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Dextromethorphan: History, Community, Culture & Applications

Dextromethorphan is a cough suppressant used in many cough and cold medicines. In 2022, the US Food and Drug Administration (FDA) approved the combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant in people with major depressive disorder.

Language: English [EN]
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Dextromethorphan topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Dextromethorphan.

Related topics
144
Source areas
9
Connected nodes
153
Extracted relationships
136
Concept neighborhoods
34
Bridge connections
153

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 35 topics
Pharmacology · 27 topics
Adverse effects · 20 topics
Society and culture · 14 topics
History · 13 topics
Chemistry · 11 topics
Interactions · 11 topics
Medical uses · 9 topics
Research · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
Addiction liability
Low–moderate
AHFS/Drugs.com
Monograph
ATC code
R05DA09 (WHO)
Bioavailability
11%
CAS Number
125-71-3 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dextromethorphan connects Entity context

The extracted context around Dextromethorphan shows recurring relationship patterns in the source. For example, Dextromethorphan → As, CIA-funded, Dextrotussion, During, FDA, Hoffmann-La Roche, In, Romilar, Swiss, The, US, US Navy, Vicks-44 Another extracted example is Dextromethorphan → At, Cough, CYP2D6, Following, It, P450, Study, The, The International Society. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dextromethorphan

Top relations

related to history · 13
Dextromethorphan → As, CIA-funded, Dextrotussion, During, FDA, Hoffmann-La Roche, In, Romilar, Swiss, The, US, US Navy, Vicks-44
related to Pharmacokinetics · 9
Dextromethorphan → At, Cough, CYP2D6, Following, It, P450, Study, The, The International Society
related to Pharmacodynamics · 8
Dextromethorphan → H1, HT1B/1D, MK-801/PCPTooltip, NETTooltip, NMDA, Serotonin, Sigma, Uncompetitive
related to Interactions · 7
Dextromethorphan → Combining, In, MAOIs, NIAAA, Serotonin, SSRIs, The
related to Recreational use · 7
Dextromethorphan → At, Each, It, NMDA, Over-the-counter, Some, These
Legal status · 6
Dextromethorphan → AU: S2 (Pharmacy medicine), CA: OTC, SE: Förteckning V, UK: P (Pharmacy medicines), UN: Unscheduled, US: OTC
related to Cough suppression · 6
Dextromethorphan → Cold, Fever Multi-Symptom, In December, Mucinex, The, United States
related to External links · 6
Dextromethorphan → DEA, Drug Enforcement Administration, DXM, Media, Wikimedia Commons, Wiktionary-logo-en-v2
related to Neurotoxicity · 5
Dextromethorphan → Neurotoxic, NMDA, Olney's, PCP, Tests
related to Research · 5
Dextromethorphan → Alzheimer's, AVP-923, In, The, When

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

drug cyp2d6 effects dissociative use major receptor dextrorphan serotonin combination approved metabolite doses cough nmda used medications including also number

Dextromethorphan relationships Subject–Predicate–Object triples

TTTA extracted 136 structured relationships around Dextromethorphan. Examples in this analysis include Dextromethorphan → 3D model (JSmol) → Interactive image and Dextromethorphan → Addiction liability → Low–moderate. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dextromethorphan3D model (JSmol)Interactive image1.00infobox
DextromethorphanAddiction liabilityLow–moderate1.00infobox
DextromethorphanAHFS/Drugs.comMonograph1.00infobox
DextromethorphanATC codeR05DA09 (WHO)1.00infobox
DextromethorphanBioavailability11%1.00infobox
DextromethorphanCAS Number125-71-3 Y1.00infobox
DextromethorphanChEBICHEBI:4470 N1.00infobox
DextromethorphanChEMBLChEMBL52440 Y1.00infobox
DextromethorphanChemSpider13109865 Y1.00infobox
DextromethorphanChiralityDextrorotatory enantiomer1.00infobox
DextromethorphanCompTox Dashboard (EPA)DTXSID30229081.00infobox
DextromethorphanDrug classAntitussive; Serotonin–norepinephrine reuptake inhibitor; NMDA receptor antagonist; Dissociative hallucinogen1.00infobox
DextromethorphanDrugBankDB00514 Y1.00infobox
DextromethorphanDuration of action3–8 hours1.00infobox
DextromethorphanECHA InfoCard100.004.3211.00infobox
DextromethorphanElimination half-life2–4 hours (extensive metabolizers); 24 hours (poor metabolizers)1.00infobox
DextromethorphanExcretionKidney1.00infobox
DextromethorphanFormulaC18H25NO1.00infobox
DextromethorphanIUPHAR/BPS69531.00infobox
DextromethorphanKEGGD03742 Y1.00infobox
DextromethorphanLegal statusAU: S2 (Pharmacy medicine)1.00infobox
DextromethorphanLegal statusCA: OTC1.00infobox
DextromethorphanLegal statusUK: P (Pharmacy medicines)1.00infobox
DextromethorphanLegal statusUS: OTC1.00infobox
DextromethorphanLegal statusUN: Unscheduled1.00infobox
DextromethorphanLegal statusSE: Förteckning V1.00infobox
DextromethorphanLicense dataUS DailyMed: Dextromethorphan1.00infobox
DextromethorphanMedlinePlusa6824921.00infobox
DextromethorphanMelting point111 °C (232 °F)1.00infobox
DextromethorphanMetabolismLiver enzymes: major CYP2D6, minor CYP3A4, and minor CYP3A51.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dextromethorphan bring nearby vocabulary together. In this analysis, examples include Drug, Effects and Dextrorphan. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dextromethorphan
    • Drug
    • Effects
    • Dextrorphan
    • Combination
    • Approved
    • Metabolite
    • Receptor
    • Dissociative
    • Major
    • Use
    • Cyp2d6
    • Hours
  • dextromethorphan
    • Drug
    • Effects
    • Dextrorphan
    • Combination
    • Approved
    • Metabolite
    • Receptor
    • Dissociative
    • Major
    • Use
    • Cyp2d6
    • Hours
  • cough suppressant
    • Hours
    • Dissociative
    • Use
    • Metabolism
    • Norepinephrine
    • Action
    • Cyp3a4
    • Disorder
    • Inhibitor
    • Phencyclidine
    • Quinidine
    • Sedation
  • cough
    • Hours
    • Dissociative
    • Use
    • Metabolism
    • Norepinephrine
    • Action
    • Cyp3a4
    • Disorder
    • Inhibitor
    • Phencyclidine
    • Quinidine
    • Sedation
  • food and drug administration
    • Action
    • Disorder
    • Us
    • Administration
    • Drug
    • Hours
    • Major
    • Combination
    • Cyp2d6
    • Metabolism
    • Norepinephrine
    • Use
  • dextromethorphan/bupropion
    • Drug
    • Effects
    • Dextrorphan
    • Combination
    • Approved
    • Metabolite
    • Receptor
    • Dissociative
    • Major
    • Use
    • Cyp2d6
    • Hours
  • major depressive disorder
    • Disorder
    • Major
    • Us
    • Nmda
    • Name
    • Effects
    • Dextrorphan
    • Metabolite
    • Receptor
    • Dissociative
    • Action
    • Phencyclidine
  • dissociative hallucinogen
    • Phencyclidine
    • Nmda
    • Dextrorphan
    • Receptor
    • Doses
    • Major
    • Norepinephrine
    • Inhibitor
    • Effects
    • Higher
    • Reuptake
    • Serotonin

Connections between topic areas Semantic bridges

For Dextromethorphan, one of the stronger structural bridges in this analysis connects Dextromethorphan with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Dextromethorphan — Overview · splits 118 ⟂ 36
Dextromethorphan — Pharmacology · splits 126 ⟂ 28
Dextromethorphan — Adverse effects · splits 133 ⟂ 21
Dextromethorphan — Society and culture · splits 139 ⟂ 15
Dextromethorphan — History · splits 140 ⟂ 14
Dextromethorphan — Interactions · splits 142 ⟂ 12
Dextromethorphan — Chemistry · splits 142 ⟂ 12
Dextromethorphan — Medical uses · splits 144 ⟂ 10
Dextromethorphan — Research · splits 149 ⟂ 5

Map overview Semantic statistics

Dextromethorphan

Nodes154
Edges153
Triples136
Avg. degree1.99
Density0.012987
Components1

Source & methodology

TTTA analyzes the structure around Dextromethorphan to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dextromethorphan · EN edition · Analysis: TopicsToTalkAbout

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