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Pethidine: Community, Culture & Applications

Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a fully synthetic opioid pain medication of the phenylpiperidine class. Synthesized in 1938 as a potential anticholinergic agent by the German chemist Otto Eisleb, its analgesic properties were first recognized by Otto Schaumann while working for IG Farben, in…

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Pethidine topic overview

The analysis highlights Community, Culture and Applications as prominent areas in the source structure around Pethidine.

Related topics
91
Source areas
9
Connected nodes
100
Extracted relationships
96
Concept neighborhoods
21
Bridge connections
100

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 26 topics
Mechanism of action · 18 topics
Veterinary use · 15 topics
Interactions · 7 topics
Adverse effects · 6 topics
Synthesis · 6 topics
Pharmacology · 5 topics
Society and culture · 5 topics
Medical uses · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
Addiction liability
High
ATC code
N02AB02 (WHO)
Bioavailability
50–60% (Oral), 80–90% (Oral, in cases of hepatic impairment)
CAS Number
57-42-1 Y
ChEBI
CHEBI:6754

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Interactions

Mechanism of action

Pharmacology

Synthesis

Society and culture

Veterinary use

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Pethidine connects Entity context

The extracted context around Pethidine shows recurring relationship patterns in the source. For example, Pethidine → ACSCN, Control, Controlled Substances Act, It, Narcotic, Narcotic Substances, Schedule II, Single Convention, The, United States Another extracted example is Pethidine → CYP450, Due, Epidural, Histamine, IM, IV, N-demethylation, Normeperidine, SC, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Pethidine

Top relations

related to Legal status · 10
Pethidine → ACSCN, Control, Controlled Substances Act, It, Narcotic, Narcotic Substances, Schedule II, Single Convention, The, United States
related to Veterinary use · 10
Pethidine → CYP450, Due, Epidural, Histamine, IM, IV, N-demethylation, Normeperidine, SC, The
has effect · 9
Pethidine → Convulsive, Due, Fatalities, Interactions, Overdose, Serotonin, SSRIs, The, Unlike
Legal status · 8
Pethidine → AU: S8 (Controlled drug), BR: Class A1 (Narcotic drugs), CA: Schedule I, DE: Anlage III (Special prescription form required), NZ: Class B, UK: Class A, UN: Narcotic Schedule I, US: Schedule II
related to Interactions · 6
Pethidine → Fatal, It, Libby Zion, Seizures, SSRIs, Such
related to Medical uses · 4
Pethidine → It, New Zealand, United Kingdom, United States
Metabolites · 3
Pethidine → Norpethidine, others, Pethidinic acid
related to Pharmacokinetics · 3
Pethidine → Norpethidine, Pethidine's, The
is a · 2
Pethidine → preferred painkiller for diverticulitis, prototype of a large family of analgesics including the pethidine 4-phenylpiperidines
related to Mechanism of action · 2
Pethidine → Like, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects opioids norpethidine due opioid morphine pain also serotonin interactions anticholinergic use addiction cause metabolite administration syndrome severe compared risk

Pethidine relationships Subject–Predicate–Object triples

TTTA extracted 96 structured relationships around Pethidine. Examples in this analysis include Pethidine → 3D model (JSmol) → Interactive image and Pethidine → Addiction liability → High. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Pethidine3D model (JSmol)Interactive image1.00infobox
PethidineAddiction liabilityHigh1.00infobox
PethidineATC codeN02AB02 (WHO)1.00infobox
PethidineBioavailability50–60% (Oral), 80–90% (Oral, in cases of hepatic impairment)1.00infobox
PethidineCAS Number57-42-1 Y1.00infobox
PethidineChEBICHEBI:67541.00infobox
PethidineChEMBLChEMBL607 Y1.00infobox
PethidineChemSpider39181.00infobox
PethidineCompTox Dashboard (EPA)DTXSID90232531.00infobox
PethidineDependence liabilityHigh1.00infobox
PethidineDrug classOpioid1.00infobox
PethidineDrugBankDB00454 Y1.00infobox
PethidineECHA InfoCard100.000.2991.00infobox
PethidineElimination half-life2.5–4 hours, 7–11 hours (liver disease)1.00infobox
PethidineExcretionRenal1.00infobox
PethidineFormulaC15H21NO21.00infobox
PethidineIUPHAR/BPS72211.00infobox
PethidineKEGGD08343 Y1.00infobox
PethidineLegal statusAU: S8 (Controlled drug)1.00infobox
PethidineLegal statusBR: Class A1 (Narcotic drugs)1.00infobox
PethidineLegal statusCA: Schedule I1.00infobox
PethidineLegal statusDE: Anlage III (Special prescription form required)1.00infobox
PethidineLegal statusNZ: Class B1.00infobox
PethidineLegal statusUK: Class A1.00infobox
PethidineLegal statusUS: Schedule II1.00infobox
PethidineLegal statusUN: Narcotic Schedule I1.00infobox
PethidineMetabolismLiver: CYP2B6, CYP3A4, CYP2C19, Carboxylesterase 11.00infobox
PethidineMetabolitesNorpethidine1.00infobox
PethidineMetabolitesPethidinic acid1.00infobox
PethidineMetabolitesothers1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Pethidine bring nearby vocabulary together. In this analysis, examples include Effects, Morphine and Administration. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Pethidine
    • Effects
    • Morphine
    • Administration
    • Norpethidine
    • Opioids
    • Controlled
    • Narcotic
    • Severe
    • Due
    • Intravenous
    • Addiction
    • Depression
  • pethidine
    • Effects
    • Morphine
    • Administration
    • Norpethidine
    • Opioids
    • Controlled
    • Narcotic
    • Severe
    • Due
    • Intravenous
    • Addiction
    • Depression
  • opioid
    • Class
    • Others
    • Addiction
    • Medical
    • Metabolites
    • Pain
    • Use
    • Interactions
    • Norpethidine
    • Intramuscular
    • Subcutaneous
    • Intravenous
  • addiction
    • Renal
    • Risk
    • Compared
    • Opioid
    • Intramuscular
    • Subcutaneous
    • Class
    • Effects
    • Intravenous
    • Others
    • Potential
    • Controlled
  • adverse effects
    • Opioids
    • Side
    • Pethidine
    • Norpethidine
    • Renal
    • Risk
    • Medical
    • Metabolites
    • Narcotic
    • Pethidine's
    • Metabolite
    • Syndrome
  • veterinary use
    • Drug
    • Medical
    • Opioid
    • Interactions
    • Norpethidine
    • Intramuscular
    • Subcutaneous
    • Class
    • Intravenous
    • Opioids
    • Others
    • Renal
  • epidural administration
    • Class
    • Also
    • Norpethidine
    • Intramuscular
    • Subcutaneous
    • Analgesic
    • Intravenous
    • Others
    • Renal
    • Pethidine
    • Controlled
    • Depression
  • drug abuse warning network
    • Use
    • Interactions
    • Intramuscular
    • Norpethidine
    • Subcutaneous
    • Intravenous
    • Others
    • Potential
    • Renal
    • Controlled
    • Medical
    • Metabolites

Connections between topic areas Semantic bridges

For Pethidine, one of the stronger structural bridges in this analysis connects Pethidine with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Pethidine — Overview · splits 74 ⟂ 27
Pethidine — Mechanism of action · splits 82 ⟂ 19
Pethidine — Veterinary use · splits 85 ⟂ 16
Pethidine — Interactions · splits 93 ⟂ 8
Pethidine — Adverse effects · splits 94 ⟂ 7
Pethidine — Synthesis · splits 94 ⟂ 7
Pethidine — Pharmacology · splits 95 ⟂ 6
Pethidine — Society and culture · splits 95 ⟂ 6
Pethidine — Medical uses · splits 97 ⟂ 4

Map overview Semantic statistics

Pethidine

Nodes101
Edges100
Triples96
Avg. degree1.98
Density0.019802
Components1

Source & methodology

TTTA analyzes the structure around Pethidine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Pethidine · EN edition · Analysis: TopicsToTalkAbout

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