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Indinavir

Indinavir (IDV; trade name Crixivan, made by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS. It is soluble white powder administered orally in combination with other antiviral drugs. The drug prevents protease from functioning normally. Consequently, HIV viruses cannot reproduce, causing a…

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History

Edward ScolnickWest Point, PennsylvaniaReninBruce D. DorseyJames P. Guare
14 related topics

Side effects

FatigueKidney stonesKidney failureMetabolicHyperlipidemia
14 related topics

Medical uses

AZT
1 related topics

Clinical trials

Lamivudine
1 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J05AE02 (WHO)
Bioavailability
~65%
CAS Number
150378-17-9 Y
ChEBI
CHEBI:44032 Y

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Overview

Medical uses

Side effects

History

Clinical trials

Advanced semantic analysis

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Map overview Semantic statistics

Indinavir

Nodes43
Edges42
Triples87
Avg. degree1.95
Density0.046512
Components1

How this topic connects Entity context

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Indinavir

Top relations

has effect · 9
Indinavir → Bilirubin, Crix, Gastrointestinal, General, HIV-negative, Impairs, Increased, Renal, The
related to ACTG 320 · 9
Indinavir → After, AZT, CD4, Just, Patients, Study, The, There, This
related to Chemical properties · 8
Indinavir → As, Each, Eventually, HIV, It, Its, The, These
related to Medical uses · 7
Indinavir → Commercially, HIV, HIV/AIDS, It, Merck, The, Therefore
related to Distribution · 6
Indinavir → Because, Merck, Stadtalnder's Pharmacy, They, This, Veteran Administration's
related to Price · 6
Indinavir → Activists, Because, In, Invirase, Merck, Norvir
related to Clinical trials · 5
Indinavir → Co, HIV, In January, Merck, They
related to Study 035 · 5
Indinavir → After, AZT, CD4, Eligible, The
related to Viral resistance · 5
Indinavir → AZT, In, Many, This, Viral
3D model (JSmol) · 1
Indinavir → Interactive image

Important terminology Word statistics

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Important terminology

drug protease hiv drugs viral aids merck treatment one patients users virus azt study research used load development lamivudine people

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Indinavir3D model (JSmol)Interactive image1.00infobox
IndinavirAHFS/Drugs.comMonograph1.00infobox
IndinavirATC codeJ05AE02 (WHO)1.00infobox
IndinavirBioavailability~65%1.00infobox
IndinavirCAS Number150378-17-9 Y1.00infobox
IndinavirChEBICHEBI:44032 Y1.00infobox
IndinavirChEMBLChEMBL540914 N1.00infobox
IndinavirChemSpider4515036 Y1.00infobox
IndinavirCompTox Dashboard (EPA)DTXSID40438021.00infobox
IndinavirDrugBankDB00224 Y1.00infobox
IndinavirElimination half-life1.8 ± 0.4 hours1.00infobox
IndinavirFormulaC36H47N5O41.00infobox
IndinavirKEGGC07051 Y1.00infobox
IndinavirLicense dataUS FDA: Indinavir1.00infobox
IndinavirMedlinePlusa6960281.00infobox
IndinavirMetabolismHepatic via CYP3A41.00infobox
IndinavirMolar mass613.803 g·mol−11.00infobox
IndinavirNIAID ChemDB0058241.00infobox
IndinavirPDB ligandMK1 (PDBe, RCSB PDB)1.00infobox
IndinavirProtein binding60%1.00infobox
IndinavirPubChem CID53624401.00infobox
IndinavirRoutes of administrationOral1.00infobox
IndinavirTrade namesCrixivan1.00infobox
IndinavirUNII9MG78X43ZT1.00infobox

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