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Sunitinib

Sunitinib, sold under the brand name Sutent, is an anti-cancer medication. It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) in January 2006. Sunitinib was the first cancer drug…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01EX01 (WHO)
Bioavailability
Unaffected by food
CAS Number
557795-19-4 Y · as salt: 341031-54-7 Y
ChEBI
CHEBI:38940 Y

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Overview

Medical uses

Mechanism of action

History

Side effects

Interactions

Society and culture

Research

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Map overview Semantic statistics

Sunitinib

Nodes73
Edges72
Triples92
Avg. degree1.97
Density0.027397
Components1

How this topic connects Entity context

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Sunitinib

Top relations

related to Other solid tumors · 11
Sunitinib → Early, If, II, In, JIMT-1, KIT, NSCLC, PDGFR, Phase II, The, VEGFR2
related to Renal cell carcinoma · 10
Sunitinib → An, Before RTKs, However, IFNα, III, In, Objective, Patients, PFS, Renal
related to Economics · 6
Sunitinib → Doctors, February, Lipitor, November, Pfizer, Sutent
related to Gastrointestinal stromal tumor · 6
Sunitinib → Before, However, III, Imatinib, Like, This
related to Leukemia · 5
Sunitinib → FLT3, His, Louis, St, Washington University
related to Mechanism of action · 5
Sunitinib → PDGF-Rs, RTKs, The, These, VEGFRs
related to Pancreatic neuroendocrine tumors · 4
Sunitinib → European Union, In May, In November, USFDA
Legal status · 3
Sunitinib → AU: S4 (Prescription only), EU: Rx-only, US: ℞-only
has effect · 3
Sunitinib → In, Phase III GIST, The
CAS Number · 2
Sunitinib → 557795-19-4 Y, as salt: 341031-54-7 Y

Important terminology Word statistics

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Important terminology

patients cell metastatic treatment renal cancer tumors placebo disease adverse carcinoma study ifnα tumor sutent therapy gastrointestinal stromal progression events

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Sunitinib3D model (JSmol)Interactive image1.00infobox
SunitinibAHFS/Drugs.comMonograph1.00infobox
SunitinibATC codeL01EX01 (WHO)1.00infobox
SunitinibBioavailabilityUnaffected by food1.00infobox
SunitinibCAS Number557795-19-4 Y1.00infobox
SunitinibCAS Numberas salt: 341031-54-7 Y1.00infobox
SunitinibChEBICHEBI:38940 Y1.00infobox
SunitinibChEMBLChEMBL535 Y1.00infobox
SunitinibChEMBLas salt: ChEMBL15671.00infobox
SunitinibChemSpider4486264 Y1.00infobox
SunitinibChemSpideras salt: 49582541.00infobox
SunitinibCompTox Dashboard (EPA)DTXSID10411341.00infobox
SunitinibDrugBankDB01268 Y1.00infobox
SunitinibDrugBankas salt: DBSALT0001661.00infobox
SunitinibElimination half-life40 to 60 hours (sunitinib) 80 to 110 hours (metabolite)1.00infobox
SunitinibExcretionFecal (61%) and kidney (16%)1.00infobox
SunitinibFormulaC22H27FN4O21.00infobox
SunitinibIUPHAR/BPS57131.00infobox
SunitinibKEGGD08552 Y1.00infobox
SunitinibKEGGas salt: D064021.00infobox
SunitinibLegal statusAU: S4 (Prescription only)1.00infobox
SunitinibLegal statusUS: ℞-only1.00infobox
SunitinibLegal statusEU: Rx-only1.00infobox
SunitinibLicense dataUS DailyMed: Sunitinib1.00infobox
SunitinibMedlinePlusa6070521.00infobox
SunitinibMetabolismLiver (CYP3A4-mediated)1.00infobox
SunitinibMolar mass398.482 g·mol−11.00infobox
SunitinibOther namesSU112481.00infobox
SunitinibPregnancy categoryAU: D1.00infobox
SunitinibProtein binding95%1.00infobox

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