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Reserpine: History, Applications & Research

Reserpine is a drug that is used for the treatment of high blood pressure, usually in combination with a thiazide diuretic or vasodilator. Large clinical trials have shown that combined treatment with reserpine plus a thiazide diuretic reduces mortality of people with hypertension. Although the use of reserpine as a solo drug has declined since it was…

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Reserpine topic overview

The analysis highlights History, Applications and Research as prominent areas in the source structure around Reserpine.

Related topics
56
Source areas
8
Connected nodes
64
Extracted relationships
83
Concept neighborhoods
19
Bridge connections
64

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

History · 18 topics
Mechanism of action · 12 topics
Overview · 9 topics
Research · 7 topics
Medical uses · 4 topics
Biosynthetic pathway · 3 topics
Adverse effects · 2 topics
Veterinary use · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Consumer Drug Information
ATC code
C02AA02 (WHO)
Bioavailability
50%
CAS Number
50-55-5 Y
ChEBI
CHEBI:28487 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Mechanism of action

Biosynthetic pathway

History

Veterinary use

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Reserpine connects Entity context

The extracted context around Reserpine shows recurring relationship patterns in the source. For example, Reserpine → Although, India, Indian, It, Its, Mahatma Gandhi, MAOIs, Notably, Rauvolfia, Reserpine-induced, Robert Wallace Wilkins, Sarpagandha, SNRIs, SSRIs, The, United States, Woodward Another extracted example is Reserpine → ALLHAT, Anti-hypertensive Agents, Cochrane, Elderly Program, Follow-up Program, Group, JNC, Moreover, Systolic Hypertension, The, The Hypertension Detection, Veterans Administration Cooperative Study. Use these groups to spot repeated connection types before inspecting the individual relationships.

Reserpine

Top relations

related to history · 17
Reserpine → Although, India, Indian, It, Its, Mahatma Gandhi, MAOIs, Notably, Rauvolfia, Reserpine-induced, Robert Wallace Wilkins, Sarpagandha, SNRIs, SSRIs, The, United States, Woodward
related to Medical uses · 12
Reserpine → ALLHAT, Anti-hypertensive Agents, Cochrane, Elderly Program, Follow-up Program, Group, JNC, Moreover, Systolic Hypertension, The, The Hypertension Detection, Veterans Administration Cooperative Study
related to Mechanism of action · 8
Reserpine → As, COMT, MAO, Thus, Unprotected, VMAT1, VMAT2, VMATs
related to External links · 6
Reserpine → Biotechnology Information, NLM Hazardous Substances Databank, Reserpine Indoloquinolizidine, Reserpine National Center, ReserpinePubChem Substance Summary, The Stork Synthesis
has effect · 4
Reserpine → At, Congested, Staphylococcus, The
related to Biosynthetic pathway · 4
Reserpine → In, Rauvolfia, Tryptamine, Various
related to Animal model of depression and amotivation · 2
Reserpine → Similarly, This
3D model (JSmol) · 1
Reserpine → Interactive image
AHFS/Drugs.com · 1
Reserpine → Consumer Drug Information
ATC code · 1
Reserpine → C02AA02 (WHO)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

treatment effects drug used doses antihypertensive neurotransmitters depression monoamine mg thiazide blood pressure diuretic adverse patients combination combined vmat2 shown

Reserpine relationships Subject–Predicate–Object triples

TTTA extracted 83 structured relationships around Reserpine. Examples in this analysis include Reserpine → 3D model (JSmol) → Interactive image and Reserpine → AHFS/Drugs.com → Consumer Drug Information. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Reserpine3D model (JSmol)Interactive image1.00infobox
ReserpineAHFS/Drugs.comConsumer Drug Information1.00infobox
ReserpineATC codeC02AA02 (WHO)1.00infobox
ReserpineBioavailability50%1.00infobox
ReserpineCAS Number50-55-5 Y1.00infobox
ReserpineChEBICHEBI:28487 Y1.00infobox
ReserpineChEMBLChEMBL772 Y1.00infobox
ReserpineChemSpider5566 Y1.00infobox
ReserpineCompTox Dashboard (EPA)DTXSID70212371.00infobox
ReserpineDrug classMonoamine-depleting agent, antihypertensive1.00infobox
ReserpineDrugBankDB00206 Y1.00infobox
ReserpineECHA InfoCard100.000.0441.00infobox
ReserpineElimination half-lifephase 1 = 4.5h, phase 2 = 271h, average = 33h1.00infobox
ReserpineExcretion62% feces / 8% urine1.00infobox
ReserpineFormulaC33H40N2O91.00infobox
ReserpineIUPHAR/BPS48231.00infobox
ReserpineKEGGD00197 Y1.00infobox
ReserpineLegal statusRx-only (banned/discontinued in some countries)1.00infobox
ReserpineLicense dataUS FDA: Reserpine1.00infobox
ReserpineMedlinePlusa6011071.00infobox
ReserpineMetabolismgut/liver1.00infobox
ReserpineMolar mass608.688 g·mol−11.00infobox
ReserpinePregnancy categoryC1.00infobox
ReserpinePubChem CID57701.00infobox
ReserpineRoutes of administrationOral1.00infobox
ReserpineTrade namesSerpasil, others1.00infobox
ReserpineUNII8B1QWR724A1.00infobox
Reserpinecausesbreast cancer in women0.90text
Reserpineis adrug that is used for the treatment of high blood pressure0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Reserpine bring nearby vocabulary together. In this analysis, examples include Monoamine, Effects and Patients. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Reserpine
    • Monoamine
    • Effects
    • Patients
    • Treatment
    • Used
    • Adverse
    • Diuretic
    • Found
    • Review
    • Shown
    • Thiazide
    • Blood
  • reserpine
    • Monoamine
    • Effects
    • Patients
    • Treatment
    • Used
    • Adverse
    • Diuretic
    • Found
    • Review
    • Shown
    • Thiazide
    • Blood
  • high blood pressure
    • Pressure
    • Lowering
    • Vasodilator
    • Treatment
    • Diuretic
    • Thiazide
    • Patients
    • Antihypertensive
    • Drug
    • Effective
    • Use
    • Combination
  • adverse effects
    • Day
    • Nasal
    • Adverse
    • Effects
    • Mg
    • Doses
    • Found
    • Review
    • Effective
    • Hypertension
    • Neurotransmitters
    • Reserpine
  • clinical depression
    • Evidence
    • Causes
    • Monoamine
    • Hypertension
    • Use
    • May
    • Reserpine
    • Review
    • Shown
    • Patients
    • Pressure
    • Neurotransmitters
  • depression
    • Evidence
    • Causes
    • Monoamine
    • Hypertension
    • Use
    • May
    • Reserpine
    • Review
    • Shown
    • Patients
    • Pressure
    • Neurotransmitters
  • systematic review
    • Found
    • Effective
    • Effects
    • Lowering
    • Adverse
    • Causes
    • Evidence
    • Blood
    • Patients
    • Pressure
    • Reserpine
    • Antihypertensive
  • thiazide
    • Vasodilator
    • Hypertension
    • Trials
    • Combined
    • Shown
    • Treatment
    • Lowering
    • Use
    • First
    • Patients
    • Used

Connections between topic areas Semantic bridges

For Reserpine, one of the stronger structural bridges in this analysis connects Reserpine with History. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Reserpine — History · splits 46 ⟂ 19
Reserpine — Mechanism of action · splits 52 ⟂ 13
Reserpine — Overview · splits 55 ⟂ 10
Reserpine — Research · splits 57 ⟂ 8
Reserpine — Medical uses · splits 60 ⟂ 5
Reserpine — Biosynthetic pathway · splits 61 ⟂ 4
Reserpine — Adverse effects · splits 62 ⟂ 3

Map overview Semantic statistics

Reserpine

Nodes65
Edges64
Triples83
Avg. degree1.97
Density0.030769
Components1

Source & methodology

TTTA analyzes the structure around Reserpine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Reserpine · EN edition · Analysis: TopicsToTalkAbout

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