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Etoposide

Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer. It is also used for hemophagocytic lymphohistiocytosis. It is used by mouth or injection into a vein.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01CB01 (WHO)
Bioavailability
Highly variable, 25 to 75%
CAS Number
33419-42-0 Y
ChEBI
CHEBI:4911 Y

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Overview

Medical uses

Side effects

Pharmacology

Chemistry

History

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Map overview Semantic statistics

Etoposide

Nodes66
Edges65
Triples72
Avg. degree1.97
Density0.030303
Components1

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Etoposide

Top relations

related to External links · 9
Etoposide → Archived, August, Drug Information Portal, July, June, Medicine, National Cancer Institute, National Library, NCI Drug Dictionary
related to history · 8
Etoposide → Another, Drug Administration, Food, Hartmann, Stähelin, The, VP-16, Wartburg
related to Chemistry · 7
Etoposide → American, Both, D-glucose, It, More, Podophyllum, The
related to Mechanism of action · 7
Etoposide → Cancer, DNA, Etoposide's, II, Therefore, This, Topoisomerase II
related to Medical uses · 3
Etoposide → Ewing's, It, Kaposi's
KEGG · 2
Etoposide → as salt: D04107 Y, D00125 Y
Legal status · 2
Etoposide → UK: POM (Prescription only), US: ℞-only
3D model (JSmol) · 1
Etoposide → Interactive image
AHFS/Drugs.com · 1
Etoposide → Monograph
ATC code · 1
Etoposide → L01CB01 (WHO)

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Important terminology

cancer used dna blood drug effects administration cell topoisomerase side podophyllotoxin pressure low leukemia medical iv name mouth form given

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Etoposide3D model (JSmol)Interactive image1.00infobox
EtoposideAHFS/Drugs.comMonograph1.00infobox
EtoposideATC codeL01CB01 (WHO)1.00infobox
EtoposideBioavailabilityHighly variable, 25 to 75%1.00infobox
EtoposideCAS Number33419-42-0 Y1.00infobox
EtoposideChEBICHEBI:4911 Y1.00infobox
EtoposideChEMBLChEMBL44657 Y1.00infobox
EtoposideChemSpider33510 Y1.00infobox
EtoposideCompTox Dashboard (EPA)DTXSID50230351.00infobox
EtoposideDrugBankDB00773 Y1.00infobox
EtoposideECHA InfoCard100.046.8121.00infobox
EtoposideElimination half-lifeOral: 6 h., IV: 6-12 h., IV in children: 3 h.1.00infobox
EtoposideExcretionKidney and fecal1.00infobox
EtoposideFormulaC29H32O131.00infobox
EtoposideIUPHAR/BPS68151.00infobox
EtoposideKEGGD00125 Y1.00infobox
EtoposideKEGGas salt: D04107 Y1.00infobox
EtoposideLegal statusUK: POM (Prescription only)1.00infobox
EtoposideLegal statusUS: ℞-only1.00infobox
EtoposideMedlinePlusa6840551.00infobox
EtoposideMelting point243.5 °C (470.3 °F)1.00infobox
EtoposideMetabolismLiver (CYP3A4 involved)1.00infobox
EtoposideMolar mass588.562 g·mol−11.00infobox
EtoposideOther namesVP-16; VP-16-2131.00infobox
EtoposidePregnancy categoryAU: D1.00infobox
EtoposidePronunciation/ˌɛtoʊˈpoʊsaɪd/1.00infobox
EtoposideProtein binding97%1.00infobox
EtoposidePubChem CID364621.00infobox
EtoposideRoutes of administrationBy mouth, intravenous1.00infobox
EtoposideTrade namesEtopophos, Toposar, Vepesid, others1.00infobox

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