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Tacrolimus: History, Applications & Research

Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After an allogenic organ transplant, the risk of organ rejection is moderate; tacrolimus is used to lower the risk of organ rejection. Tacrolimus is also sold as a topical medication for treating T cell-mediated diseases, such as eczema and psoriasis. For example…

Language: English [EN]
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Tacrolimus topic overview

The analysis highlights History, Applications and Research as prominent areas in the source structure around Tacrolimus.

Related topics
132
Source areas
11
Connected nodes
143
Extracted relationships
139
Concept neighborhoods
25
Bridge connections
143

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 32 topics
Pharmacology · 27 topics
Side effects · 20 topics
Medical uses · 14 topics
Contraindications and precautions · 12 topics
History · 8 topics
Biosynthesis · 6 topics
Available forms · 4 topics
Interactions · 4 topics
Research · 4 topics
Topical use · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
D11AH01 (WHO) L04AD02 (WHO)
Bioavailability
24% (5–67%), less after eating food rich in fat
CAS Number
104987-11-3 Y
ChEBI
CHEBI:61049

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Medical uses

Contraindications and precautions

Topical use

Side effects

Interactions

Pharmacology

Available forms

Biosynthesis

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Tacrolimus connects Entity context

The extracted context around Tacrolimus shows recurring relationship patterns in the source. For example, Tacrolimus → Archived, Drug Administration, FDA, FDA Approves New Use, Food, July, Medicine Medical Subject Headings, MedlinePlus, MeSH, National Library, Real-World Evidence, September, Tacrolimus Injection, Tacrolimus Topical, Transplant Drug Based Another extracted example is Tacrolimus → Achieving, Across, African, Caucasian, CYP3A5, Genetic, However, In, NR1I2, PXR, SNP, Studies, The, There. Use these groups to spot repeated connection types before inspecting the individual relationships.

Tacrolimus

Top relations

related to External links · 15
Tacrolimus → Archived, Drug Administration, FDA, FDA Approves New Use, Food, July, Medicine Medical Subject Headings, MedlinePlus, MeSH, National Library, Real-World Evidence, September, Tacrolimus Injection, Tacrolimus Topical, Transplant Drug Based
related to Pharmacogenetics · 14
Tacrolimus → Achieving, Across, African, Caucasian, CYP3A5, Genetic, However, In, NR1I2, PXR, SNP, Studies, The, There
related to Biosynthesis · 10
Tacrolimus → Acyl Carrier, Allylmalonyl-CoA, CoA, DHCHC, However, NRPS, Once, PKS, The, There
related to history · 10
Tacrolimus → Easter Island, FK-506, It, Japanese, Rapa Nui, Streptomyces, The, Thomas Starzl's, Tohru Kino, Tsukuba
related to Mechanism of action · 8
Tacrolimus → Although, Calcineurin, FK506, FKBP12, IL-2, In, NF-AT, This FKBP12
related to Pharmacokinetics · 8
Tacrolimus → All, Biological, Cmax, CYP3A, In, Oral, Taking, The
related to Organ transplantation · 6
Tacrolimus → Clinical, Dosages, IL-2, Immunosuppression, It, Long-term
related to Interactions · 5
Tacrolimus → Also, As, Interactions, Macrolide, P450
related to Skin · 5
Tacrolimus → An, As, Clinical, It, Recently
Legal status · 4
Tacrolimus → CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), US: ℞-only

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

drug also transplant rejection used liver topical risk use include kidney calcineurin macrolide molecule one enzyme cyp3a5 cancer name first

Tacrolimus relationships Subject–Predicate–Object triples

TTTA extracted 139 structured relationships around Tacrolimus. Examples in this analysis include Tacrolimus → 3D model (JSmol) → Interactive image and Tacrolimus → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Tacrolimus3D model (JSmol)Interactive image1.00infobox
TacrolimusAHFS/Drugs.comMonograph1.00infobox
TacrolimusATC codeD11AH01 (WHO) L04AD02 (WHO)1.00infobox
TacrolimusBioavailability24% (5–67%), less after eating food rich in fat1.00infobox
TacrolimusCAS Number104987-11-3 Y1.00infobox
TacrolimusChEBICHEBI:610491.00infobox
TacrolimusChEMBLChEMBL269732 Y1.00infobox
TacrolimusChemSpider393220 Y1.00infobox
TacrolimusCompTox Dashboard (EPA)DTXSID50463541.00infobox
TacrolimusDrugBankDB00864 Y1.00infobox
TacrolimusECHA InfoCard100.155.3671.00infobox
TacrolimusElimination half-life11.3 h for transplant patients (range 3.5–40.6 h)1.00infobox
TacrolimusExcretionMostly fecal1.00infobox
TacrolimusFormulaC44H69NO121.00infobox
TacrolimusKEGGD08556 Y1.00infobox
TacrolimusKEGGD00107 Y1.00infobox
TacrolimusLegal statusCA: ℞-only1.00infobox
TacrolimusLegal statusUS: ℞-only1.00infobox
TacrolimusLegal statusEU: Rx-only1.00infobox
TacrolimusLegal statusIn general: ℞ (Prescription only)1.00infobox
TacrolimusLicense dataUS DailyMed: Tacrolimus1.00infobox
TacrolimusMedlinePlusa6011171.00infobox
TacrolimusMetabolismLiver CYP3A4, CYP3A51.00infobox
TacrolimusMolar mass804.031 g·mol−11.00infobox
TacrolimusOther namesFK-506, fujimycin1.00infobox
TacrolimusPDB ligandFK5 (PDBe, RCSB PDB)1.00infobox
TacrolimusPregnancy categoryAU: C1.00infobox
TacrolimusProtein binding≥98.8%1.00infobox
TacrolimusPubChem CID4456431.00infobox
TacrolimusRoutes of administrationTopical, by mouth, intravenous1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Tacrolimus bring nearby vocabulary together. In this analysis, examples include Concentrations, Topical and Use. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Tacrolimus
    • Concentrations
    • Topical
    • Use
    • Used
    • Liver
    • Also
    • Approved
    • Eczema
    • Activity
    • Cyp3a5
    • First
    • Macrolide
  • tacrolimus
    • Concentrations
    • Topical
    • Use
    • Used
    • Liver
    • Also
    • Approved
    • Eczema
    • Activity
    • Cyp3a5
    • First
    • Macrolide
  • organ transplant
    • Liver
    • Patients
    • Treatment
    • Cancer
    • Kidney
    • Include
    • Use
    • Bioavailability
    • Prescribed
    • Biosynthesis
    • Concentrations
    • Cyp3a5
  • international agency for research on cancer
    • Risk
    • Drugs
    • Skin
    • Liver
    • Transplant
    • Bioavailability
    • Eczema
    • Biosynthesis
    • Cyp3a5
    • First
    • Macrolide
    • Name
  • lung cancer
    • Risk
    • Drugs
    • Skin
    • Liver
    • Transplant
    • Bioavailability
    • Eczema
    • Biosynthesis
    • Cyp3a5
    • First
    • Macrolide
    • Name
  • immunosuppressive drug
    • Fda
    • Risk
    • Transplant
    • Concentrations
    • Name
    • Number
    • Patients
    • Tacrolimus
    • Use
    • Rejection
    • Approved
    • Bioavailability
  • food and drug administration
    • Fda
    • Risk
    • Transplant
    • Concentrations
    • Name
    • Number
    • Patients
    • Tacrolimus
    • Use
    • Rejection
    • Approved
    • Bioavailability
  • liver transplantation
    • Kidney
    • Include
    • Transplant
    • Patients
    • Skin
    • Treatment
    • Us
    • Use
    • Rejection
    • Tacrolimus
    • Approved
    • Activity

Connections between topic areas Semantic bridges

For Tacrolimus, one of the stronger structural bridges in this analysis connects Tacrolimus with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Tacrolimus — Overview · splits 111 ⟂ 33
Tacrolimus — Pharmacology · splits 116 ⟂ 28
Tacrolimus — Side effects · splits 123 ⟂ 21
Tacrolimus — Medical uses · splits 129 ⟂ 15
Tacrolimus — Contraindications and precautions · splits 131 ⟂ 13
Tacrolimus — History · splits 135 ⟂ 9
Tacrolimus — Biosynthesis · splits 137 ⟂ 7
Tacrolimus — Interactions · splits 139 ⟂ 5
Tacrolimus — Available forms · splits 139 ⟂ 5
Tacrolimus — Research · splits 139 ⟂ 5

Map overview Semantic statistics

Tacrolimus

Nodes144
Edges143
Triples139
Avg. degree1.99
Density0.013889
Components1

Source & methodology

TTTA analyzes the structure around Tacrolimus to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Tacrolimus · EN edition · Analysis: TopicsToTalkAbout

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