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Duloxetine: History, Applications, Research & Standards

Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, and other types of chronic pain. It is taken by mouth.

Language: English [EN]
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Duloxetine topic overview

The analysis highlights History, Applications, Research and Standards as prominent areas in the source structure around Duloxetine.

Related topics
132
Source areas
7
Connected nodes
139
Extracted relationships
198
Concept neighborhoods
31
Bridge connections
139

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Adverse effects · 40 topics
Overview · 33 topics
Medical uses · 31 topics
History · 11 topics
Contraindications · 7 topics
Pharmacology · 5 topics
Research · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AX21 (WHO)
Bioavailability
~50% (32–80%)
CAS Number
116539-59-4 Y · as HCl: 136434-34-9 Y
ChEBI
CHEBI:36795 Y · as HCl: CHEBI:31526 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Adverse effects

Pharmacology

Research

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Duloxetine connects Entity context

The extracted context around Duloxetine shows recurring relationship patterns in the source. For example, Duloxetine → Additionally, Company, David Robertson, David Wong, Drug Administration, Eli Lilly, FDA, Good Manufacturing Practice, In, Indianapolis, It, Joseph Krushinski, Lilly, LY227942, LY248686, NDA, New Drug Application, QTc, The, The FDA Another extracted example is Duloxetine → Australia's Therapeutic Goods Administration, Characteristic, European Medicines Agency's Pharmacovigilance, Health Canada, In, Post-SSRI, PRAC, PSSD, Risk Assessment Committee, SNRI, SNRIs, SSRI, SSRIs, The, The DSM-5. Use these groups to spot repeated connection types before inspecting the individual relationships.

Duloxetine

Top relations

related to history · 23
Duloxetine → Additionally, Company, David Robertson, David Wong, Drug Administration, Eli Lilly, FDA, Good Manufacturing Practice, In, Indianapolis, It, Joseph Krushinski, Lilly, LY227942, LY248686, NDA, New Drug Application, QTc, The, The FDA
related to Post-SSRI sexual dysfunction · 15
Duloxetine → Australia's Therapeutic Goods Administration, Characteristic, European Medicines Agency's Pharmacovigilance, Health Canada, In, Post-SSRI, PRAC, PSSD, Risk Assessment Committee, SNRI, SNRIs, SSRI, SSRIs, The, The DSM-5
related to Suicidality · 14
Duloxetine → As, Cymbalta, Drug Administration, FDA, In, No, SUI, The, The FDA, This, To, United States, US, US Food
related to Research · 12
Duloxetine → Also, Antidepressants, Cytokines, IL-10, IL-1β, IL-6, In, Major, Some, THA, TKA, TNF-α
related to Neuropathic pain · 11
Duloxetine → Another, BMC Neurology, Cochrane, Combination, Comparing, DPN, Drug Administration, FDA, Prescrire International, The, US Food
related to Medical uses · 10
Duloxetine → American Association, American Society, Clinical Oncology, European Federation, German Interdisciplinary Association, Grade, Neurological Societies, Neurology, Pain Therapy, The
related to Contraindications · 8
Duloxetine → Central, CNS, Cymbalta, Hypersensitivity, MAOIs, Monoamine, The, Uncontrolled
related to Major depressive disorder · 8
Duloxetine → Additionally, All, Cochrane Review, Generic, Hamilton Depression Rating Scale, It, SSRIs, There
related to Increased sweating · 7
Duloxetine → However, Norepinephrine, SNRIs, Such, Sympathetic, The, Therefore
related to Sexual dysfunction · 7
Duloxetine → Frequency, In, Loss, MDD, Rates, Specifically, SSRIs

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects may treatment patients pain serotonin side fda risk sexual increased dysfunction antidepressants diabetic reuptake drug also approved neuropathic fibromyalgia

Duloxetine relationships Subject–Predicate–Object triples

TTTA extracted 198 structured relationships around Duloxetine. Examples in this analysis include Duloxetine → 3D model (JSmol) → Interactive image and Duloxetine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Duloxetine3D model (JSmol)Interactive image1.00infobox
DuloxetineAHFS/Drugs.comMonograph1.00infobox
DuloxetineATC codeN06AX21 (WHO)1.00infobox
DuloxetineBioavailability~50% (32–80%)1.00infobox
DuloxetineCAS Number116539-59-4 Y1.00infobox
DuloxetineCAS Numberas HCl: 136434-34-9 Y1.00infobox
DuloxetineChEBICHEBI:36795 Y1.00infobox
DuloxetineChEBIas HCl: CHEBI:31526 Y1.00infobox
DuloxetineChEMBLChEMBL1175 Y1.00infobox
DuloxetineChEMBLas HCl: ChEMBL1200328 Y1.00infobox
DuloxetineChemSpider54822 Y1.00infobox
DuloxetineCompTox Dashboard (EPA)DTXSID60483851.00infobox
DuloxetineDrug classSerotonin–norepinephrine reuptake inhibitor (SNRI)1.00infobox
DuloxetineDrugBankDB00476 Y1.00infobox
DuloxetineECHA InfoCard100.116.8251.00infobox
DuloxetineElimination half-life10–12 hours1.00infobox
DuloxetineExcretion70% in urine, 20% in feces1.00infobox
DuloxetineFormulaC18H19NOS1.00infobox
DuloxetineIUPHAR/BPS2021.00infobox
DuloxetineKEGGD07880 Y1.00infobox
DuloxetineKEGGas HCl: D01179 Y1.00infobox
DuloxetineLegal statusAU: S4 (Prescription only)1.00infobox
DuloxetineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
DuloxetineLegal statusCA: ℞-only1.00infobox
DuloxetineLegal statusUK: POM (Prescription only)1.00infobox
DuloxetineLegal statusUS: ℞-only1.00infobox
DuloxetineLegal statusEU: Rx-only1.00infobox
DuloxetineLicense dataUS DailyMed: Duloxetine1.00infobox
DuloxetineMedlinePlusa6040301.00infobox
DuloxetineMetabolismLiver, two P450 isozymes, CYP2D6 and CYP1A21.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Duloxetine bring nearby vocabulary together. In this analysis, examples include Treatment, Pain and Effects. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Duloxetine
    • Treatment
    • Pain
    • Effects
    • Patients
    • Fda
    • Approved
    • Including
    • Review
    • Diabetic
    • Antidepressants
    • Side
    • Administration
  • duloxetine
    • Treatment
    • Pain
    • Effects
    • Patients
    • Fda
    • Approved
    • Including
    • Review
    • Diabetic
    • Antidepressants
    • Side
    • Administration
  • major depressive disorder
    • Major
    • Fibromyalgia
    • Neuropathic
    • Adverse
    • Placebo
    • Treatment
    • Increased
    • Pain
    • Medication
    • Nausea
    • Norepinephrine
    • Liver
  • generalized anxiety disorder
    • Major
    • Fibromyalgia
    • Neuropathic
    • Adverse
    • Placebo
    • Treatment
    • Increased
    • Pain
    • Medication
    • Nausea
    • Norepinephrine
    • Liver
  • obsessive–compulsive disorder
    • Major
    • Fibromyalgia
    • Neuropathic
    • Adverse
    • Placebo
    • Treatment
    • Increased
    • Pain
    • Medication
    • Nausea
    • Norepinephrine
    • Liver
  • fibromyalgia
    • Neuropathic
    • Diabetic
    • Major
    • Us
    • Administration
    • Adverse
    • Pain
    • Drug
    • Treatment
    • Medication
    • Norepinephrine
    • Liver
  • neuropathic pain
    • Pain
    • Diabetic
    • Also
    • Patients
    • Us
    • Placebo
    • Treatment
    • Trials
    • Clinical
    • Including
    • Review
    • Norepinephrine
  • serotonin–norepinephrine reuptake inhibitor
    • Serotonin
    • Reuptake
    • Increased
    • Sexual
    • Adverse
    • Dysfunction
    • Including
    • Also
    • Diabetic
    • Liver
    • Cause
    • May

Connections between topic areas Semantic bridges

For Duloxetine, one of the stronger structural bridges in this analysis connects Duloxetine with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DuloxetineAdverse effects · splits 99 ⟂ 41
DuloxetineOverview · splits 106 ⟂ 34
DuloxetineMedical uses · splits 108 ⟂ 32
DuloxetineHistory · splits 128 ⟂ 12
DuloxetineContraindications · splits 132 ⟂ 8
DuloxetinePharmacology · splits 134 ⟂ 6
DuloxetineResearch · splits 134 ⟂ 6

Map overview Semantic statistics

Duloxetine

Nodes140
Edges139
Triples198
Avg. degree1.99
Density0.014286
Components1

Source & methodology

TTTA analyzes the structure around Duloxetine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications, Research & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Duloxetine · EN edition · Analysis: TopicsToTalkAbout

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