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Verapamil

Verapamil, sold under various trade names, is a calcium channel blocker medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia. It may also be used for the prevention of migraines and cluster headaches. It is given by mouth or by injection into a vein.

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C08DA01 (WHO)
Bioavailability
35.1%
CAS Number
52-53-9 Y
ChEBI
CHEBI:9948 Y

Topics to explore

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Overview

Medical uses

Contraindications

Side effects

Mechanism of action

Pharmacokinetic details

Uses in cell biology

Advanced semantic analysis

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Map overview Semantic statistics

Verapamil

Nodes104
Edges103
Triples87
Avg. degree1.98
Density0.019231
Components1

How this topic connects Entity context

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Verapamil

Top relations

related to Pharmacokinetic details · 10
Verapamil → As, Because, Biphasic, It, IV, L/kg, More, Onset, Plasma, This
related to Uses in cell biology · 10
Verapamil → ABC, ATP-binding, CSC, DNA, DNA-binding, Hoechst, It, P-glycoprotein, Radioactively, This
related to Mechanism of action · 7
Verapamil → AV, In, IV, Kv, Since, Specific, Verapamil's
Legal status · 4
Verapamil → EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
has effect · 4
Verapamil → Along, Other, The, While
related to Contraindications · 4
Verapamil → Hg, It, Use, Wolff-Parkinson-White
related to Cluster headaches · 3
Verapamil → CGRP-release, CGRPs, Preventive
related to Medical uses · 3
Verapamil → Prinzmetal, PSVT, SVT
related to Overdose · 3
Verapamil → Acute, Blood, Plasma
KEGG · 2
Verapamil → as HCl: D00619 Y, D02356 Y

Important terminology Word statistics

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Important terminology

used calcium blood channel also heart use side pressure cell effects blocker angina plasma may rate include medication medical drug

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Verapamil3D model (JSmol)Interactive image1.00infobox
VerapamilAHFS/Drugs.comMonograph1.00infobox
VerapamilATC codeC08DA01 (WHO)1.00infobox
VerapamilBioavailability35.1%1.00infobox
VerapamilCAS Number52-53-9 Y1.00infobox
VerapamilChEBICHEBI:9948 Y1.00infobox
VerapamilChEMBLChEMBL6966 Y1.00infobox
VerapamilChemSpider2425 Y1.00infobox
VerapamilChiralityRacemic mixture1.00infobox
VerapamilCompTox Dashboard (EPA)DTXSID90411521.00infobox
VerapamilDrug classCalcium channel blocker1.00infobox
VerapamilDrugBankDB00661 Y1.00infobox
VerapamilECHA InfoCard100.000.1331.00infobox
VerapamilElimination half-life2.8–7.4 hours1.00infobox
VerapamilExcretionKidney: 11%1.00infobox
VerapamilFormulaC27H38N2O41.00infobox
VerapamilIUPHAR/BPS24061.00infobox
VerapamilKEGGD02356 Y1.00infobox
VerapamilKEGGas HCl: D00619 Y1.00infobox
VerapamilLegal statusUK: POM (Prescription only)1.00infobox
VerapamilLegal statusUS: ℞-only1.00infobox
VerapamilLegal statusEU: Rx-only1.00infobox
VerapamilLegal statusIn general: ℞ (Prescription only)1.00infobox
VerapamilLicense dataUS DailyMed: Verapamil1.00infobox
VerapamilMedlinePlusa6840301.00infobox
VerapamilMetabolismLiver1.00infobox
VerapamilMolar mass454.611 g·mol−11.00infobox
VerapamilOnset of action1 to 2 hours (oral); 3 to 5 minutes (IV bolus)1.00infobox
VerapamilPregnancy categoryAU: C1.00infobox
VerapamilPronunciation/vɛˈræpəmɪl/ ve-RAP-ə-mil1.00infobox

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