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Fluvoxamine

Fluvoxamine, sold under the brand name Luvox among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is primarily used to treat major depressive disorder and, perhaps more especially, obsessive–compulsive disorder (OCD), but is also used to treat anxiety disorders such as panic disorder, social anxiety disorder…

History, Applications, Research & Standards

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AB08 (WHO)
Bioavailability
53% (90% confidence interval: 44–62%)
CAS Number
54739-18-3 Y
ChEBI
CHEBI:5138 Y

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Overview

Medical uses

Adverse effects

Interactions

Pharmacology

History

Research directions

Environment

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Map overview Semantic statistics

Fluvoxamine

Nodes160
Edges159
Triples119
Avg. degree1.99
Density0.0125
Components1

How this topic connects Entity context

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Fluvoxamine

Top relations

related to history · 25
Fluvoxamine → Abbott, Abbott Laboratories, At, BayPharma, Belgium, Drug Administration, FDA, Floxyfral, Food, In India, In Japan, It, Kali-Duphar, Luvox, Manufacturers, OCD, Solvay Pharmaceuticals, SSRI, Switzerland, Synthon
related to Medical uses · 11
Fluvoxamine → Australia, In, In Japan, OCD, Of, Russia, SSRIs, The NICE, There, United Kingdom, United States
related to Post-SSRI sexual dysfunction · 9
Fluvoxamine → Characteristic, EMA's, Post-SSRI, PSSD, SNRIs, SRI, SSRIs, The, The DSM-5
related to Pharmacokinetics · 8
Fluvoxamine → CYP1A2, CYP2D6, CYP3A4, However, In, Literature, Steady-state, The
has effect · 7
Fluvoxamine → Fluvoxamine's, Gastrointestinal, However, In, It, Mosapride, SSRIs
related to Interactions · 7
Fluvoxamine → CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, P450
related to Research directions · 7
Fluvoxamine → COVID-19, Drug Administration, FDA, Food, In May, The, While
Legal status · 5
Fluvoxamine → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, UK: POM (Prescription only), US: ℞-only
related to Pharmacodynamics · 5
Fluvoxamine → It, SSRI, SSRIs, This, Unlike
related to Environment · 2
Fluvoxamine → Christensen, European Union

Important terminology Word statistics

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Important terminology

may ssris effects ssri serotonin anxiety also treatment sexual drug etc dysfunction reuptake ocd risk cyp2d6 cyp1a2 mg disorder social

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Fluvoxamine3D model (JSmol)Interactive image1.00infobox
FluvoxamineAHFS/Drugs.comMonograph1.00infobox
FluvoxamineATC codeN06AB08 (WHO)1.00infobox
FluvoxamineBioavailability53% (90% confidence interval: 44–62%)1.00infobox
FluvoxamineCAS Number54739-18-3 Y1.00infobox
FluvoxamineChEBICHEBI:5138 Y1.00infobox
FluvoxamineChEMBLChEMBL814 Y1.00infobox
FluvoxamineChemSpider4481878 Y1.00infobox
FluvoxamineCompTox Dashboard (EPA)DTXSID20440021.00infobox
FluvoxamineDrug classSelective serotonin reuptake inhibitor (SSRI)1.00infobox
FluvoxamineDrugBankDB00176 N1.00infobox
FluvoxamineECHA InfoCard100.125.4761.00infobox
FluvoxamineElimination half-life12–13 hours (single dose), 22 hours (repeated dosing)1.00infobox
FluvoxamineExcretionKidney (98%; 94% as metabolites, 4% as unchanged drug)1.00infobox
FluvoxamineFormulaC15H21F3N2O21.00infobox
FluvoxamineIUPHAR/BPS71891.00infobox
FluvoxamineKEGGD07984 Y1.00infobox
FluvoxamineLegal statusAU: S4 (Prescription only)1.00infobox
FluvoxamineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
FluvoxamineLegal statusCA: ℞-only1.00infobox
FluvoxamineLegal statusUK: POM (Prescription only)1.00infobox
FluvoxamineLegal statusUS: ℞-only1.00infobox
FluvoxamineLicense dataUS DailyMed: Fluvoxamine1.00infobox
FluvoxamineMedlinePlusa6950041.00infobox
FluvoxamineMetabolismLiver (primarily O-demethylation) Major: CYP2D6 or CYP1A2 Minor: CYP3A4, CYP2C19, and/or CYP1A21.00infobox
FluvoxamineMolar mass318.340 g·mol−11.00infobox
FluvoxaminePregnancy categoryAU: C1.00infobox
FluvoxaminePronunciationfloo-VAHK-sə-meen UK: /fluːˈvɒksəmiːn/ US: /fluːˈvɑːksəˌmiːn/1.00infobox
FluvoxamineProtein binding77–80%1.00infobox
FluvoxaminePubChem CID53243461.00infobox

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