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Codeine

Codeine is an opiate and prodrug of morphine mainly used to treat pain, coughing, and diarrhea. It is commonly used as a recreational drug. It is found naturally in the sap of the opium poppy, Papaver somniferum. It is typically used to treat mild to moderate degrees of pain.[failed verification] Greater benefit may occur when combined with paracetamol…

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Key facts & relationships

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3D model (JSmol)
Interactive image
Addiction liability
High
AHFS/Drugs.com
Monograph
ATC code
R05DA04 (WHO) Combinations: N02AA59 (WHO), N02AA79 (WHO), N02AJ08 (WHO), N02AJ06 (WHO), N02AJ07 (WHO)
Bioavailability
c. 60% (by mouth)
CAS Number
76-57-3

Topics to explore

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Overview

Medical uses

Side effects

Pharmacology

Chemistry

History

Society and culture

Advanced semantic analysis

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Map overview Semantic statistics

Codeine

Nodes156
Edges155
Triples160
Avg. degree1.99
Density0.012821
Components1

How this topic connects Entity context

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Codeine

Top relations

related to Legal status · 26
Codeine → Around, As, Bulgaria, Canada, Cyprus, Denmark, Estonia, European Union, III, In, In Australia, Ireland, Latvia, Lithuania, Malta, Narcotic Drugs, New Zealand, OTC, Poland, Romania
Legal status · 9
Codeine → AU: S8 (Controlled drug) / S4 (Prescription only)[a], BR: Class A2 (Narcotic drugs) / Class C1[b], CA: Schedule I, DE: Anlage III (Special prescription form required), NZ: Class C2, SE: Förteckning III, UK: Class B / Pharmacy medicine[c], UN: Narcotic Schedule II / Narcotic Schedule III[e], US: Schedule II / Schedule III–V[d]
has effect · 9
Codeine → As, Common, Drug Administration, February, In August, Less, Rare, Some, United States Food
related to Detection · 9
Codeine → Blood, Drug, Furthermore, It Codeine, L-DOPA, Many, Parkinson's, Poppy, Urinary
related to Pharmacokinetics · 9
Codeine → CYP2D6, CYP3A4, Life-threatening, P450, Srinivasan, Tebbett, The, UGT2B7, Wielbo
related to Formulations · 8
Codeine → Emprazil, No, Nurofen Plus, Panadeine, Paracod, These, Tylenol, Tylenol-with-codeine
related to Pain · 7
Codeine → Drug Administration, FDA, It, Pediatrics, The American Academy, The Food, Weak
related to Withdrawal and dependence · 6
Codeine → Also, As, CYP2D6, These, To, Withdrawal
related to Chemistry · 5
Codeine → Corcoran, Junning Ma, O-methylation, Robert, While
related to history · 5
Codeine → Ancient Greek, Opium, Papaver, Papaveraceae, The

Important terminology Word statistics

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Important terminology

morphine prescription used drug available use pain may containing mg cough effects paracetamol schedule preparations opium without also products aspirin

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Codeine3D model (JSmol)Interactive image1.00infobox
CodeineAddiction liabilityHigh1.00infobox
CodeineAHFS/Drugs.comMonograph1.00infobox
CodeineATC codeR05DA04 (WHO) Combinations: N02AA59 (WHO), N02AA79 (WHO), N02AJ08 (WHO), N02AJ06 (WHO), N02AJ07 (WHO)1.00infobox
CodeineBioavailabilityc. 60% (by mouth)1.00infobox
CodeineCAS Number76-57-31.00infobox
CodeineChEBICHEBI:167141.00infobox
CodeineChEMBLChEMBL4851.00infobox
CodeineChemSpider44474471.00infobox
CodeineCompTox Dashboard (EPA)DTXSID20203411.00infobox
CodeineDependence liabilityHigh1.00infobox
CodeineDrug classOpioid;1.00infobox
CodeineDrug classAntitussive1.00infobox
CodeineDrugBankDB003181.00infobox
CodeineDuration of action4–6 hours1.00infobox
CodeineECHA InfoCard100.000.8821.00infobox
CodeineElimination half-life2.5–3 hours1.00infobox
CodeineFormulaC18H21NO31.00infobox
CodeineIUPHAR/BPS16731.00infobox
CodeineKEGGC061741.00infobox
CodeineLegal statusAU: S8 (Controlled drug) / S4 (Prescription only)[a]1.00infobox
CodeineLegal statusBR: Class A2 (Narcotic drugs) / Class C1[b]1.00infobox
CodeineLegal statusCA: Schedule I1.00infobox
CodeineLegal statusDE: Anlage III (Special prescription form required)1.00infobox
CodeineLegal statusNZ: Class C21.00infobox
CodeineLegal statusUK: Class B / Pharmacy medicine[c]1.00infobox
CodeineLegal statusUS: Schedule II / Schedule III–V[d]1.00infobox
CodeineLegal statusUN: Narcotic Schedule II / Narcotic Schedule III[e]1.00infobox
CodeineLegal statusSE: Förteckning III1.00infobox
CodeineLicense dataUS DailyMed: Codeine1.00infobox

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    Min side: 3
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