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CYP2C19

Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system. This subfamily includes enzymes that catalyze metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs. In humans, it is the CYP2C19 gene that encodes the CYP2C19…

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1.14.14.1
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1.14.14.51
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1.14.14.52
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1.14.14.53
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1.14.14.75
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Aliases
CYP2C19, CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19, cytochrome P450 family 2 subfamily C member 19

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Pharmacogenomics

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CYP2C19

Nodes65
Edges64
Triples98
Avg. degree1.97
Density0.030769
Components1

How this topic connects Entity context

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CYP2C19

Top relations

Gene ontology · 24
CYP2C19 → arachidonic acid epoxygenase activity, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, enzyme binding, epoxygenase P450 pathway, heme binding, heterocycle metabolic process, intracellular membrane-bounded organelle, iron ion binding, membrane, metal ion binding, monooxygenase activity, monoterpenoid metabolic process, omega-hydroxylase P450 pathway, organelle membrane, organic acid metabolic process, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom…
Bgee · 10
CYP2C19 → body of stomach, duodenum, fundus, gallbladder, gastric mucosa, liver, mucosa of transverse colon, right lobe of liver, skin of abdomen, vagina
RNA expression pattern · 10
CYP2C19 → body of stomach, duodenum, fundus, gallbladder, gastric mucosa, liver, mucosa of transverse colon, right lobe of liver, skin of abdomen, vagina
related to Pharmacogenomics · 10
CYP2C19 → Consortium, CPIC, Pharmacogene Variation Consortium, Pharmacogenomics, Pro227Pro, The, The Clinical Pharmacogenetics Implementation, There, These, Trp212Ter
related to Function · 8
CYP2C19 → CYP2C, Enzymes, It, P450, Polymorphism, The, These, This
related to External links · 4
CYP2C19 → Annotated PGx Gene Information, CYP2C19Human CYP2C19, PharmGKB, UCSC Genome Browser
related to Ligands · 3
CYP2C19 → Inhibitors, The, Where
1.14.14.1 · 1
CYP2C19 → ↗
1.14.14.51 · 1
CYP2C19 → ↗
1.14.14.52 · 1
CYP2C19 → ↗

Important terminology Word statistics

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Important terminology

17 clopidogrel enzyme gene drugs p450 cytochrome 10 activity response patients variant allele substrates one inhibitors drug alleles least also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CYP2C191.14.14.1↗1.00infobox
CYP2C191.14.14.51↗1.00infobox
CYP2C191.14.14.52↗1.00infobox
CYP2C191.14.14.53↗1.00infobox
CYP2C191.14.14.75↗1.00infobox
CYP2C19AliasesCYP2C19, CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19, cytochrome P450 family 2 subfamily C member 191.00infobox
CYP2C19Available structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes4GQS1.00infobox
CYP2C19Band10q23.331.00infobox
CYP2C19Bgeeliver1.00infobox
CYP2C19Bgeeduodenum1.00infobox
CYP2C19Bgeeright lobe of liver1.00infobox
CYP2C19Bgeegallbladder1.00infobox
CYP2C19Bgeegastric mucosa1.00infobox
CYP2C19Bgeebody of stomach1.00infobox
CYP2C19Bgeemucosa of transverse colon1.00infobox
CYP2C19Bgeevagina1.00infobox
CYP2C19Bgeefundus1.00infobox
CYP2C19Bgeeskin of abdomen1.00infobox
CYP2C19BioGPSMore reference expression data1.00infobox
CYP2C19Chr.Chromosome 10 (human)1.00infobox
CYP2C19DatabasesNCBI: entry; OMA: entry1.00infobox
CYP2C19End94,855,547 bp1.00infobox
CYP2C19EnsemblENSG000001658411.00infobox
CYP2C19Entrez15571.00infobox
CYP2C19Enzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc1.14.14.1↗↗↗↗1.14.14.51↗↗↗↗1.14.14.52↗↗↗↗1.14.14.53↗↗↗↗1.14.14.75↗↗↗↗1.00infobox
CYP2C19External IDsOMIM: 124020; GeneCards: CYP2C191.00infobox
CYP2C19Gene location (Human)Gene location (Human)Chr.Chromosome 10 (human)Band10q23.33Start94,762,681 bpEnd94,855,547 bp1.00infobox
CYP2C19Gene ontologyiron ion binding1.00infobox
CYP2C19Gene ontologyoxygen binding1.00infobox
CYP2C19Gene ontologyarachidonic acid epoxygenase activity1.00infobox

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