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Pethidine

Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a fully synthetic opioid pain medication of the phenylpiperidine class. Synthesized in 1938 as a potential anticholinergic agent by the German chemist Otto Eisleb, its analgesic properties were first recognized by Otto Schaumann while working for IG Farben, in…

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3D model (JSmol)
Interactive image
Addiction liability
High
ATC code
N02AB02 (WHO)
Bioavailability
50–60% (Oral), 80–90% (Oral, in cases of hepatic impairment)
CAS Number
57-42-1 Y
ChEBI
CHEBI:6754

Topics to explore

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Overview

Medical uses

Adverse effects

Interactions

Mechanism of action

Pharmacology

Synthesis

Society and culture

Veterinary use

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Map overview Semantic statistics

Pethidine

Nodes101
Edges100
Triples96
Avg. degree1.98
Density0.019802
Components1

How this topic connects Entity context

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Pethidine

Top relations

related to Legal status · 10
Pethidine → ACSCN, Control, Controlled Substances Act, It, Narcotic, Narcotic Substances, Schedule II, Single Convention, The, United States
related to Veterinary use · 10
Pethidine → CYP450, Due, Epidural, Histamine, IM, IV, N-demethylation, Normeperidine, SC, The
has effect · 9
Pethidine → Convulsive, Due, Fatalities, Interactions, Overdose, Serotonin, SSRIs, The, Unlike
Legal status · 8
Pethidine → AU: S8 (Controlled drug), BR: Class A1 (Narcotic drugs), CA: Schedule I, DE: Anlage III (Special prescription form required), NZ: Class B, UK: Class A, UN: Narcotic Schedule I, US: Schedule II
related to Interactions · 6
Pethidine → Fatal, It, Libby Zion, Seizures, SSRIs, Such
related to Medical uses · 4
Pethidine → It, New Zealand, United Kingdom, United States
Metabolites · 3
Pethidine → Norpethidine, others, Pethidinic acid
related to Pharmacokinetics · 3
Pethidine → Norpethidine, Pethidine's, The
is a · 2
Pethidine → preferred painkiller for diverticulitis, prototype of a large family of analgesics including the pethidine 4-phenylpiperidines
related to Mechanism of action · 2
Pethidine → Like, The

Important terminology Word statistics

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Important terminology

effects opioids norpethidine due opioid morphine pain also serotonin interactions anticholinergic use addiction cause metabolite administration syndrome severe compared risk

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Pethidine3D model (JSmol)Interactive image1.00infobox
PethidineAddiction liabilityHigh1.00infobox
PethidineATC codeN02AB02 (WHO)1.00infobox
PethidineBioavailability50–60% (Oral), 80–90% (Oral, in cases of hepatic impairment)1.00infobox
PethidineCAS Number57-42-1 Y1.00infobox
PethidineChEBICHEBI:67541.00infobox
PethidineChEMBLChEMBL607 Y1.00infobox
PethidineChemSpider39181.00infobox
PethidineCompTox Dashboard (EPA)DTXSID90232531.00infobox
PethidineDependence liabilityHigh1.00infobox
PethidineDrug classOpioid1.00infobox
PethidineDrugBankDB00454 Y1.00infobox
PethidineECHA InfoCard100.000.2991.00infobox
PethidineElimination half-life2.5–4 hours, 7–11 hours (liver disease)1.00infobox
PethidineExcretionRenal1.00infobox
PethidineFormulaC15H21NO21.00infobox
PethidineIUPHAR/BPS72211.00infobox
PethidineKEGGD08343 Y1.00infobox
PethidineLegal statusAU: S8 (Controlled drug)1.00infobox
PethidineLegal statusBR: Class A1 (Narcotic drugs)1.00infobox
PethidineLegal statusCA: Schedule I1.00infobox
PethidineLegal statusDE: Anlage III (Special prescription form required)1.00infobox
PethidineLegal statusNZ: Class B1.00infobox
PethidineLegal statusUK: Class A1.00infobox
PethidineLegal statusUS: Schedule II1.00infobox
PethidineLegal statusUN: Narcotic Schedule I1.00infobox
PethidineMetabolismLiver: CYP2B6, CYP3A4, CYP2C19, Carboxylesterase 11.00infobox
PethidineMetabolitesNorpethidine1.00infobox
PethidineMetabolitesPethidinic acid1.00infobox
PethidineMetabolitesothers1.00infobox

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