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Indinavir: History, Applications & Companies

Indinavir (IDV; trade name Crixivan, made by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS. It is soluble white powder administered orally in combination with other antiviral drugs. The drug prevents protease from functioning normally. Consequently, HIV viruses cannot reproduce, causing a…

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Indinavir topic overview

The analysis highlights History, Applications and Companies as prominent areas in the source structure around Indinavir.

Related topics
37
Source areas
5
Connected nodes
42
Extracted relationships
87
Concept neighborhoods
15
Bridge connections
42

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

History · 14 topics
Side effects · 14 topics
Overview · 7 topics
Clinical trials · 1 topics
Medical uses · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J05AE02 (WHO)
Bioavailability
~65%
CAS Number
150378-17-9 Y
ChEBI
CHEBI:44032 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

History

Clinical trials

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Indinavir connects Entity context

The extracted context around Indinavir shows recurring relationship patterns in the source. For example, Indinavir → Bilirubin, Crix, Gastrointestinal, General, HIV-negative, Impairs, Increased, Renal, The Another extracted example is Indinavir → After, AZT, CD4, Just, Patients, Study, The, There, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Indinavir

Top relations

has effect · 9
Indinavir → Bilirubin, Crix, Gastrointestinal, General, HIV-negative, Impairs, Increased, Renal, The
related to ACTG 320 · 9
Indinavir → After, AZT, CD4, Just, Patients, Study, The, There, This
related to Chemical properties · 8
Indinavir → As, Each, Eventually, HIV, It, Its, The, These
related to Medical uses · 7
Indinavir → Commercially, HIV, HIV/AIDS, It, Merck, The, Therefore
related to Distribution · 6
Indinavir → Because, Merck, Stadtalnder's Pharmacy, They, This, Veteran Administration's
related to Price · 6
Indinavir → Activists, Because, In, Invirase, Merck, Norvir
related to Clinical trials · 5
Indinavir → Co, HIV, In January, Merck, They
related to Study 035 · 5
Indinavir → After, AZT, CD4, Eligible, The
related to Viral resistance · 5
Indinavir → AZT, In, Many, This, Viral
3D model (JSmol) · 1
Indinavir → Interactive image

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

drug protease hiv drugs viral aids merck treatment one patients users virus azt study research used load development lamivudine people

Indinavir relationships Subject–Predicate–Object triples

TTTA extracted 87 structured relationships around Indinavir. Examples in this analysis include Indinavir → 3D model (JSmol) → Interactive image and Indinavir → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Indinavir3D model (JSmol)Interactive image1.00infobox
IndinavirAHFS/Drugs.comMonograph1.00infobox
IndinavirATC codeJ05AE02 (WHO)1.00infobox
IndinavirBioavailability~65%1.00infobox
IndinavirCAS Number150378-17-9 Y1.00infobox
IndinavirChEBICHEBI:44032 Y1.00infobox
IndinavirChEMBLChEMBL540914 N1.00infobox
IndinavirChemSpider4515036 Y1.00infobox
IndinavirCompTox Dashboard (EPA)DTXSID40438021.00infobox
IndinavirDrugBankDB00224 Y1.00infobox
IndinavirElimination half-life1.8 ± 0.4 hours1.00infobox
IndinavirFormulaC36H47N5O41.00infobox
IndinavirKEGGC07051 Y1.00infobox
IndinavirLicense dataUS FDA: Indinavir1.00infobox
IndinavirMedlinePlusa6960281.00infobox
IndinavirMetabolismHepatic via CYP3A41.00infobox
IndinavirMolar mass613.803 g·mol−11.00infobox
IndinavirNIAID ChemDB0058241.00infobox
IndinavirPDB ligandMK1 (PDBe, RCSB PDB)1.00infobox
IndinavirProtein binding60%1.00infobox
IndinavirPubChem CID53624401.00infobox
IndinavirRoutes of administrationOral1.00infobox
IndinavirTrade namesCrixivan1.00infobox
IndinavirUNII9MG78X43ZT1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Indinavir bring nearby vocabulary together. In this analysis, examples include Merck, Hiv and Azt. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Indinavir
    • Merck
    • Hiv
    • Azt
    • Used
    • Aids
    • Sulfate
    • Lamivudine
    • One
    • Patients
    • Viral
    • Administration
    • Antiretroviral
  • indinavir
    • Merck
    • Hiv
    • Azt
    • Used
    • Aids
    • Sulfate
    • Lamivudine
    • One
    • Patients
    • Viral
    • Administration
    • Antiretroviral
  • hiv/aids
    • Aids
    • Hiv
    • Used
    • Crixivan
    • Research
    • Treatment
    • Side
    • Effects
    • Indinavir
    • Viral
    • Drugs
    • Development
  • united states food and drug administration
    • March
    • Users
    • Antiretroviral
    • Side
    • Use
    • Crixivan
    • Effects
    • Price
    • Resistance
    • Trials
    • People
    • Merck
  • food and drug administration
    • March
    • Users
    • Antiretroviral
    • Side
    • Use
    • Crixivan
    • Effects
    • Price
    • Resistance
    • Trials
    • People
    • Merck
  • highly active antiretroviral therapy
    • Therapy
    • Inhibitor
    • Azt
    • Used
    • Administration
    • Patients
    • Crixivan
    • Lamivudine
    • March
    • Protease
    • Three
    • Trials
  • merck
    • Sulfate
    • Used
    • Research
    • Drug
    • Drugs
    • Price
    • Therapy
    • Trials
    • Company
    • Inhibitor
    • March
    • Development
  • protease inhibitor
    • Protease
    • Therapy
    • Lamivudine
    • Inhibitors
    • Study
    • Patients
    • Virus
    • Viral
    • Resistance
    • Research
    • Drug
    • One

Connections between topic areas Semantic bridges

For Indinavir, one of the stronger structural bridges in this analysis connects Indinavir with Side effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Indinavir — Side effects · splits 28 ⟂ 15
Indinavir — History · splits 28 ⟂ 15
Indinavir — Overview · splits 35 ⟂ 8

Map overview Semantic statistics

Indinavir

Nodes43
Edges42
Triples87
Avg. degree1.95
Density0.046512
Components1

Source & methodology

TTTA analyzes the structure around Indinavir to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Companies, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Indinavir · EN edition · Analysis: TopicsToTalkAbout

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