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Loperamide

Loperamide, sold under the brand name Imodium, among others, is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. It is often used for this purpose in irritable bowel syndrome, inflammatory bowel disease, short bowel syndrome, Crohn's disease, and ulcerative colitis. Loperamide is taken by mouth.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A07DA03 (WHO) A07DA05 (WHO) (oxide)
Bioavailability
<1%
CAS Number
53179-11-6
ChEBI
CHEBI:6532

Topics to explore

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Overview

Medical uses

Side effects

Drug interactions

Mechanism of action

Chemistry

History

Society and culture

Research

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Map overview Semantic statistics

Loperamide

Nodes100
Edges99
Triples102
Avg. degree1.98
Density0.02
Components1

How this topic connects Entity context

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Loperamide

Top relations

related to Contraindications · 7
Loperamide → Additionally, H7, HIV/AIDS, If, O157, Salmonella, Treatment
related to history · 7
Loperamide → Beerse, Belgium, Janssen Pharmaceuticals, Paul Janssen, R-18553, R-58425, The
related to Off-label/unapproved use · 7
Loperamide → At, Dubbing, However, In, Since, The, The FDA
Legal status · 6
Loperamide → AU: S2 (Pharmacy medicine), BR: Class C1 (Other controlled substances), CA: OTC, SE: OTC, UK: General sales list (GSL, OTC), US: OTC / Rx-only
has effect · 6
Loperamide → Adverse, High, Johnson, Rare, Stevens, The
related to Blood–brain barrier · 6
Loperamide → At, Concurrent, Efflux, High, P-glycoprotein, Symptoms
related to Mechanism of action · 6
Loperamide → Efflux, It, Loperamide's, MPTP-like, P-glycoprotein, This
related to Drug interactions · 4
Loperamide → As, Common P-glycoprotein, P-glycoprotein, These
related to Pregnancy and breast feeding · 4
Loperamide → One, Studies, This, United Kingdom
related to Children · 3
Loperamide → In, Pakistan, The

Important terminology Word statistics

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Important terminology

imodium diarrhea used effects treatment pregnancy medication p-glycoprotein drug opioid doses use united name constipation risk first children brand side

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Loperamide3D model (JSmol)Interactive image1.00infobox
LoperamideAHFS/Drugs.comMonograph1.00infobox
LoperamideATC codeA07DA03 (WHO) A07DA05 (WHO) (oxide)1.00infobox
LoperamideBioavailability<1%1.00infobox
LoperamideCAS Number53179-11-61.00infobox
LoperamideChEBICHEBI:65321.00infobox
LoperamideChEMBLChEMBL8411.00infobox
LoperamideChemSpider38181.00infobox
LoperamideCompTox Dashboard (EPA)DTXSID60451651.00infobox
LoperamideDrugBankDB008361.00infobox
LoperamideDuration of actionUp to 3 days1.00infobox
LoperamideECHA InfoCard100.053.0881.00infobox
LoperamideElimination half-life9–14 hours1.00infobox
LoperamideExcretionFeces (30–40%), urine (1%)1.00infobox
LoperamideFormulaC29H33ClN2O21.00infobox
LoperamideIUPHAR/BPS72151.00infobox
LoperamideKEGGD081441.00infobox
LoperamideLegal statusAU: S2 (Pharmacy medicine)1.00infobox
LoperamideLegal statusBR: Class C1 (Other controlled substances)1.00infobox
LoperamideLegal statusCA: OTC1.00infobox
LoperamideLegal statusUK: General sales list (GSL, OTC)1.00infobox
LoperamideLegal statusUS: OTC / Rx-only1.00infobox
LoperamideLegal statusSE: OTC1.00infobox
LoperamideLicense dataUS DailyMed: Loperamide1.00infobox
LoperamideMedlinePlusa6822801.00infobox
LoperamideMetabolismLiver (extensive)1.00infobox
LoperamideMetabolitesN-Desmethyloperamide, Loperamide-N-oxide, Loperamide carbinolamide metabolite1.00infobox
LoperamideMolar mass477.05 g·mol−11.00infobox
LoperamideOnset of action~1 hour1.00infobox
LoperamideOther namesR-18553, Loperamide hydrochloride (USAN US)1.00infobox

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