Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Duloxetine

Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, and other types of chronic pain. It is taken by mouth.

History, Applications, Research & Standards

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around Duloxetine. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AX21 (WHO)
Bioavailability
~50% (32–80%)
CAS Number
116539-59-4 Y · as HCl: 136434-34-9 Y
ChEBI
CHEBI:36795 Y · as HCl: CHEBI:31526 Y

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Adverse effects

Pharmacology

Research

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Duloxetine

Nodes140
Edges139
Triples198
Avg. degree1.99
Density0.014286
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Duloxetine

Top relations

related to history · 23
Duloxetine → Additionally, Company, David Robertson, David Wong, Drug Administration, Eli Lilly, FDA, Good Manufacturing Practice, In, Indianapolis, It, Joseph Krushinski, Lilly, LY227942, LY248686, NDA, New Drug Application, QTc, The, The FDA
related to Post-SSRI sexual dysfunction · 15
Duloxetine → Australia's Therapeutic Goods Administration, Characteristic, European Medicines Agency's Pharmacovigilance, Health Canada, In, Post-SSRI, PRAC, PSSD, Risk Assessment Committee, SNRI, SNRIs, SSRI, SSRIs, The, The DSM-5
related to Suicidality · 14
Duloxetine → As, Cymbalta, Drug Administration, FDA, In, No, SUI, The, The FDA, This, To, United States, US, US Food
related to Research · 12
Duloxetine → Also, Antidepressants, Cytokines, IL-10, IL-1β, IL-6, In, Major, Some, THA, TKA, TNF-α
related to Neuropathic pain · 11
Duloxetine → Another, BMC Neurology, Cochrane, Combination, Comparing, DPN, Drug Administration, FDA, Prescrire International, The, US Food
related to Medical uses · 10
Duloxetine → American Association, American Society, Clinical Oncology, European Federation, German Interdisciplinary Association, Grade, Neurological Societies, Neurology, Pain Therapy, The
related to Contraindications · 8
Duloxetine → Central, CNS, Cymbalta, Hypersensitivity, MAOIs, Monoamine, The, Uncontrolled
related to Major depressive disorder · 8
Duloxetine → Additionally, All, Cochrane Review, Generic, Hamilton Depression Rating Scale, It, SSRIs, There
related to Increased sweating · 7
Duloxetine → However, Norepinephrine, SNRIs, Such, Sympathetic, The, Therefore
related to Sexual dysfunction · 7
Duloxetine → Frequency, In, Loss, MDD, Rates, Specifically, SSRIs

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects may treatment patients pain serotonin side fda risk sexual increased dysfunction antidepressants diabetic reuptake drug also approved neuropathic fibromyalgia

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Duloxetine3D model (JSmol)Interactive image1.00infobox
DuloxetineAHFS/Drugs.comMonograph1.00infobox
DuloxetineATC codeN06AX21 (WHO)1.00infobox
DuloxetineBioavailability~50% (32–80%)1.00infobox
DuloxetineCAS Number116539-59-4 Y1.00infobox
DuloxetineCAS Numberas HCl: 136434-34-9 Y1.00infobox
DuloxetineChEBICHEBI:36795 Y1.00infobox
DuloxetineChEBIas HCl: CHEBI:31526 Y1.00infobox
DuloxetineChEMBLChEMBL1175 Y1.00infobox
DuloxetineChEMBLas HCl: ChEMBL1200328 Y1.00infobox
DuloxetineChemSpider54822 Y1.00infobox
DuloxetineCompTox Dashboard (EPA)DTXSID60483851.00infobox
DuloxetineDrug classSerotonin–norepinephrine reuptake inhibitor (SNRI)1.00infobox
DuloxetineDrugBankDB00476 Y1.00infobox
DuloxetineECHA InfoCard100.116.8251.00infobox
DuloxetineElimination half-life10–12 hours1.00infobox
DuloxetineExcretion70% in urine, 20% in feces1.00infobox
DuloxetineFormulaC18H19NOS1.00infobox
DuloxetineIUPHAR/BPS2021.00infobox
DuloxetineKEGGD07880 Y1.00infobox
DuloxetineKEGGas HCl: D01179 Y1.00infobox
DuloxetineLegal statusAU: S4 (Prescription only)1.00infobox
DuloxetineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
DuloxetineLegal statusCA: ℞-only1.00infobox
DuloxetineLegal statusUK: POM (Prescription only)1.00infobox
DuloxetineLegal statusUS: ℞-only1.00infobox
DuloxetineLegal statusEU: Rx-only1.00infobox
DuloxetineLicense dataUS DailyMed: Duloxetine1.00infobox
DuloxetineMedlinePlusa6040301.00infobox
DuloxetineMetabolismLiver, two P450 isozymes, CYP2D6 and CYP1A21.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.