent areas in the source structure around P-glycoprotein.

Related topics
159
Source areas
8
Connected nodes
167
Extracted relationships
115
Concept neighborhoods
35
Bridge connections
167

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 45 topics
Clinical significance · 42 topics
Regulation of expression and function of P-gp in cancer cells · 34 topics
Overview · 26 topics
Single nucleotide polymorphism rs1045642 · 5 topics
Research · 4 topics
Species, tissue, and subcellular distribution · 2 topics
History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

7.6.2.1
7.6.2.2
Aliases
ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, ATP binding cassette subfamily B member 1, P-glycoprotein, P-gp, Pgp
Band
5 A1|5 3.43 cM
Bgee
left colon · iris · Paneth cell · jejunum · crypt of lieberkuhn of small intestine
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Species, tissue, and subcellular distribution

Function

Regulation of expression and function of P-gp in cancer cells

Clinical significance

History

Research

Single nucleotide polymorphism rs1045642

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How P-glycoprotein connects Entity context

The extracted context around P-glycoprotein shows recurring relationship patterns in the source. For example, P-glycoprotein → ABC-type xenobiotic transporter activity, apical plasma membrane, ATP binding, ATPase activity, ATPase-coupled transmembrane transporter activity, cell surface, ceramide floppase activity, ceramide translocation, extracellular exosome, G2/M transition of mitotic cell cycle, hydrolase activity, integral component of membrane, membrane, nucleotide binding, phosphatidylcholine floppase activity, phosphatidylethanolamine flippase activity, phospholipid translocation, plasma membrane, positive regulation of anion channel activity, protein binding Another extracted example is P-glycoprotein → ABCB1, Common, CP, Elacridar, GT, INR, John's, Lastly, P-gp, Patients, SNP, Some, St, The, TT, Zosuquidar. Use these groups to spot repeated connection types before inspecting the individual relationships.

P-glycoprotein

Top relations

Gene ontology · 28
P-glycoprotein → ABC-type xenobiotic transporter activity, apical plasma membrane, ATP binding, ATPase activity, ATPase-coupled transmembrane transporter activity, cell surface, ceramide floppase activity, ceramide translocation, extracellular exosome, G2/M transition of mitotic cell cycle, hydrolase activity, integral component of membrane, membrane, nucleotide binding, phosphatidylcholine floppase activity, phosphatidylethanolamine flippase activity, phospholipid translocation, plasma membrane, positive regulation of anion channel activity, protein binding
related to Drug interactions · 16
P-glycoprotein → ABCB1, Common, CP, Elacridar, GT, INR, John's, Lastly, P-gp, Patients, SNP, Some, St, The, TT, Zosuquidar
related to Protein · 13
P-glycoprotein → ABC, Additional, ATP-binding, In, MD, MDR3, MsbA, N-terminal, P-gp, Pichia, The, The N-terminal, Through Molecular Dynamic
Bgee · 10
P-glycoprotein → ciliary body, crypt of lieberkuhn of small intestine, gallbladder, ileum, intestinal villus, iris, jejunum, left colon, Paneth cell, substantia nigra
RNA expression pattern · 10
P-glycoprotein → ciliary body, crypt of lieberkuhn of small intestine, gallbladder, ileum, intestinal villus, iris, jejunum, left colon, Paneth cell, substantia nigra
related to External links · 8
P-glycoprotein → ABCB1, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, UCSC Genome Browser, United States National Library
related to Gene · 3
P-glycoprotein → ABCB1, Although, RNA
7.6.2.1 · 1
P-glycoprotein → ↗
7.6.2.2 · 1
P-glycoprotein → ↗
Aliases · 1
P-glycoprotein → ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, ATP binding cassette subfamily B member 1, P-glycoprotein, P-gp, Pgp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

p-gp expression protein abcb1 drugs gene also cells drug substrates resistance xenobiotics cell substrate binding multidrug intestinal inhibitors many human

P-glycoprotein relationships Subject–Predicate–Object triples

TTTA extracted 115 structured relationships around P-glycoprotein. Examples in this analysis include P-glycoprotein → 7.6.2.1 → ↗ and P-glycoprotein → Aliases → ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, ATP binding cassette subfamily B member 1, P-glycoprotein, P-gp, Pgp. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
P-glycoprotein7.6.2.11.00infobox
P-glycoprotein7.6.2.21.00infobox
P-glycoproteinAliasesABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, ATP binding cassette subfamily B member 1, P-glycoprotein, P-gp, Pgp1.00infobox
P-glycoproteinBand5 A1|5 3.43 cM1.00infobox
P-glycoproteinBgeeleft colon1.00infobox
P-glycoproteinBgeeiris1.00infobox
P-glycoproteinBgeePaneth cell1.00infobox
P-glycoproteinBgeejejunum1.00infobox
P-glycoproteinBgeecrypt of lieberkuhn of small intestine1.00infobox
P-glycoproteinBgeeileum1.00infobox
P-glycoproteinBgeegallbladder1.00infobox
P-glycoproteinBgeeciliary body1.00infobox
P-glycoproteinBgeeintestinal villus1.00infobox
P-glycoproteinBgeesubstantia nigra1.00infobox
P-glycoproteinBioGPSMore reference expression data1.00infobox
P-glycoproteinChr.Chromosome 5 (mouse)1.00infobox
P-glycoproteinDatabasesNCBI: entry; OMA: entry1.00infobox
P-glycoproteinEnd8,798,575 bp1.00infobox
P-glycoproteinEnsemblENSG000000855631.00infobox
P-glycoproteinEntrez52431.00infobox
P-glycoproteinEnzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc7.6.2.1↗↗↗↗7.6.2.2↗↗↗↗1.00infobox
P-glycoproteinExternal IDsOMIM: 171050; MGI: 97570; GeneCards: ABCB11.00infobox
P-glycoproteinGene location (Mouse)Gene location (Mouse)Chr.Chromosome 5 (mouse)Band5 A1|5 3.43 cMStart8,710,077 bpEnd8,798,575 bp1.00infobox
P-glycoproteinGene ontologyATPase-coupled transmembrane transporter activity1.00infobox
P-glycoproteinGene ontologynucleotide binding1.00infobox
P-glycoproteinGene ontologytransporter activity1.00infobox
P-glycoproteinGene ontologyATPase activity1.00infobox
P-glycoproteinGene ontologyprotein binding1.00infobox
P-glycoproteinGene ontologyhydrolase activity1.00infobox
P-glycoproteinGene ontologyATP binding1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around P-glycoprotein bring nearby vocabulary together. In this analysis, examples include Drug, Transport and Intestinal. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • P-glycoprotein
    • Drug
    • Transport
    • Intestinal
    • Expression
    • Plasma
    • Inhibitors
    • Multidrug
    • Substrates
    • Abcb1
    • Cells
    • Resistance
    • Bp
  • p-glycoprotein
    • Drug
    • Transport
    • Intestinal
    • Expression
    • Plasma
    • Inhibitors
    • Multidrug
    • Substrates
    • Abcb1
    • Cells
    • Resistance
    • Bp
  • cell membrane
    • Membrane
    • Mouse
    • Expressed
    • Protein
    • Atp
    • Binding
    • Many
    • Regulation
    • Substrate
    • Bp
    • P-glycoprotein
    • Colchicine
  • intestinal epithelium
    • Transport
    • Plasma
    • Xenobiotics
    • Drugs
    • P-glycoprotein
    • Lumen
    • Expression
    • Brain
    • Function
    • Decreased
    • Many
    • Human
  • liver cells
    • Multidrug
    • Resistance
    • Brain
    • Drugs
    • Drug
    • Lumen
    • P-glycoprotein
    • Decreased
    • Xenobiotics
    • Intestinal
    • P-gp
    • Protein
  • multidrug resistant
    • Resistance
    • Cells
    • Decreased
    • Drug
    • Mdr
    • Plasma
    • Drugs
    • P-glycoprotein
    • Transport
    • Intestinal
    • Lumen
    • Subfamily
  • endothelial cells
    • Multidrug
    • Resistance
    • Brain
    • Drugs
    • Drug
    • Lumen
    • P-glycoprotein
    • Decreased
    • Xenobiotics
    • Intestinal
    • P-gp
    • Protein
  • inner leaflet of the membrane
    • Mouse
    • Protein
    • Binding
    • Substrate
    • Bp
    • P-glycoprotein
    • Colchicine
    • Expressed
    • Activity
    • Function
    • Intracellular
    • P-gp

Connections between topic areas Semantic bridges

For P-glycoprotein, one of the stronger structural bridges in this analysis connects P-glycoprotein with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
P-glycoproteinFunction · splits 122 ⟂ 46
P-glycoproteinClinical significance · splits 125 ⟂ 43
P-glycoproteinRegulation of expression and function of P-gp in cancer cells · splits 133 ⟂ 35
P-glycoproteinOverview · splits 141 ⟂ 27
P-glycoproteinSingle nucleotide polymorphism rs1045642 · splits 162 ⟂ 6
P-glycoproteinResearch · splits 163 ⟂ 5
P-glycoproteinSpecies, tissue, and subcellular distribution · splits 165 ⟂ 3

Map overview Semantic statistics

P-glycoprotein

Nodes168
Edges167
Triples115
Avg. degree1.99
Density0.011905
Components1

Source & methodology

TTTA analyzes the structure around P-glycoprotein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — P-glycoprotein · EN edition · Analysis: TopicsToTalkAbout

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