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CYP2C19: Function, Pharmacogenomics & Overview
Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system. This subfamily includes enzymes that catalyze metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs. In humans, it is the CYP2C19 gene that encodes the CYP2C19…
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CYP2C19 topic overview
The analysis highlights Function, Pharmacogenomics and Overview as prominent areas in the source structure around CYP2C19.
Related topics
60
Source areas
4
Connected nodes
64
Extracted relationships
98
Concept neighborhoods
14
Bridge connections
64
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Function · 20 topics
Pharmacogenomics · 20 topics
Overview · 15 topics
Ligands · 5 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
1.14.14.1
↗
1.14.14.51
↗
1.14.14.52
↗
1.14.14.53
↗
1.14.14.75
↗
Aliases
CYP2C19, CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19, cytochrome P450 family 2 subfamily C member 19
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How CYP2C19 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around CYP2C19 shows recurring relationship patterns in the source. For example, CYP2C19 → arachidonic acid epoxygenase activity, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, enzyme binding, epoxygenase P450 pathway, heme binding, heterocycle metabolic process, intracellular membrane-bounded organelle, iron ion binding, membrane, metal ion binding, monooxygenase activity, monoterpenoid metabolic process, omega-hydroxylase P450 pathway, organelle membrane, organic acid metabolic process, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom… Another extracted example is CYP2C19 → body of stomach, duodenum, fundus, gallbladder, gastric mucosa, liver, mucosa of transverse colon, right lobe of liver, skin of abdomen, vagina. Use these groups to spot repeated connection types before inspecting the individual relationships.
CYP2C19
Top relations
Gene ontology· 24
CYP2C19 → arachidonic acid epoxygenase activity, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, enzyme binding, epoxygenase P450 pathway, heme binding, heterocycle metabolic process, intracellular membrane-bounded organelle, iron ion binding, membrane, metal ion binding, monooxygenase activity, monoterpenoid metabolic process, omega-hydroxylase P450 pathway, organelle membrane, organic acid metabolic process, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom…
Bgee· 10
CYP2C19 → body of stomach, duodenum, fundus, gallbladder, gastric mucosa, liver, mucosa of transverse colon, right lobe of liver, skin of abdomen, vagina
RNA expression pattern· 10
CYP2C19 → body of stomach, duodenum, fundus, gallbladder, gastric mucosa, liver, mucosa of transverse colon, right lobe of liver, skin of abdomen, vagina
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 98 structured relationships around CYP2C19. Examples in this analysis include CYP2C19 → 1.14.14.1 → ↗ and CYP2C19 → Aliases → CYP2C19, CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19, cytochrome P450 family 2 subfamily C member 19. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
CYP2C19
1.14.14.1
↗
1.00
infobox
CYP2C19
1.14.14.51
↗
1.00
infobox
CYP2C19
1.14.14.52
↗
1.00
infobox
CYP2C19
1.14.14.53
↗
1.00
infobox
CYP2C19
1.14.14.75
↗
1.00
infobox
CYP2C19
Aliases
CYP2C19, CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19, cytochrome P450 family 2 subfamily C member 19
1.00
infobox
CYP2C19
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes4GQS
Gene location (Human)Chr.Chromosome 10 (human)Band10q23.33Start94,762,681 bpEnd94,855,547 bp
1.00
infobox
CYP2C19
Gene ontology
iron ion binding
1.00
infobox
CYP2C19
Gene ontology
oxygen binding
1.00
infobox
CYP2C19
Gene ontology
arachidonic acid epoxygenase activity
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around CYP2C19 bring nearby vocabulary together. In this analysis, examples include Enzyme, Allele and Activity. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
CYP2C19
Enzyme
Allele
Activity
Variant
Clopidogrel
Drugs
Also
Alleles
Cytochrome
P450
Gene
Among
cyp2c19
Enzyme
Allele
Activity
Variant
Clopidogrel
Drugs
Also
Alleles
Cytochrome
P450
Gene
Among
enzyme
Activity
Associated
P450
Bp
Uniprot
Gene
Chromosome
Drugs
Human
Protein
Alleles
Drug
clopidogrel
Patients
Omeprazole
Associated
Cyp2c19
Higher
Alleles
Activity
Enzyme
Gene
Escitalopram
Metabolism
Also
gene
Activity
P450
Chromosome
Human
Bp
Uniprot
Protein
Patients
Clopidogrel
Escitalopram
Reference
Subfamily
gain-of-function allele
Alleles
Cyp2c19
Higher
Studies
Response
Enzyme
Drugs
Omeprazole
Escitalopram
Proton
Pump
Reference
cytochrome p450
P450
Chromosome
Human
Subfamily
Gene
Bp
Uniprot
Protein
Enzyme
Enzymes
Activity
Cyp2c19
uniprot
Bp
Chromosome
Human
Cytochrome
P450
Activity
Enzyme
Gene
Protein
Reference
Subfamily
Enzymes
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For CYP2C19, one of the stronger structural bridges in this analysis connects CYP2C19 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
CYP2C19
Nodes65
Edges64
Triples98
Avg. degree1.97
Density0.030769
Components1
Source & methodology
TTTA analyzes the structure around CYP2C19 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Pharmacogenomics & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
