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Reserpine

Reserpine is a drug that is used for the treatment of high blood pressure, usually in combination with a thiazide diuretic or vasodilator. Large clinical trials have shown that combined treatment with reserpine plus a thiazide diuretic reduces mortality of people with hypertension. Although the use of reserpine as a solo drug has declined since it was…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Consumer Drug Information
ATC code
C02AA02 (WHO)
Bioavailability
50%
CAS Number
50-55-5 Y
ChEBI
CHEBI:28487 Y

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Overview

Medical uses

Adverse effects

Mechanism of action

Biosynthetic pathway

History

Veterinary use

Research

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Map overview Semantic statistics

Reserpine

Nodes65
Edges64
Triples83
Avg. degree1.97
Density0.030769
Components1

How this topic connects Entity context

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Reserpine

Top relations

related to history · 17
Reserpine → Although, India, Indian, It, Its, Mahatma Gandhi, MAOIs, Notably, Rauvolfia, Reserpine-induced, Robert Wallace Wilkins, Sarpagandha, SNRIs, SSRIs, The, United States, Woodward
related to Medical uses · 12
Reserpine → ALLHAT, Anti-hypertensive Agents, Cochrane, Elderly Program, Follow-up Program, Group, JNC, Moreover, Systolic Hypertension, The, The Hypertension Detection, Veterans Administration Cooperative Study
related to Mechanism of action · 8
Reserpine → As, COMT, MAO, Thus, Unprotected, VMAT1, VMAT2, VMATs
related to External links · 6
Reserpine → Biotechnology Information, NLM Hazardous Substances Databank, Reserpine Indoloquinolizidine, Reserpine National Center, ReserpinePubChem Substance Summary, The Stork Synthesis
has effect · 4
Reserpine → At, Congested, Staphylococcus, The
related to Biosynthetic pathway · 4
Reserpine → In, Rauvolfia, Tryptamine, Various
related to Animal model of depression and amotivation · 2
Reserpine → Similarly, This
3D model (JSmol) · 1
Reserpine → Interactive image
AHFS/Drugs.com · 1
Reserpine → Consumer Drug Information
ATC code · 1
Reserpine → C02AA02 (WHO)

Important terminology Word statistics

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Important terminology

treatment effects drug used doses antihypertensive neurotransmitters depression monoamine mg thiazide blood pressure diuretic adverse patients combination combined vmat2 shown

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Reserpine3D model (JSmol)Interactive image1.00infobox
ReserpineAHFS/Drugs.comConsumer Drug Information1.00infobox
ReserpineATC codeC02AA02 (WHO)1.00infobox
ReserpineBioavailability50%1.00infobox
ReserpineCAS Number50-55-5 Y1.00infobox
ReserpineChEBICHEBI:28487 Y1.00infobox
ReserpineChEMBLChEMBL772 Y1.00infobox
ReserpineChemSpider5566 Y1.00infobox
ReserpineCompTox Dashboard (EPA)DTXSID70212371.00infobox
ReserpineDrug classMonoamine-depleting agent, antihypertensive1.00infobox
ReserpineDrugBankDB00206 Y1.00infobox
ReserpineECHA InfoCard100.000.0441.00infobox
ReserpineElimination half-lifephase 1 = 4.5h, phase 2 = 271h, average = 33h1.00infobox
ReserpineExcretion62% feces / 8% urine1.00infobox
ReserpineFormulaC33H40N2O91.00infobox
ReserpineIUPHAR/BPS48231.00infobox
ReserpineKEGGD00197 Y1.00infobox
ReserpineLegal statusRx-only (banned/discontinued in some countries)1.00infobox
ReserpineLicense dataUS FDA: Reserpine1.00infobox
ReserpineMedlinePlusa6011071.00infobox
ReserpineMetabolismgut/liver1.00infobox
ReserpineMolar mass608.688 g·mol−11.00infobox
ReserpinePregnancy categoryC1.00infobox
ReserpinePubChem CID57701.00infobox
ReserpineRoutes of administrationOral1.00infobox
ReserpineTrade namesSerpasil, others1.00infobox
ReserpineUNII8B1QWR724A1.00infobox
Reserpinecausesbreast cancer in women0.90text
Reserpineis adrug that is used for the treatment of high blood pressure0.90text

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