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Tipranavir

Tipranavir (TPV) is a nonpeptidic HIV-1 protease inhibitor manufactured by Boehringer Ingelheim under the trade name Aptivus. It is used as part of combination antiretroviral therapy for treatment-experienced patients with HIV-1 infection whose virus is resistant to more than one protease inhibitor. It is not approved for treatment-naïve patients.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J05AE09 (WHO)
CAS Number
174484-41-4 Y
ChEMBL
ChEMBL183041 N
ChemSpider
10482313 Y

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Map overview Semantic statistics

Tipranavir

Nodes17
Edges16
Triples35
Avg. degree1.88
Density0.117647
Components1

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Tipranavir

Top relations

related to External links · 5
Tipranavir → Archived, August, Drug Information Portal, Medicine, National Library
Legal status · 3
Tipranavir → EU: Rx-only, UK: POM (Prescription only), US: ℞-only
License data · 3
Tipranavir → EU EMA: by INN, US DailyMed: Tipranavir, US FDA: Tipranavir
3D model (JSmol) · 1
Tipranavir → Interactive image
AHFS/Drugs.com · 1
Tipranavir → Monograph
ATC code · 1
Tipranavir → J05AE09 (WHO)
CAS Number · 1
Tipranavir → 174484-41-4 Y
ChEMBL · 1
Tipranavir → ChEMBL183041 N
ChemSpider · 1
Tipranavir → 10482313 Y
CompTox Dashboard (EPA) · 1
Tipranavir → DTXSID6048622

Important terminology Word statistics

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Important terminology

patients protease drug hiv-1 aptivus inhibitor ritonavir hepatotoxicity used combination antiretroviral therapy treatment-experienced resistant approved resistance june salvage current side

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Tipranavir3D model (JSmol)Interactive image1.00infobox
TipranavirAHFS/Drugs.comMonograph1.00infobox
TipranavirATC codeJ05AE09 (WHO)1.00infobox
TipranavirCAS Number174484-41-4 Y1.00infobox
TipranavirChEMBLChEMBL183041 N1.00infobox
TipranavirChemSpider10482313 Y1.00infobox
TipranavirCompTox Dashboard (EPA)DTXSID60486221.00infobox
TipranavirDrugBankDB00932 Y1.00infobox
TipranavirECHA InfoCard100.158.0661.00infobox
TipranavirElimination half-life4.8–6 hours1.00infobox
TipranavirExcretionFeces (82.3%), urine (4.4%)1.00infobox
TipranavirFormulaC31H33F3N2O5S1.00infobox
TipranavirLegal statusUK: POM (Prescription only)1.00infobox
TipranavirLegal statusUS: ℞-only1.00infobox
TipranavirLegal statusEU: Rx-only1.00infobox
TipranavirLicense dataEU EMA: by INN1.00infobox
TipranavirLicense dataUS DailyMed: Tipranavir1.00infobox
TipranavirLicense dataUS FDA: Tipranavir1.00infobox
TipranavirMedlinePlusa6060091.00infobox
TipranavirMetabolismLiver1.00infobox
TipranavirMolar mass602.67 g·mol−11.00infobox
TipranavirNIAID ChemDB0329411.00infobox
TipranavirPDB ligandTPV (PDBe, RCSB PDB)1.00infobox
TipranavirPregnancy categoryAU: B31.00infobox
TipranavirPronunciation/tɪpˈrænəvɪər/ tip-RAN-ə-veer1.00infobox
TipranavirProtein binding99.9%1.00infobox
TipranavirPubChem CID546824611.00infobox
TipranavirRoutes of administrationBy mouth (soft capsules)1.00infobox
TipranavirTrade namesAptivus (AP-tiv-əs)1.00infobox
TipranavirUNIIZZT404XD091.00infobox

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