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Tacrolimus

Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After an allogenic organ transplant, the risk of organ rejection is moderate; tacrolimus is used to lower the risk of organ rejection. Tacrolimus is also sold as a topical medication for treating T cell-mediated diseases, such as eczema and psoriasis. For example…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
D11AH01 (WHO) L04AD02 (WHO)
Bioavailability
24% (5–67%), less after eating food rich in fat
CAS Number
104987-11-3 Y
ChEBI
CHEBI:61049

Topics to explore

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Overview

History

Medical uses

Contraindications and precautions

Topical use

Side effects

Interactions

Pharmacology

Available forms

Biosynthesis

Research

Advanced semantic analysis

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Map overview Semantic statistics

Tacrolimus

Nodes144
Edges143
Triples139
Avg. degree1.99
Density0.013889
Components1

How this topic connects Entity context

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Tacrolimus

Top relations

related to External links · 15
Tacrolimus → Archived, Drug Administration, FDA, FDA Approves New Use, Food, July, Medicine Medical Subject Headings, MedlinePlus, MeSH, National Library, Real-World Evidence, September, Tacrolimus Injection, Tacrolimus Topical, Transplant Drug Based
related to Pharmacogenetics · 14
Tacrolimus → Achieving, Across, African, Caucasian, CYP3A5, Genetic, However, In, NR1I2, PXR, SNP, Studies, The, There
related to Biosynthesis · 10
Tacrolimus → Acyl Carrier, Allylmalonyl-CoA, CoA, DHCHC, However, NRPS, Once, PKS, The, There
related to history · 10
Tacrolimus → Easter Island, FK-506, It, Japanese, Rapa Nui, Streptomyces, The, Thomas Starzl's, Tohru Kino, Tsukuba
related to Mechanism of action · 8
Tacrolimus → Although, Calcineurin, FK506, FKBP12, IL-2, In, NF-AT, This FKBP12
related to Pharmacokinetics · 8
Tacrolimus → All, Biological, Cmax, CYP3A, In, Oral, Taking, The
related to Organ transplantation · 6
Tacrolimus → Clinical, Dosages, IL-2, Immunosuppression, It, Long-term
related to Interactions · 5
Tacrolimus → Also, As, Interactions, Macrolide, P450
related to Skin · 5
Tacrolimus → An, As, Clinical, It, Recently
Legal status · 4
Tacrolimus → CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), US: ℞-only

Important terminology Word statistics

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Important terminology

drug also transplant rejection used liver topical risk use include kidney calcineurin macrolide molecule one enzyme cyp3a5 cancer name first

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Tacrolimus3D model (JSmol)Interactive image1.00infobox
TacrolimusAHFS/Drugs.comMonograph1.00infobox
TacrolimusATC codeD11AH01 (WHO) L04AD02 (WHO)1.00infobox
TacrolimusBioavailability24% (5–67%), less after eating food rich in fat1.00infobox
TacrolimusCAS Number104987-11-3 Y1.00infobox
TacrolimusChEBICHEBI:610491.00infobox
TacrolimusChEMBLChEMBL269732 Y1.00infobox
TacrolimusChemSpider393220 Y1.00infobox
TacrolimusCompTox Dashboard (EPA)DTXSID50463541.00infobox
TacrolimusDrugBankDB00864 Y1.00infobox
TacrolimusECHA InfoCard100.155.3671.00infobox
TacrolimusElimination half-life11.3 h for transplant patients (range 3.5–40.6 h)1.00infobox
TacrolimusExcretionMostly fecal1.00infobox
TacrolimusFormulaC44H69NO121.00infobox
TacrolimusKEGGD08556 Y1.00infobox
TacrolimusKEGGD00107 Y1.00infobox
TacrolimusLegal statusCA: ℞-only1.00infobox
TacrolimusLegal statusUS: ℞-only1.00infobox
TacrolimusLegal statusEU: Rx-only1.00infobox
TacrolimusLegal statusIn general: ℞ (Prescription only)1.00infobox
TacrolimusLicense dataUS DailyMed: Tacrolimus1.00infobox
TacrolimusMedlinePlusa6011171.00infobox
TacrolimusMetabolismLiver CYP3A4, CYP3A51.00infobox
TacrolimusMolar mass804.031 g·mol−11.00infobox
TacrolimusOther namesFK-506, fujimycin1.00infobox
TacrolimusPDB ligandFK5 (PDBe, RCSB PDB)1.00infobox
TacrolimusPregnancy categoryAU: C1.00infobox
TacrolimusProtein binding≥98.8%1.00infobox
TacrolimusPubChem CID4456431.00infobox
TacrolimusRoutes of administrationTopical, by mouth, intravenous1.00infobox

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