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Loperamide: History, Community, Culture & Applications

Loperamide, sold under the brand name Imodium, among others, is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. It is often used for this purpose in irritable bowel syndrome, inflammatory bowel disease, short bowel syndrome, Crohn's disease, and ulcerative colitis. Loperamide is taken by mouth.

Language: English [EN]
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Loperamide topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Loperamide.

Related topics
90
Source areas
9
Connected nodes
99
Extracted relationships
102
Concept neighborhoods
27
Bridge connections
99

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 28 topics
Side effects · 19 topics
History · 15 topics
Mechanism of action · 11 topics
Drug interactions · 8 topics
Chemistry · 4 topics
Society and culture · 3 topics
Medical uses · 1 topics
Research · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A07DA03 (WHO) A07DA05 (WHO) (oxide)
Bioavailability
<1%
CAS Number
53179-11-6
ChEBI
CHEBI:6532

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Drug interactions

Mechanism of action

Chemistry

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Loperamide connects Entity context

The extracted context around Loperamide shows recurring relationship patterns in the source. For example, Loperamide → Additionally, H7, HIV/AIDS, If, O157, Salmonella, Treatment Another extracted example is Loperamide → Beerse, Belgium, Janssen Pharmaceuticals, Paul Janssen, R-18553, R-58425, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Loperamide

Top relations

related to Contraindications · 7
Loperamide → Additionally, H7, HIV/AIDS, If, O157, Salmonella, Treatment
related to history · 7
Loperamide → Beerse, Belgium, Janssen Pharmaceuticals, Paul Janssen, R-18553, R-58425, The
related to Off-label/unapproved use · 7
Loperamide → At, Dubbing, However, In, Since, The, The FDA
Legal status · 6
Loperamide → AU: S2 (Pharmacy medicine), BR: Class C1 (Other controlled substances), CA: OTC, SE: OTC, UK: General sales list (GSL, OTC), US: OTC / Rx-only
has effect · 6
Loperamide → Adverse, High, Johnson, Rare, Stevens, The
related to Blood–brain barrier · 6
Loperamide → At, Concurrent, Efflux, High, P-glycoprotein, Symptoms
related to Mechanism of action · 6
Loperamide → Efflux, It, Loperamide's, MPTP-like, P-glycoprotein, This
related to Drug interactions · 4
Loperamide → As, Common P-glycoprotein, P-glycoprotein, These
related to Pregnancy and breast feeding · 4
Loperamide → One, Studies, This, United Kingdom
related to Children · 3
Loperamide → In, Pakistan, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

imodium diarrhea used effects treatment pregnancy medication p-glycoprotein drug opioid doses use united name constipation risk first children brand side

Loperamide relationships Subject–Predicate–Object triples

TTTA extracted 102 structured relationships around Loperamide. Examples in this analysis include Loperamide → 3D model (JSmol) → Interactive image and Loperamide → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Loperamide3D model (JSmol)Interactive image1.00infobox
LoperamideAHFS/Drugs.comMonograph1.00infobox
LoperamideATC codeA07DA03 (WHO) A07DA05 (WHO) (oxide)1.00infobox
LoperamideBioavailability<1%1.00infobox
LoperamideCAS Number53179-11-61.00infobox
LoperamideChEBICHEBI:65321.00infobox
LoperamideChEMBLChEMBL8411.00infobox
LoperamideChemSpider38181.00infobox
LoperamideCompTox Dashboard (EPA)DTXSID60451651.00infobox
LoperamideDrugBankDB008361.00infobox
LoperamideDuration of actionUp to 3 days1.00infobox
LoperamideECHA InfoCard100.053.0881.00infobox
LoperamideElimination half-life9–14 hours1.00infobox
LoperamideExcretionFeces (30–40%), urine (1%)1.00infobox
LoperamideFormulaC29H33ClN2O21.00infobox
LoperamideIUPHAR/BPS72151.00infobox
LoperamideKEGGD081441.00infobox
LoperamideLegal statusAU: S2 (Pharmacy medicine)1.00infobox
LoperamideLegal statusBR: Class C1 (Other controlled substances)1.00infobox
LoperamideLegal statusCA: OTC1.00infobox
LoperamideLegal statusUK: General sales list (GSL, OTC)1.00infobox
LoperamideLegal statusUS: OTC / Rx-only1.00infobox
LoperamideLegal statusSE: OTC1.00infobox
LoperamideLicense dataUS DailyMed: Loperamide1.00infobox
LoperamideMedlinePlusa6822801.00infobox
LoperamideMetabolismLiver (extensive)1.00infobox
LoperamideMetabolitesN-Desmethyloperamide, Loperamide-N-oxide, Loperamide carbinolamide metabolite1.00infobox
LoperamideMolar mass477.05 g·mol−11.00infobox
LoperamideOnset of action~1 hour1.00infobox
LoperamideOther namesR-18553, Loperamide hydrochloride (USAN US)1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Loperamide bring nearby vocabulary together. In this analysis, examples include Imodium, Diarrhea and Drug. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Loperamide
    • Imodium
    • Diarrhea
    • Drug
    • Treatment
    • P-glycoprotein
    • Use
    • Brand
    • Age
    • Children
    • First
    • Name
    • Years
  • loperamide
    • Imodium
    • Diarrhea
    • Drug
    • Treatment
    • P-glycoprotein
    • Use
    • Brand
    • Age
    • Children
    • First
    • Name
    • Years
  • diarrhea
    • Treatment
    • Sold
    • Age
    • Children
    • Imodium
    • Name
    • Opioid
    • Years
    • Use
    • Effects
    • Action
    • Uk
  • blood–brain barrier
    • P-glycoprotein
    • Action
    • Effects
    • Uk
    • List
    • Mouth
    • Brand
    • Controlled
    • Drugs
    • Pregnancy
    • Side
    • States
  • loperamide oxide
    • Imodium
    • Diarrhea
    • Drug
    • Treatment
    • P-glycoprotein
    • Use
    • Brand
    • Age
    • Children
    • First
    • Name
    • Years
  • loperamide and simethicone
    • Imodium
    • Diarrhea
    • Drug
    • Treatment
    • P-glycoprotein
    • Use
    • Brand
    • Age
    • Children
    • First
    • Name
    • Years
  • side effects
    • Side
    • Mouth
    • Barrier
    • Constipation
    • Include
    • Uk
    • Doses
    • List
    • P-glycoprotein
    • Controlled
    • Drugs
    • States
  • mechanism of action
    • Uk
    • List
    • Mouth
    • Barrier
    • Brand
    • Controlled
    • Drugs
    • Found
    • Pregnancy
    • Side
    • States
    • Children

Connections between topic areas Semantic bridges

For Loperamide, one of the stronger structural bridges in this analysis connects Loperamide with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Loperamide — Overview · splits 71 ⟂ 29
Loperamide — Side effects · splits 80 ⟂ 20
Loperamide — History · splits 84 ⟂ 16
Loperamide — Mechanism of action · splits 88 ⟂ 12
Loperamide — Drug interactions · splits 91 ⟂ 9
Loperamide — Chemistry · splits 95 ⟂ 5
Loperamide — Society and culture · splits 96 ⟂ 4

Map overview Semantic statistics

Loperamide

Nodes100
Edges99
Triples102
Avg. degree1.98
Density0.02
Components1

Source & methodology

TTTA analyzes the structure around Loperamide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Loperamide · EN edition · Analysis: TopicsToTalkAbout

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