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ZEB1: Clinical significance & Overview

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.

Language: English [EN]
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ZEB1 topic overview

The analysis highlights Clinical significance and Overview as prominent areas in the source structure around ZEB1.

Related topics
14
Source areas
2
Connected nodes
16
Extracted relationships
113
Concept neighborhoods
12
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics
Clinical significance · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E19
Band
10p11.22 · 18 4.42 cM|18 A1
Bgee
Achilles tendon · epithelium of colon · decidua · optic nerve · glutes
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 18 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ZEB1 connects Entity context

The extracted context around ZEB1 shows recurring relationship patterns in the source. For example, ZEB1 → animal organ development, cartilage development, cell differentiation, cell population proliferation, cellular response to amino acid stimulus, central nervous system development, chromatin binding, cochlea morphogenesis, cytokine-mediated signaling pathway, cytosol, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, embryonic camera-type eye morphogenesis, embryonic morphogenesis, embryonic skeletal system morphogenesis, immune response, metal ion binding Another extracted example is ZEB1 → Achilles tendon, ascending aorta, biceps brachii, carotid body, decidua, endothelial cell, epithelium of colon, external carotid artery, glutes, Gonadal ridge, internal carotid artery, motor neuron, optic nerve, Rostral migratory stream, semi-lunar valve, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, substantia nigra, suprachiasmatic nucleus, tendon of biceps brachii. Use these groups to spot repeated connection types before inspecting the individual relationships.

ZEB1

Top relations

Gene ontology · 46
ZEB1 → animal organ development, cartilage development, cell differentiation, cell population proliferation, cellular response to amino acid stimulus, central nervous system development, chromatin binding, cochlea morphogenesis, cytokine-mediated signaling pathway, cytosol, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, embryonic camera-type eye morphogenesis, embryonic morphogenesis, embryonic skeletal system morphogenesis, immune response, metal ion binding
Bgee · 20
ZEB1 → Achilles tendon, ascending aorta, biceps brachii, carotid body, decidua, endothelial cell, epithelium of colon, external carotid artery, glutes, Gonadal ridge, internal carotid artery, motor neuron, optic nerve, Rostral migratory stream, semi-lunar valve, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, substantia nigra, suprachiasmatic nucleus, tendon of biceps brachii
RNA expression pattern · 20
ZEB1 → Achilles tendon, ascending aorta, biceps brachii, carotid body, decidua, endothelial cell, epithelium of colon, external carotid artery, glutes, Gonadal ridge, internal carotid artery, motor neuron, optic nerve, Rostral migratory stream, semi-lunar valve, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, substantia nigra, suprachiasmatic nucleus, tendon of biceps brachii
related to Clinical significance · 3
ZEB1 → E-cadherin, Mutations, Overexpression
Band · 2
ZEB1 → 10p11.22, 18 4.42 cM|18 A1
Chr. · 2
ZEB1 → Chromosome 10 (human), Chromosome 18 (mouse)
End · 2
ZEB1 → 31,529,814 bp, 5,775,467 bp
Aliases · 1
ZEB1 → ZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
Available structures · 1
ZEB1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E19
BioGPS · 1
ZEB1 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

zinc gene homeodomain bp chr finger human band protein chromosome 10 transcription binding external factor location mouse homeobox tcf8 expression

ZEB1 relationships Subject–Predicate–Object triples

TTTA extracted 113 structured relationships around ZEB1. Examples in this analysis include ZEB1 → Aliases → ZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A and ZEB1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E19. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ZEB1AliasesZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A1.00infobox
ZEB1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E191.00infobox
ZEB1Band10p11.221.00infobox
ZEB1Band18 4.42 cM|18 A11.00infobox
ZEB1BgeeAchilles tendon1.00infobox
ZEB1Bgeeepithelium of colon1.00infobox
ZEB1Bgeedecidua1.00infobox
ZEB1Bgeeoptic nerve1.00infobox
ZEB1Bgeeglutes1.00infobox
ZEB1Bgeeendothelial cell1.00infobox
ZEB1BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
ZEB1Bgeebiceps brachii1.00infobox
ZEB1Bgeetendon of biceps brachii1.00infobox
ZEB1BgeeSkeletal muscle tissue of biceps brachii1.00infobox
ZEB1Bgeeinternal carotid artery1.00infobox
ZEB1Bgeesubstantia nigra1.00infobox
ZEB1Bgeemotor neuron1.00infobox
ZEB1Bgeeexternal carotid artery1.00infobox
ZEB1Bgeesemi-lunar valve1.00infobox
ZEB1Bgeecarotid body1.00infobox
ZEB1Bgeeascending aorta1.00infobox
ZEB1BgeeRostral migratory stream1.00infobox
ZEB1Bgeesuprachiasmatic nucleus1.00infobox
ZEB1BgeeGonadal ridge1.00infobox
ZEB1BioGPSMore reference expression data1.00infobox
ZEB1Chr.Chromosome 10 (human)1.00infobox
ZEB1Chr.Chromosome 18 (mouse)1.00infobox
ZEB1DatabasesNCBI: entry; OMA: entry1.00infobox
ZEB1End31,529,814 bp1.00infobox
ZEB1End5,775,467 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ZEB1 bring nearby vocabulary together. In this analysis, examples include Zinc, Gene and Binding. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • ZEB1
    • Zinc
    • Gene
    • Binding
    • Factor
    • Transcription
    • Homeodomain
    • Development
    • E-box
    • Epithelial
    • Expression
    • External
    • Mesenchymal
  • zeb1
    • Zinc
    • Gene
    • Binding
    • Factor
    • Transcription
    • Homeodomain
    • Development
    • E-box
    • Epithelial
    • Expression
    • External
    • Mesenchymal
  • protein
    • Zinc
    • Zeb1
    • Gene
    • Cm
    • Development
    • E-box
    • End
    • Epithelial
    • Expression
    • External
    • Mesenchymal
    • Mouse
  • gene
    • Binding
    • Location
    • Zinc
    • Chromosome
    • Human
    • Zeb1
    • Bp
    • Chr
    • Cm
    • E-box
    • End
    • Expression
  • zinc finger
    • Zeb1
    • Finger
    • Zinc
    • Gene
    • Binding
    • Homeobox
    • Protein
    • Tcf8
    • Transcription
    • Homeodomain
    • E-box
    • Expression
  • transcription factor
    • Expression
    • Negative
    • Binding
    • Factor
    • Transcription
    • Zinc
    • Zeb1
    • Gene
    • Il2
    • Paralog
    • Zeb2
    • Cm
  • transcription start site
    • Expression
    • Negative
    • Binding
    • Factor
    • Zinc
    • Zeb1
    • Il2
    • Paralog
    • Zeb2
    • Cm
    • Development
    • E-box
  • epithelial to mesenchymal transition
    • Epithelial
    • Mesenchymal
    • Expression
    • External
    • Mouse
    • Negative
    • Search
    • Factor
    • Location
    • Protein
    • Transcription
    • Zeb1

Connections between topic areas Semantic bridges

For ZEB1, one of the stronger structural bridges in this analysis connects ZEB1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ZEB1Overview · splits 7 ⟂ 10
ZEB1Clinical significance · splits 11 ⟂ 6

Map overview Semantic statistics

ZEB1

Nodes17
Edges16
Triples113
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around ZEB1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ZEB1 · EN edition · Analysis: TopicsToTalkAbout

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