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Dextromethorphan

Dextromethorphan is a cough suppressant used in many cough and cold medicines. In 2022, the US Food and Drug Administration (FDA) approved the combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant in people with major depressive disorder.

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Adverse effects

20 related topics

Pharmacology

27 related topics

History

13 related topics

Society and culture

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Key facts & relationships

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3D model (JSmol)
Interactive image
Addiction liability
Low–moderate
AHFS/Drugs.com
Monograph
ATC code
R05DA09 (WHO)
Bioavailability
11%
CAS Number
125-71-3 Y

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Overview

Medical uses

Adverse effects

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

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Map overview Semantic statistics

Dextromethorphan

Nodes154
Edges153
Triples136
Avg. degree1.99
Density0.012987
Components1

How this topic connects Entity context

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Dextromethorphan

Top relations

related to history · 13
Dextromethorphan → As, CIA-funded, Dextrotussion, During, FDA, Hoffmann-La Roche, In, Romilar, Swiss, The, US, US Navy, Vicks-44
related to Pharmacokinetics · 9
Dextromethorphan → At, Cough, CYP2D6, Following, It, P450, Study, The, The International Society
related to Pharmacodynamics · 8
Dextromethorphan → H1, HT1B/1D, MK-801/PCPTooltip, NETTooltip, NMDA, Serotonin, Sigma, Uncompetitive
related to Interactions · 7
Dextromethorphan → Combining, In, MAOIs, NIAAA, Serotonin, SSRIs, The
related to Recreational use · 7
Dextromethorphan → At, Each, It, NMDA, Over-the-counter, Some, These
Legal status · 6
Dextromethorphan → AU: S2 (Pharmacy medicine), CA: OTC, SE: Förteckning V, UK: P (Pharmacy medicines), UN: Unscheduled, US: OTC
related to Cough suppression · 6
Dextromethorphan → Cold, Fever Multi-Symptom, In December, Mucinex, The, United States
related to External links · 6
Dextromethorphan → DEA, Drug Enforcement Administration, DXM, Media, Wikimedia Commons, Wiktionary-logo-en-v2
related to Neurotoxicity · 5
Dextromethorphan → Neurotoxic, NMDA, Olney's, PCP, Tests
related to Research · 5
Dextromethorphan → Alzheimer's, AVP-923, In, The, When

Important terminology Word statistics

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Important terminology

drug cyp2d6 effects dissociative use major receptor dextrorphan serotonin combination approved metabolite doses cough nmda used medications including also number

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dextromethorphan3D model (JSmol)Interactive image1.00infobox
DextromethorphanAddiction liabilityLow–moderate1.00infobox
DextromethorphanAHFS/Drugs.comMonograph1.00infobox
DextromethorphanATC codeR05DA09 (WHO)1.00infobox
DextromethorphanBioavailability11%1.00infobox
DextromethorphanCAS Number125-71-3 Y1.00infobox
DextromethorphanChEBICHEBI:4470 N1.00infobox
DextromethorphanChEMBLChEMBL52440 Y1.00infobox
DextromethorphanChemSpider13109865 Y1.00infobox
DextromethorphanChiralityDextrorotatory enantiomer1.00infobox
DextromethorphanCompTox Dashboard (EPA)DTXSID30229081.00infobox
DextromethorphanDrug classAntitussive; Serotonin–norepinephrine reuptake inhibitor; NMDA receptor antagonist; Dissociative hallucinogen1.00infobox
DextromethorphanDrugBankDB00514 Y1.00infobox
DextromethorphanDuration of action3–8 hours1.00infobox
DextromethorphanECHA InfoCard100.004.3211.00infobox
DextromethorphanElimination half-life2–4 hours (extensive metabolizers); 24 hours (poor metabolizers)1.00infobox
DextromethorphanExcretionKidney1.00infobox
DextromethorphanFormulaC18H25NO1.00infobox
DextromethorphanIUPHAR/BPS69531.00infobox
DextromethorphanKEGGD03742 Y1.00infobox
DextromethorphanLegal statusAU: S2 (Pharmacy medicine)1.00infobox
DextromethorphanLegal statusCA: OTC1.00infobox
DextromethorphanLegal statusUK: P (Pharmacy medicines)1.00infobox
DextromethorphanLegal statusUS: OTC1.00infobox
DextromethorphanLegal statusUN: Unscheduled1.00infobox
DextromethorphanLegal statusSE: Förteckning V1.00infobox
DextromethorphanLicense dataUS DailyMed: Dextromethorphan1.00infobox
DextromethorphanMedlinePlusa6824921.00infobox
DextromethorphanMelting point111 °C (232 °F)1.00infobox
DextromethorphanMetabolismLiver enzymes: major CYP2D6, minor CYP3A4, and minor CYP3A51.00infobox

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