Tacrolimus

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Tacrolimus topic overview

The analysis highlights History, Applications and Research as prominent areas in the source structure around Tacrolimus.

Related topics: 132
Source areas: 11
Connected nodes: 143
Extracted relationships: 102
Related term clusters: 25
Bridge connections: 143

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 32 topics

Pharmacology · 27 topics

Side effects · 20 topics

Medical uses · 14 topics

Contraindications and precautions · 12 topics

History · 8 topics

Biosynthesis · 6 topics

Available forms · 4 topics

Interactions · 4 topics

Research · 4 topics

Topical use · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
AHFS/Drugs.com: Monograph
ATC code: D11AH01 (WHO) L04AD02 (WHO)
Bioavailability: 24% (5–67%), less after eating food rich in fat
CAS Number: 104987-11-3 Y
ChEBI: CHEBI:61049

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Tacrolimus

13Immunosuppressive drug · Allotransplantation · Organ transplant

6Calcineurin · Interleukin-2 · Molecule

7CYP3A5 · Genetic variation · Homozygous

16Macrolide · Lactone · Streptomyces tsukubensis

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

History

Medical uses

Contraindications and precautions

Topical use

Flu-like symptoms

Interactions

Available forms

Biosynthesis

Research

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Tacrolimus connects Entity context

The extracted context around Tacrolimus shows recurring relationship patterns in the source. For example, Tacrolimus → Achieving, Across, African, Caucasian, CYP3A5, Genetic, NR1I2, PXR, SNP, Studies Another extracted example is Tacrolimus → Easter Island, FK-506, Japanese, Rapa Nui, Streptomyces, Thomas Starzl's, Tohru Kino, Tsukuba. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Pharmacogenetics · 10

Tacrolimus → Achieving, Across, African, Caucasian, CYP3A5, Genetic, NR1I2, PXR, SNP, Studies

related to history · 8

Tacrolimus → Easter Island, FK-506, Japanese, Rapa Nui, Streptomyces, Thomas Starzl's, Tohru Kino, Tsukuba

related to Mechanism of action · 7

Tacrolimus → Although, Calcineurin, FK506, FKBP12, IL-2, NF-AT, This FKBP12

related to Biosynthesis · 6

Tacrolimus → Acyl Carrier, Allylmalonyl-CoA, CoA, DHCHC, NRPS, PKS

related to Organ transplantation · 5

Tacrolimus → Clinical, Dosages, IL-2, Immunosuppression, Long-term

related to Pharmacokinetics · 5

Tacrolimus → Biological, Cmax, CYP3A, Oral, Taking

Legal status · 4

Tacrolimus → CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), US: ℞-only

related to Interactions · 4

Tacrolimus → Also, Interactions, Macrolide, P450

related to Ulcerative colitis · 3

Tacrolimus → Although, Cochrane, UC

KEGG · 2

Tacrolimus → D00107 Y, D08556 Y

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

drug also transplant rejection used liver topical risk use include kidney calcineurin macrolide molecule one enzyme cyp3a5 cancer name prescribed

Tacrolimus relationships Subject–Predicate–Object triples

TTTA extracted 102 structured relationships around Tacrolimus. Examples in this analysis include Tacrolimus → 3D model (JSmol) → Interactive image and Tacrolimus → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Tacrolimus	3D model (JSmol)	Interactive image	1.00	infobox
Tacrolimus	AHFS/Drugs.com	Monograph	1.00	infobox
Tacrolimus	ATC code	D11AH01 (WHO) L04AD02 (WHO)	1.00	infobox
Tacrolimus	Bioavailability	24% (5–67%), less after eating food rich in fat	1.00	infobox
Tacrolimus	CAS Number	104987-11-3 Y	1.00	infobox
Tacrolimus	ChEBI	CHEBI:61049	1.00	infobox
Tacrolimus	ChEMBL	ChEMBL269732 Y	1.00	infobox
Tacrolimus	ChemSpider	393220 Y	1.00	infobox
Tacrolimus	CompTox Dashboard (EPA)	DTXSID5046354	1.00	infobox
Tacrolimus	DrugBank	DB00864 Y	1.00	infobox
Tacrolimus	ECHA InfoCard	100.155.367	1.00	infobox
Tacrolimus	Elimination half-life	11.3 h for transplant patients (range 3.5–40.6 h)	1.00	infobox
Tacrolimus	Excretion	Mostly fecal	1.00	infobox
Tacrolimus	Formula	C44H69NO12	1.00	infobox
Tacrolimus	KEGG	D08556 Y	1.00	infobox
Tacrolimus	KEGG	D00107 Y	1.00	infobox
Tacrolimus	Legal status	CA: ℞-only	1.00	infobox
Tacrolimus	Legal status	US: ℞-only	1.00	infobox
Tacrolimus	Legal status	EU: Rx-only	1.00	infobox
Tacrolimus	Legal status	In general: ℞ (Prescription only)	1.00	infobox
Tacrolimus	License data	US DailyMed: Tacrolimus	1.00	infobox
Tacrolimus	MedlinePlus	a601117	1.00	infobox
Tacrolimus	Metabolism	Liver CYP3A4, CYP3A5	1.00	infobox
Tacrolimus	Molar mass	804.031 g·mol−1	1.00	infobox
Tacrolimus	Other names	FK-506, fujimycin	1.00	infobox
Tacrolimus	PDB ligand	FK5 (PDBe, RCSB PDB)	1.00	infobox
Tacrolimus	Pregnancy category	AU: C	1.00	infobox
Tacrolimus	Protein binding	≥98.8%	1.00	infobox
Tacrolimus	PubChem CID	445643	1.00	infobox
Tacrolimus	Routes of administration	Topical, by mouth, intravenous	1.00	infobox

Related concept clusters Related term clusters

The concept neighborhoods around Tacrolimus bring nearby vocabulary together. In this analysis, examples include Concentrations, Topical and Use. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Tacrolimus
- Concentrations
- Topical
- Use
- Used
- Liver
- Also
- Approved
- Eczema
- Activity
- Cyp3a5
- Macrolide
- Us
tacrolimus
- Concentrations
- Topical
- Use
- Used
- Liver
- Also
- Approved
- Eczema
- Activity
- Cyp3a5
- Macrolide
- Us
organ transplant
- Liver
- Patients
- Treatment
- Cancer
- Kidney
- Include
- Use
- Bioavailability
- Prescribed
- Biosynthesis
- Concentrations
- Cyp3a5
international agency for research on cancer
- Risk
- Drugs
- Skin
- Liver
- Transplant
- Bioavailability
- Eczema
- Biosynthesis
- Cyp3a5
- Macrolide
- Name
- Number
lung cancer
- Risk
- Drugs
- Skin
- Liver
- Transplant
- Bioavailability
- Eczema
- Biosynthesis
- Cyp3a5
- Macrolide
- Name
- Number
liver transplantation
- Kidney
- Include
- Transplant
- Patients
- Skin
- Treatment
- Us
- Use
- Rejection
- Tacrolimus
- Approved
- Activity
immunosuppressive drug
- Fda
- Risk
- Transplant
- Concentrations
- Name
- Number
- Patients
- Tacrolimus
- Use
- Rejection
- Approved
- Bioavailability
skin cancers
- Cancer
- Liver
- Bioavailability
- Biosynthesis
- Cyp3a5
- Drugs
- Macrolide
- Number
- Patients
- Protein
- Similar
- Us

Connections between topic areas Semantic bridges

For Tacrolimus, one of the stronger structural bridges in this analysis connects Tacrolimus with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Tacrolimus — Overview · splits 111 ⟂ 33

Tacrolimus — Pharmacology · splits 116 ⟂ 28

Tacrolimus — Side effects · splits 123 ⟂ 21

Tacrolimus — Medical uses · splits 129 ⟂ 15

Tacrolimus — Contraindications and precautions · splits 131 ⟂ 13

Tacrolimus — History · splits 135 ⟂ 9

Tacrolimus — Biosynthesis · splits 137 ⟂ 7

Tacrolimus — Interactions · splits 139 ⟂ 5

Tacrolimus — Available forms · splits 139 ⟂ 5

Tacrolimus — Research · splits 139 ⟂ 5

Map overview Semantic statistics

Tacrolimus

Nodes144

Edges143

Triples102

Avg. degree1.99

Density0.013889

Components1

Source & methodology

TTTA analyzes the structure around Tacrolimus to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Tacrolimus · EN edition · Analysis: TopicsToTalkAbout

Tacrolimus: History, Applications & Research

Tacrolimus topic overview

What this topic covers Research coverage

Key facts & relationships

Start with your topic. Discover where to go next.

Questions to explore

Explore all related topics Closing gaps

Overview

History

Medical uses

Contraindications and precautions

Topical use

Side effects

Interactions

Pharmacology

Available forms

Biosynthesis

Research

For the semantics nerds

Advanced semantic analysis

How Tacrolimus connects Entity context

Tacrolimus

Top relations

Important terminology

Important terminology

Tacrolimus relationships Subject–Predicate–Object triples

Related concept clusters Related term clusters

Connections between topic areas Semantic bridges

Map overview Semantic statistics

Tacrolimus

Source & methodology