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Digoxin: History, Community, Culture & Applications

Digoxin, sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. Digoxin is one of the oldest medications used in the field of cardiology. It works by increasing myocardial contractility, increasing stroke volume and…

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Digoxin topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Digoxin.

Related topics
132
Source areas
8
Connected nodes
140
Extracted relationships
168
Concept neighborhoods
36
Bridge connections
140

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 49 topics
Medical uses · 21 topics
Overview · 18 topics
Side effects · 18 topics
History · 10 topics
Society and culture · 10 topics
Overdose · 5 topics
Digoxin and cancer · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C01AA05 (WHO)
Bioavailability
60 to 80% (by mouth)
CAS Number
20830-75-5 Y
ChEBI
CHEBI:4551 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Overdose

Pharmacology

History

Society and culture

Digoxin and cancer

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Digoxin connects Entity context

The extracted context around Digoxin shows recurring relationship patterns in the source. For example, Digoxin → Cardigox, Cardiogoxin, Cardioxin, Cardoxin, Coragoxine, Digacin, Digicor, Digitek, Digomal, Digon, Digosin, Digoxin-Sandoz, Digoxin-Zori, Digoxina-Sandoz, Digoxine Navtivelle, Dilanacin, Eudigox, Fargoxin, Grexin, Lanacordin Another extracted example is Digoxin → An Account, Arthur Robertson Cushny, Derivatives, Digitalis, Dr, Dropsy, Foxglove, In, Initially, Its, Keller, Medical Uses With Practical, Nicholas Culpeper, Other Diseases, Remarks, Sir James Mackenzie, Sydney Smith, The, The English, William Withering. Use these groups to spot repeated connection types before inspecting the individual relationships.

Digoxin

Top relations

related to Brand names · 37
Digoxin → Cardigox, Cardiogoxin, Cardioxin, Cardoxin, Coragoxine, Digacin, Digicor, Digitek, Digomal, Digon, Digosin, Digoxin-Sandoz, Digoxin-Zori, Digoxina-Sandoz, Digoxine Navtivelle, Dilanacin, Eudigox, Fargoxin, Grexin, Lanacordin
related to history · 20
Digoxin → An Account, Arthur Robertson Cushny, Derivatives, Digitalis, Dr, Dropsy, Foxglove, In, Initially, Its, Keller, Medical Uses With Practical, Nicholas Culpeper, Other Diseases, Remarks, Sir James Mackenzie, Sydney Smith, The, The English, William Withering
related to Society and culture · 14
Digoxin → Actavis, Charles Cullen, Class, Digitek, Drug Administration, FDA, Food, Icelandic, Mylan, New Jersey, On April, On March, Pennsylvania, Some
related to Overdose · 8
Digoxin → ATPase-dependent Na/K, Digibind, Digifab, FAB, If, In, The, Therefore
related to Pharmacokinetics · 8
Digoxin → Examples, In, IV, P-glycoprotein, The, United States, Vd, While IV
has effect · 7
Digoxin → ATPase, AV, Gynaecomastia, It, PAT, The, This
related to Heart failure · 7
Digoxin → ACE, Alongside, Digitalis, In, SGLT-2, Since, William Withering
related to Pharmacodynamics · 7
Digoxin → ATPase, Ca2, Digoxin's, Increased, Na, The, This
related to Pharmacomicrobiomics · 6
Digoxin → Eggerthella, Further, North Americans, Southern Indians, The, These
related to Irregular heartbeat · 5
Digoxin → Cardiac, Early, Evidence, However, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

heart also increased used effects patients may cardiac digitalis levels increase failure function drug calcium rate due atrial fibrillation av

Digoxin relationships Subject–Predicate–Object triples

TTTA extracted 168 structured relationships around Digoxin. Examples in this analysis include Digoxin → 3D model (JSmol) → Interactive image and Digoxin → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Digoxin3D model (JSmol)Interactive image1.00infobox
DigoxinAHFS/Drugs.comMonograph1.00infobox
DigoxinATC codeC01AA05 (WHO)1.00infobox
DigoxinBioavailability60 to 80% (by mouth)1.00infobox
DigoxinCAS Number20830-75-5 Y1.00infobox
DigoxinChEBICHEBI:4551 Y1.00infobox
DigoxinChEMBLChEMBL1751 Y1.00infobox
DigoxinChemSpider2006532 Y1.00infobox
DigoxinCompTox Dashboard (EPA)DTXSID50229341.00infobox
DigoxinDrugBankDB00390 Y1.00infobox
DigoxinECHA InfoCard100.040.0471.00infobox
DigoxinElimination half-life36 to 48 hours (normal kidney function) 3.5 to 5 days (impaired kidney function)1.00infobox
DigoxinExcretionKidney1.00infobox
DigoxinFormulaC41H64O141.00infobox
DigoxinIUPHAR/BPS47261.00infobox
DigoxinKEGGD00298 Y1.00infobox
DigoxinLegal statusAU: S4 (Prescription only)1.00infobox
DigoxinLegal statusUK: POM (Prescription only)1.00infobox
DigoxinLegal statusUS: ℞-only1.00infobox
DigoxinLicense dataUS DailyMed: Digoxin1.00infobox
DigoxinMedlinePlusa6823011.00infobox
DigoxinMelting point249.3 °C (480.7 °F)1.00infobox
DigoxinMetabolismLiver (16%)1.00infobox
DigoxinMolar mass780.949 g·mol−11.00infobox
DigoxinPDB ligandDGX (PDBe, RCSB PDB)1.00infobox
DigoxinPregnancy categoryAU: A1.00infobox
DigoxinPronunciation/dɪˈdʒɒksɪn/1.00infobox
DigoxinProtein binding25%1.00infobox
DigoxinPubChem CID27243851.00infobox
DigoxinRoutes of administrationBy mouth, intravenous1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Digoxin bring nearby vocabulary together. In this analysis, examples include Also, Heart and Patients. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Digoxin
    • Also
    • Heart
    • Patients
    • Used
    • Cancer
    • Risk
    • Due
    • Drug
    • Cardiac
    • May
    • Effects
    • Increased
  • digoxin
    • Also
    • Heart
    • Patients
    • Used
    • Cancer
    • Risk
    • Due
    • Drug
    • Cardiac
    • May
    • Effects
    • Increased
  • heart conditions
    • Failure
    • Rate
    • Used
    • Atrial
    • Fibrillation
    • Patients
    • Effects
    • Less
    • Also
    • Function
    • Levels
    • May
  • atrial fibrillation
    • Fibrillation
    • Failure
    • Drugs
    • Less
    • Heart
    • Rate
    • May
    • Effects
    • Used
    • Half-life
    • Brand
    • Hours
  • atrial flutter
    • Fibrillation
    • Failure
    • Drugs
    • Less
    • Heart
    • Rate
    • Effects
    • Used
    • Half-life
    • Brand
    • Hours
    • Medical
  • heart failure
    • Failure
    • Heart
    • Rate
    • Fibrillation
    • Used
    • Effects
    • Atrial
    • Drugs
    • Patients
    • Less
    • Also
    • May
  • heart rate
    • Failure
    • Rate
    • Used
    • Atrial
    • Fibrillation
    • Patients
    • Effects
    • Less
    • Also
    • Levels
    • Function
    • May
  • calcium channel blockers
    • Increase
    • Sodium
    • Action
    • Increased
    • Cardiac
    • Levels
    • Half-life
    • Arrhythmias
    • Hours
    • Medical
    • Side
    • Cancer

Connections between topic areas Semantic bridges

For Digoxin, one of the stronger structural bridges in this analysis connects Digoxin with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DigoxinPharmacology · splits 91 ⟂ 50
DigoxinMedical uses · splits 119 ⟂ 22
DigoxinOverview · splits 122 ⟂ 19
DigoxinSide effects · splits 122 ⟂ 19
DigoxinHistory · splits 130 ⟂ 11
DigoxinSociety and culture · splits 130 ⟂ 11
DigoxinOverdose · splits 135 ⟂ 6

Map overview Semantic statistics

Digoxin

Nodes141
Edges140
Triples168
Avg. degree1.99
Density0.014184
Components1

Source & methodology

TTTA analyzes the structure around Digoxin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Digoxin · EN edition · Analysis: TopicsToTalkAbout

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