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Tacrine

Tacrine is a centrally acting acetylcholinesterase inhibitor and indirect cholinergic agonist (parasympathomimetic). It was the first centrally acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was marketed under the trade name Cognex. Tacrine was first synthesised by Adrien Albert at the University of Sydney in 1949.…

Applications, Adverse effects & Clinical use

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06DA01 (WHO)
Bioavailability
2.4–36% (oral)
Boiling point
358 °C (676 °F)
CAS Number
321-64-2 Y

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Overview

Clinical use

Adverse effects

Pharmacokinetics

Advanced semantic analysis

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Map overview Semantic statistics

Tacrine

Nodes27
Edges26
Triples58
Avg. degree1.93
Density0.074074
Components1

How this topic connects Entity context

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Tacrine

Top relations

has effect · 6
Tacrine → ALADiarrheaDizzinessHeadacheNauseaVomiting Abdominal, BelchingConfusionConjunctivitis, ConstipationDiaphoresis, FatigueHallucinationsIndigestionInsomniaMyalgia, Increased, LFT
related to Clinical use · 5
Tacrine → Alzheimer's, Studies, Summers, US, William
Legal status · 4
Tacrine → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), UK: POM (Prescription only), US: ℞-only
related to Pharmacokinetics · 3
Tacrine → CYP1A2, Major, This
related to Overdose · 2
Tacrine → As, Atropine
3D model (JSmol) · 1
Tacrine → Interactive image
AHFS/Drugs.com · 1
Tacrine → Monograph
ATC code · 1
Tacrine → N06DA01 (WHO)
Bioavailability · 1
Tacrine → 2.4–36% (oral)
Boiling point · 1
Tacrine → 358 °C (676 °F)

Important terminology Word statistics

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Important terminology

treatment inhibitor also centrally acting first effects trade name cognex cyp1a2 pdbe liver link conclusively proven acetylcholinesterase cholinesterase alzheimer's disease

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Tacrine3D model (JSmol)Interactive image1.00infobox
TacrineAHFS/Drugs.comMonograph1.00infobox
TacrineATC codeN06DA01 (WHO)1.00infobox
TacrineBioavailability2.4–36% (oral)1.00infobox
TacrineBoiling point358 °C (676 °F)1.00infobox
TacrineCAS Number321-64-2 Y1.00infobox
TacrineChEBICHEBI:45980 Y1.00infobox
TacrineChEMBLChEMBL95 Y1.00infobox
TacrineChemSpider1859 Y1.00infobox
TacrineCompTox Dashboard (EPA)DTXSID10372721.00infobox
TacrineDrugBankDB00382 Y1.00infobox
TacrineECHA InfoCard100.005.7211.00infobox
TacrineElimination half-life2–4 hours1.00infobox
TacrineExcretionRenal1.00infobox
TacrineFormulaC13H14N21.00infobox
TacrineIUPHAR/BPS66871.00infobox
TacrineLegal statusAU: S4 (Prescription only)1.00infobox
TacrineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
TacrineLegal statusUK: POM (Prescription only)1.00infobox
TacrineLegal statusUS: ℞-only1.00infobox
TacrineMedlinePlusa6930391.00infobox
TacrineMelting point183 °C (361 °F)1.00infobox
TacrineMetabolismHepatic (CYP1A2)1.00infobox
TacrineMolar mass198.269 g·mol−11.00infobox
TacrinePDB ligandTHA (PDBe, RCSB PDB)1.00infobox
TacrinePregnancy categoryAU: C1.00infobox
TacrineProtein binding55%1.00infobox
TacrineRoutes of administrationOral, rectal1.00infobox
TacrineTrade namesCognex1.00infobox
TacrineUNII4VX7YNB5371.00infobox

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