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Cyclophosphamide

Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. As an immune suppressor it is used in nephrotic syndrome…

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01AA01 (WHO)
Bioavailability
>75% (by mouth)
CAS Number
50-18-0 Y
ChEBI
CHEBI:4027 Y

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Overview

Medical uses

Cancer

Contraindications

Side effects

Pharmacology

Mechanism of action

History

Society and culture

Research

  • EPA United States Environmental Protection Agency

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Map overview Semantic statistics

Cyclophosphamide

Nodes147
Edges146
Triples113
Avg. degree1.99
Density0.013605
Components1

How this topic connects Entity context

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Cyclophosphamide

Top relations

related to history · 12
Cyclophosphamide → As, ASTA, Baxter Oncology, Brock, Colvin, FDA, In, Norbert Brock, Once, The, They, This
related to Cancer · 9
Cyclophosphamide → AML, CMF-therapy, For, Hodgkin, Myeloproliferative, Other, Secondary, The, This
related to Mechanism of action · 7
Cyclophosphamide → ALDH, ALDHs, DNA, N-7, Phosphoramide, The, This
related to External links · 6
Cyclophosphamide → Archived, Drug Information Portal, Medicine, National Library, Novel, September
related to Pharmacology · 6
Cyclophosphamide → ALDH, It, Most, Oral, P450, The
related to Research · 6
Cyclophosphamide → Because, MCAN, Particularly, Rodents, The EPA, This
Legal status · 5
Cyclophosphamide → AU: S4 (Prescription only), CA: ℞-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
has effect · 5
Cyclophosphamide → Adverse, Cardiotoxicity, Other, Potential, Pulmonary
related to Autoimmune diseases · 4
Cyclophosphamide → Because, DMARDs, For, Goodpasture
related to Graft-versus-host disease · 4
Cyclophosphamide → Graft-versus-host, GVHD, T-cell, The

Important terminology Word statistics

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Important terminology

used cancer effects bladder mustard cell leukemia treatment side may drug dose use include acrolein infertility chemotherapy active metabolites cells

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Cyclophosphamide3D model (JSmol)Interactive image1.00infobox
CyclophosphamideAHFS/Drugs.comMonograph1.00infobox
CyclophosphamideATC codeL01AA01 (WHO)1.00infobox
CyclophosphamideBioavailability>75% (by mouth)1.00infobox
CyclophosphamideCAS Number50-18-0 Y1.00infobox
CyclophosphamideChEBICHEBI:4027 Y1.00infobox
CyclophosphamideChEMBLChEMBL88 Y1.00infobox
CyclophosphamideChemSpider2804 Y1.00infobox
CyclophosphamideCompTox Dashboard (EPA)DTXSID50203641.00infobox
CyclophosphamideDrugBankDB00531 Y1.00infobox
CyclophosphamideECHA InfoCard100.000.0151.00infobox
CyclophosphamideElimination half-life3–12 hours1.00infobox
CyclophosphamideExcretionKidney1.00infobox
CyclophosphamideFormulaC7H15Cl2N2O2P1.00infobox
CyclophosphamideKEGGD07760 Y1.00infobox
CyclophosphamideLegal statusAU: S4 (Prescription only)1.00infobox
CyclophosphamideLegal statusCA: ℞-only1.00infobox
CyclophosphamideLegal statusUK: POM (Prescription only)1.00infobox
CyclophosphamideLegal statusUS: ℞-only1.00infobox
CyclophosphamideLegal statusIn general: ℞ (Prescription only)1.00infobox
CyclophosphamideMedlinePlusa6820801.00infobox
CyclophosphamideMelting point2 °C (36 °F)1.00infobox
CyclophosphamideMetabolismLiver1.00infobox
CyclophosphamideMolar mass261.08 g·mol−11.00infobox
CyclophosphamidePregnancy categoryAU: D1.00infobox
CyclophosphamidePronunciation/ˌsaɪkloʊˈfɒsfəˌmaɪd, -lə-/1.00infobox
CyclophosphamideProtein binding>60%1.00infobox
CyclophosphamidePubChem CID29071.00infobox
CyclophosphamideRoutes of administrationBy mouth, by injection into a vein1.00infobox
CyclophosphamideTrade namesLyophilized Cytoxan, Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cycloblastin1.00infobox

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