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Quinidine: History, Applications & Art

Quinidine is a class IA antiarrhythmic agent used to treat heart rhythm disturbances. It is a diastereomer of antimalarial agent quinine, originally derived from the bark of the cinchona tree. The drug causes increased action potential duration, as well as a prolonged QT interval. As of 2019, its IV formulation is no longer being manufactured for use in…

Language: English [EN]
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Quinidine topic overview

The analysis highlights History, Applications and Art as prominent areas in the source structure around Quinidine.

Related topics
72
Source areas
6
Connected nodes
78
Extracted relationships
70
Concept neighborhoods
23
Bridge connections
78

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 27 topics
Side effects · 15 topics
Pharmacology · 14 topics
Medical uses · 12 topics
History · 3 topics
Chemistry · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C01BA01 (WHO)
Bioavailability
70–85%
CAS Number
56-54-2 Y
ChEBI
CHEBI:28593 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Pharmacology

History

Chemistry

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Quinidine connects Entity context

The extracted context around Quinidine shows recurring relationship patterns in the source. For example, Quinidine → As, France, Herzens, It, Jean-Baptiste, Louis XV, Opium, Sénac, The Another extracted example is Quinidine → Inhibition, It, Kv1, Kv4, M3, Nav1. Use these groups to spot repeated connection types before inspecting the individual relationships.

Quinidine

Top relations

related to history · 9
Quinidine → As, France, Herzens, It, Jean-Baptiste, Louis XV, Opium, Sénac, The
related to Pharmacodynamics · 6
Quinidine → Inhibition, It, Kv1, Kv4, M3, Nav1
Legal status · 4
Quinidine → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only
has effect · 4
Quinidine → P-glycoprotein, P450, Quinidine-induced, Torsades
related to Other uses · 4
Quinidine → Although, Plasmodium, The, There
related to Chemistry · 3
Quinidine → AD-mix-β, Quinidine-based, Sharpless
related to Medical uses · 2
Quinidine → Brugada Syndrome, It
3D model (JSmol) · 1
Quinidine → Interactive image
AHFS/Drugs.com · 1
Quinidine → Monograph
ATC code · 1
Quinidine → C01BA01 (WHO)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

used agent effects also heart action one antiarrhythmic use class treat qt antimalarial cinchona quinine elimination atrial lead low dose

Quinidine relationships Subject–Predicate–Object triples

TTTA extracted 70 structured relationships around Quinidine. Examples in this analysis include Quinidine → 3D model (JSmol) → Interactive image and Quinidine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Quinidine3D model (JSmol)Interactive image1.00infobox
QuinidineAHFS/Drugs.comMonograph1.00infobox
QuinidineATC codeC01BA01 (WHO)1.00infobox
QuinidineBioavailability70–85%1.00infobox
QuinidineCAS Number56-54-2 Y1.00infobox
QuinidineChEBICHEBI:28593 Y1.00infobox
QuinidineChEMBLChEMBL97 N1.00infobox
QuinidineChemSpider389880 Y1.00infobox
QuinidineCompTox Dashboard (EPA)DTXSID40235491.00infobox
QuinidineDrugBankDB00908 Y1.00infobox
QuinidineECHA InfoCard100.000.2541.00infobox
QuinidineElimination half-life6–8 hours1.00infobox
QuinidineExcretionBy the liver (20% as unchanged quinidine via urine)1.00infobox
QuinidineFormulaC20H24N2O21.00infobox
QuinidineIUPHAR/BPS23421.00infobox
QuinidineKEGGD08458 N1.00infobox
QuinidineLegal statusAU: S4 (Prescription only)1.00infobox
QuinidineLegal statusCA: ℞-only1.00infobox
QuinidineLegal statusUK: POM (Prescription only)1.00infobox
QuinidineLegal statusUS: ℞-only1.00infobox
QuinidineMetabolism50–90% (by liver)1.00infobox
QuinidineMolar mass324.424 g·mol−11.00infobox
QuinidineOther names(2-Ethenyl-4-azabicyclo[2.2.2]oct-5-yl)-(6-methoxyquinolin-4-yl)-methanol1.00infobox
QuinidinePregnancy categoryAU: C1.00infobox
QuinidinePubChem CID4410741.00infobox
QuinidineRoutes of administrationBy mouth, intramuscular injection, intravenous1.00infobox
QuinidineTrade namesQuinaglute, Quinidex1.00infobox
QuinidineUNIIITX08688JL1.00infobox
Quinidineis aclass IA antiarrhythmic agent used to treat heart rhythm disturbances0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Quinidine bring nearby vocabulary together. In this analysis, examples include Used, Also and Treat. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Quinidine
    • Used
    • Also
    • Treat
    • Channels
    • Syndrome
    • Uncertain
    • Dose
    • Low
    • Use
    • Effects
    • Elimination
    • Rhythm
  • quinidine
    • Used
    • Also
    • Treat
    • Channels
    • Syndrome
    • Uncertain
    • Dose
    • Low
    • Use
    • Effects
    • Elimination
    • Rhythm
  • class ia antiarrhythmic agent
    • Antiarrhythmic
    • Class
    • Agent
    • Uncertain
    • Used
    • Treat
    • Action
    • Effects
    • Elimination
    • Rhythm
    • Arrhythmias
    • Current
  • cardiac action potential
    • Interval
    • Potential
    • Effect
    • Qt
    • Cardiac
    • Causes
    • Agent
    • Channels
    • Current
    • Inward
    • Sodium
    • Cinchona
  • antimalarial agent
    • Class
    • Antiarrhythmic
    • Uncertain
    • Used
    • Iv
    • Treat
    • Action
    • Bark
    • Channels
    • Cinchona
    • Quinine
    • Effects
  • action potential
    • Interval
    • Potential
    • Effect
    • Qt
    • Cardiac
    • Causes
    • Agent
    • Channels
    • Current
    • Inward
    • Sodium
    • Elimination
  • antiarrhythmic agents
    • Class
    • Agent
    • Effects
    • Used
    • Elimination
    • Rhythm
    • Quinidine
    • Arrhythmias
    • Current
    • Inward
    • Sodium
    • Syndrome
  • side effects
    • Elimination
    • Arrhythmias
    • Fibrillation
    • Increased
    • Syndrome
    • System
    • Two
    • Uncertain
    • Quinidine
    • Atrial
    • Cardiac
    • Lead

Connections between topic areas Semantic bridges

For Quinidine, one of the stronger structural bridges in this analysis connects Quinidine with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Quinidine — Overview · splits 51 ⟂ 28
Quinidine — Side effects · splits 63 ⟂ 16
Quinidine — Pharmacology · splits 64 ⟂ 15
Quinidine — Medical uses · splits 66 ⟂ 13
Quinidine — History · splits 75 ⟂ 4

Map overview Semantic statistics

Quinidine

Nodes79
Edges78
Triples70
Avg. degree1.97
Density0.025316
Components1

Source & methodology

TTTA analyzes the structure around Quinidine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Art, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Quinidine · EN edition · Analysis: TopicsToTalkAbout

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