Tacrine

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Tacrine topic overview

The analysis highlights Applications, Adverse effects and Clinical use as prominent areas in the source structure around Tacrine.

Related topics: 22
Source areas: 4
Connected nodes: 26
Extracted relationships: 58
Concept neighborhoods: 14
Bridge connections: 26

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Adverse effects · 9 topics

Overview · 7 topics

Clinical use · 4 topics

Pharmacokinetics · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
AHFS/Drugs.com: Monograph
ATC code: N06DA01 (WHO)
Bioavailability: 2.4–36% (oral)
Boiling point: 358 °C (676 °F)
CAS Number: 321-64-2 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Acetylcholinesterase inhibitor Anticholinesterase inhibitor
Cholinergic
Parasympathomimetic
Alzheimer's disease
Adrien Albert
University of Sydney
Histamine N-methyltransferase

Clinical use

Adverse effects

Pharmacokinetics

CYP1A2
1-hydroxy-tacrine 1-hydroxytacrine

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Tacrine connects Entity context

The extracted context around Tacrine shows recurring relationship patterns in the source. For example, Tacrine → ALADiarrheaDizzinessHeadacheNauseaVomiting Abdominal, BelchingConfusionConjunctivitis, ConstipationDiaphoresis, FatigueHallucinationsIndigestionInsomniaMyalgia, Increased, LFT Another extracted example is Tacrine → Alzheimer's, Studies, Summers, US, William. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

has effect · 6

Tacrine → ALADiarrheaDizzinessHeadacheNauseaVomiting Abdominal, BelchingConfusionConjunctivitis, ConstipationDiaphoresis, FatigueHallucinationsIndigestionInsomniaMyalgia, Increased, LFT

related to Clinical use · 5

Tacrine → Alzheimer's, Studies, Summers, US, William

Legal status · 4

Tacrine → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), UK: POM (Prescription only), US: ℞-only

related to Pharmacokinetics · 3

Tacrine → CYP1A2, Major, This

related to Overdose · 2

Tacrine → As, Atropine

3D model (JSmol) · 1

Tacrine → Interactive image

AHFS/Drugs.com · 1

Tacrine → Monograph

ATC code · 1

Tacrine → N06DA01 (WHO)

Bioavailability · 1

Tacrine → 2.4–36% (oral)

Boiling point · 1

Tacrine → 358 °C (676 °F)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

treatment inhibitor also centrally acting first effects trade name cognex cyp1a2 pdbe liver link conclusively proven acetylcholinesterase cholinesterase alzheimer's disease

Tacrine relationships Subject–Predicate–Object triples

TTTA extracted 58 structured relationships around Tacrine. Examples in this analysis include Tacrine → 3D model (JSmol) → Interactive image and Tacrine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Tacrine	3D model (JSmol)	Interactive image	1.00	infobox
Tacrine	AHFS/Drugs.com	Monograph	1.00	infobox
Tacrine	ATC code	N06DA01 (WHO)	1.00	infobox
Tacrine	Bioavailability	2.4–36% (oral)	1.00	infobox
Tacrine	Boiling point	358 °C (676 °F)	1.00	infobox
Tacrine	CAS Number	321-64-2 Y	1.00	infobox
Tacrine	ChEBI	CHEBI:45980 Y	1.00	infobox
Tacrine	ChEMBL	ChEMBL95 Y	1.00	infobox
Tacrine	ChemSpider	1859 Y	1.00	infobox
Tacrine	CompTox Dashboard (EPA)	DTXSID1037272	1.00	infobox
Tacrine	DrugBank	DB00382 Y	1.00	infobox
Tacrine	ECHA InfoCard	100.005.721	1.00	infobox
Tacrine	Elimination half-life	2–4 hours	1.00	infobox
Tacrine	Excretion	Renal	1.00	infobox
Tacrine	Formula	C13H14N2	1.00	infobox
Tacrine	IUPHAR/BPS	6687	1.00	infobox
Tacrine	Legal status	AU: S4 (Prescription only)	1.00	infobox
Tacrine	Legal status	BR: Class C1 (Other controlled substances)	1.00	infobox
Tacrine	Legal status	UK: POM (Prescription only)	1.00	infobox
Tacrine	Legal status	US: ℞-only	1.00	infobox
Tacrine	MedlinePlus	a693039	1.00	infobox
Tacrine	Melting point	183 °C (361 °F)	1.00	infobox
Tacrine	Metabolism	Hepatic (CYP1A2)	1.00	infobox
Tacrine	Molar mass	198.269 g·mol−1	1.00	infobox
Tacrine	PDB ligand	THA (PDBe, RCSB PDB)	1.00	infobox
Tacrine	Pregnancy category	AU: C	1.00	infobox
Tacrine	Protein binding	55%	1.00	infobox
Tacrine	Routes of administration	Oral, rectal	1.00	infobox
Tacrine	Trade names	Cognex	1.00	infobox
Tacrine	UNII	4VX7YNB537	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Tacrine bring nearby vocabulary together. In this analysis, examples include Treatment, Conclusively and Sweating. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

acetylcholinesterase inhibitor
- Alzheimer's
- Cholinergic
- Cholinesterase
- Cognex
- Disease
- Name
- Parasympathomimetic
- Trade
- Acting
- Centrally
- Pdb
- Pdbe
adverse effects
- Bradycardia
- Hypotension
- Alzheimer's
- Cholinesterase
- Clinical
- Cognex
- Cyp1a2
- Disease
- Effect
- Effects
- May
- Metabolism
cholinesterase inhibitor
- Alzheimer's
- Cognex
- Disease
- Name
- Trade
- Cholinesterase
- Inhibitor
- Adverse
- Clinical
- Cyp1a2
- Effects
- First
clinical use
- Adverse
- Alzheimer's
- Cholinesterase
- Clinical
- Cognex
- Cyp1a2
- Disease
- Effect
- Effects
- May
- Metabolism
- Name
alzheimer's disease
- Cholinesterase
- Cognex
- Disease
- Name
- Trade
- Inhibitor
- Adverse
- Centrally
- Clinical
- Cyp1a2
- Effects
- First
Tacrine
- Treatment
- Conclusively
- Sweating
- Us
- Link
- Proven
- Bradycardia
- Hypotension
- Cyp1a2
- May
- Metabolism
- Nausea
tacrine
- Treatment
- Conclusively
- Sweating
- Us
- Link
- Proven
- Bradycardia
- Hypotension
- Cyp1a2
- May
- Metabolism
- Nausea
liver function tests
- Nausea
- Vomiting
- Bradycardia
- Hypotension
- Conclusively
- Major
- May
- Metabolism
- Pain
- Sweating
- Urinary
- Link

Connections between topic areas Semantic bridges

For Tacrine, one of the stronger structural bridges in this analysis connects Tacrine with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Tacrine — Adverse effects · splits 17 ⟂ 10

Tacrine — Overview · splits 19 ⟂ 8

Tacrine — Clinical use · splits 22 ⟂ 5

Tacrine — Pharmacokinetics · splits 24 ⟂ 3

Map overview Semantic statistics

Tacrine

Nodes27

Edges26

Triples58

Avg. degree1.93

Density0.074074

Components1

Source & methodology

TTTA analyzes the structure around Tacrine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Adverse effects & Clinical use, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Tacrine · EN edition · Analysis: TopicsToTalkAbout