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Etoposide: History & Applications

Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer. It is also used for hemophagocytic lymphohistiocytosis. It is used by mouth or injection into a vein.

Language: English [EN]
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Etoposide topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Etoposide.

Related topics
59
Source areas
6
Connected nodes
65
Extracted relationships
72
Concept neighborhoods
29
Bridge connections
65

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Side effects · 17 topics
Overview · 16 topics
Chemistry · 10 topics
Medical uses · 8 topics
Pharmacology · 6 topics
History · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01CB01 (WHO)
Bioavailability
Highly variable, 25 to 75%
CAS Number
33419-42-0 Y
ChEBI
CHEBI:4911 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Pharmacology

Chemistry

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Etoposide connects Entity context

The extracted context around Etoposide shows recurring relationship patterns in the source. For example, Etoposide → Archived, August, Drug Information Portal, July, June, Medicine, National Cancer Institute, National Library, NCI Drug Dictionary Another extracted example is Etoposide → Another, Drug Administration, Food, Hartmann, Stähelin, The, VP-16, Wartburg. Use these groups to spot repeated connection types before inspecting the individual relationships.

Etoposide

Top relations

related to External links · 9
Etoposide → Archived, August, Drug Information Portal, July, June, Medicine, National Cancer Institute, National Library, NCI Drug Dictionary
related to history · 8
Etoposide → Another, Drug Administration, Food, Hartmann, Stähelin, The, VP-16, Wartburg
related to Chemistry · 7
Etoposide → American, Both, D-glucose, It, More, Podophyllum, The
related to Mechanism of action · 7
Etoposide → Cancer, DNA, Etoposide's, II, Therefore, This, Topoisomerase II
related to Medical uses · 3
Etoposide → Ewing's, It, Kaposi's
KEGG · 2
Etoposide → as salt: D04107 Y, D00125 Y
Legal status · 2
Etoposide → UK: POM (Prescription only), US: ℞-only
3D model (JSmol) · 1
Etoposide → Interactive image
AHFS/Drugs.com · 1
Etoposide → Monograph
ATC code · 1
Etoposide → L01CB01 (WHO)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer used dna blood drug effects administration cell topoisomerase side podophyllotoxin pressure low leukemia medical iv name mouth form given

Etoposide relationships Subject–Predicate–Object triples

TTTA extracted 72 structured relationships around Etoposide. Examples in this analysis include Etoposide → 3D model (JSmol) → Interactive image and Etoposide → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Etoposide3D model (JSmol)Interactive image1.00infobox
EtoposideAHFS/Drugs.comMonograph1.00infobox
EtoposideATC codeL01CB01 (WHO)1.00infobox
EtoposideBioavailabilityHighly variable, 25 to 75%1.00infobox
EtoposideCAS Number33419-42-0 Y1.00infobox
EtoposideChEBICHEBI:4911 Y1.00infobox
EtoposideChEMBLChEMBL44657 Y1.00infobox
EtoposideChemSpider33510 Y1.00infobox
EtoposideCompTox Dashboard (EPA)DTXSID50230351.00infobox
EtoposideDrugBankDB00773 Y1.00infobox
EtoposideECHA InfoCard100.046.8121.00infobox
EtoposideElimination half-lifeOral: 6 h., IV: 6-12 h., IV in children: 3 h.1.00infobox
EtoposideExcretionKidney and fecal1.00infobox
EtoposideFormulaC29H32O131.00infobox
EtoposideIUPHAR/BPS68151.00infobox
EtoposideKEGGD00125 Y1.00infobox
EtoposideKEGGas salt: D04107 Y1.00infobox
EtoposideLegal statusUK: POM (Prescription only)1.00infobox
EtoposideLegal statusUS: ℞-only1.00infobox
EtoposideMedlinePlusa6840551.00infobox
EtoposideMelting point243.5 °C (470.3 °F)1.00infobox
EtoposideMetabolismLiver (CYP3A4 involved)1.00infobox
EtoposideMolar mass588.562 g·mol−11.00infobox
EtoposideOther namesVP-16; VP-16-2131.00infobox
EtoposidePregnancy categoryAU: D1.00infobox
EtoposidePronunciation/ˌɛtoʊˈpoʊsaɪd/1.00infobox
EtoposideProtein binding97%1.00infobox
EtoposidePubChem CID364621.00infobox
EtoposideRoutes of administrationBy mouth, intravenous1.00infobox
EtoposideTrade namesEtopophos, Toposar, Vepesid, others1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Etoposide bring nearby vocabulary together. In this analysis, examples include Leukemia, Phosphate and Used. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Etoposide
    • Leukemia
    • Phosphate
    • Used
    • Chemotherapy
    • Lung
    • Lymphoma
    • Medication
    • Number
    • Others
    • Vepesid
    • Medical
    • Mouth
  • etoposide
    • Leukemia
    • Phosphate
    • Used
    • Chemotherapy
    • Lung
    • Lymphoma
    • Medication
    • Number
    • Others
    • Vepesid
    • Medical
    • Mouth
  • leukemia
    • Lung
    • Lymphoma
    • Number
    • Name
    • Testicular
    • Used
    • Common
    • Diarrhea
    • Fever
    • Medication
    • Others
    • Vepesid
  • acute myeloid leukemia
    • Lung
    • Lymphoma
    • Number
    • Name
    • Testicular
    • Used
    • Common
    • Diarrhea
    • Fever
    • Medication
    • Others
    • Vepesid
  • food and drug administration
    • Mouth
    • Often
    • Iv
    • Pressure
    • Blood
    • Common
    • Diarrhea
    • Fever
    • Others
    • Pregnancy
    • Vepesid
    • Leukemia
  • low blood cell counts
    • Pressure
    • Low
    • Diarrhea
    • Fever
    • Cell
    • Include
    • Often
    • Administration
    • Given
    • Iv
    • Dna
    • Mouth
  • blood stem cell
    • Pressure
    • Low
    • Diarrhea
    • Fever
    • Cell
    • Include
    • Often
    • Administration
    • Given
    • Iv
    • Dna
    • Common
  • white blood cell
    • Pressure
    • Low
    • Diarrhea
    • Fever
    • Cell
    • Include
    • Often
    • Administration
    • Given
    • Iv
    • Dna
    • Common

Connections between topic areas Semantic bridges

For Etoposide, one of the stronger structural bridges in this analysis connects Etoposide with Side effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Etoposide — Side effects · splits 48 ⟂ 18
Etoposide — Overview · splits 49 ⟂ 17
Etoposide — Chemistry · splits 55 ⟂ 11
Etoposide — Medical uses · splits 57 ⟂ 9
Etoposide — Pharmacology · splits 59 ⟂ 7
Etoposide — History · splits 63 ⟂ 3

Map overview Semantic statistics

Etoposide

Nodes66
Edges65
Triples72
Avg. degree1.97
Density0.030303
Components1

Source & methodology

TTTA analyzes the structure around Etoposide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Etoposide · EN edition · Analysis: TopicsToTalkAbout

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